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Protein

Inactive caspase-12

Gene

CASP12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei172Sequence analysis1
Active sitei220Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SIGNORiQ6UXS9

Protein family/group databases

MEROPSiC14.P01

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive caspase-12
Short name:
CASP-12
Gene namesi
Name:CASP12
ORF Names:UNQ9415/PRO34398
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000204403.9
HGNCiHGNC:19004 CASP12
MIMi608633 gene
neXtProtiNX_Q6UXS9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi100506742

Chemistry databases

ChEMBLiCHEMBL3831289

Polymorphism and mutation databases

BioMutaiCASP12
DMDMi395398427

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174411 – 341Inactive caspase-12Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineBy similarity1
Modified residuei90PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6UXS9
PaxDbiQ6UXS9
PeptideAtlasiQ6UXS9
PRIDEiQ6UXS9
ProteomicsDBi67653
67654 [Q6UXS9-2]
67655 [Q6UXS9-3]

PTM databases

iPTMnetiQ6UXS9
PhosphoSitePlusiQ6UXS9

Expressioni

Tissue specificityi

Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis.1 Publication

Gene expression databases

BgeeiENSG00000204403 Expressed in 85 organ(s), highest expression level in right lung
GenevisibleiQ6UXS9 HS

Interactioni

Protein-protein interaction databases

BioGridi125680, 10 interactors
IntActiQ6UXS9, 1 interactor
STRINGi9606.ENSP00000424038

Structurei

3D structure databases

ProteinModelPortaliQ6UXS9
SMRiQ6UXS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92CARDPROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
HOGENOMiHOG000234399
HOVERGENiHBG076981
InParanoidiQ6UXS9
KOiK04741
PhylomeDBiQ6UXS9
TreeFamiTF102023

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR029030 Caspase-like_dom_sf
IPR035713 Caspase_12
IPR033139 Caspase_cys_AS
IPR011029 DEATH-like_dom_sf
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PANTHERiPTHR10454:SF134 PTHR10454:SF134, 2 hits
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00115 CASc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS01122 CASPASE_CYS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6UXS9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADEKPSNGV LVHMVKLLIK TFLDGIFDDL MENNVLNTDE IHLIGKCLKF
60 70 80 90 100
VVSNAENLVD DITETAQIAG KIFREHLWNS KKQLSSDISS DGEREANMPG
110 120 130 140 150
LNIRNKEFNY LHNRNGSELD LLGMRDLLEN LGYSVVIKEN LTAQEMETAL
160 170 180 190 200
RQFAAHPEHQ SSDSTFLVFM SHSILNGICG TKHWDQEPDV LHDDTIFEIF
210 220 230 240 250
NNRNCQSLKD KPKVIIMQAC RGNGAGIVWF TTDSGKASAD THGRLLQGNI
260 270 280 290 300
CNDAVTKAHV EKDFIAFKSS TPHNVSWRHE TNGSVFISQI IYYFREYSWS
310 320 330 340
HHLEEIFQKV QHSFETPNIL TQLPTIERLS MTRYFYLFPG N
Length:341
Mass (Da):38,907
Last modified:September 12, 2018 - v3
Checksum:i5D7DFAA40D91B18A
GO
Isoform 2 (identifier: Q6UXS9-2) [UniParc]FASTAAdd to basket
Also known as: Alpha, Beta

The sequence of this isoform differs from the canonical sequence as follows:
     87-168: DISSDGEREA...HQSSDSTFLV → AFLEIQGAQP...YLKTLDTQWL
     169-341: Missing.

Show »
Length:168
Mass (Da):19,136
Checksum:i979C2D9458B975B8
GO
Isoform 3 (identifier: Q6UXS9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-86: Missing.

Note: No experimental confirmation available.
Show »
Length:257
Mass (Da):29,429
Checksum:iB1552F06D2451585
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q6UXS9-2)
Sequence conflicti88F → L in AF486844 (PubMed:12054529).Curated1
Sequence conflicti88F → L in AF486845 (PubMed:12054529).Curated1

Polymorphismi

The most frequent variant has a stop codon instead of Arg-125, giving rise to truncated forms of isoform 1 (named delta, epsilon, eta, gamma) and isoform 3 (iota, teta). The variant Arg-125 (Csp12-L) is rare, except in some populations from sub-Saharan Africa. Csp12-L may increase the susceptibility to severe sepsis, and may also increase the mortality rate in sepsis patients.4 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08063868I → T. Corresponds to variant dbSNP:rs693001Ensembl.1
Natural variantiVAR_080639125 – 341Missing 4 PublicationsCorresponds to variant dbSNP:rs497116Add BLAST217
Natural variantiVAR_080640238S → G. Corresponds to variant dbSNP:rs647039Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0309533 – 86Missing in isoform 3. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_03095487 – 168DISSD…STFLV → AFLEIQGAQPSGKLKLCPHA HFHELKTKRADEIYPVMEKE RRTCLASTSATKNSTIFIIE MVLNLTFWGCEIYLKTLDTQ WL in isoform 2. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_030955169 – 341Missing in isoform 2. 1 PublicationAdd BLAST173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF464191 mRNA No translation available.
AF464192 mRNA No translation available.
AF464193 mRNA No translation available.
AF464194 mRNA No translation available.
AF464195 mRNA No translation available.
AF486844 mRNA No translation available.
AF486845 mRNA No translation available.
AF486846 mRNA No translation available.
AF486847 mRNA No translation available.
AY358222 mRNA Translation: AAQ88589.1
RefSeqiNP_001177945.2, NM_001191016.2
UniGeneiHs.476989

Genome annotation databases

EnsembliENST00000375726; ENSP00000424038; ENSG00000204403
ENST00000417998; ENSP00000424963; ENSG00000204403
ENST00000422698; ENSP00000427128; ENSG00000204403
ENST00000458137; ENSP00000421408; ENSG00000204403
ENST00000508062; ENSP00000426566; ENSG00000204403
GeneIDi100506742
KEGGihsa:100506742
UCSCiuc031qdp.3 human [Q6UXS9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCASPC_HUMAN
AccessioniPrimary (citable) accession number: Q6UXS9
Secondary accession number(s): D6RBN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 12, 2018
Last modified: September 12, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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