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Entry version 93 (11 Dec 2019)
Sequence version 2 (18 May 2010)
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Protein

Protein FAM151B

Gene

FAM151B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM151B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM151B
ORF Names:UNQ9217/PRO28685
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000152380.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33716 FAM151B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UXP7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000152380

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162386486

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6UXP7 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM151B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434497

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003171051 – 276Protein FAM151BAdd BLAST276

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6UXP7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6UXP7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UXP7

PeptideAtlas

More...
PeptideAtlasi
Q6UXP7

PRoteomics IDEntifications database

More...
PRIDEi
Q6UXP7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67643

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6UXP7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UXP7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152380 Expressed in 93 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6UXP7 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043805

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9C0193EBI-8456391,EBI-2342111

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127948, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q6UXP7, 2 interactors

Molecular INTeraction database

More...
MINTi
Q6UXP7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000282226

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6UXP7 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM151 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3748 Eukaryota
ENOG410ZS9E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063681

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000286039

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UXP7

Identification of Orthologs from Complete Genome Data

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OMAi
QPVMAHP

Database of Orthologous Groups

More...
OrthoDBi
1117332at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UXP7

TreeFam database of animal gene trees

More...
TreeFami
TF315079

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019356 DUF2181

The PANTHER Classification System

More...
PANTHERi
PTHR21184 PTHR21184, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10223 DUF2181, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6UXP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASAGGPGS WSENILEYFL RNSQITAEDG AEITWYHAAN HKAQTNEALK
60 70 80 90 100
STAHMIEADV LLPSDGSEHS QPIMAHPPET NSDNTLQEWL TEVMKSNKGI
110 120 130 140 150
KLDFKSLAVV EPSMMLLENV KRHLKRPVWI NADILPGPNG NSKVIDAKPF
160 170 180 190 200
LDTVISFFPD VTFSLGWTTG WHPEKVNEGY SWTMVKEMEY ICNELSQPVT
210 220 230 240 250
FPVRAALVRQ SCSQLLWLLK KSNRYSLTIW TGKNDNYSVE DLLYIRDHFD
260 270
KKQVFYDILE PQNHEFKQAI GIKVNL
Length:276
Mass (Da):31,367
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00A8A1ED8D37D723
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RD51D6RD51_HUMAN
Protein FAM151B
FAM151B
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053992155I → T2 PublicationsCorresponds to variant dbSNP:rs369998Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358256 mRNA Translation: AAQ88623.1
AC008771 Genomic DNA No translation available.
AC018764 Genomic DNA No translation available.
CH471084 Genomic DNA Translation: EAW95855.1
BC131563 mRNA Translation: AAI31564.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4051.1

NCBI Reference Sequences

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RefSeqi
NP_991111.2, NM_205548.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282226; ENSP00000282226; ENSG00000152380

Database of genes from NCBI RefSeq genomes

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GeneIDi
167555

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:167555

UCSC genome browser

More...
UCSCi
uc003kgv.3 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358256 mRNA Translation: AAQ88623.1
AC008771 Genomic DNA No translation available.
AC018764 Genomic DNA No translation available.
CH471084 Genomic DNA Translation: EAW95855.1
BC131563 mRNA Translation: AAI31564.1
CCDSiCCDS4051.1
RefSeqiNP_991111.2, NM_205548.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi127948, 1 interactor
IntActiQ6UXP7, 2 interactors
MINTiQ6UXP7
STRINGi9606.ENSP00000282226

PTM databases

iPTMnetiQ6UXP7
PhosphoSitePlusiQ6UXP7

Polymorphism and mutation databases

BioMutaiFAM151B
DMDMi296434497

Proteomic databases

MassIVEiQ6UXP7
MaxQBiQ6UXP7
PaxDbiQ6UXP7
PeptideAtlasiQ6UXP7
PRIDEiQ6UXP7
ProteomicsDBi67643

Genome annotation databases

EnsembliENST00000282226; ENSP00000282226; ENSG00000152380
GeneIDi167555
KEGGihsa:167555
UCSCiuc003kgv.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
167555
EuPathDBiHostDB:ENSG00000152380.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM151B
HGNCiHGNC:33716 FAM151B
HPAiHPA043805
neXtProtiNX_Q6UXP7
OpenTargetsiENSG00000152380
PharmGKBiPA162386486

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3748 Eukaryota
ENOG410ZS9E LUCA
GeneTreeiENSGT00530000063681
HOGENOMiHOG000286039
InParanoidiQ6UXP7
OMAiQPVMAHP
OrthoDBi1117332at2759
PhylomeDBiQ6UXP7
TreeFamiTF315079

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM151B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
167555
PharosiQ6UXP7 Tdark

Protein Ontology

More...
PROi
PR:Q6UXP7
RNActiQ6UXP7 protein

Gene expression databases

BgeeiENSG00000152380 Expressed in 93 organ(s), highest expression level in kidney
ExpressionAtlasiQ6UXP7 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR019356 DUF2181
PANTHERiPTHR21184 PTHR21184, 1 hit
PfamiView protein in Pfam
PF10223 DUF2181, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF151B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UXP7
Secondary accession number(s): A2RRE4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: December 11, 2019
This is version 93 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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