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Protein

Protocadherin-23

Gene

DCHS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent cell-adhesion protein.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin-23
Alternative name(s):
Cadherin-27
Cadherin-like protein CDHJ
Cadherin-like protein VR8
Protein dachsous homolog 2
Protocadherin PCDHJ
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCHS2
Synonyms:CDH27, CDHJ, PCDH23, PCDHJ
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197410.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23111 DCHS2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612486 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6V1P9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2541 – 2561HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54798

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134953793

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DCHS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762378

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003434101 – 2916Protocadherin-23Add BLAST2916

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi245N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi467N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi539N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi673N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi820N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1032N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1443N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1599N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1615N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1874N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2024N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2042N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2522N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2635N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6V1P9

PeptideAtlas

More...
PeptideAtlasi
Q6V1P9

PRoteomics IDEntifications database

More...
PRIDEi
Q6V1P9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67706

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6V1P9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6V1P9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Cerebral cortex and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197410 Expressed in 85 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_DCHS2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6V1P9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA064159

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120157, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000349768

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6V1P9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6V1P9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 177Cadherin 1PROSITE-ProRule annotationAdd BLAST122
Domaini178 – 382Cadherin 2PROSITE-ProRule annotationAdd BLAST205
Domaini378 – 480Cadherin 3PROSITE-ProRule annotationAdd BLAST103
Domaini481 – 583Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini586 – 692Cadherin 5PROSITE-ProRule annotationAdd BLAST107
Domaini693 – 839Cadherin 6PROSITE-ProRule annotationAdd BLAST147
Domaini844 – 960Cadherin 7PROSITE-ProRule annotationAdd BLAST117
Domaini949 – 1055Cadherin 8PROSITE-ProRule annotationAdd BLAST107
Domaini1056 – 1165Cadherin 9PROSITE-ProRule annotationAdd BLAST110
Domaini1165 – 1269Cadherin 10PROSITE-ProRule annotationAdd BLAST105
Domaini1270 – 1374Cadherin 11PROSITE-ProRule annotationAdd BLAST105
Domaini1375 – 1478Cadherin 12PROSITE-ProRule annotationAdd BLAST104
Domaini1479 – 1583Cadherin 13PROSITE-ProRule annotationAdd BLAST105
Domaini1584 – 1685Cadherin 14PROSITE-ProRule annotationAdd BLAST102
Domaini1685 – 1787Cadherin 15PROSITE-ProRule annotationAdd BLAST103
Domaini1788 – 1892Cadherin 16PROSITE-ProRule annotationAdd BLAST105
Domaini1892 – 1992Cadherin 17PROSITE-ProRule annotationAdd BLAST101
Domaini1993 – 2094Cadherin 18PROSITE-ProRule annotationAdd BLAST102
Domaini2095 – 2210Cadherin 19PROSITE-ProRule annotationAdd BLAST116
Domaini2211 – 2314Cadherin 20PROSITE-ProRule annotationAdd BLAST104
Domaini2315 – 2425Cadherin 21PROSITE-ProRule annotationAdd BLAST111
Domaini2426 – 2533Cadherin 22PROSITE-ProRule annotationAdd BLAST108

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1219 Eukaryota
KOG3594 Eukaryota
ENOG410XPEI LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000172328

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053522

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6V1P9

KEGG Orthology (KO)

More...
KOi
K16507

Identification of Orthologs from Complete Genome Data

More...
OMAi
HYLFRVV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0023

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6V1P9

TreeFam database of animal gene trees

More...
TreeFami
TF330641

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 19 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 21 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 22 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 13 hits
PS50268 CADHERIN_2, 22 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6V1P9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLDEITKSE NEDGEKKMFT QQFESTDACV YEVYVKINSI VKSQSQCGLK
60 70 80 90 100
RGSPETELWG AIVFRSQEEN AKPVKETEVT ASDADSGLYG FIEYSLYDGF
110 120 130 140 150
LSYEAPQAFR IDPHDGQICV SQDIDRERDP ATYDLLVEAK DGDEQRMTHL
160 170 180 190 200
ALVKGGLSAQ AFVRVDLEDV NDNHPVFNPS TYVTSISDET QPGTEIINVL
210 220 230 240 250
ATDQDSGIYG TVAYELIPGN VSSLFTIDST TGLYSPEVEI LSAVNFSADK
260 270 280 290 300
EVMNSLEMFL PLLRHFKKVE RDEEAAEKKF EASRGWFMRF KGRRHLHYLK
310 320 330 340 350
VQDEAASADG EAAARYVANL AKILGEGIIY LTLPLSHLES TTLSLMVSAQ
360 370 380 390 400
DGGGLTAVIN ADVTIHIFQT TLAPAEFERP KYTFLVYEDV PEDSPIGTVK
410 420 430 440 450
AREPLNSSEP IFYRISSGDL GGKFSIHPRL GTIRTRKPLD HETQPVVVLT
460 470 480 490 500
VQAQLGSAPA CSSTEVNITV MDVNDNHPAF LRTSDEIRIS QTTPPGTALY
510 520 530 540 550
LARAEDRDSG RNGLIRYSIA SPQPGVFAID RALGVLFLNG SLGAGEQREL
560 570 580 590 600
TLTLRAEDQG VHPQAALLVL TVVIEKREHS PSWTFEHLVY QVEVSESLSP
610 620 630 640 650
MTQMLQTQAH PLGPQRAASP LRYSLEPSVD SAMFGIRPYT GWIYLRRQFD
660 670 680 690 700
YESTQTYNFR VFAWIPEDGF LQNVSTTVIV RVWDENDNSP TFLHDVLFLK
710 720 730 740 750
VEESPVPQGV IGKITAIDMD SGKNGQLLYF LLSDGKFFKM NPNTGPAGTI
760 770 780 790 800
YVITWADGAA AFSGTDFAFS SDELQAFVLK SLFCELGEGE LINWVALDRE
810 820 830 840 850
HRGHHEMTVL VTDRGSPPRN ATMAVYVSVT DINDNRPFFP QCLPGKELHV
860 870 880 890 900
KVLEGQPVNM LVTTVFAKDP DEGNNAEVTY SVSSEDSSDH FKIDANNGEI
910 920 930 940 950
RTTTILSYDY RPSYRMSVIA TDQGVPPLQG QAVVNIQVIP LSKGRAIMSQ
960 970 980 990 1000
NIRHLIIPEN LKPTKIMSLI KSSDHLQQHY NGKLHFSIVA DDKDGHFEID
1010 1020 1030 1040 1050
SSTGDLFLSK ELDYETTSHY LFRVITTDHS KNLSLSSTVF LSIDVEDQND
1060 1070 1080 1090 1100
HSPSFQDELI VISVEENVPI GTLVYVFNAK DDDGSFLNSR IQYYIESHNP
1110 1120 1130 1140 1150
GTNPFLIHPS FGTLVTVSRL DRESIPTVIL TVTASDQAVN VTDRRLRSLT
1160 1170 1180 1190 1200
AQIVILDVND HNPTFISFPN AHVKEDVTVG SLVHHITAHD PDEGRNGKVT
1210 1220 1230 1240 1250
YSILSGNENM TFMLDESSGL LTTTCPLDYE MKTQHILTVL ALDDGTPALS
1260 1270 1280 1290 1300
SSQTLTVTVL DVNDEAPVFK QHLYEASVKE NQNPGEFVTR VEALDRDSGV
1310 1320 1330 1340 1350
NSKLQFEIMP GASFELFEIN SDTGEVVTTT ILDREIQEVF TLRVLVRDGG
1360 1370 1380 1390 1400
FPSLSSTTTI LCTVEDENDH APEFIVSSYD IEVLENQEPE VVYTVLASDM
1410 1420 1430 1440 1450
DAGNNRAVEY HIIDGNTDEC FTINEMSGEL STTRALDREQ ISNFTLVILC
1460 1470 1480 1490 1500
SDLGDPPRSS VIHLQVRVLD ANDHSPSFPT LYYQSSVRED AEVGTVVLVL
1510 1520 1530 1540 1550
SAVDKDEGLN GQTEYFLTDE ASGAFTIDPM SGTLKTSNTL DREARSQHTF
1560 1570 1580 1590 1600
SAVARDCSIQ GSRSTTVIIK VYVTDVNDND PVLEQNPFDV FLSPESPTNQ
1610 1620 1630 1640 1650
TTVIVRADDL DLGPNGTVVF SFAETQSMFS IDKYTGEIQF QQNPSSEYFP
1660 1670 1680 1690 1700
IWLQLKVTDQ GIPARTTTGL LVIHMEGEDV KISFSHHLYK GLVTENCEAG
1710 1720 1730 1740 1750
TSIVTVKAFA PDSIQDSMKY SIFSGNEDGV LSLCSKSGQL TVKEPKFLDF
1760 1770 1780 1790 1800
EVRNEVQLIV LAESSGHRAY CKVAVLIQDE NDNSPCFEQS IYQASVSESQ
1810 1820 1830 1840 1850
LYNAHVIQVF ATDLDSGLNG LIEYSILSGN QEEAFQIDAL SGVITTKAIL
1860 1870 1880 1890 1900
DYELTSSYSL IVQATDKGMP RLSNTTVIKV QVTDINDNAP AFLPSEAVEI
1910 1920 1930 1940 1950
TEDSLPGVIV THVSVHDVDL NSAFIFSFAK ESNPGTKFAI DQNTGVVVLV
1960 1970 1980 1990 2000
KTLDFEEMTE YELLIQISDS VHYTEGALVV RVLDVNDNPP VFSQDFYQVT
2010 2020 2030 2040 2050
VPESIPVGYS VLTLSATDLE SNENISYRIL SSSKEFSIDP KNGTIFTISP
2060 2070 2080 2090 2100
VLLLDTISTT QFLVEASDGG NPDLRALTLV EIGIEDMNNY APEFTVKSYN
2110 2120 2130 2140 2150
LSLSEDALVG STLVTFSNID HDWTRENTYV EYSIISGNSQ NNFHVETKFF
2160 2170 2180 2190 2200
HSEYPYKQVG YLVLLHSLDR EASASHELVI LASDSGCPPL SSTAVISIQV
2210 2220 2230 2240 2250
LDVNDNPPNF SSLSYHTHVK ESTPLGSHIT VVSANDRDTG SHAEIIYNII
2260 2270 2280 2290 2300
SGNEKGHFYL EENTGVLYLI KPLDYEKMTK FTLTVQASDA EKKHFSFAVV
2310 2320 2330 2340 2350
FVSVLDDNDH APQFMFSSFS CIVPENLPIS STICSINALD FDAGPYGELT
2360 2370 2380 2390 2400
YSIVSPCFLT HGMSYDHDLF LIDPLTGDIH AKQILDYENG NKYCLTVQAK
2410 2420 2430 2440 2450
DKGDATASLV VWVDIEGIDE FEPIFTQDQY FFTLPEKNKD RQLIGRVEAS
2460 2470 2480 2490 2500
DADAGIDGVI LYSLGTSSPF FSVNKTNGNI YLIRALPLIK SQLNKEDTLE
2510 2520 2530 2540 2550
MKIIAHSPKS DSKFASCTVF VNVSFSSEGT PLAVFASSFS ISLVVSFLVF
2560 2570 2580 2590 2600
LILICILIVM ILRHKQKDTI NNYEEKKTSS LDADLRVTRD ASVLKAFQKT
2610 2620 2630 2640 2650
DDCSNEVVPV DATPEWLSLI SIMEKDIVNL YRHSNSSGHC SVEGETAEDK
2660 2670 2680 2690 2700
EIQRINEHPY RKCSDSALSD HESRVPDSGI PRDSDQLSCL SGETDVMVTA
2710 2720 2730 2740 2750
ETAEASQTFG EGDQGEGCST TCAQNNVLPQ TVQKREAKES ILADVRKESV
2760 2770 2780 2790 2800
FISGDQEVRC AALSTQTTSD HDGKDNYHWN YLLSWEPKFQ PLASVFNDIA
2810 2820 2830 2840 2850
KLKDEHLHMP GIPKEKKSFV FPPPLITAVA QPGIKAVPPR MPAVNLGQVP
2860 2870 2880 2890 2900
PKHPRSPIPY HLGSLPEGMT PNFSPSLSLL TMQPPALSPL LREGELLGTH
2910
ISGTCHELKA EDEVQI
Length:2,916
Mass (Da):322,234
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25B2F4496468ABB5
GO
Isoform 4 (identifier: Q6V1P9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MRLDEITKSE...ENAKPVKETE → MSPCGRKMGE...HAPVGHCFLQ
     143-154: Missing.
     232-326: Missing.
     745-788: Missing.
     885-914: EDSSDHFKIDANNGEIRTTTILSYDYRPSY → ARHMPLKGKTAFGKQSCKKTNKQTNKILT
     915-2916: Missing.

Show »
Length:1,368
Mass (Da):149,191
Checksum:i8BBD22FA06CE9263
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LNH0A0A096LNH0_HUMAN
Protocadherin-23
DCHS2
3,371Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRC0A0A0A0MRC0_HUMAN
Protocadherin-23
DCHS2
1,369Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAY41019 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA90911 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Isoform 4 : The sequence BAC87093 differs from that shown. Reason: Frameshift at position 1364.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2061Q → R in BAA90911 (PubMed:14702039).Curated1
Sequence conflicti2074L → P in BAA90911 (PubMed:14702039).Curated1
Sequence conflicti2475K → R in BAA90911 (PubMed:14702039).Curated1
Sequence conflicti2633H → Y in BAA90911 (PubMed:14702039).Curated1
Isoform 4 (identifier: Q6V1P9-4)
Sequence conflicti446C → G in BAC87093 (PubMed:14702039).Curated1
Sequence conflicti1358K → KQ in BAC87093 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044362153V → A. Corresponds to variant dbSNP:rs11721758Ensembl.1
Natural variantiVAR_044363174H → R1 PublicationCorresponds to variant dbSNP:rs10017772Ensembl.1
Natural variantiVAR_044364344S → L2 PublicationsCorresponds to variant dbSNP:rs6858712Ensembl.1
Natural variantiVAR_044365827V → I. Corresponds to variant dbSNP:rs7666283Ensembl.1
Natural variantiVAR_044366897N → S. Corresponds to variant dbSNP:rs1352714Ensembl.1
Natural variantiVAR_0443671205S → L. Corresponds to variant dbSNP:rs11935573Ensembl.1
Natural variantiVAR_0443681480T → R. Corresponds to variant dbSNP:rs17031394Ensembl.1
Natural variantiVAR_0610751595E → Q. Corresponds to variant dbSNP:rs28561984Ensembl.1
Natural variantiVAR_0443692112T → M. Corresponds to variant dbSNP:rs17031279Ensembl.1
Natural variantiVAR_0443702303S → N. Corresponds to variant dbSNP:rs6824133Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0345861 – 78MRLDE…VKETE → MSPCGRKMGEGRQQQRAPVG KLLLLPGRRDTPHGRSGSSG ARTQRSLLWLLVHVWLWAAS GSSAQLFNLTLSVDEGLPPD TLVGDIRAGLPAAQQQEGSG FFLSEDSDDSPLLDDFHVHP DTGIIRTARRLDRERRDHYS FVAATLLGAVVQVEIRVNDV NDHSPRFPLDSLQLDVSELS PPGTAFRLPGAHDPDAGLFS TQGYTLVQPSDLPKDPAGPF FQLRYRTPGPLPSPLLPGSS SPLEPLDLVLLRRLDREEAA AHRLQIEAWDGGRPRRTGLL SVELRVLDENDNPPVFEQDE YRAAVREDAQPGAEVCRVRA TDRDLGPNGFVRYSVRARQV PGAGSGGGALGDAAYFAVEE LSGVVRVWRPLDREAQAWHQ LVVEARDGGAEPEVATVRVS IAVLDVNDNRPAIHVLFLTE GGVARVSEGARPGDYVARVS VSDADCDWEKEDEATGELGV GLGDGSISLSLEGGEGDFAL LPGGPPGVFFLCVEGPLDRE SRDLYELLLVATDAGSPPLS TEETLLLRVADLNDQPPLFS QQHYKASVSEAAAPGTVVMW VSASDADEAGSDHAWLRYTV VQLSAPCNLGSLESKMVHTA ECGPSFAIDSESGVISTIRA LDREVQEAVELKVVAQDLGE PPLSATCLVSITVDDVNDNE PIFWRQVYNATIAEHAPVGH CFLQ in isoform 4. 2 PublicationsAdd BLAST78
Alternative sequenceiVSP_034587143 – 154Missing in isoform 4. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_034588232 – 326Missing in isoform 4. 2 PublicationsAdd BLAST95
Alternative sequenceiVSP_034589745 – 788Missing in isoform 4. 2 PublicationsAdd BLAST44
Alternative sequenceiVSP_046654885 – 914EDSSD…YRPSY → ARHMPLKGKTAFGKQSCKKT NKQTNKILT in isoform 4. 2 PublicationsAdd BLAST30
Alternative sequenceiVSP_046655915 – 2916Missing in isoform 4. 2 PublicationsAdd BLAST2002

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY354497 mRNA Translation: AAR10443.1
AK000054 mRNA Translation: BAA90911.1 Different initiation.
AK127704 mRNA Translation: BAC87093.1 Frameshift.
AC079298 Genomic DNA Translation: AAY41019.1 Sequence problems.
AC110608 Genomic DNA No translation available.
AC110775 Genomic DNA No translation available.
BC140919 mRNA Translation: AAI40920.1

NCBI Reference Sequences

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RefSeqi
NP_001136024.1, NM_001142552.1
NP_060109.2, NM_017639.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.655664

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000623607; ENSP00000485514; ENSG00000197410
ENST00000638949; ENSP00000491296; ENSG00000284227

Database of genes from NCBI RefSeq genomes

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GeneIDi
54798

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54798

UCSC genome browser

More...
UCSCi
uc003inw.2 human [Q6V1P9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY354497 mRNA Translation: AAR10443.1
AK000054 mRNA Translation: BAA90911.1 Different initiation.
AK127704 mRNA Translation: BAC87093.1 Frameshift.
AC079298 Genomic DNA Translation: AAY41019.1 Sequence problems.
AC110608 Genomic DNA No translation available.
AC110775 Genomic DNA No translation available.
BC140919 mRNA Translation: AAI40920.1
RefSeqiNP_001136024.1, NM_001142552.1
NP_060109.2, NM_017639.3
UniGeneiHs.655664

3D structure databases

ProteinModelPortaliQ6V1P9
SMRiQ6V1P9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120157, 1 interactor
STRINGi9606.ENSP00000349768

PTM databases

iPTMnetiQ6V1P9
PhosphoSitePlusiQ6V1P9

Polymorphism and mutation databases

BioMutaiDCHS2
DMDMi74762378

Proteomic databases

PaxDbiQ6V1P9
PeptideAtlasiQ6V1P9
PRIDEiQ6V1P9
ProteomicsDBi67706

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000623607; ENSP00000485514; ENSG00000197410
ENST00000638949; ENSP00000491296; ENSG00000284227
GeneIDi54798
KEGGihsa:54798
UCSCiuc003inw.2 human [Q6V1P9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54798
DisGeNETi54798
EuPathDBiHostDB:ENSG00000197410.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DCHS2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0004584
HGNCiHGNC:23111 DCHS2
HPAiHPA064159
MIMi612486 gene
neXtProtiNX_Q6V1P9
PharmGKBiPA134953793

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1219 Eukaryota
KOG3594 Eukaryota
ENOG410XPEI LUCA
HOGENOMiHOG000172328
HOVERGENiHBG053522
InParanoidiQ6V1P9
KOiK16507
OMAiHYLFRVV
OrthoDBiEOG091G0023
PhylomeDBiQ6V1P9
TreeFamiTF330641

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DCHS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54798

Protein Ontology

More...
PROi
PR:Q6V1P9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197410 Expressed in 85 organ(s), highest expression level in secondary oocyte
CleanExiHS_DCHS2
GenevisibleiQ6V1P9 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 19 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 21 hits
SUPFAMiSSF49313 SSF49313, 22 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 13 hits
PS50268 CADHERIN_2, 22 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCD23_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6V1P9
Secondary accession number(s): B2RU14
, E9PC11, Q4W5P9, Q6ZS61, Q9NXU8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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