UniProtKB - Q6UXV1 (IZUM2_HUMAN)
Protein
Izumo sperm-egg fusion protein 2
Gene
IZUMO2
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
Izumo is the name of a Japanese shrine to marriage.
Enzyme and pathway databases
PathwayCommonsi | Q6UXV1 |
Reactomei | R-HSA-1300645, Acrosome Reaction and Sperm:Oocyte Membrane Binding |
Protein family/group databases
TCDBi | 8.A.55.2.1, the izumo sperm-egg fusion protein 1 (izumo1) family |
Names & Taxonomyi
Protein namesi | Recommended name: Izumo sperm-egg fusion protein 2 |
Gene namesi | Name:IZUMO2 Synonyms:C19orf41, SCRL ORF Names:UNQ6978/PRO21961 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28518, IZUMO2 |
MIMi | 618895, gene |
neXtProti | NX_Q6UXV1 |
VEuPathDBi | HostDB:ENSG00000161652.12 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 186 | ExtracellularSequence analysisAdd BLAST | 166 | |
Transmembranei | 187 – 207 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 208 – 221 | CytoplasmicSequence analysisAdd BLAST | 14 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000161652 |
PharmGKBi | PA165393535 |
Miscellaneous databases
Pharosi | Q6UXV1, Tdark |
Genetic variation databases
BioMutai | IZUMO2 |
DMDMi | 74738278 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000295736 | 21 – 221 | Izumo sperm-egg fusion protein 2Add BLAST | 201 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 91 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q6UXV1 |
PaxDbi | Q6UXV1 |
PeptideAtlasi | Q6UXV1 |
PRIDEi | Q6UXV1 |
ProteomicsDBi | 67666 [Q6UXV1-1] 67667 [Q6UXV1-2] |
PTM databases
GlyGeni | Q6UXV1, 1 site |
iPTMneti | Q6UXV1 |
PhosphoSitePlusi | Q6UXV1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000161652, Expressed in right testis and 76 other tissues |
ExpressionAtlasi | Q6UXV1, baseline and differential |
Genevisiblei | Q6UXV1, HS |
Organism-specific databases
HPAi | ENSG00000161652, Tissue enriched (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 125957, 2 interactors |
STRINGi | 9606.ENSP00000293405 |
Miscellaneous databases
RNActi | Q6UXV1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Izumo family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S57B, Eukaryota |
GeneTreei | ENSGT00390000015068 |
HOGENOMi | CLU_104457_0_0_1 |
InParanoidi | Q6UXV1 |
OMAi | KEEVWDC |
OrthoDBi | 1528398at2759 |
PhylomeDBi | Q6UXV1 |
TreeFami | TF337020 |
Family and domain databases
InterProi | View protein in InterPro IPR029389, IZUMO IPR042920, IZUMO2 |
PANTHERi | PTHR47745, PTHR47745, 1 hit |
Pfami | View protein in Pfam PF15005, IZUMO, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6UXV1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPLALTLLLL SGLGAPGGWG CLQCDPLVLE ALGHLRSALI PSRFQLEQLQ
60 70 80 90 100
ARAGAVLMGM EGPFFRDYAL NVFVGKVETN QLDLVASFVK NQTQHLMGNS
110 120 130 140 150
LKDEPLLEEL VTLRANVIKE FKKVLISYEL KACNPKLCRL LKEEVLDCLH
160 170 180 190 200
CQRITPKCIH KKYCFVDRQP RVALQYQMDS KYPRNQALLG ILISVSLAVF
210 220
VFVVIVVSAC TYRQNRKLLL Q
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R2L8 | M0R2L8_HUMAN | Izumo sperm-egg fusion protein 2 | IZUMO2 | 234 | Annotation score: | ||
M0QZG1 | M0QZG1_HUMAN | Izumo sperm-egg fusion protein 2 | IZUMO2 | 93 | Annotation score: | ||
M0QXA9 | M0QXA9_HUMAN | Izumo sperm-egg fusion protein 2 | IZUMO2 | 89 | Annotation score: |
Sequence cautioni
