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Entry version 138 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Dipeptidyl peptidase 8

Gene

DPP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.1 Publication6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by zinc. Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfluorophosphate. Specifically inhibited by isoindoline derivatives.3 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=208 µM for Ala-Pro-AMC3 Publications
  2. KM=130 µM for Ala-Pro-AFC3 Publications
  3. KM=120 µM for H-Ala-Pro-pNa3 Publications
  4. KM=1420 µM for H-Ala-Ala-pNa3 Publications
  5. KM=310 µM for H-Arg-Pro-pNa3 Publications
  6. KM=2050 µM for H-Asp-Pro-pNa3 Publications
  7. KM=480 µM for H-Gly-Pro-pNa3 Publications

    pH dependencei

    Optimum pH is 7.4-8.5. Little activity below pH 6.5.3 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei755Charge relay system2 Publications1
    Active sitei833Charge relay system2 Publications1
    Active sitei865Charge relay system2 Publications1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease
    Biological processApoptosis

    Enzyme and pathway databases

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q6V1X1

    Protein family/group databases

    ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

    More...
    ESTHERi
    human-DPP8 DPP4N_Peptidase_S9

    MEROPS protease database

    More...
    MEROPSi
    S09.018

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Dipeptidyl peptidase 8 (EC:3.4.14.56 Publications)
    Short name:
    DP81 Publication
    Alternative name(s):
    Dipeptidyl peptidase IV-related protein 1
    Short name:
    DPRP-1
    Dipeptidyl peptidase VIII
    Short name:
    DPP VIII
    Prolyl dipeptidase DPP8
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:DPP8
    Synonyms:DPRP1
    ORF Names:MSTP097, MSTP135, MSTP141
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:16490 DPP8

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    606819 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q6V1X1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi275E → K: 13-fold reduction in affinity for Ala-Pro-AFC; no effect on subcellular location. 1 Publication1
    Mutagenesisi451D → F: Reduced dimerization and reduced enzyme activity. 1 Publication1
    Mutagenesisi755S → A: Abolishes activity; no effect on subcellular location. 1 Publication1
    Mutagenesisi788D → A, S or V: Strongly reduced enzyme activity. 1 Publication1
    Mutagenesisi788D → E: Loss of enzyme activity. Loss of dimerization. 1 Publication1
    Mutagenesisi833D → A: Abolishes activity; no effect on subcellular location. 1 Publication1
    Mutagenesisi865H → A: Abolishes activity; no effect on subcellular location. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    54878

    Open Targets

    More...
    OpenTargetsi
    ENSG00000074603

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA27470

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q6V1X1

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4657

    DrugCentral

    More...
    DrugCentrali
    Q6V1X1

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2356

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    DPP8

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    67460301

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001224131 – 898Dipeptidyl peptidase 8Add BLAST898

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q6V1X1

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q6V1X1

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q6V1X1

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q6V1X1

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q6V1X1

    PeptideAtlas

    More...
    PeptideAtlasi
    Q6V1X1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q6V1X1

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    67709 [Q6V1X1-1]
    67710 [Q6V1X1-2]
    67711 [Q6V1X1-3]
    67712 [Q6V1X1-4]
    67713 [Q6V1X1-5]
    67714 [Q6V1X1-6]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q6V1X1

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q6V1X1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain.2 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    In activated T-cells.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000074603 Expressed in 241 organ(s), highest expression level in buccal mucosa cell

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q6V1X1 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q6V1X1 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA008706

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    120226, 30 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q6V1X1, 17 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q6V1X1

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000339208

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q6V1X1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1898
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q6V1X1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase S9B family. DPPIV subfamily.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2281 Eukaryota
    COG1506 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160717

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q6V1X1

    KEGG Orthology (KO)

    More...
    KOi
    K08655

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    QIVLIPP

    Database of Orthologous Groups

    More...
    OrthoDBi
    137965at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q6V1X1

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313309

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.140.10.30, 1 hit
    3.40.50.1820, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029058 AB_hydrolase
    IPR001375 Peptidase_S9
    IPR002469 Peptidase_S9B_N
    IPR038554 Peptidase_S9B_N_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00930 DPPIV_N, 1 hit
    PF00326 Peptidase_S9, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53474 SSF53474, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q6V1X1-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MWKRSEQMKI KSGKCNMAAA METEQLGVEI FETADCEENI ESQDRPKLEP
    60 70 80 90 100
    FYVERYSWSQ LKKLLADTRK YHGYMMAKAP HDFMFVKRND PDGPHSDRIY
    110 120 130 140 150
    YLAMSGENRE NTLFYSEIPK TINRAAVLML SWKPLLDLFQ ATLDYGMYSR
    160 170 180 190 200
    EEELLRERKR IGTVGIASYD YHQGSGTFLF QAGSGIYHVK DGGPQGFTQQ
    210 220 230 240 250
    PLRPNLVETS CPNIRMDPKL CPADPDWIAF IHSNDIWISN IVTREERRLT
    260 270 280 290 300
    YVHNELANME EDARSAGVAT FVLQEEFDRY SGYWWCPKAE TTPSGGKILR
    310 320 330 340 350
    ILYEENDESE VEIIHVTSPM LETRRADSFR YPKTGTANPK VTFKMSEIMI
    360 370 380 390 400
    DAEGRIIDVI DKELIQPFEI LFEGVEYIAR AGWTPEGKYA WSILLDRSQT
    410 420 430 440 450
    RLQIVLISPE LFIPVEDDVM ERQRLIESVP DSVTPLIIYE ETTDIWINIH
    460 470 480 490 500
    DIFHVFPQSH EEEIEFIFAS ECKTGFRHLY KITSILKESK YKRSSGGLPA
    510 520 530 540 550
    PSDFKCPIKE EIAITSGEWE VLGRHGSNIQ VDEVRRLVYF EGTKDSPLEH
    560 570 580 590 600
    HLYVVSYVNP GEVTRLTDRG YSHSCCISQH CDFFISKYSN QKNPHCVSLY
    610 620 630 640 650
    KLSSPEDDPT CKTKEFWATI LDSAGPLPDY TPPEIFSFES TTGFTLYGML
    660 670 680 690 700
    YKPHDLQPGK KYPTVLFIYG GPQVQLVNNR FKGVKYFRLN TLASLGYVVV
    710 720 730 740 750
    VIDNRGSCHR GLKFEGAFKY KMGQIEIDDQ VEGLQYLASR YDFIDLDRVG
    760 770 780 790 800
    IHGWSYGGYL SLMALMQRSD IFRVAIAGAP VTLWIFYDTG YTERYMGHPD
    810 820 830 840 850
    QNEQGYYLGS VAMQAEKFPS EPNRLLLLHG FLDENVHFAH TSILLSFLVR
    860 870 880 890
    AGKPYDLQIY PQERHSIRVP ESGEHYELHL LHYLQENLGS RIAALKVI
    Length:898
    Mass (Da):103,358
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60B0D036F026DE2A
    GO
    Isoform 2 (identifier: Q6V1X1-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         723-773: Missing.

    Show »
    Length:847
    Mass (Da):97,464
    Checksum:iAB07EF0087231B56
    GO
    Isoform 3 (identifier: Q6V1X1-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-16: Missing.

    Show »
    Length:882
    Mass (Da):101,422
    Checksum:iAD801C302DB4652B
    GO
    Isoform 4 (identifier: Q6V1X1-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-16: Missing.
         674-773: Missing.

    Show »
    Length:782
    Mass (Da):89,908
    Checksum:i784922477DB8F5B5
    GO
    Isoform 5 (identifier: Q6V1X1-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         674-722: Missing.

    Show »
    Length:849
    Mass (Da):97,739
    Checksum:i4B6C88F29CA55475
    GO
    Isoform 6 (identifier: Q6V1X1-6) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         358-530: Missing.

    Show »
    Length:725
    Mass (Da):83,398
    Checksum:i0476E0AEBD94131B
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H0YK36H0YK36_HUMAN
    Dipeptidyl peptidase 8
    DPP8
    361Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BNM2H3BNM2_HUMAN
    Dipeptidyl peptidase 8
    DPP8
    311Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3KPT0J3KPT0_HUMAN
    Dipeptidyl peptidase 8
    DPP8
    729Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YKA2H0YKA2_HUMAN
    Dipeptidyl peptidase 8
    DPP8
    219Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YN53H0YN53_HUMAN
    Dipeptidyl peptidase 8
    DPP8
    120Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BQ40H3BQ40_HUMAN
    Dipeptidyl peptidase 8
    DPP8
    162Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YMV1H0YMV1_HUMAN
    Dipeptidyl peptidase 8
    DPP8
    84Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAQ13623 differs from that shown. Reason: Frameshift.Curated
    The sequence AAQ13650 differs from that shown. Reason: Frameshift.Curated
    The sequence AAQ13657 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence BAA91059 differs from that shown. Reason: Frameshift.Curated
    The sequence BAB55395 differs from that shown. Reason: Erroneous initiation.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti233S → G in BC040203 (PubMed:15489334).Curated1
    Sequence conflicti570G → S in BAB55395 (PubMed:14702039).Curated1
    Sequence conflicti673Q → K in AAQ13650 (Ref. 6) Curated1
    Sequence conflicti686Y → F in AAQ13650 (Ref. 6) Curated1
    Sequence conflicti693 – 694AS → PF in AAQ13650 (Ref. 6) Curated2
    Sequence conflicti701V → G in AAQ13650 (Ref. 6) Curated1
    Sequence conflicti709H → P in AAQ13650 (Ref. 6) Curated1
    Sequence conflicti720Y → F in AAQ13650 (Ref. 6) Curated1
    Sequence conflicti799 – 803PDQNE → LTRMN in AAQ13623 (Ref. 6) Curated5
    Sequence conflicti820S → F in AAQ13623 (Ref. 6) Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0138601 – 16Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST16
    Alternative sequenceiVSP_013861358 – 530Missing in isoform 6. 1 PublicationAdd BLAST173
    Alternative sequenceiVSP_013862674 – 773Missing in isoform 4. 2 PublicationsAdd BLAST100
    Alternative sequenceiVSP_013863674 – 722Missing in isoform 5. 1 PublicationAdd BLAST49
    Alternative sequenceiVSP_013864723 – 773Missing in isoform 2. 2 PublicationsAdd BLAST51

