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Protein

MICOS complex subunit MIC27

Gene

APOOL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979).2 Publications

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC27
Alternative name(s):
Apolipoprotein O-like
Protein FAM121A
Gene namesi
Name:APOOL
Synonyms:CXorf33, FAM121A, MIC27
ORF Names:UNQ8193/PRO23204
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000155008.13
HGNCiHGNC:24009 APOOL
MIMi300955 gene
neXtProtiNX_Q6UXV4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 110Mitochondrial intermembraneSequence analysisAdd BLAST83
Transmembranei111 – 129HelicalSequence analysisAdd BLAST19
Topological domaini130 – 137Mitochondrial matrixSequence analysis8
Transmembranei138 – 155HelicalSequence analysisAdd BLAST18
Topological domaini156 – 268Mitochondrial intermembraneSequence analysisAdd BLAST113

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000155008
PharmGKBiPA162376732

Polymorphism and mutation databases

BioMutaiAPOOL
DMDMi74749432

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionSequence analysisAdd BLAST27
ChainiPRO_000004205228 – 268MICOS complex subunit MIC27Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei204PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6UXV4
MaxQBiQ6UXV4
PaxDbiQ6UXV4
PeptideAtlasiQ6UXV4
PRIDEiQ6UXV4
ProteomicsDBi67669
TopDownProteomicsiQ6UXV4

PTM databases

iPTMnetiQ6UXV4
PhosphoSitePlusiQ6UXV4

Expressioni

Gene expression databases

BgeeiENSG00000155008 Expressed in 223 organ(s), highest expression level in myocardium
CleanExiHS_APOOL
ExpressionAtlasiQ6UXV4 baseline and differential
GenevisibleiQ6UXV4 HS

Organism-specific databases

HPAiHPA000612

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex (PubMed:25764979, PubMed:25781180, PubMed:23704930, PubMed:25764979, PubMed:25781180, PubMed:25997101).The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with MINOS1/MIC10, IMMT/MIC60 and APOO/MIC23/MIC26 (PubMed:25764979, PubMed:25781180, PubMed:23704930, PubMed:25764979, PubMed:25781180, PubMed:25997101).4 Publications

Protein-protein interaction databases

BioGridi126558, 46 interactors
CORUMiQ6UXV4
DIPiDIP-47309N
IntActiQ6UXV4, 5 interactors
MINTiQ6UXV4
STRINGi9606.ENSP00000362268

Structurei

3D structure databases

ProteinModelPortaliQ6UXV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4798 Eukaryota
ENOG4112AZQ LUCA
GeneTreeiENSGT00530000063666
HOGENOMiHOG000034010
HOVERGENiHBG055885
InParanoidiQ6UXV4
OMAiRYIGWCK
PhylomeDBiQ6UXV4
TreeFamiTF315313

Family and domain databases

InterProiView protein in InterPro
IPR019166 MIC26/MIC27
IPR033182 MIC26/MIC27_animal
PANTHERiPTHR14564 PTHR14564, 1 hit
PfamiView protein in Pfam
PF09769 ApoO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q6UXV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAIRMGKLT TMPAGLIYAS VSVHAAKQEE SKKQLVKPEQ LPIYTAPPLQ
60 70 80 90 100
SKYVEEQPGH LQMGFASIRT ATGCYIGWCK GVYVFVKNGI MDTVQFGKDA
110 120 130 140 150
YVYLKNPPRD FLPKMGVITV SGLAGLVSAR KGSKFKKITY PLGLATLGAT
160 170 180 190 200
VCYPVQSVII AKVTAKKVYA TSQQIFGAVK SLWTKSSKEE SLPKPKEKTK
210 220 230 240 250
LGSSSEIEVP AKTTHVLKHS VPLPTELSSE AKTKSESTSG ATQFMPDPKL
260
MDHGQSHPED IDMYSTRS
Length:268
Mass (Da):29,159
Last modified:July 5, 2004 - v1
Checksum:i2BA4B3AACFBDA298
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYF7A0A087WYF7_HUMAN
MICOS complex subunit
APOOL
268Annotation score:
A0A087WUX8A0A087WUX8_HUMAN
MICOS complex subunit
APOOL
263Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358193 mRNA Translation: AAQ88560.1
Z83820 Genomic DNA No translation available.
Z99571 Genomic DNA No translation available.
BC107096 mRNA Translation: AAI07097.1
CCDSiCCDS48138.1
RefSeqiNP_940852.3, NM_198450.5
UniGeneiHs.512181
Hs.729014

Genome annotation databases

EnsembliENST00000373173; ENSP00000362268; ENSG00000155008
GeneIDi139322
KEGGihsa:139322
UCSCiuc004eem.4 human

Similar proteinsi

Entry informationi

Entry nameiMIC27_HUMAN
AccessioniPrimary (citable) accession number: Q6UXV4
Secondary accession number(s): Q3KNU7, Q5H9D1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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