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Entry version 138 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Protein sidekick-2

Gene

Sdk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion (PubMed:26287463). Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion (PubMed:26287463). Promotes synaptic connectivity via homophilic interactions (PubMed:26287463).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-373756, SDK interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein sidekick-21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sdk21 PublicationImported
Synonyms:Kiaa15141 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443847, Sdk2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 1936ExtracellularSequence analysisAdd BLAST1912
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1937 – 1957HelicalSequence analysisAdd BLAST21
Topological domaini1958 – 2176CytoplasmicSequence analysisAdd BLAST219

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and fertile but show decreased synaptic connectivity between the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2174 – 2176Missing : Abolishes localization to synapses and induces diffuse expression in photoreceptor cells. 1 Publication3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022697925 – 2176Protein sidekick-2Add BLAST2152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi52 ↔ 95PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi241 ↔ 288PROSITE-ProRule annotation
Disulfide bondi334 ↔ 384PROSITE-ProRule annotation
Disulfide bondi427 ↔ 479PROSITE-ProRule annotation
Disulfide bondi521 ↔ 573PROSITE-ProRule annotation
Glycosylationi747N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi940N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi952N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1592N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6V4S5

PeptideAtlas

More...
PeptideAtlasi
Q6V4S5

PRoteomics IDEntifications database

More...
PRIDEi
Q6V4S5

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2645, 4 N-Linked glycans (10 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6V4S5, 14 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6V4S5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6V4S5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in retinal ganglion cells (RGCs) that form synapses in distinct inner plexiform layer (IPL) sublaminae. Specifically expressed in specific subsets of retinal ganglion cells (RGCs), named W3B-RGCs, that specifically respond when the timing of the movement of a small object differs from that of the background, but not when they coincide (at protein level). Also present in excitatory amacrine cell type called VG3-ACs, that provide strong and selective input W3B-RGCs (at protein level) (PubMed:26287463). Expressed at low levels in the glomeruli (PubMed:15213259).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in many fetal tissues, inlcuding kidney but shows markedly lower expression in adult organs. Expression in kidney is high throughout development with maximal expression occurring near birth.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000041592, Expressed in camera-type eye and 215 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6V4S5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6V4S5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; mediates homophilic interactions to promote cell adhesion (PubMed:15703275, PubMed:26287463).

Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4 (PubMed:20219992).

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
231935, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000038972

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6V4S5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6V4S5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 112Ig-like C2-type 1Add BLAST83
Domaini117 – 204Ig-like C2-type 2Add BLAST88
Domaini219 – 298Ig-like C2-type 3Add BLAST80
Domaini312 – 402Ig-like C2-type 4Add BLAST91
Domaini406 – 495Ig-like C2-type 5Add BLAST90
Domaini500 – 589Ig-like C2-type 6Add BLAST90
Domaini596 – 692Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST97
Domaini697 – 793Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini798 – 897Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST100
Domaini901 – 995Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95
Domaini999 – 1098Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST100
Domaini1103 – 1201Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST99
Domaini1206 – 1303Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST98
Domaini1307 – 1401Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini1406 – 1503Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST98
Domaini1508 – 1625Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST118
Domaini1630 – 1726Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST97
Domaini1730 – 1825Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST96
Domaini1828 – 1930Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST103

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2170 – 2176PDZ-binding1 Publication7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

the PDZ-binding motif mediates interaction with PDZ domain-containing proteins MAGI1, MAGI2, DLG2, DLG3 and DLG4 and is required for is required for synaptic localization in photoreceptors.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sidekick family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3510, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155761

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001875_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6V4S5

KEGG Orthology (KO)

More...
KOi
K16353

Database of Orthologous Groups

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OrthoDBi
134749at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6V4S5

TreeFam database of animal gene trees

More...
TreeFami
TF316846

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 13 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 19 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 13 hits
PF07679, I-set, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 13 hits
SM00409, IG, 6 hits
SM00408, IGc2, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 5 hits
SSF49265, SSF49265, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 13 hits
PS50835, IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6V4S5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSSMWRLPL WTLLALHRIH SAGAQDDVPP YFKTEPVRTQ VHLEGNRLVL
60 70 80 90 100
TCMAEGSWPL EFKWLHNNRE LTRFSLEYRY MITSLDRTHA GFYRCIVRNR
110 120 130 140 150
MGALLQRQTE VQVAYMGSFE EGEKRQSVNH GEAAVIRAPR ISSFPRPQVT
160 170 180 190 200
WFRDGRKIPP SSRIAITLEN TLVILSTVAP DAGRYYVQAV NDKNGDNKTS
210 220 230 240 250
QPITLAVENV GGPADPIAPT IIIPPKNTSV VAGTSEVTME CVANARPLIK
260 270 280 290 300
LHIVWKKDGA PLSSGISDYN RRLTIANPTV SDAGYYECEA MLRSSSVAPV
310 320 330 340 350
TRGAYLSVLE PPQFVREPER HITAEMEKVV DIPCRAKGVP PPSITWYKDA
360 370 380 390 400
ALVEVGKLTR FKQRSDGGLQ ISGLLPDDTG MLQCFAHNAA GEAQTSTYLA
410 420 430 440 450
VTSIAPNITR GPLDSTVIDG MSVVLACETS GAPRPAITWQ KGERILASGS
460 470 480 490 500
VQLPRFTLLE SGSLLISPTH ISDAGTYTCL ATNSRGVDEA SADLVVWART
510 520 530 540 550
RITKPPQDQS VIKGTQASMV CGVTHDPRVT VRYVWEKDGA TLAVETNPRI
560 570 580 590 600
RLDRNGSLHI SQTWSGDIGT YTCRVLSAGG NDSRNAHLRV RQLPHAPEHP
610 620 630 640 650
VATLSTVERR AINLTWAKPF DGNSPLMRYV LEMSENNAPW TILLASVDPE
660 670 680 690 700
ATSVMVKGLV PARSYQFRLC AVNDVGKGQF SKDTERVSLP EEPPTAPPQN
710 720 730 740 750
VIASGRTNQS IMIQWQPPPE SHQNGILKGY IIRYCLAGLP VGYQFKNITD
760 770 780 790 800
ADVNNLLLED LIIWTNYEIE VAAYNSAGLG VYSSKVTEWT LQGVPTVPPG
810 820 830 840 850
NVHAEATNST TIRFTWNAPS PQFINGINQG YKLIAWEPAQ EEEVTMVTAR
860 870 880 890 900
PNFQDSIHVG FVSGLKKFTE YFTSVLCFTT PGDGPRSSPQ LVRTHEDVPG
910 920 930 940 950
PVGHLSFNDI LDTSLKVSWQ EPGEKNGILT GYRISWEEYN RTNTRVTHYL
960 970 980 990 1000
PNVTLEYRVT GLTALTTYTI EVAAMTSKGQ GQVSASTISS GVPPELPGAP
1010 1020 1030 1040 1050
TNLGISNIGP RSVTLQFRPG YDGKTSISRW VVEAQVGVIG EGEEWLLIYQ
1060 1070 1080 1090 1100
LGNEPDARSM EVPDLNPFTY YSFRMRQVNI VGTSPPSQPS RKIQTLQAPP
1110 1120 1130 1140 1150
DIAPANVTLR TASETSLWLR WMPLPEMEYN GNPESVGYKI KYGRSDGHGK
1160 1170 1180 1190 1200
TLSHTVQDRV EREYTIEDLE EWTEYRVQVQ AFNAIGSGPW SQAVVGRTRE
1210 1220 1230 1240 1250
SVPSSGPTNV SALATTSSSM LVRWSEIPEA DRNGLVLGYK VRYKEKDSDS
1260 1270 1280 1290 1300
QPRFWLVEGN SSRSAQLTGL GKYVLYEVQV LAFTRIGDGS PSHPPILERT
1310 1320 1330 1340 1350
LDDVPGPPMG ILFPEVRTTS VRLIWQPPAA PNGIILAYQI THRLNATTAN
1360 1370 1380 1390 1400
TATVEVLAPS ARQYMATGLK PESVYLFRIT AQTRKGWGEA AEALVVTTEK
1410 1420 1430 1440 1450
RDRPQPPSKP VVQQEDVKAR SVLLSWEPGS DGLSPVRYYT IQTRELPSGR
1460 1470 1480 1490 1500
WALHSASVSH NASAFTVDRL KPFTSYKFRV KATNDIGDSE FSEESESLTT
1510 1520 1530 1540 1550
LQAAPDEAPT ILSVTPHTTT SVLIRWQPPS EDKINGILLG FRIRYRELLY
1560 1570 1580 1590 1600
DGLRGFTLRG INNPGAKWAE LTSLYSMRNL TRPSLTQYEL DNLSKHRRYE
1610 1620 1630 1640 1650
IRMSIYNAVG EGPLSPPQEV FVGEAVPTAA PQNVAIHSAT ATQLDVTWEP
1660 1670 1680 1690 1700
PPLDNQNGDI QGYKIYFWEV QRRNLTERVK TLFLAENSVK LKNLTGYTAY
1710 1720 1730 1740 1750
MVSVAAFNAA GDGPRSTPTR GQTQQAAPSA PGSVKFSELT TTSVNVSWDA
1760 1770 1780 1790 1800
PQFPNGPLEG YRLVYEPCTP VDGVSKIVTV DVKGNSPLWL KVKDLAEGMT
1810 1820 1830 1840 1850
YRFRIKAKTF TYGPEIEANI TTGPGEGAPG PPGVPIIVRY SSAIAIHWSS
1860 1870 1880 1890 1900
GDPGKGPITR YVIEARPSDE GLWDILIKDI PKEVTSYTFS MDILKPGVSY
1910 1920 1930 1940 1950
DFRVIAVNDY GFGTPSSPSQ SVPAQKASPF YEEWWFLVVI ALVGLIFILL
1960 1970 1980 1990 2000
LVFVLIIRGQ SKKYSKKTDS GGNTKSGALG HGEMLSLDES SFPALELNNR
2010 2020 2030 2040 2050
RLSVKNSFCR KNGLYTRSPP RPSPGSLHYS DEDVTKYNDL IPAESSSLTE
2060 2070 2080 2090 2100
KPSEISDSQG SDSEYEVDTN TQKAHSFVNH YISDPTYYNS WRRQQKGISR
2110 2120 2130 2140 2150
AQAYSYTESD SGEPDHVTVP NSNSTQQGSL FRPKASRTPT PQNPPNPQSQ
2160 2170
QSTLYRPPSS LAPGSRAPIA GFSSFV
Length:2,176
Mass (Da):239,902
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCAF12063E0A6EAD3
GO
Isoform 2 (identifier: Q6V4S5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1602: Missing.