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF221634 mRNA Translation: AAG29766.1
    AF221635 mRNA Translation: AAG29767.1
    AF221636 mRNA Translation: AAG29768.1
    AF221637 mRNA Translation: AAG29769.1
    AY172659 mRNA Translation: AAO17261.1
    AY354202 mRNA Translation: AAQ63887.1
    AK000290 mRNA Translation: BAA91059.1 Frameshift.
    AK027826 mRNA Translation: BAB55395.1 Different initiation.
    BC030688 mRNA Translation: AAH30688.3
    BC040203 mRNA No translation available.
    AF176779 mRNA Translation: AAQ13657.1 Different initiation.
    AF175225 mRNA Translation: AAQ13650.1 Frameshift.
    AF173382 mRNA Translation: AAQ13623.1 Frameshift.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS10207.1 [Q6V1X1-1]
    CCDS10208.1 [Q6V1X1-2]
    CCDS10209.1 [Q6V1X1-4]
    CCDS10210.1 [Q6V1X1-3]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001307804.1, NM_001320875.1 [Q6V1X1-1]
    NP_001307805.1, NM_001320876.1 [Q6V1X1-3]
    NP_060213.2, NM_017743.5 [Q6V1X1-4]
    NP_569118.1, NM_130434.4 [Q6V1X1-3]
    NP_932064.1, NM_197960.3 [Q6V1X1-1]
    NP_932065.1, NM_197961.3 [Q6V1X1-2]
    XP_016877862.1, XM_017022373.1
    XP_016877863.1, XM_017022374.1 [Q6V1X1-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000300141; ENSP00000300141; ENSG00000074603 [Q6V1X1-3]
    ENST00000321147; ENSP00000318111; ENSG00000074603 [Q6V1X1-2]
    ENST00000341861; ENSP00000339208; ENSG00000074603 [Q6V1X1-1]
    ENST00000358939; ENSP00000351817; ENSG00000074603 [Q6V1X1-4]
    ENST00000559233; ENSP00000453954; ENSG00000074603 [Q6V1X1-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    54878

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:54878

    UCSC genome browser

    More...
    UCSCi
    uc002aov.4 human [Q6V1X1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF221634 mRNA Translation: AAG29766.1
    AF221635 mRNA Translation: AAG29767.1
    AF221636 mRNA Translation: AAG29768.1
    AF221637 mRNA Translation: AAG29769.1
    AY172659 mRNA Translation: AAO17261.1
    AY354202 mRNA Translation: AAQ63887.1
    AK000290 mRNA Translation: BAA91059.1 Frameshift.
    AK027826 mRNA Translation: BAB55395.1 Different initiation.
    BC030688 mRNA Translation: AAH30688.3
    BC040203 mRNA No translation available.
    AF176779 mRNA Translation: AAQ13657.1 Different initiation.
    AF175225 mRNA Translation: AAQ13650.1 Frameshift.
    AF173382 mRNA Translation: AAQ13623.1 Frameshift.
    CCDSiCCDS10207.1 [Q6V1X1-1]
    CCDS10208.1 [Q6V1X1-2]
    CCDS10209.1 [Q6V1X1-4]
    CCDS10210.1 [Q6V1X1-3]
    RefSeqiNP_001307804.1, NM_001320875.1 [Q6V1X1-1]
    NP_001307805.1, NM_001320876.1 [Q6V1X1-3]
    NP_060213.2, NM_017743.5 [Q6V1X1-4]
    NP_569118.1, NM_130434.4 [Q6V1X1-3]
    NP_932064.1, NM_197960.3 [Q6V1X1-1]
    NP_932065.1, NM_197961.3 [Q6V1X1-2]
    XP_016877862.1, XM_017022373.1
    XP_016877863.1, XM_017022374.1 [Q6V1X1-2]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6EOOX-ray2.50A/B/C1-898[»]
    6EOPX-ray2.40A/B/C1-898[»]
    6EOSX-ray3.10A/B/C/D/E/F1-898[»]
    6EOTX-ray3.50A/B/D/G/I/K1-898[»]
    6HP8X-ray2.50A/B/C1-898[»]
    SMRiQ6V1X1
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi120226, 30 interactors
    IntActiQ6V1X1, 17 interactors
    MINTiQ6V1X1
    STRINGi9606.ENSP00000339208

    Chemistry databases

    BindingDBiQ6V1X1
    ChEMBLiCHEMBL4657
    DrugCentraliQ6V1X1
    GuidetoPHARMACOLOGYi2356

    Protein family/group databases

    ESTHERihuman-DPP8 DPP4N_Peptidase_S9
    MEROPSiS09.018

    PTM databases

    iPTMnetiQ6V1X1
    PhosphoSitePlusiQ6V1X1

    Polymorphism and mutation databases

    BioMutaiDPP8
    DMDMi67460301

    Proteomic databases

    EPDiQ6V1X1
    jPOSTiQ6V1X1
    MassIVEiQ6V1X1
    MaxQBiQ6V1X1
    PaxDbiQ6V1X1
    PeptideAtlasiQ6V1X1
    PRIDEiQ6V1X1
    ProteomicsDBi67709 [Q6V1X1-1]
    67710 [Q6V1X1-2]
    67711 [Q6V1X1-3]
    67712 [Q6V1X1-4]
    67713 [Q6V1X1-5]
    67714 [Q6V1X1-6]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    54878

    Genome annotation databases

    EnsembliENST00000300141; ENSP00000300141; ENSG00000074603 [Q6V1X1-3]
    ENST00000321147; ENSP00000318111; ENSG00000074603 [Q6V1X1-2]
    ENST00000341861; ENSP00000339208; ENSG00000074603 [Q6V1X1-1]
    ENST00000358939; ENSP00000351817; ENSG00000074603 [Q6V1X1-4]
    ENST00000559233; ENSP00000453954; ENSG00000074603 [Q6V1X1-1]
    GeneIDi54878
    KEGGihsa:54878
    UCSCiuc002aov.4 human [Q6V1X1-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    54878
    DisGeNETi54878

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    DPP8
    HGNCiHGNC:16490 DPP8
    HPAiHPA008706
    MIMi606819 gene
    neXtProtiNX_Q6V1X1
    OpenTargetsiENSG00000074603
    PharmGKBiPA27470

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2281 Eukaryota
    COG1506 LUCA
    GeneTreeiENSGT00940000160717
    InParanoidiQ6V1X1
    KOiK08655
    OMAiQIVLIPP
    OrthoDBi137965at2759
    PhylomeDBiQ6V1X1
    TreeFamiTF313309

    Enzyme and pathway databases

    SABIO-RKiQ6V1X1

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    DPP8 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    DPP8

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    54878
    PharosiQ6V1X1

    Protein Ontology

    More...
    PROi
    PR:Q6V1X1

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000074603 Expressed in 241 organ(s), highest expression level in buccal mucosa cell
    ExpressionAtlasiQ6V1X1 baseline and differential
    GenevisibleiQ6V1X1 HS

    Family and domain databases

    Gene3Di2.140.10.30, 1 hit
    3.40.50.1820, 1 hit
    InterProiView protein in InterPro
    IPR029058 AB_hydrolase
    IPR001375 Peptidase_S9
    IPR002469 Peptidase_S9B_N
    IPR038554 Peptidase_S9B_N_sf
    PfamiView protein in Pfam
    PF00930 DPPIV_N, 1 hit
    PF00326 Peptidase_S9, 1 hit
    SUPFAMiSSF53474 SSF53474, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPP8_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6V1X1
    Secondary accession number(s): Q7Z4C8
    , Q7Z4D3, Q7Z4E1, Q8IWG7, Q8NEM5, Q96JX1, Q9HBM2, Q9HBM3, Q9HBM4, Q9HBM5, Q9NXF4
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: July 5, 2004
    Last modified: October 16, 2019
    This is version 138 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
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