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Entry version 125 (07 Apr 2021)
Sequence version 2 (28 Mar 2018)
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Protein

Carcinoembryonic antigen-related cell adhesion molecule 20

Gene

CEACAM20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6UY09

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 20Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEACAM20Imported
ORF Names:UNQ9366/PRO34155Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24879, CEACAM20

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UY09

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000273777.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 450ExtracellularSequence analysisAdd BLAST420
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei451 – 471HelicalSequence analysisAdd BLAST21
Topological domaini472 – 585CytoplasmicSequence analysisAdd BLAST114

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
125931

Open Targets

More...
OpenTargetsi
ENSG00000273777

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672134

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6UY09, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CEACAM20

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73619948

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001457731 – 596Carcinoembryonic antigen-related cell adhesion molecule 20Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi90 ↔ 138PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi276 ↔ 324PROSITE-ProRule annotation
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi375 ↔ 416PROSITE-ProRule annotation
Glycosylationi415N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei578PhosphotyrosineBy similarity1
Modified residuei589PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues by SYK, SRC and FYN in vitro.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6UY09

PeptideAtlas

More...
PeptideAtlasi
Q6UY09

PRoteomics IDEntifications database

More...
PRIDEi
Q6UY09

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67689

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6UY09, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6UY09

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UY09

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000273777, Expressed in duodenum and 29 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6UY09, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via extracellular domain) with PTPRH (via extracellular domain); the interaction dephosphorylates CEACAM20.

Interacts (phosphorylated form) with SYK (via SH2 domains); the interaction further enhances CEACAM20 phosphorylation.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000481937

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6UY09, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6UY09

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 154Ig-like C2-type 1Add BLAST97
Domaini160 – 246Ig-like C2-type 2Add BLAST87
Domaini256 – 341Ig-like C2-type 3Add BLAST86
Domaini346 – 432Ig-like C2-type 4Add BLAST87

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RXPD, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00960000186634

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UY09

Identification of Orthologs from Complete Genome Data

More...
OMAi
YSHGPRK

Database of Orthologous Groups

More...
OrthoDBi
998214at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UY09

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 4 hits
SM00408, IGc2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UY09-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPADSWGHH WMGILLSASL CTVWSPPAAA QLTLNANPLD ATQSEDVVLP
60 70 80 90 100
VFGTPRTPQI HGRSRELAKP SIAVSPGTAI EQKDMVTFYC TTKDVNITIH
110 120 130 140 150
WVSNNLSIVF HERMQLSKDG KILTILIVQR EDSGTYQCEA RDALLSQRSD
160 170 180 190 200
PIFLDVKYGP DPVEIKLESG VASGEVVEVM EGSSMTFLAE TKSHPPCAYT
210 220 230 240 250
WFLLDSILSH TTRTFTIHAV SREHEGLYRC LVSNSATHLS SLGTLKVRVL
260 270 280 290 300
ETLTMPQVVP SSLNLVENAR SVDLTCQTVN QSVNVQWFLS GQPLLPSEHL
310 320 330 340 350
QLSADNRTLI IHGLQRNDTG PYACEVWNWG SRARSEPLEL TINYGPDQVH
360 370 380 390 400
ITRESASEMI STIEAELNSS LTLQCWAESK PGAEYRWTLE HSTGEHLGEQ
410 420 430 440 450
LIIRALTWEH DGIYNCTASN SLTGLARSTS VLVKVVGPQS SSLSSGAIAG
460 470 480 490 500
IVIGILAVIA VASELGYFLC IRNARRPSRK TTEDPSHETS QPIPKEEHPT
510 520 530 540 550
EPSSESLSPE YRNISQLQGR IRVELMQPPD LPEETYETKL PSASRRGNSF
560 570 580 590
SPWKPPPKPL MPPLRLVSTV PKNMESIYEE LVNPEPNTYI QINPSV
Length:596
Mass (Da):65,808
Last modified:March 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30472CDCEBB2FD28
GO
Isoform 2 (identifier: Q6UY09-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     526-537: Missing.

Show »
Length:584
Mass (Da):64,377
Checksum:i142C0D55AE492266
GO
Isoform 3 (identifier: Q6UY09-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-437: YGPDQVHITR...STSVLVKVVG → C

Show »
Length:503
Mass (Da):55,582
Checksum:i7F6AF296201309F1
GO
Isoform 4 (identifier: Q6UY09-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-437: YGPDQVHITR...STSVLVKVVG → C
     526-537: Missing.

Show »
Length:491
Mass (Da):54,152
Checksum:iC887D1A5F658D745
GO
Isoform 5 (identifier: Q6UY09-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     580-596: ELVNPEPNTYIQINPSV → VLGMQQ

