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UniProtKB - Q6VB84 (FX4L3_HUMAN)
Protein
Forkhead box protein D4-like 3
Gene
FOXD4L3
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 108 – 202 | Fork-headPROSITE-ProRule annotationAdd BLAST | 95 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- cell differentiation Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q6VB84 |
SignaLinki | Q6VB84 |
Names & Taxonomyi
Protein namesi | Recommended name: Forkhead box protein D4-like 3Short name: FOXD4-like 3 |
Gene namesi | Name:FOXD4L3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18523, FOXD4L3 |
MIMi | 611086, gene |
neXtProti | NX_Q6VB84 |
VEuPathDBi | HostDB:ENSG00000187559 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 286380 |
PharmGKBi | PA134941846 |
Miscellaneous databases
Pharosi | Q6VB84, Tdark |
Genetic variation databases
BioMutai | FOXD4L3 |
DMDMi | 317373356 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000301980 | 1 – 417 | Forkhead box protein D4-like 3Add BLAST | 417 |
Proteomic databases
MassIVEi | Q6VB84 |
PaxDbi | Q6VB84 |
PeptideAtlasi | Q6VB84 |
PRIDEi | Q6VB84 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187559, Expressed in right uterine tube and 27 other tissues |
Organism-specific databases
HPAi | ENSG00000187559, Tissue enhanced (brain) |
Interactioni
Binary interactionsi
Q6VB84
Protein-protein interaction databases
BioGRIDi | 130365, 16 interactors |
IntActi | Q6VB84, 16 interactors |
STRINGi | 9606.ENSP00000341961 |
Miscellaneous databases
RNActi | Q6VB84, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 50 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 70 – 105 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 11 – 25 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 26 – 47 | Acidic residuesSequence analysisAdd BLAST | 22 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000163353 |
HOGENOMi | CLU_040357_3_1_1 |
InParanoidi | Q6VB84 |
OrthoDBi | 1270467at2759 |
PhylomeDBi | Q6VB84 |
TreeFami | TF316127 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6VB84-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF
60 70 80 90 100
LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS
110 120 130 140 150
EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP
160 170 180 190 200
AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR
210 220 230 240 250
RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PRPGPLLGAP APPQPVPGAY
260 270 280 290 300
PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS
310 320 330 340 350
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRICPRPRG
360 370 380 390 400
ATATCSSDHQ ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL
410
PPRARCWAGT CRPRRPC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 | L → P in AAQ76880 (PubMed:15233989).Curated | 1 | |
Sequence conflicti | 47 | S → R in AAQ76880 (PubMed:15233989).Curated | 1 | |
Sequence conflicti | 289 | A → D in AAQ76880 (PubMed:15233989).Curated | 1 | |
Sequence conflicti | 344 | I → V in AAQ76880 (PubMed:15233989).Curated | 1 | |
Sequence conflicti | 366 | R → K in AAQ76880 (PubMed:15233989).Curated | 1 | |
Sequence conflicti | 416 | P → R in AAQ76880 (PubMed:15233989).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY344642 mRNA Translation: AAQ76880.1 AL353608 Genomic DNA No translation available. |
CCDSi | CCDS43833.1 |
RefSeqi | NP_954586.4, NM_199135.4 |
Genome annotation databases
Ensembli | ENST00000342833; ENSP00000341961; ENSG00000187559 |
GeneIDi | 286380 |
KEGGi | hsa:286380 |
MANE-Selecti | ENST00000342833.4; ENSP00000341961.2; NM_199135.4; NP_954586.4 |
UCSCi | uc004agm.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY344642 mRNA Translation: AAQ76880.1 AL353608 Genomic DNA No translation available. |
CCDSi | CCDS43833.1 |
RefSeqi | NP_954586.4, NM_199135.4 |
3D structure databases
SMRi | Q6VB84 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130365, 16 interactors |
IntActi | Q6VB84, 16 interactors |
STRINGi | 9606.ENSP00000341961 |
Genetic variation databases
BioMutai | FOXD4L3 |
DMDMi | 317373356 |
Proteomic databases
MassIVEi | Q6VB84 |
PaxDbi | Q6VB84 |
PeptideAtlasi | Q6VB84 |
PRIDEi | Q6VB84 |
Protocols and materials databases
Antibodypediai | 43289, 10 antibodies from 4 providers |
DNASUi | 286380 |
Genome annotation databases
Ensembli | ENST00000342833; ENSP00000341961; ENSG00000187559 |
GeneIDi | 286380 |
KEGGi | hsa:286380 |
MANE-Selecti | ENST00000342833.4; ENSP00000341961.2; NM_199135.4; NP_954586.4 |
UCSCi | uc004agm.2, human |
Organism-specific databases
CTDi | 286380 |
DisGeNETi | 286380 |
GeneCardsi | FOXD4L3 |
HGNCi | HGNC:18523, FOXD4L3 |
HPAi | ENSG00000187559, Tissue enhanced (brain) |
MIMi | 611086, gene |
neXtProti | NX_Q6VB84 |
PharmGKBi | PA134941846 |
VEuPathDBi | HostDB:ENSG00000187559 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000163353 |
HOGENOMi | CLU_040357_3_1_1 |
InParanoidi | Q6VB84 |
OrthoDBi | 1270467at2759 |
PhylomeDBi | Q6VB84 |
TreeFami | TF316127 |
Enzyme and pathway databases
PathwayCommonsi | Q6VB84 |
SignaLinki | Q6VB84 |
Miscellaneous databases
BioGRID-ORCSi | 286380, 23 hits in 226 CRISPR screens |
GenomeRNAii | 286380 |
Pharosi | Q6VB84, Tdark |
PROi | PR:Q6VB84 |
RNActi | Q6VB84, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187559, Expressed in right uterine tube and 27 other tissues |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FX4L3_HUMAN | |
Accessioni | Q6VB84Primary (citable) accession number: Q6VB84 Secondary accession number(s): Q5JTX9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 23, 2022 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot