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UniProtKB - Q6UY14 (ATL4_HUMAN)

Protein

ADAMTS-like protein 4

Gene

ADAMTSL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis.2 Publications

Caution

Although similar to members of the ADAMTS family, it lacks the metalloprotease and disintegrin-like domains which are typical of that family.Curated

GO - Molecular functioni

  • peptidase activity Source: InterPro
  • protease binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Names & Taxonomyi

Protein namesi
Recommended name:
ADAMTS-like protein 4
Short name:
ADAMTSL-4
Alternative name(s):
Thrombospondin repeat-containing protein 1
Gene namesi
Name:ADAMTSL4
Synonyms:TSRC1Imported
ORF Names:PP1396, UNQ2803/PRO34012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143382.13
HGNCiHGNC:19706 ADAMTSL4
MIMi610113 gene
neXtProtiNX_Q6UY14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Ectopia lentis 2, isolated, autosomal recessive (ECTOL2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn ocular abnormality characterized by partial or complete displacement of the lens from its space resulting from defective zonule formation.
See also OMIM:225100
Ectopia lentis et pupillae (ECTOLP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn ocular abnormality characterized by displacement of the lenses and the pupils, associated with other ocular anomalies, but without systemic manifestations. The condition is usually bilateral, with the lenses and pupils displaced in opposite directions. Additional signs include enlarged corneal diameter, increased corneal astigmatism, increased anterior chamber depth, thinning and flattening of the iris with loss of crypts, angle malformation caused by enlarged iris processes, persistent pupillary membrane, loss of zonular fibers, tilted disk, and increased axial length. Secondary manifestations include refractive errors, glaucoma, early cataract development, and retinal detachment. Membrane formation on the posterior aspect of the iris has been observed both in histologic sections and on ultrasound biomicroscopy.
See also OMIM:225200

Organism-specific databases

DisGeNETi54507
GeneReviewsiADAMTSL4
MalaCardsiADAMTSL4
MIMi225100 phenotype
225200 phenotype
OpenTargetsiENSG00000143382
Orphaneti1885 Isolated ectopia lentis
PharmGKBiPA134879921

Polymorphism and mutation databases

BioMutaiADAMTSL4
DMDMi118573317

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000025796625 – 1074ADAMTS-like protein 4Sequence analysisAdd BLAST1050

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi490N-linked (GlcNAc...) (complex) asparagine2 Publications1
Glycosylationi773N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6UY14
PaxDbiQ6UY14
PeptideAtlasiQ6UY14
PRIDEiQ6UY14
ProteomicsDBi67693
67694 [Q6UY14-2]

PTM databases

GlyConnecti991
iPTMnetiQ6UY14
PhosphoSitePlusiQ6UY14

Expressioni

Tissue specificityi

Expressed in colon, heart, leukocyte, liver, lung, skeletal muscle, spleen, testis and placenta. Weaker expression in bone marrow, brain tissue, kidney and pancreas. Expression studies in fetal tissues reveal strong expression in heart, kidney, liver, lung and skeletal muscle, but weaker expression in fetal brain and skin.1 Publication

Gene expression databases

BgeeiENSG00000143382 Expressed in 160 organ(s), highest expression level in placenta
CleanExiHS_ADAMTSL4
GenevisibleiQ6UY14 HS

Organism-specific databases

HPAiHPA006279

Interactioni

Subunit structurei

Interacts with CTSB. Interacts with FBN1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q53FW83EBI-10173507,EBI-10242473
ADAMTSL5Q6ZMM2-23EBI-10173507,EBI-10254938
AMMECR1Q9Y4X03EBI-10173507,EBI-8583355
AMMECR1Q9Y4X0-33EBI-10173507,EBI-12823597
ApoL6B3KTP43EBI-10173507,EBI-10175904
ASPSCR1Q9BZE93EBI-10173507,EBI-1993677
CCDC26Q8TAB73EBI-10173507,EBI-10271580
CFAP206Q8IYR05EBI-10173507,EBI-749051
CHCHD2Q9Y6H13EBI-10173507,EBI-2321769
CHRNGP07510-23EBI-10173507,EBI-11979451
CLEC18AA5D8T83EBI-10173507,EBI-10173491
CPNE7Q9UBL63EBI-10173507,EBI-744841
CREB5Q02930-35EBI-10173507,EBI-10192698
CST2P092283EBI-10173507,EBI-8832659
CTSBP078583EBI-742002,EBI-715062
CYP2S1Q96SQ93EBI-10173507,EBI-8633740
CYSRT1A8MQ034EBI-10173507,EBI-3867333
DIP2AQ14689-63EBI-10173507,EBI-10233719
DSCR8Q96T753EBI-10173507,EBI-10294182
EIF4E2O605733EBI-10173507,EBI-398610
FAHP169303EBI-10173507,EBI-4397076
FAM124BQ9H5Z63EBI-10173507,EBI-741626
FARS2O953633EBI-10173507,EBI-2513774
FBXW5Q969U65EBI-10173507,EBI-741068
FKBP1BP681063EBI-10173507,EBI-6693977
FLNAP21333-23EBI-10173507,EBI-9641086
FRS3O435595EBI-10173507,EBI-725515
GATA2P237693EBI-10173507,EBI-2806671
GIPP096813EBI-10173507,EBI-8588553
GMCL2Q8NEA95EBI-10173507,EBI-745707
GNEQ9Y2233EBI-10173507,EBI-4291090
GOLGA8DPQ0D2H93EBI-10173507,EBI-10181276
HEL-S-182mPV9HW603EBI-10173507,EBI-10180762
HGFP142103EBI-10173507,EBI-1039104
HOXA1P496397EBI-10173507,EBI-740785
Hoxa1P090223EBI-742002,EBI-3957603From Mus musculus.
KRTAP10-11P604123EBI-10173507,EBI-10217483
KRTAP10-5P603705EBI-10173507,EBI-10172150
KRTAP10-8P604105EBI-10173507,EBI-10171774
KRTAP10-9P604115EBI-10173507,EBI-10172052
KRTAP4-11Q9BYQ65EBI-10173507,EBI-10302392
KRTAP4-12Q9BQ663EBI-10173507,EBI-739863
KRTAP4-2Q9BYR55EBI-10173507,EBI-10172511
KRTAP5-6Q6L8G93EBI-10173507,EBI-10250562
KRTAP5-9P263719EBI-10173507,EBI-3958099
KRTAP9-2Q9BYQ45EBI-10173507,EBI-1044640
KRTAP9-4Q9BYQ23EBI-10173507,EBI-10185730
LCE1BQ5T7P35EBI-10173507,EBI-10245913
LCE2BO146334EBI-10173507,EBI-11478468
LCE2DQ5TA825EBI-10173507,EBI-10246750
LCE3CQ5T5A85EBI-10173507,EBI-10245291
LCE3EQ5T5B05EBI-10173507,EBI-10245456
LCE4AQ5TA785EBI-10173507,EBI-10246358
LGALS14Q8TCE93EBI-10173507,EBI-10274069
LHX4A0A0S2Z5S93EBI-10173507,EBI-16429099
LMO1P258003EBI-10173507,EBI-8639312
LMO2P257913EBI-10173507,EBI-739696
LONRF1Q17RB85EBI-10173507,EBI-2341787
LRRC29Q8WV353EBI-10173507,EBI-10276755
MAPKBP1O603365EBI-10173507,EBI-947402
MID2Q9UJV3-25EBI-10173507,EBI-10172526
MORN3Q6PF183EBI-10173507,EBI-9675802
NATD1Q8N6N65EBI-10173507,EBI-8656665
NMUR2Q9GZQ43EBI-10173507,EBI-10303844
NTF4P341303EBI-10173507,EBI-3907456
OLFM3Q96PB73EBI-10173507,EBI-10292253
PID1Q7Z2X43EBI-10173507,EBI-10256685
PIN1Q135263EBI-10173507,EBI-714158
PTGER3P43115-123EBI-10173507,EBI-10234038
RAB2BQ8WUD13EBI-10173507,EBI-5542466
RCHY1Q96PM53EBI-10173507,EBI-947779
RHOJQ9H4E53EBI-10173507,EBI-6285694
RYDENQ9NUL53EBI-10173507,EBI-10313866
SLC23A1Q9UHI73EBI-10173507,EBI-1759386
SLC6A20Q9NP913EBI-10173507,EBI-10311198
SMARCC1Q929225EBI-10173507,EBI-355653
SPATA8Q6RVD63EBI-10173507,EBI-8635958
SPINK2P201553EBI-10173507,EBI-10200479
STK16O757163EBI-742002,EBI-749295
SUSD6Q925373EBI-10173507,EBI-2866213
TCEA2Q155603EBI-10173507,EBI-710310
TMEM150AQ86TG13EBI-10173507,EBI-2799342
TOP3BO959853EBI-10173507,EBI-373403
TRIM42Q8IWZ53EBI-10173507,EBI-5235829
TRIP6Q156543EBI-10173507,EBI-742327
TSSK3Q96PN83EBI-10173507,EBI-3918381
VWC2Q2TAL64EBI-10173507,EBI-11957238
ZNF417Q8TAU35EBI-10173507,EBI-740727
ZNF587Q96SQ53EBI-10173507,EBI-6427977

