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Protein

Transmembrane and immunoglobulin domain-containing protein 1

Gene

TMIGD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival.1 Publication

GO - Biological processi

  • negative regulation of apoptotic process Source: UniProtKB
  • regulation of cell migration Source: UniProtKB
  • regulation of cell proliferation Source: UniProtKB
  • regulation of membrane permeability Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and immunoglobulin domain-containing protein 1
Gene namesi
Name:TMIGD1Imported
Synonyms:TMIGDImported
ORF Names:UNQ9372/PRO34164
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000182271.12
HGNCiHGNC:32431 TMIGD1
neXtProtiNX_Q6UXZ0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 220ExtracellularSequence analysisAdd BLAST191
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Topological domaini242 – 262CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182271
PharmGKBiPA142670725

Polymorphism and mutation databases

BioMutaiTMIGD1
DMDMi74758583

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000004579030 – 262Transmembrane and immunoglobulin domain-containing protein 1Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 103PROSITE-ProRule annotation
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 195PROSITE-ProRule annotation
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UXZ0
PeptideAtlasiQ6UXZ0
PRIDEiQ6UXZ0
ProteomicsDBi67681
67682 [Q6UXZ0-2]
TopDownProteomicsiQ6UXZ0-2 [Q6UXZ0-2]

PTM databases

iPTMnetiQ6UXZ0
PhosphoSitePlusiQ6UXZ0

Expressioni

Gene expression databases

BgeeiENSG00000182271 Expressed in 22 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_TMIGD1

Organism-specific databases

HPAiHPA021946

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiQ6UXZ0, 1 interactor
MINTiQ6UXZ0
STRINGi9606.ENSP00000332404

Structurei

3D structure databases

ProteinModelPortaliQ6UXZ0
SMRiQ6UXZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 114Ig-like C2-type 1Add BLAST85
Domaini122 – 207Ig-like C2-type 2Add BLAST86

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJG7 Eukaryota
ENOG41129HZ LUCA
GeneTreeiENSGT00510000048311
HOGENOMiHOG000154640
HOVERGENiHBG063617
InParanoidiQ6UXZ0
OMAiIMKLCIK
OrthoDBiEOG091G0MG3
PhylomeDBiQ6UXZ0
TreeFamiTF336634

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6UXZ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWKSSVIMQ MGRFLLLVIL FLPREMTSSV LTVNGKTENY ILDTTPGSQA
60 70 80 90 100
SLICAVQNHT REEELLWYRE EGRVDLKSGN KINSSSVCVS SISENDNGIS
110 120 130 140 150
FTCRLGRDQS VSVSVVLNVT FPPLLSGNDF QTVEEGSNVK LVCNVKANPQ
160 170 180 190 200
AQMMWYKNSS LLDLEKSRHQ IQQTSESFQL SITKVEKPDN GTYSCIAKSS
210 220 230 240 250
LKTESLDFHL IVKDKTVGVP IEPIIAACVV IFLTLCFGLI ARRKKIMKLC
260
MKDKDPHSET AL
Length:262
Mass (Da):29,185
Last modified:July 5, 2004 - v1
Checksum:i004383C6D7948952
GO
Isoform 2 (identifier: Q6UXZ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-218: DKTVG → ALHEG
     219-262: Missing.

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):24,283
Checksum:iC7C44EE2A6327234
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017075214 – 218DKTVG → ALHEG in isoform 2. 1 Publication5
Alternative sequenceiVSP_017076219 – 262Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172838 mRNA Translation: BAD18803.1
AK290266 mRNA Translation: BAF82955.1
AY358153 mRNA Translation: AAQ88520.1
CCDSiCCDS32605.1 [Q6UXZ0-1]
CCDS82099.1 [Q6UXZ0-2]
RefSeqiNP_001306871.1, NM_001319942.1 [Q6UXZ0-2]
NP_996663.1, NM_206832.2 [Q6UXZ0-1]
XP_011523089.1, XM_011524787.1 [Q6UXZ0-1]
UniGeneiHs.371005

Genome annotation databases

EnsembliENST00000328886; ENSP00000332404; ENSG00000182271 [Q6UXZ0-1]
ENST00000538566; ENSP00000446118; ENSG00000182271 [Q6UXZ0-2]
GeneIDi388364
KEGGihsa:388364
UCSCiuc002hfa.1 human [Q6UXZ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172838 mRNA Translation: BAD18803.1
AK290266 mRNA Translation: BAF82955.1
AY358153 mRNA Translation: AAQ88520.1
CCDSiCCDS32605.1 [Q6UXZ0-1]
CCDS82099.1 [Q6UXZ0-2]
RefSeqiNP_001306871.1, NM_001319942.1 [Q6UXZ0-2]
NP_996663.1, NM_206832.2 [Q6UXZ0-1]
XP_011523089.1, XM_011524787.1 [Q6UXZ0-1]
UniGeneiHs.371005

3D structure databases

ProteinModelPortaliQ6UXZ0
SMRiQ6UXZ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6UXZ0, 1 interactor
MINTiQ6UXZ0
STRINGi9606.ENSP00000332404

PTM databases

iPTMnetiQ6UXZ0
PhosphoSitePlusiQ6UXZ0

Polymorphism and mutation databases

BioMutaiTMIGD1
DMDMi74758583

Proteomic databases

PaxDbiQ6UXZ0
PeptideAtlasiQ6UXZ0
PRIDEiQ6UXZ0
ProteomicsDBi67681
67682 [Q6UXZ0-2]
TopDownProteomicsiQ6UXZ0-2 [Q6UXZ0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328886; ENSP00000332404; ENSG00000182271 [Q6UXZ0-1]
ENST00000538566; ENSP00000446118; ENSG00000182271 [Q6UXZ0-2]
GeneIDi388364
KEGGihsa:388364
UCSCiuc002hfa.1 human [Q6UXZ0-1]

Organism-specific databases

CTDi388364
EuPathDBiHostDB:ENSG00000182271.12
GeneCardsiTMIGD1
HGNCiHGNC:32431 TMIGD1
HPAiHPA021946
neXtProtiNX_Q6UXZ0
OpenTargetsiENSG00000182271
PharmGKBiPA142670725
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJG7 Eukaryota
ENOG41129HZ LUCA
GeneTreeiENSGT00510000048311
HOGENOMiHOG000154640
HOVERGENiHBG063617
InParanoidiQ6UXZ0
OMAiIMKLCIK
OrthoDBiEOG091G0MG3
PhylomeDBiQ6UXZ0
TreeFamiTF336634

Miscellaneous databases

GenomeRNAii388364
PROiPR:Q6UXZ0

Gene expression databases

BgeeiENSG00000182271 Expressed in 22 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_TMIGD1

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTMIG1_HUMAN
AccessioniPrimary (citable) accession number: Q6UXZ0
Secondary accession number(s): A8K2K1, Q6ZMC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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