Show »
Length:585
Mass (Da):64,555
Checksum:i6E9827AFAE07F5F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0T2A0A087X0T2_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM20
584Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti108I → V in ABS57247 (Ref. 1) Curated1
Sequence conflicti108I → V in ABS57248 (Ref. 1) Curated1
Sequence conflicti108I → V in ABS57249 (Ref. 1) Curated1
Sequence conflicti108I → V in ABS57250 (Ref. 1) Curated1
Sequence conflicti444S → P in ABS57247 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05603041A → V. Corresponds to variant dbSNP:rs10408247Ensembl.1
Natural variantiVAR_06131287T → I. Corresponds to variant dbSNP:rs36053277Ensembl.1
Natural variantiVAR_056031113R → H. Corresponds to variant dbSNP:rs13345196Ensembl.1
Natural variantiVAR_056032127I → V. Corresponds to variant dbSNP:rs35443082Ensembl.1
Natural variantiVAR_056033355S → L. Corresponds to variant dbSNP:rs16959164Ensembl.1
Natural variantiVAR_056034369S → F. Corresponds to variant dbSNP:rs10414398Ensembl.1
Natural variantiVAR_059385512R → C. Corresponds to variant dbSNP:rs8100718Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059367344 – 437YGPDQ…VKVVG → C in isoform 3 and isoform 4. Add BLAST94
Alternative sequenceiVSP_059368526 – 537Missing in isoform 2 and isoform 4. Add BLAST12
Alternative sequenceiVSP_059369580 – 596ELVNP…INPSV → VLGMQQ in isoform 5. Add BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU008600 mRNA Translation: ABS57247.1
EU008601 mRNA Translation: ABS57248.1
EU008602 mRNA Translation: ABS57249.1
EU008603 mRNA Translation: ABS57250.1
AY358129 mRNA Translation: AAQ88496.1
AC245748 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS74390.1 [Q6UY09-4]
CCDS74391.1 [Q6UY09-3]
CCDS74392.1 [Q6UY09-2]
CCDS74393.1 [Q6UY09-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001096067.2, NM_001102597.2 [Q6UY09-1]
NP_001096068.2, NM_001102598.2 [Q6UY09-4]
NP_001096069.2, NM_001102599.2 [Q6UY09-3]
NP_001096070.2, NM_001102600.2 [Q6UY09-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000611497; ENSP00000483912; ENSG00000273777 [Q6UY09-2]
ENST00000614577; ENSP00000482943; ENSG00000273777 [Q6UY09-3]
ENST00000614924; ENSP00000481937; ENSG00000273777 [Q6UY09-1]
ENST00000620096; ENSP00000481812; ENSG00000273777 [Q6UY09-4]
ENST00000621342; ENSP00000480940; ENSG00000273777 [Q6UY09-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
125931

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:125931

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU008600 mRNA Translation: ABS57247.1
EU008601 mRNA Translation: ABS57248.1
EU008602 mRNA Translation: ABS57249.1
EU008603 mRNA Translation: ABS57250.1
AY358129 mRNA Translation: AAQ88496.1
AC245748 Genomic DNA No translation available.
CCDSiCCDS74390.1 [Q6UY09-4]
CCDS74391.1 [Q6UY09-3]
CCDS74392.1 [Q6UY09-2]
CCDS74393.1 [Q6UY09-1]
RefSeqiNP_001096067.2, NM_001102597.2 [Q6UY09-1]
NP_001096068.2, NM_001102598.2 [Q6UY09-4]
NP_001096069.2, NM_001102599.2 [Q6UY09-3]
NP_001096070.2, NM_001102600.2 [Q6UY09-2]

3D structure databases

SMRiQ6UY09
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000481937

PTM databases

GlyGeniQ6UY09, 7 sites
iPTMnetiQ6UY09
PhosphoSitePlusiQ6UY09

Genetic variation databases

BioMutaiCEACAM20
DMDMi73619948

Proteomic databases

MassIVEiQ6UY09
PeptideAtlasiQ6UY09
PRIDEiQ6UY09
ProteomicsDBi67689

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
72273, 21 antibodies

Genome annotation databases

EnsembliENST00000611497; ENSP00000483912; ENSG00000273777 [Q6UY09-2]
ENST00000614577; ENSP00000482943; ENSG00000273777 [Q6UY09-3]
ENST00000614924; ENSP00000481937; ENSG00000273777 [Q6UY09-1]
ENST00000620096; ENSP00000481812; ENSG00000273777 [Q6UY09-4]
ENST00000621342; ENSP00000480940; ENSG00000273777 [Q6UY09-5]
GeneIDi125931
KEGGihsa:125931

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
125931
DisGeNETi125931

GeneCards: human genes, protein and diseases

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GeneCardsi
CEACAM20
HGNCiHGNC:24879, CEACAM20
neXtProtiNX_Q6UY09
OpenTargetsiENSG00000273777
PharmGKBiPA142672134
VEuPathDBiHostDB:ENSG00000273777.4

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RXPD, Eukaryota
GeneTreeiENSGT00960000186634
InParanoidiQ6UY09
OMAiYSHGPRK
OrthoDBi998214at2759
PhylomeDBiQ6UY09

Enzyme and pathway databases

PathwayCommonsiQ6UY09

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
125931, 5 hits in 123 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CEACAM20, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
125931
PharosiQ6UY09, Tdark

Protein Ontology

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PROi
PR:Q6UY09
RNActiQ6UY09, protein

Gene expression databases

BgeeiENSG00000273777, Expressed in duodenum and 29 other tissues
ExpressionAtlasiQ6UY09, baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
SMARTiView protein in SMART
SM00409, IG, 4 hits
SM00408, IGc2, 4 hits
SUPFAMiSSF48726, SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEA20_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UY09
Secondary accession number(s): A0A087WXE1
, A0A087WYH6, A0A087WYM6, A0A087WZX4, A0A087X155, A7LFK7, A7LFK8, A7LFK9, A7LFL0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 28, 2018
Last modified: April 7, 2021
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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