UniProtKB - Q6VAB6 (KSR2_HUMAN)

BLAST

>sp|Q6VAB6|KSR2_HUMAN Kinase suppressor of Ras 2 OS=Homo sapiens OX=9606 GN=KSR2 PE=1 SV=2
MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE
SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD
IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE
NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK
GILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL
SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMG
KEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL

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History
Entry version 126 (12 Sep 2018)
Sequence version 2 (29 May 2007)
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Protein

Kinase suppressor of Ras 2

Gene

KSR2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.3 Publications

Caution

KSR2 binds ATP and has very low in vitro protein kinase activity; the physiological relevance of this activity is unknown. KSR2 is proposed to be in an inactive conformation by itself or in complex with MAP2K1. Interaction with BRAF is proposed to induce a conformation change that increases the low intrinsic kinase activity (PubMed:21441910).1 Publication

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.1 Publication

Activity regulationⁱ

Kinase activity is inhibited by ASC24.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	413	Zinc 1By similarity	1
Metal bindingⁱ	425	Zinc 2By similarity	1
Metal bindingⁱ	428	Zinc 2By similarity	1
Metal bindingⁱ	438	Zinc 1By similarity	1
Metal bindingⁱ	441	Zinc 1By similarity	1
Metal bindingⁱ	446	Zinc 2By similarity	1
Metal bindingⁱ	449	Zinc 2By similarity	1
Metal bindingⁱ	456	Zinc 1By similarity	1
Active siteⁱ	786	Proton donor/acceptor1 Publication	1
Binding siteⁱ	788	ATP1 Publication	1
Binding siteⁱ	803	ATP1 Publication	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	412 – 456	Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST		45
Nucleotide bindingⁱ	672 – 680	ATPPROSITE-ProRule annotation1 Publication		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
protein kinase activity Source: GO_Central
protein serine/threonine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-mediated signaling Source: GO_Central
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 28180061
positive regulation of MAPK cascade Source: GO_Central
protein phosphorylation Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAⁱ	2.7.11.25 2681
Reactomeⁱ	R-HSA-5674135 MAP2K and MAPK activation R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802948 Signaling by high-kinase activity BRAF mutants R-HSA-6802949 Signaling by RAS mutants R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
SignaLinkⁱ	Q6VAB6
SIGNORⁱ	Q6VAB6

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kinase suppressor of Ras 2 (EC:2.7.11.1) Short name: hKSR2
Gene namesⁱ	Name:KSR2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171435.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18610 KSR2
MIMⁱ	610737 gene
neXtProtⁱ	NX_Q6VAB6

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	718	R → H: Impairs formation of heterotetramers with MAP2K1, but not the formation of heterodimers. 1 Publication	1
Mutagenesisⁱ	786	D → A: Loss of kinase activity. 1 Publication	1
Mutagenesisⁱ	879	A → L: Impairs MAP2K1 binding. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	283455
Open Targets More...OpenTargetsⁱ	ENSG00000171435
PharmGKBⁱ	PA134914125

Chemistry databases

ChEMBLⁱ	CHEMBL3627583

ChEMBLⁱ

CHEMBL3627583

Polymorphism and mutation databases

BioMutaⁱ	KSR2
DMDMⁱ	148886599

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086231	1 – 950	Kinase suppressor of Ras 2Add BLAST		950

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	272	PhosphothreonineBy similarity	1
Modified residueⁱ	276	PhosphothreonineBy similarity	1
Modified residueⁱ	474	Phosphoserine; by MARK3By similarity	1
Modified residueⁱ	497	PhosphothreonineBy similarity	1

Post-translational modificationⁱ

Phosphorylated on Ser-474 by MARK3.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q6VAB6
PeptideAtlas More...PeptideAtlasⁱ	Q6VAB6
PRIDEⁱ	Q6VAB6
ProteomicsDBⁱ	67721 67722 [Q6VAB6-2]