Show »
Length:574
Mass (Da):62,688
Checksum:iE1361FB34886BAAE
GO
Isoform 3 (identifier: Q6V4S5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-542: VWEKDGATL → SMQSGKGRL
     543-2176: Missing.

Note: Due to intron retention.Curated
Show »
Length:542
Mass (Da):59,495
Checksum:iAB43214E341C4198
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ASR7B1ASR7_MOUSE
Protein sidekick-2
Sdk2
895Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0175261 – 1602Missing in isoform 2. 1 PublicationAdd BLAST1602
Alternative sequenceiVSP_017527534 – 542VWEKDGATL → SMQSGKGRL in isoform 3. 1 Publication9
Alternative sequenceiVSP_017528543 – 2176Missing in isoform 3. 1 PublicationAdd BLAST1634

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY351699 mRNA Translation: AAQ57661.1
AK161326 mRNA Translation: BAE36324.1
BC038036 mRNA Translation: AAH38036.1
AK129379 mRNA Translation: BAC98189.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS25605.1 [Q6V4S5-1]

NCBI Reference Sequences

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RefSeqi
NP_766388.2, NM_172800.2 [Q6V4S5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000041627; ENSMUSP00000038972; ENSMUSG00000041592 [Q6V4S5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
237979

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:237979

UCSC genome browser

More...
UCSCi
uc007mfd.1, mouse [Q6V4S5-2]
uc007mfe.1, mouse [Q6V4S5-1]
uc007mfg.1, mouse [Q6V4S5-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Discerning change - Issue 176 of February 2016

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY351699 mRNA Translation: AAQ57661.1
AK161326 mRNA Translation: BAE36324.1
BC038036 mRNA Translation: AAH38036.1
AK129379 mRNA Translation: BAC98189.1
CCDSiCCDS25605.1 [Q6V4S5-1]
RefSeqiNP_766388.2, NM_172800.2 [Q6V4S5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5K6XX-ray2.70A/B22-403[»]
5K6YX-ray3.20A/B22-403[»]
5K6ZX-ray2.70A/B22-211[»]
5K70X-ray2.70A/B/C/D22-403[»]
5XX0X-ray2.40A/B1-403[»]
SMRiQ6V4S5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi231935, 3 interactors
STRINGi10090.ENSMUSP00000038972

PTM databases

GlyConnecti2645, 4 N-Linked glycans (10 sites)
GlyGeniQ6V4S5, 14 sites
iPTMnetiQ6V4S5
PhosphoSitePlusiQ6V4S5

Proteomic databases

PaxDbiQ6V4S5
PeptideAtlasiQ6V4S5
PRIDEiQ6V4S5

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2228, 17 antibodies

Genome annotation databases

EnsembliENSMUST00000041627; ENSMUSP00000038972; ENSMUSG00000041592 [Q6V4S5-1]
GeneIDi237979
KEGGimmu:237979
UCSCiuc007mfd.1, mouse [Q6V4S5-2]
uc007mfe.1, mouse [Q6V4S5-1]
uc007mfg.1, mouse [Q6V4S5-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54549
MGIiMGI:2443847, Sdk2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG3510, Eukaryota
GeneTreeiENSGT00940000155761
HOGENOMiCLU_001875_1_0_1
InParanoidiQ6V4S5
KOiK16353
OrthoDBi134749at2759
PhylomeDBiQ6V4S5
TreeFamiTF316846

Enzyme and pathway databases

ReactomeiR-MMU-373756, SDK interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
237979, 4 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sdk2, mouse

Protein Ontology

More...
PROi
PR:Q6V4S5
RNActiQ6V4S5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000041592, Expressed in camera-type eye and 215 other tissues
ExpressionAtlasiQ6V4S5, baseline and differential
GenevisibleiQ6V4S5, MM

Family and domain databases

CDDicd00063, FN3, 13 hits
Gene3Di2.60.40.10, 19 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
PfamiView protein in Pfam
PF00041, fn3, 13 hits
PF07679, I-set, 4 hits
SMARTiView protein in SMART
SM00060, FN3, 13 hits
SM00409, IG, 6 hits
SM00408, IGc2, 6 hits
SUPFAMiSSF48726, SSF48726, 5 hits
SSF49265, SSF49265, 7 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 13 hits
PS50835, IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSDK2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6V4S5
Secondary accession number(s): Q3TTK1, Q5U5W7, Q6ZPP2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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