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Protein

C-type lectin domain family 9 member A

Gene

CLEC9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 9 member A
Alternative name(s):
CD_antigen: CD370
Gene namesi
Name:CLEC9A
ORF Names:UNQ9341/PRO34046
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000197992.6
HGNCiHGNC:26705 CLEC9A
MIMi612252 gene
neXtProtiNX_Q6UXN8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini57 – 241ExtracellularSequence analysisAdd BLAST185

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi131W → A: Abolishes binding to damaged cells; when associated with A-227. 1 Publication1
Mutagenesisi227W → A: Abolishes binding to damaged cells; when associated with A-131. 1 Publication1

Organism-specific databases

DisGeNETi283420
OpenTargetsiENSG00000197992
PharmGKBiPA142672093

Polymorphism and mutation databases

BioMutaiCLEC9A
DMDMi73917794

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466371 – 241C-type lectin domain family 9 member AAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi113 ↔ 124PROSITE-ProRule annotation1 Publication
Disulfide bondi141 ↔ 232PROSITE-ProRule annotation1 Publication
Disulfide bondi211 ↔ 224PROSITE-ProRule annotation1 Publication
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UXN8
PRIDEiQ6UXN8
ProteomicsDBi67640

PTM databases

iPTMnetiQ6UXN8
PhosphoSitePlusiQ6UXN8

Expressioni

Tissue specificityi

In peripheral blood highly restricted on the surface of BDCA31+ dendritic cells and on a small subset of CD14+ and CD16- monocytes.2 Publications

Gene expression databases

BgeeiENSG00000197992 Expressed in 78 organ(s), highest expression level in substantia nigra
CleanExiHS_CLEC9A

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

IntActiQ6UXN8, 35 interactors
STRINGi9606.ENSP00000348074

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6UXN8
SMRiQ6UXN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 233C-type lectinPROSITE-ProRule annotationAdd BLAST114

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 10ITAM-like6

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104266
HOGENOMiHOG000048721
HOVERGENiHBG056591
InParanoidiQ6UXN8
KOiK17515
OMAiDNWIQNG
OrthoDBiEOG091G0CXT
PhylomeDBiQ6UXN8
TreeFamiTF336674

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6UXN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHEEEIYTSL QWDSPAPDTY QKCLSSNKCS GACCLVMVIS CVFCMGLLTA
60 70 80 90 100
SIFLGVKLLQ VSTIAMQQQE KLIQQERALL NFTEWKRSCA LQMKYCQAFM
110 120 130 140 150
QNSLSSAHNS SPCPNNWIQN RESCYYVSEI WSIWHTSQEN CLKEGSTLLQ
160 170 180 190 200
IESKEEMDFI TGSLRKIKGS YDYWVGLSQD GHSGRWLWQD GSSPSPGLLP
210 220 230 240
AERSQSANQV CGYVKSNSLL SSNCSTWKYF ICEKYALRSS V
Length:241
Mass (Da):27,324
Last modified:July 5, 2004 - v1
Checksum:i6158B3AC44EEC9C3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050112107A → G. Corresponds to variant dbSNP:rs11831360Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU339276 mRNA Translation: ABZ04557.1
AY358265 mRNA Translation: AAQ88632.1
CCDSiCCDS8611.1
RefSeqiNP_997228.1, NM_207345.3
UniGeneiHs.531189

Genome annotation databases

EnsembliENST00000355819; ENSP00000348074; ENSG00000197992
GeneIDi283420
KEGGihsa:283420
UCSCiuc001qxa.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU339276 mRNA Translation: ABZ04557.1
AY358265 mRNA Translation: AAQ88632.1
CCDSiCCDS8611.1
RefSeqiNP_997228.1, NM_207345.3
UniGeneiHs.531189

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VPPX-ray1.64A/B110-241[»]
ProteinModelPortaliQ6UXN8
SMRiQ6UXN8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6UXN8, 35 interactors
STRINGi9606.ENSP00000348074

PTM databases

iPTMnetiQ6UXN8
PhosphoSitePlusiQ6UXN8

Polymorphism and mutation databases

BioMutaiCLEC9A
DMDMi73917794

Proteomic databases

PaxDbiQ6UXN8
PRIDEiQ6UXN8
ProteomicsDBi67640

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355819; ENSP00000348074; ENSG00000197992
GeneIDi283420
KEGGihsa:283420
UCSCiuc001qxa.4 human

Organism-specific databases

CTDi283420
DisGeNETi283420
EuPathDBiHostDB:ENSG00000197992.6
GeneCardsiCLEC9A
HGNCiHGNC:26705 CLEC9A
MIMi612252 gene
neXtProtiNX_Q6UXN8
OpenTargetsiENSG00000197992
PharmGKBiPA142672093
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104266
HOGENOMiHOG000048721
HOVERGENiHBG056591
InParanoidiQ6UXN8
KOiK17515
OMAiDNWIQNG
OrthoDBiEOG091G0CXT
PhylomeDBiQ6UXN8
TreeFamiTF336674

Miscellaneous databases

ChiTaRSiCLEC9A human
GenomeRNAii283420
PROiPR:Q6UXN8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197992 Expressed in 78 organ(s), highest expression level in substantia nigra
CleanExiHS_CLEC9A

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLC9A_HUMAN
AccessioniPrimary (citable) accession number: Q6UXN8
Secondary accession number(s): B0ZBM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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