PTM databases

iPTMnetⁱ	Q6VAB6
PhosphoSitePlusⁱ	Q6VAB6

Expressionⁱ

Tissue specificityⁱ

Mainly expressed in brain and kidney.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000171435 Expressed in 86 organ(s), highest expression level in Brodmann (1909) area 23
CleanExⁱ	HS_KSR2
ExpressionAtlasⁱ	Q6VAB6 baseline and differential
Genevisibleⁱ	Q6VAB6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035536

HPAⁱ

HPA035536

Interactionⁱ

Subunit structureⁱ

Interacts with MAP2K1, forming a heterodimer that can dimerize to form a heterotetramer. Interacts with MAP3K8, MAPK, RAS and RAF. Interacts with BRAF; this increases the low intrinsic protein kinase activity of KSR2.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CDC37	Q16543	6	EBI-6424389,EBI-295634
FKBP5	Q13451	6	EBI-6424389,EBI-306914
HSP90AA1	P07900	5	EBI-6424389,EBI-296047
MAP2K1	P29678	6	EBI-15916808,EBI-1631983	From Oryctolagus cuniculus.

Protein-protein interaction databases

BioGridⁱ	129567, 5 interactors
Database of interacting proteins More...DIPⁱ	DIP-59195N
IntActⁱ	Q6VAB6, 133 interactors
Molecular INTeraction database More...MINTⁱ	Q6VAB6
STRINGⁱ	9606.ENSP00000339952

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	656 – 658	Combined sources	3
Beta strandⁱ	659 – 661	Combined sources	3
Beta strandⁱ	675 – 693	Combined sources	19
Turnⁱ	704 – 710	Combined sources	7
Helixⁱ	711 – 714	Combined sources	4
Beta strandⁱ	727 – 730	Combined sources	4
Beta strandⁱ	735 – 738	Combined sources	4
Beta strandⁱ	744 – 746	Combined sources	3
Helixⁱ	747 – 750	Combined sources	4
Helixⁱ	761 – 779	Combined sources	19
Beta strandⁱ	792 – 794	Combined sources	3
Helixⁱ	827 – 830	Combined sources	4
Helixⁱ	834 – 837	Combined sources	4
Helixⁱ	853 – 869	Combined sources	17
Beta strandⁱ	873 – 876	Combined sources	4
Helixⁱ	879 – 887	Combined sources	9
Helixⁱ	903 – 911	Combined sources	9
Turnⁱ	915 – 917	Combined sources	3
Helixⁱ	921 – 928	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	Q6VAB6
SMRⁱ	Q6VAB6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	666 – 931	Protein kinasePROSITE-ProRule annotationAdd BLAST		266

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	181 – 293	Pro-richAdd BLAST		113
Compositional biasⁱ	510 – 550	Pro-richAdd BLAST		41

Domainⁱ

The protein kinase domain is predicted to be catalytically inactive and seems to have very low intrinsic kinase activity. This low kinase activity can be increased by interaction with BRAF.

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	412 – 456	Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST		45

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0193 Eukaryota ENOG410Y4UP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140880
HOGENOMⁱ	HOG000113263
HOVERGENⁱ	HBG052293
InParanoidⁱ	Q6VAB6
KEGG Orthology (KO) More...KOⁱ	K18529
OMAⁱ	HWDSWDR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02ZN
PhylomeDBⁱ	Q6VAB6
TreeFamⁱ	TF317006

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00029 C1, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR025561 KSR_SAM-like_dom IPR002219 PE/DAG-bd IPR000719 Prot_kinase_dom IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13543 KSR1-SAM, 1 hit PF07714 Pkinase_Tyr, 1 hit
SMARTⁱ	View protein in SMART SM00109 C1, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit PS00479 ZF_DAG_PE_1, 1 hit PS50081 ZF_DAG_PE_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q6VAB6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MDEENMTKSE EQQPLSLQKA LQQCELVQNM IDLSISNLEG LRTKCATSND 
        60         70         80         90        100
LTQKEIRTLE SKLVKYFSRQ LSCKKKVALQ ERNAELDGFP QLRHWFRIVD 
       110        120        130        140        150
VRKEVLEEIS PGQLSLEDLL EMTDEQVCET VEKYGANREE CARLNASLSC 
       160        170        180        190        200
LRNVHMSGGN LSKQDWTIQW PTTETGKENN PVCPPEPTPW IRTHLSQSPR 
       210        220        230        240        250
VPSKCVQHYC HTSPTPGAPV YTHVDRLTVD AYPGLCPPPP LESGHRSLPP 
       260        270        280        290        300
SPRQRHAVRT PPRTPNIVTT VTPPGTPPMR KKNKLKPPGT PPPSSRKLIH 
       310        320        330        340        350
LIPGFTALHR SKSHEFQLGH RVDEAHTPKA KKKSKPLNLK IHSSVGSCEN 
       360        370        380        390        400
IPSQQRSPLL SERSLRSFFV GHAPFLPSTP PVHTEANFSA NTLSVPRWSP 
       410        420        430        440        450
QIPRRDLGNS IKHRFSTKYW MSQTCTVCGK GMLFGLKCKN CKLKCHNKCT 
       460        470        480        490        500
KEAPPCHLLI IHRGDPARLV RTESVPCDIN NPLRKPPRYS DLHISQTLPK 
       510        520        530        540        550
TNKINKDHIP VPYQPDSSSN PSSTTSSTPS SPAPPLPPSA TPPSPLHPSP 
       560        570        580        590        600
QCTRQQKNFN LPASHYYKYK QQFIFPDVVP VPETPTRAPQ VILHPVTSNP 
       610        620        630        640        650
ILEGNPLLQI EVEPTSENEE VHDEAEESED DFEEMNLSLL SARSFPRKAS 
       660        670        680        690        700
QTSIFLQEWD IPFEQLEIGE LIGKGRFGQV YHGRWHGEVA IRLIDIERDN 
       710        720        730        740        750
EDQLKAFKRE VMAYRQTRHE NVVLFMGACM SPPHLAIITS LCKGRTLYSV 
       760        770        780        790        800
VRDAKIVLDV NKTRQIAQEI VKGMGYLHAK GILHKDLKSK NVFYDNGKVV 
       810        820        830        840        850
ITDFGLFSIS GVLQAGRRED KLRIQNGWLC HLAPEIIRQL SPDTEEDKLP 
       860        870        880        890        900
FSKHSDVFAL GTIWYELHAR EWPFKTQPAE AIIWQMGTGM KPNLSQIGMG 
       910        920        930        940        950
KEISDILLFC WAFEQEERPT FTKLMDMLEK LPKRNRRLSH PGHFWKSAEL

Length:950

Mass (Da):107,632

Last modified:May 29, 2007 - v2

Checksum:ⁱDFBC20F4E71077AD

Isoform 2 (identifier: Q6VAB6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-303: Missing.
     304-329: GFTALHRSKSHEFQLGHRVDEAHTPK → MYNKKAKMEPNASESAIPARRQRQPR
     740-742: SLC → RPV
     743-950: Missing.

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        10         20         30         40         50
MYNKKAKMEP NASESAIPAR RQRQPRAKKK SKPLNLKIHS SVGSCENIPS 
        60         70         80         90        100
QQRSPLLSER SLRSFFVGHA PFLPSTPPVH TEANFSANTL SVPRWSPQIP 
       110        120        130        140        150
RRDLGNSIKH RFSTKYWMSQ TCTVCGKGML FGLKCKNCKL KCHNKCTKEA 
       160        170        180        190        200
PPCHLLIIHR GDPARLVRTE SVPCDINNPL RKPPRYSDLH ISQTLPKTNK 
       210        220        230        240        250
INKDHIPVPY QPDSSSNPSS TTSSTPSSPA PPLPPSATPP SPLHPSPQCT 
       260        270        280        290        300
RQQKNFNLPA SHYYKYKQQF IFPDVVPVPE TPTRAPQVIL HPVTSNPILE 
       310        320        330        340        350
GNPLLQIEVE PTSENEEVHD EAEESEDDFE EMNLSLLSAR SFPRKASQTS 
       360        370        380        390        400
IFLQEWDIPF EQLEIGELIG KGRFGQVYHG RWHGEVAIRL IDIERDNEDQ 
       410        420        430 
LKAFKREVMA YRQTRHENVV LFMGACMSPP HLAIITRPV

