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Protein

Forkhead box protein D4-like 3

Gene

FOXD4L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi108 – 202Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: GO_Central
  • cell differentiation Source: GO_Central
  • regulation of transcription by RNA polymerase II Source: GO_Central

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4-like 3
Short name:
FOXD4-like 3
Gene namesi
Name:FOXD4L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000187559.5
HGNCiHGNC:18523 FOXD4L3
MIMi611086 gene
neXtProtiNX_Q6VB84

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941846

Polymorphism and mutation databases

BioMutaiFOXD4L3
DMDMi317373356

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003019801 – 417Forkhead box protein D4-like 3Add BLAST417

Proteomic databases

PaxDbiQ6VB84
PeptideAtlasiQ6VB84
PRIDEiQ6VB84
ProteomicsDBi67723

Expressioni

Gene expression databases

BgeeiENSG00000187559 Expressed in 20 organ(s), highest expression level in right uterine tube

Organism-specific databases

HPAiHPA012836

Interactioni

Protein-protein interaction databases

IntActiQ6VB84, 17 interactors
STRINGi9606.ENSP00000341961

Structurei

3D structure databases

ProteinModelPortaliQ6VB84
SMRiQ6VB84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000231285
HOVERGENiHBG051641
InParanoidiQ6VB84
KOiK09397
OrthoDBiEOG091G0HW9
PhylomeDBiQ6VB84
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6VB84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF
60 70 80 90 100
LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS
110 120 130 140 150
EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP
160 170 180 190 200
AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR
210 220 230 240 250
RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PRPGPLLGAP APPQPVPGAY
260 270 280 290 300
PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS
310 320 330 340 350
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRICPRPRG
360 370 380 390 400
ATATCSSDHQ ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL
410
PPRARCWAGT CRPRRPC
Length:417
Mass (Da):45,820
Last modified:January 11, 2011 - v2
Checksum:i1FD6BD6801493FCE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9L → P in AAQ76880 (PubMed:15233989).Curated1
Sequence conflicti47S → R in AAQ76880 (PubMed:15233989).Curated1
Sequence conflicti289A → D in AAQ76880 (PubMed:15233989).Curated1
Sequence conflicti344I → V in AAQ76880 (PubMed:15233989).Curated1
Sequence conflicti366R → K in AAQ76880 (PubMed:15233989).Curated1
Sequence conflicti416P → R in AAQ76880 (PubMed:15233989).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344642 mRNA Translation: AAQ76880.1
AL353608 Genomic DNA No translation available.
CCDSiCCDS43833.1
RefSeqiNP_954586.4, NM_199135.4
UniGeneiHs.449471

Genome annotation databases

EnsembliENST00000342833; ENSP00000341961; ENSG00000187559
GeneIDi286380
KEGGihsa:286380
UCSCiuc004agm.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344642 mRNA Translation: AAQ76880.1
AL353608 Genomic DNA No translation available.
CCDSiCCDS43833.1
RefSeqiNP_954586.4, NM_199135.4
UniGeneiHs.449471

3D structure databases

ProteinModelPortaliQ6VB84
SMRiQ6VB84
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6VB84, 17 interactors
STRINGi9606.ENSP00000341961

Polymorphism and mutation databases

BioMutaiFOXD4L3
DMDMi317373356

Proteomic databases

PaxDbiQ6VB84
PeptideAtlasiQ6VB84
PRIDEiQ6VB84
ProteomicsDBi67723

Protocols and materials databases

DNASUi286380
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342833; ENSP00000341961; ENSG00000187559
GeneIDi286380
KEGGihsa:286380
UCSCiuc004agm.2 human

Organism-specific databases

CTDi286380
EuPathDBiHostDB:ENSG00000187559.5
GeneCardsiFOXD4L3
HGNCiHGNC:18523 FOXD4L3
HPAiHPA012836
MIMi611086 gene
neXtProtiNX_Q6VB84
PharmGKBiPA134941846
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000231285
HOVERGENiHBG051641
InParanoidiQ6VB84
KOiK09397
OrthoDBiEOG091G0HW9
PhylomeDBiQ6VB84
TreeFamiTF316127

Miscellaneous databases

GenomeRNAii286380
PROiPR:Q6VB84
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187559 Expressed in 20 organ(s), highest expression level in right uterine tube

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFX4L3_HUMAN
AccessioniPrimary (citable) accession number: Q6VB84
Secondary accession number(s): Q5JTX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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