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Protein

8-hydroxygeraniol dehydrogenase

Gene

10HGO

Organism
Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dehydrogenase involved in the biosynthesis of oxogeranial from hydroxygeraniol, a precursor of the terpenoid indole alkaloids such as vinblastine and vincristine.1 Publication

Miscellaneous

The recommended numbering of geraniol gives (6E)-8-hydroxygeraniol as the substrate rather than 10-hydroxygeraniol and (6E)-8-oxogeranial as the product rather than 10-oxogeranial as used in most publications.

Catalytic activityi

(6E)-8-hydroxygeraniol + 2 NADP+ = (6E)-8-oxogeranial + 2 NADPH.1 Publication

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50Zinc 1; catalyticBy similarity1
Metal bindingi72Zinc 1; catalyticBy similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi109Zinc 2By similarity1
Metal bindingi117Zinc 2By similarity1
Metal bindingi166Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NADP, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-20519

Names & Taxonomyi

Protein namesi
Recommended name:
8-hydroxygeraniol dehydrogenase (EC:1.1.1.324)
Short name:
Cr10HGO
Gene namesi
Name:10HGO
OrganismiCatharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Taxonomic identifieri4058 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsGentianalesApocynaceaeRauvolfioideaeVinceaeCatharanthinaeCatharanthus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004189791 – 3608-hydroxygeraniol dehydrogenaseAdd BLAST360

Proteomic databases

PRIDEiQ6V4H0

Expressioni

Tissue specificityi

Present in seedlings and vascular tissues (at protein level). Restricted to the epidermis.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6V4H0
SMRiQ6V4H0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q6V4H0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKSPEVEHP VKAFGWAARD TSGHLSPFHF SRRATGEHDV QFKVLYCGIC
60 70 80 90 100
HSDLHMIKNE WGFTKYPIVP GHEIVGIVTE VGSKVEKFKV GDKVGVGCLV
110 120 130 140 150
GSCRKCDMCT KDLENYCPGQ ILTYSATYTD GTTTYGGYSD LMVADEHFVI
160 170 180 190 200
RWPENLPMDI GAPLLCAGIT TYSPLRYFGL DKPGTHVGVV GLGGLGHVAV
210 220 230 240 250
KFAKAFGAKV TVISTSESKK QEALEKLGAD SFLVSRDPEQ MKAAAASLDG
260 270 280 290 300
IIDTVSAIHP IMPLLSILKS HGKLILVGAP EKPLELPSFP LIAGRKIIAG
310 320 330 340 350
SAIGGLKETQ EMIDFAAKHN VLPDVELVSM DYVNTAMERL LKADVKYRFV
360
IDVANTLKSA
Length:360
Mass (Da):38,937
Last modified:July 5, 2004 - v1
Checksum:iAB701A2D8921005E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY352047 mRNA Translation: AAQ55962.1

Similar proteinsi

Entry informationi

Entry namei10HGO_CATRO
AccessioniPrimary (citable) accession number: Q6V4H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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