Show »

Length:439

Mass (Da):49,607

Checksum:ⁱA5D6F1DEAFDA51FC

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E9PB13	E9PB13_HUMAN		Kinase suppressor of Ras 2 Kinase suppressor of Ras 2	KSR2	921	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_040659	676	R → S in a lung adenocarcinoma sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_012234	1 – 303	Missing in isoform 2. 1 PublicationAdd BLAST	303
Alternative sequenceⁱVSP_012235	304 – 329	GFTAL…AHTPK → MYNKKAKMEPNASESAIPAR RQRQPR in isoform 2. 1 PublicationAdd BLAST	26
Alternative sequenceⁱVSP_012236	740 – 742	SLC → RPV in isoform 2. 1 Publication	3
Alternative sequenceⁱVSP_012237	743 – 950	Missing in isoform 2. 1 PublicationAdd BLAST	208

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK098831 mRNA Translation: BAC05426.1 AC073864 Genomic DNA No translation available. AC079127 Genomic DNA No translation available. AC084291 Genomic DNA No translation available. AC092936 Genomic DNA No translation available. AY345972 mRNA Translation: AAQ24226.1 BC107106 mRNA Translation: AAI07107.1 BC107107 mRNA Translation: AAI07108.1 BC127603 mRNA Translation: AAI27604.1
NCBI Reference Sequences More...RefSeqⁱ	NP_775869.3, NM_173598.4 XP_011536527.1, XM_011538225.2
UniGeneⁱ	Hs.375836

Genome annotation databases

Ensemblⁱ	ENST00000339824; ENSP00000339952; ENSG00000171435 [Q6VAB6-1]
GeneIDⁱ	283455
KEGGⁱ	hsa:283455
UCSC genome browser More...UCSCⁱ	uc058tua.1 human [Q6VAB6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6VAB6	KSR2 isoform 1		PANTR		950	UniRef100_Q6VAB6
Uncharacterized protein		PANPA		950
Kinase suppressor of Ras 2		HUMAN		921
KSR2 isoform 3		PANTR		921
UPI0002746ECB		PANPA		949
+1

Protein	Similar proteins		Species	Score	Length	Source
Q6VAB6	Kinase suppressor of Ras 2		MOUSE		959	UniRef90_Q6VAB6
KSR2 isoform 1		PANTR		950
Uncharacterized protein		PANPA		950
Kinase suppressor of Ras 2		HUMAN		921
Uncharacterized protein		ICTTR		1058
+173

Protein	Similar proteins		Species	Score	Length	Source
Q6VAB6	Kinase suppressor of Ras 2		MOUSE		959	UniRef50_Q6VAB6
KSR2 isoform 1		PANTR		950
Uncharacterized protein		PANPA		950
Kinase suppressor of Ras 2		HUMAN		921
Uncharacterized protein		ICTTR		1058
+263
Q6VAB6-2	Kinase suppressor of Ras 2 (Fragment)		NESNO		457	UniRef50_Q6VAB6-2
UPI000C2A4F2B		Ugandan red Colobus		444
UPI000496D65D		bicolor damselfish		430
UPI000528A6E6		Buceros rhinoceros silvestris		407
UPI000523C91E		NESNO		508

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK098831 mRNA Translation: BAC05426.1 AC073864 Genomic DNA No translation available. AC079127 Genomic DNA No translation available. AC084291 Genomic DNA No translation available. AC092936 Genomic DNA No translation available. AY345972 mRNA Translation: AAQ24226.1 BC107106 mRNA Translation: AAI07107.1 BC107107 mRNA Translation: AAI07108.1 BC127603 mRNA Translation: AAI27604.1
RefSeqⁱ	NP_775869.3, NM_173598.4 XP_011536527.1, XM_011538225.2
UniGeneⁱ	Hs.375836

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2Y4I	X-ray	3.46	B	634-950	[»]
	5KKR	X-ray	3.51	B	634-950	[»]
ProteinModelPortalⁱ	Q6VAB6
SMRⁱ	Q6VAB6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129567, 5 interactors
DIPⁱ	DIP-59195N
IntActⁱ	Q6VAB6, 133 interactors
MINTⁱ	Q6VAB6
STRINGⁱ	9606.ENSP00000339952

Chemistry databases

ChEMBLⁱ	CHEMBL3627583

ChEMBLⁱ

CHEMBL3627583

PTM databases

iPTMnetⁱ	Q6VAB6
PhosphoSitePlusⁱ	Q6VAB6

Polymorphism and mutation databases

BioMutaⁱ	KSR2
DMDMⁱ	148886599

Proteomic databases

PaxDbⁱ	Q6VAB6
PeptideAtlasⁱ	Q6VAB6
PRIDEⁱ	Q6VAB6
ProteomicsDBⁱ	67721 67722 [Q6VAB6-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000339824; ENSP00000339952; ENSG00000171435 [Q6VAB6-1]
GeneIDⁱ	283455
KEGGⁱ	hsa:283455
UCSCⁱ	uc058tua.1 human [Q6VAB6-1]

Organism-specific databases

CTDⁱ	283455
DisGeNETⁱ	283455
EuPathDBⁱ	HostDB:ENSG00000171435.13
GeneCardsⁱ	KSR2
H-InvDBⁱ	HIX0018992
HGNCⁱ	HGNC:18610 KSR2
HPAⁱ	HPA035536
MIMⁱ	610737 gene
neXtProtⁱ	NX_Q6VAB6
OpenTargetsⁱ	ENSG00000171435
PharmGKBⁱ	PA134914125
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0193 Eukaryota ENOG410Y4UP LUCA
GeneTreeⁱ	ENSGT00900000140880
HOGENOMⁱ	HOG000113263
HOVERGENⁱ	HBG052293
InParanoidⁱ	Q6VAB6
KOⁱ	K18529
OMAⁱ	HWDSWDR
OrthoDBⁱ	EOG091G02ZN
PhylomeDBⁱ	Q6VAB6
TreeFamⁱ	TF317006

Enzyme and pathway databases

BRENDAⁱ	2.7.11.25 2681
Reactomeⁱ	R-HSA-5674135 MAP2K and MAPK activation R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802948 Signaling by high-kinase activity BRAF mutants R-HSA-6802949 Signaling by RAS mutants R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
SignaLinkⁱ	Q6VAB6
SIGNORⁱ	Q6VAB6

Miscellaneous databases

ChiTaRSⁱ	KSR2 human
GenomeRNAiⁱ	283455
Protein Ontology More...PROⁱ	PR:Q6VAB6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171435 Expressed in 86 organ(s), highest expression level in Brodmann (1909) area 23
CleanExⁱ	HS_KSR2
ExpressionAtlasⁱ	Q6VAB6 baseline and differential
Genevisibleⁱ	Q6VAB6 HS

Family and domain databases

CDDⁱ	cd00029 C1, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR025561 KSR_SAM-like_dom IPR002219 PE/DAG-bd IPR000719 Prot_kinase_dom IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF13543 KSR1-SAM, 1 hit PF07714 Pkinase_Tyr, 1 hit
SMARTⁱ	View protein in SMART SM00109 C1, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit PS00479 ZF_DAG_PE_1, 1 hit PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KSR2_HUMAN
Accessionⁱ	Q6VAB6Primary (citable) accession number: Q6VAB6 Secondary accession number(s): A0PJT2, Q3B828, Q8N775
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
	Last sequence update:	May 29, 2007
	Last modified:	September 12, 2018
	This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q6VAB6 (KSR2_HUMAN)

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Kinase suppressor of Ras 2

KSR2

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

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Sequence similaritiesⁱ

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Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

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