Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein ABHD15

Gene

ABHD15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei360Charge relay systemBy similarity1
Active sitei391Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERihuman-ABHD15 abh_upf0017

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD15Curated (EC:3.1.1.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 15Curated
Short name:
Abhydrolase domain-containing protein 15Imported
Gene namesi
Name:ABHD15Imported
ORF Names:UNQ6510/PRO21435
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000168792.4
HGNCiHGNC:26971 ABHD15
neXtProtiNX_Q6UXT9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168792
PharmGKBiPA164714659

Polymorphism and mutation databases

BioMutaiABHD15
DMDMi308153403

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000034539524 – 468Protein ABHD15Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei434PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6UXT9
MaxQBiQ6UXT9
PaxDbiQ6UXT9
PeptideAtlasiQ6UXT9
PRIDEiQ6UXT9
ProteomicsDBi67657

PTM databases

iPTMnetiQ6UXT9
PhosphoSitePlusiQ6UXT9

Expressioni

Gene expression databases

BgeeiENSG00000168792 Expressed in 129 organ(s), highest expression level in liver
GenevisibleiQ6UXT9 HS

Organism-specific databases

HPAiHPA014470

Interactioni

Protein-protein interaction databases

BioGridi125492, 10 interactors
IntActiQ6UXT9, 7 interactors
STRINGi9606.ENSP00000302657

Structurei

3D structure databases

ProteinModelPortaliQ6UXT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410INFX Eukaryota
ENOG410Z0Y9 LUCA
GeneTreeiENSGT00530000062981
HOGENOMiHOG000033769
InParanoidiQ6UXT9
KOiK13707
OMAiETLFCHT
OrthoDBiEOG091G0LZO
PhylomeDBiQ6UXT9
TreeFamiTF332985

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR022742 Hydrolase_4
PfamiView protein in Pfam
PF12146 Hydrolase_4, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPWGAALAL ILAVLALLGL LGPRLRGPWG RAVGERTLPG AQDRDDGEEA
60 70 80 90 100
DGGGPADQFS DGREPLPGGC SLVCKPSALA QCLLRALRRS EALEAGPRSW
110 120 130 140 150
FSGPHLQTLC HFVLPVAPGP ELAREYLQLA DDGLVALDWV VGPCVRGRRI
160 170 180 190 200
TSAGGLPAVL LVIPNAWGRL TRNVLGLCLL ALERGYYPVI FHRRGHHGCP
210 220 230 240 250
LVSPRLQPFG DPSDLKEAVT YIRFRHPAAP LFAVSEGSGS ALLLSYLGEC
260 270 280 290 300
GSSSYVTGAA CISPVLRCRE WFEAGLPWPY ERGFLLHQKI ALSRYATALE
310 320 330 340 350
DTVDTSRLFR SRSLREFEEA LFCHTKSFPI SWDTYWDRND PLRDVDEAAV
360 370 380 390 400
PVLCICSADD PVCGPPDHTL TTELFHSNPY FFLLLSRHGG HCGFLRQEPL
410 420 430 440 450
PAWSHEVILE SFRALTEFFR TEERIKGLSR HRASFLGGRR RGGALQRREV
460
SSSSNLEEIF NWKRSYTR
Length:468
Mass (Da):51,771
Last modified:October 5, 2010 - v2
Checksum:iA910F5F4294B0CC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti287H → Y in AAH12476 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045821334T → A2 PublicationsCorresponds to variant dbSNP:rs542939Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358212 mRNA Translation: AAQ88579.1
AC104564 Genomic DNA No translation available.
BC012476 mRNA Translation: AAH12476.2
CCDSiCCDS32602.1
RefSeqiNP_937790.2, NM_198147.2
UniGeneiHs.106510

Genome annotation databases

EnsembliENST00000307201; ENSP00000302657; ENSG00000168792
GeneIDi116236
KEGGihsa:116236
UCSCiuc002hed.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358212 mRNA Translation: AAQ88579.1
AC104564 Genomic DNA No translation available.
BC012476 mRNA Translation: AAH12476.2
CCDSiCCDS32602.1
RefSeqiNP_937790.2, NM_198147.2
UniGeneiHs.106510

3D structure databases

ProteinModelPortaliQ6UXT9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125492, 10 interactors
IntActiQ6UXT9, 7 interactors
STRINGi9606.ENSP00000302657

Protein family/group databases

ESTHERihuman-ABHD15 abh_upf0017

PTM databases

iPTMnetiQ6UXT9
PhosphoSitePlusiQ6UXT9

Polymorphism and mutation databases

BioMutaiABHD15
DMDMi308153403

Proteomic databases

EPDiQ6UXT9
MaxQBiQ6UXT9
PaxDbiQ6UXT9
PeptideAtlasiQ6UXT9
PRIDEiQ6UXT9
ProteomicsDBi67657

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307201; ENSP00000302657; ENSG00000168792
GeneIDi116236
KEGGihsa:116236
UCSCiuc002hed.3 human

Organism-specific databases

CTDi116236
EuPathDBiHostDB:ENSG00000168792.4
GeneCardsiABHD15
H-InvDBiHIX0013677
HGNCiHGNC:26971 ABHD15
HPAiHPA014470
neXtProtiNX_Q6UXT9
OpenTargetsiENSG00000168792
PharmGKBiPA164714659
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INFX Eukaryota
ENOG410Z0Y9 LUCA
GeneTreeiENSGT00530000062981
HOGENOMiHOG000033769
InParanoidiQ6UXT9
KOiK13707
OMAiETLFCHT
OrthoDBiEOG091G0LZO
PhylomeDBiQ6UXT9
TreeFamiTF332985

Miscellaneous databases

ChiTaRSiABHD15 human
GenomeRNAii116236
PROiPR:Q6UXT9

Gene expression databases

BgeeiENSG00000168792 Expressed in 129 organ(s), highest expression level in liver
GenevisibleiQ6UXT9 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR022742 Hydrolase_4
PfamiView protein in Pfam
PF12146 Hydrolase_4, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABH15_HUMAN
AccessioniPrimary (citable) accession number: Q6UXT9
Secondary accession number(s): Q96EC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 5, 2010
Last modified: September 12, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again