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Protein

Transmembrane protein 92

Gene

TMEM92

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 92
Gene namesi
Name:TMEM92
ORF Names:UNQ5801/PRO19608
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167105.7
HGNCiHGNC:26579 TMEM92
neXtProtiNX_Q6UXU6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 57ExtracellularSequence analysisAdd BLAST31
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 159CytoplasmicSequence analysisAdd BLAST81

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167105
PharmGKBiPA142670744

Polymorphism and mutation databases

BioMutaiTMEM92
DMDMi74738274

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000025170927 – 159Transmembrane protein 92Add BLAST133

Proteomic databases

MaxQBiQ6UXU6
PaxDbiQ6UXU6
PeptideAtlasiQ6UXU6
PRIDEiQ6UXU6
ProteomicsDBi67664

Expressioni

Gene expression databases

BgeeiENSG00000167105 Expressed in 104 organ(s), highest expression level in body of stomach
CleanExiHS_TMEM92
GenevisibleiQ6UXU6 HS

Organism-specific databases

HPAiHPA063009
HPA069820

Interactioni

Protein-protein interaction databases

BioGridi127818, 16 interactors
IntActiQ6UXU6, 6 interactors
STRINGi9606.ENSP00000300433

Structurei

3D structure databases

ProteinModelPortaliQ6UXU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi86 – 144Pro-richAdd BLAST59

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3FY Eukaryota
ENOG41117DU LUCA
GeneTreeiENSGT00390000014943
HOGENOMiHOG000133046
HOVERGENiHBG084496
InParanoidiQ6UXU6
OMAiSLFCICG
OrthoDBiEOG091G11G2
PhylomeDBiQ6UXU6
TreeFamiTF338534

Family and domain databases

InterProiView protein in InterPro
IPR021684 WBP1-like
PfamiView protein in Pfam
PF11669 WBP-1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQAWVPGLA PTLLFSLLAG PQKIAAKCGL ILACPKGFKC CGDSCCQENE
60 70 80 90 100
LFPGPVRIFV IIFLVILSVF CICGLAKCFC RNCREPEPDS PVDCRGPLEL
110 120 130 140 150
PSIIPPERVR VSLSAPPPPY SEVILKPSLG PTPTEPPPPY SFRPEEYTGD

QRGIDNPAF
Length:159
Mass (Da):17,229
Last modified:July 5, 2004 - v1
Checksum:i4C6C0678F3EA547C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0617154A → T. Corresponds to variant dbSNP:rs9894445Ensembl.1
Natural variantiVAR_02770490S → N. Corresponds to variant dbSNP:rs6504642Ensembl.1
Natural variantiVAR_02770390S → T2 PublicationsCorresponds to variant dbSNP:rs6504642Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358204 mRNA Translation: AAQ88571.1
AK090637 mRNA Translation: BAC03495.1
BC064507 mRNA Translation: AAH64507.1
CCDSiCCDS11562.1
RefSeqiNP_001161687.1, NM_001168215.1
NP_694961.2, NM_153229.2
UniGeneiHs.224630

Genome annotation databases

EnsembliENST00000300433; ENSP00000300433; ENSG00000167105
ENST00000507382; ENSP00000425144; ENSG00000167105
GeneIDi162461
KEGGihsa:162461
UCSCiuc002iqn.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358204 mRNA Translation: AAQ88571.1
AK090637 mRNA Translation: BAC03495.1
BC064507 mRNA Translation: AAH64507.1
CCDSiCCDS11562.1
RefSeqiNP_001161687.1, NM_001168215.1
NP_694961.2, NM_153229.2
UniGeneiHs.224630

3D structure databases

ProteinModelPortaliQ6UXU6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127818, 16 interactors
IntActiQ6UXU6, 6 interactors
STRINGi9606.ENSP00000300433

Polymorphism and mutation databases

BioMutaiTMEM92
DMDMi74738274

Proteomic databases

MaxQBiQ6UXU6
PaxDbiQ6UXU6
PeptideAtlasiQ6UXU6
PRIDEiQ6UXU6
ProteomicsDBi67664

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300433; ENSP00000300433; ENSG00000167105
ENST00000507382; ENSP00000425144; ENSG00000167105
GeneIDi162461
KEGGihsa:162461
UCSCiuc002iqn.2 human

Organism-specific databases

CTDi162461
EuPathDBiHostDB:ENSG00000167105.7
GeneCardsiTMEM92
HGNCiHGNC:26579 TMEM92
HPAiHPA063009
HPA069820
neXtProtiNX_Q6UXU6
OpenTargetsiENSG00000167105
PharmGKBiPA142670744
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3FY Eukaryota
ENOG41117DU LUCA
GeneTreeiENSGT00390000014943
HOGENOMiHOG000133046
HOVERGENiHBG084496
InParanoidiQ6UXU6
OMAiSLFCICG
OrthoDBiEOG091G11G2
PhylomeDBiQ6UXU6
TreeFamiTF338534

Miscellaneous databases

ChiTaRSiTMEM92 human
GenomeRNAii162461
PROiPR:Q6UXU6

Gene expression databases

BgeeiENSG00000167105 Expressed in 104 organ(s), highest expression level in body of stomach
CleanExiHS_TMEM92
GenevisibleiQ6UXU6 HS

Family and domain databases

InterProiView protein in InterPro
IPR021684 WBP1-like
PfamiView protein in Pfam
PF11669 WBP-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM92_HUMAN
AccessioniPrimary (citable) accession number: Q6UXU6
Secondary accession number(s): Q8NBF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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