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi120002, 108 interactors
IntActiQ6UY14, 198 interactors
MINTiQ6UY14
STRINGi9606.ENSP00000271643

Structurei

3D structure databases

ProteinModelPortaliQ6UY14
SMRiQ6UY14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 93TSP type-1 1PROSITE-ProRule annotationAdd BLAST46
Domaini723 – 782TSP type-1 2PROSITE-ProRule annotationAdd BLAST60
Domaini783 – 842TSP type-1 3PROSITE-ProRule annotationAdd BLAST60
Domaini845 – 909TSP type-1 4PROSITE-ProRule annotationAdd BLAST65
Domaini910 – 969TSP type-1 5PROSITE-ProRule annotationAdd BLAST60
Domaini970 – 1026TSP type-1 6PROSITE-ProRule annotationAdd BLAST57
Domaini1029 – 1066PLACPROSITE-ProRule annotationAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi602 – 664Pro-richSequence analysisAdd BLAST63

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
KOG4597 Eukaryota
ENOG41102GD LUCA
GeneTreeiENSGT00900000140774
HOGENOMiHOG000034174
HOVERGENiHBG080879
InParanoidiQ6UY14
OMAiRSRQVRC
OrthoDBiEOG091G14M8
PhylomeDBiQ6UY14
TreeFamiTF316874

Family and domain databases

Gene3Di2.20.100.10, 6 hits
InterProiView protein in InterPro
IPR010294 ADAM_spacer1
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF08686 PLAC, 1 hit
PF00090 TSP_1, 5 hits
SMARTiView protein in SMART
SM00209 TSP1, 6 hits
SUPFAMiSSF82895 SSF82895, 6 hits
PROSITEiView protein in PROSITE
PS50900 PLAC, 1 hit
PS50092 TSP1, 6 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 11 Publication (identifier: Q6UY14-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENWTGRPWL YLLLLLSLPQ LCLDQEVLSG HSLQTPTEEG QGPEGVWGPW 
        60         70         80         90        100
VQWASCSQPC GVGVQRRSRT CQLPTVQLHP SLPLPPRPPR HPEALLPRGQ 
       110        120        130        140        150
GPRPQTSPET LPLYRTQSRG RGGPLRGPAS HLGREETQEI RAARRSRLRD 
       160        170        180        190        200
PIKPGMFGYG RVPFALPLHR NRRHPRSPPR SELSLISSRG EEAIPSPTPR 
       210        220        230        240        250
AEPFSANGSP QTELPPTELS VHTPSPQAEP LSPETAQTEV APRTRPAPLR 
       260        270        280        290        300
HHPRAQASGT EPPSPTHSLG EGGFFRASPQ PRRPSSQGWA SPQVAGRRPD 
       310        320        330        340        350
PFPSVPRGRG QQGQGPWGTG GTPHGPRLEP DPQHPGAWLP LLSNGPHASS 
       360        370        380        390        400
LWSLFAPSSP IPRCSGESEQ LRACSQAPCP PEQPDPRALQ CAAFNSQEFM 
       410        420        430        440        450
GQLYQWEPFT EVQGSQRCEL NCRPRGFRFY VRHTEKVQDG TLCQPGAPDI 
       460        470        480        490        500
CVAGRCLSPG CDGILGSGRR PDGCGVCGGD DSTCRLVSGN LTDRGGPLGY 
       510        520        530        540        550
QKILWIPAGA LRLQIAQLRP SSNYLALRGP GGRSIINGNW AVDPPGSYRA 
       560        570        580        590        600
GGTVFRYNRP PREEGKGESL SAEGPTTQPV DVYMIFQEEN PGVFYQYVIS 
       610        620        630        640        650
SPPPILENPT PEPPVPQLQP EILRVEPPLA PAPRPARTPG TLQRQVRIPQ 
       660        670        680        690        700
MPAPPHPRTP LGSPAAYWKR VGHSACSASC GKGVWRPIFL CISRESGEEL 
       710        720        730        740        750
DERSCAAGAR PPASPEPCHG TPCPPYWEAG EWTSCSRSCG PGTQHRQLQC 
       760        770        780        790        800
RQEFGGGGSS VPPERCGHLP RPNITQSCQL RLCGHWEVGS PWSQCSVRCG 
       810        820        830        840        850
RGQRSRQVRC VGNNGDEVSE QECASGPPQP PSREACDMGP CTTAWFHSDW 
       860        870        880        890        900
SSKCSAECGT GIQRRSVVCL GSGAALGPGQ GEAGAGTGQS CPTGSRPPDM 
       910        920        930        940        950
RACSLGPCER TWRWYTGPWG ECSSECGSGT QRRDIICVSK LGTEFNVTSP 
       960        970        980        990       1000
SNCSHLPRPP ALQPCQGQAC QDRWFSTPWS PCSRSCQGGT QTREVQCLST 
      1010       1020       1030       1040       1050
NQTLSTRCPP QLRPSRKRPC NSQPCSQRPD DQCKDSSPHC PLVVQARLCV 
      1060       1070 
YPYYTATCCR SCAHVLERSP QDPS
Note: Gene prediction confirmed by EST data.Curated
Length:1,074
Mass (Da):116,545
Last modified:October 31, 2006 - v2
Checksum:i79AE0E5DF5488CA1
GO
Isoform 21 Publication (identifier: Q6UY14-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     854-877: CSAECGTGIQRRSVVCLGSGAALG → VSPEPPAISCILGNHAQDTSAFPA
     878-1074: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:877
Mass (Da):95,132
Checksum:iB778D79DB24E4EA9
GO
Isoform 3 (identifier: Q6UY14-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     411-411: E → EAPLLPLRHAFFLLPGAGSGDSTG

Note: No experimental confirmation available.
Show »
Length:1,097
Mass (Da):118,822
Checksum:iF7C5EB712A3EA448
GO

Sequence cautioni

The sequence AAG17217 differs from that shown. Reason: Frameshift at position 719.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061918193A → P1 PublicationCorresponds to variant dbSNP:rs41317515EnsemblClinVar.1
Natural variantiVAR_0619191028R → H. Corresponds to variant dbSNP:rs56411234Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055759411E → EAPLLPLRHAFFLLPGAGSG DSTG in isoform 3. Curated1
Alternative sequenceiVSP_052183854 – 877CSAEC…GAALG → VSPEPPAISCILGNHAQDTS AFPA in isoform 2. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_052184878 – 1074Missing in isoform 2. 2 PublicationsAdd BLAST197

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358122 mRNA Translation: AAQ88489.1
AL356356 Genomic DNA Translation: CAI15499.1
AL356356 Genomic DNA Translation: CAI15500.2
BC027478 mRNA Translation: AAH27478.2
BC071852 mRNA Translation: AAH71852.1
BC094811 mRNA Translation: AAH94811.1
BC140800 mRNA Translation: AAI40801.1
AF217974 mRNA Translation: AAG17217.1 Frameshift.
CCDSiCCDS30852.1 [Q6UY14-2]
CCDS72908.1 [Q6UY14-3]
CCDS955.1 [Q6UY14-1]
RefSeqiNP_001275536.1, NM_001288607.1
NP_001275537.1, NM_001288608.1 [Q6UY14-3]
NP_061905.2, NM_019032.5 [Q6UY14-1]
NP_079284.2, NM_025008.4 [Q6UY14-2]
XP_011507950.1, XM_011509648.2 [Q6UY14-3]
XP_016856995.1, XM_017001506.1 [Q6UY14-3]
UniGeneiHs.516243

Genome annotation databases

EnsembliENST00000271643; ENSP00000271643; ENSG00000143382 [Q6UY14-1]
ENST00000369038; ENSP00000358034; ENSG00000143382 [Q6UY14-1]
ENST00000369039; ENSP00000358035; ENSG00000143382 [Q6UY14-3]
ENST00000369041; ENSP00000358037; ENSG00000143382 [Q6UY14-2]
GeneIDi54507
KEGGihsa:54507
UCSCiuc001euw.5 human [Q6UY14-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358122 mRNA Translation: AAQ88489.1
AL356356 Genomic DNA Translation: CAI15499.1
AL356356 Genomic DNA Translation: CAI15500.2
BC027478 mRNA Translation: AAH27478.2
BC071852 mRNA Translation: AAH71852.1
BC094811 mRNA Translation: AAH94811.1
BC140800 mRNA Translation: AAI40801.1
AF217974 mRNA Translation: AAG17217.1 Frameshift.
CCDSiCCDS30852.1 [Q6UY14-2]
CCDS72908.1 [Q6UY14-3]
CCDS955.1 [Q6UY14-1]
RefSeqiNP_001275536.1, NM_001288607.1
NP_001275537.1, NM_001288608.1 [Q6UY14-3]
NP_061905.2, NM_019032.5 [Q6UY14-1]
NP_079284.2, NM_025008.4 [Q6UY14-2]
XP_011507950.1, XM_011509648.2 [Q6UY14-3]
XP_016856995.1, XM_017001506.1 [Q6UY14-3]
UniGeneiHs.516243

3D structure databases

ProteinModelPortaliQ6UY14
SMRiQ6UY14
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120002, 108 interactors
IntActiQ6UY14, 198 interactors
MINTiQ6UY14
STRINGi9606.ENSP00000271643

PTM databases

GlyConnecti991
iPTMnetiQ6UY14
PhosphoSitePlusiQ6UY14

Polymorphism and mutation databases

BioMutaiADAMTSL4
DMDMi118573317

Proteomic databases

EPDiQ6UY14
PaxDbiQ6UY14
PeptideAtlasiQ6UY14
PRIDEiQ6UY14
ProteomicsDBi67693
67694 [Q6UY14-2]

Protocols and materials databases

DNASUi54507
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271643; ENSP00000271643; ENSG00000143382 [Q6UY14-1]
ENST00000369038; ENSP00000358034; ENSG00000143382 [Q6UY14-1]
ENST00000369039; ENSP00000358035; ENSG00000143382 [Q6UY14-3]
ENST00000369041; ENSP00000358037; ENSG00000143382 [Q6UY14-2]
GeneIDi54507
KEGGihsa:54507
UCSCiuc001euw.5 human [Q6UY14-1]

Organism-specific databases

CTDi54507
DisGeNETi54507
EuPathDBiHostDB:ENSG00000143382.13
GeneCardsiADAMTSL4
GeneReviewsiADAMTSL4
HGNCiHGNC:19706 ADAMTSL4
HPAiHPA006279
MalaCardsiADAMTSL4
MIMi225100 phenotype
225200 phenotype
610113 gene
neXtProtiNX_Q6UY14
OpenTargetsiENSG00000143382
Orphaneti1885 Isolated ectopia lentis
PharmGKBiPA134879921
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
KOG4597 Eukaryota
ENOG41102GD LUCA
GeneTreeiENSGT00900000140774
HOGENOMiHOG000034174
HOVERGENiHBG080879
InParanoidiQ6UY14
OMAiRSRQVRC
OrthoDBiEOG091G14M8
PhylomeDBiQ6UY14
TreeFamiTF316874

Enzyme and pathway databases

ReactomeiR-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

ChiTaRSiADAMTSL4 human
GeneWikiiADAMTSL4
GenomeRNAii54507
PROiPR:Q6UY14
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143382 Expressed in 160 organ(s), highest expression level in placenta
CleanExiHS_ADAMTSL4
GenevisibleiQ6UY14 HS

Family and domain databases

Gene3Di2.20.100.10, 6 hits
InterProiView protein in InterPro
IPR010294 ADAM_spacer1
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF08686 PLAC, 1 hit
PF00090 TSP_1, 5 hits
SMARTiView protein in SMART
SM00209 TSP1, 6 hits
SUPFAMiSSF82895 SSF82895, 6 hits
PROSITEiView protein in PROSITE
PS50900 PLAC, 1 hit
PS50092 TSP1, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiATL4_HUMAN
AccessioniPrimary (citable) accession number: Q6UY14
Secondary accession number(s): B2RTT0
, F8WAD0, Q5T5F7, Q6IPM6, Q8N643, Q9HBS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: October 10, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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