The sequence AAQ05826 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAQ05827 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050912 | 139 | R → C. Corresponds to variant dbSNP:rs3745498Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027043 | 136 – 221 | KLCRL…KLLLQ → AWPCSTRWTANTRGTRRCWA SSFLCLWLSLSSWSSWSRLV HTDKTENSCCSRTVVWG in isoform 2. 1 PublicationAdd BLAST | 86 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF479645 Genomic DNA Translation: AAQ05826.1 Sequence problems. AF479645 Genomic DNA Translation: AAQ05827.1 Sequence problems. AY358196 mRNA Translation: AAQ88563.1 AK131024 mRNA Translation: BAC85478.1 BC029535 mRNA Translation: AAH29535.2 |
CCDSi | CCDS12792.2 [Q6UXV1-1] |
RefSeqi | NP_001308378.1, NM_001321449.1 NP_689571.2, NM_152358.2 [Q6UXV1-1] |
Genome annotation databases
Ensembli | ENST00000293405; ENSP00000293405; ENSG00000161652 [Q6UXV1-1] |
GeneIDi | 126123 |
KEGGi | hsa:126123 |
UCSCi | uc002prp.2, human [Q6UXV1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF479645 Genomic DNA Translation: AAQ05826.1 Sequence problems. AF479645 Genomic DNA Translation: AAQ05827.1 Sequence problems. AY358196 mRNA Translation: AAQ88563.1 AK131024 mRNA Translation: BAC85478.1 BC029535 mRNA Translation: AAH29535.2 |
CCDSi | CCDS12792.2 [Q6UXV1-1] |
RefSeqi | NP_001308378.1, NM_001321449.1 NP_689571.2, NM_152358.2 [Q6UXV1-1] |
3D structure databases
SMRi | Q6UXV1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125957, 2 interactors |
STRINGi | 9606.ENSP00000293405 |
Protein family/group databases
TCDBi | 8.A.55.2.1, the izumo sperm-egg fusion protein 1 (izumo1) family |
PTM databases
GlyGeni | Q6UXV1, 1 site |
iPTMneti | Q6UXV1 |
PhosphoSitePlusi | Q6UXV1 |
Genetic variation databases
BioMutai | IZUMO2 |
DMDMi | 74738278 |
Proteomic databases
MassIVEi | Q6UXV1 |
PaxDbi | Q6UXV1 |
PeptideAtlasi | Q6UXV1 |
PRIDEi | Q6UXV1 |
ProteomicsDBi | 67666 [Q6UXV1-1] 67667 [Q6UXV1-2] |
Protocols and materials databases
Antibodypediai | 49261, 29 antibodies |
DNASUi | 126123 |
Genome annotation databases
Ensembli | ENST00000293405; ENSP00000293405; ENSG00000161652 [Q6UXV1-1] |
GeneIDi | 126123 |
KEGGi | hsa:126123 |
UCSCi | uc002prp.2, human [Q6UXV1-1] |
Organism-specific databases
CTDi | 126123 |
GeneCardsi | IZUMO2 |
HGNCi | HGNC:28518, IZUMO2 |
HPAi | ENSG00000161652, Tissue enriched (testis) |
MIMi | 618895, gene |
neXtProti | NX_Q6UXV1 |
OpenTargetsi | ENSG00000161652 |
PharmGKBi | PA165393535 |
VEuPathDBi | HostDB:ENSG00000161652.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S57B, Eukaryota |
GeneTreei | ENSGT00390000015068 |
HOGENOMi | CLU_104457_0_0_1 |
InParanoidi | Q6UXV1 |
OMAi | KEEVWDC |
OrthoDBi | 1528398at2759 |
PhylomeDBi | Q6UXV1 |
TreeFami | TF337020 |
Enzyme and pathway databases
PathwayCommonsi | Q6UXV1 |
Reactomei | R-HSA-1300645, Acrosome Reaction and Sperm:Oocyte Membrane Binding |
Miscellaneous databases
BioGRID-ORCSi | 126123, 4 hits in 865 CRISPR screens |
ChiTaRSi | IZUMO2, human |
GenomeRNAii | 126123 |
Pharosi | Q6UXV1, Tdark |
PROi | PR:Q6UXV1 |
RNActi | Q6UXV1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000161652, Expressed in right testis and 76 other tissues |
ExpressionAtlasi | Q6UXV1, baseline and differential |
Genevisiblei | Q6UXV1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029389, IZUMO IPR042920, IZUMO2 |
PANTHERi | PTHR47745, PTHR47745, 1 hit |
Pfami | View protein in Pfam PF15005, IZUMO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IZUM2_HUMAN | |
Accessioni | Q6UXV1Primary (citable) accession number: Q6UXV1 Secondary accession number(s): Q5GRG3 Q8NHR8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants