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Entry version 119 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
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Protein

TOMM20-like protein 1

Gene

TOMM20L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6UXN7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TOMM20-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOMM20L
ORF Names:UNQ9438/PRO34772
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33752, TOMM20L

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UXN7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000196860.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9Mitochondrial intermembraneSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 29HelicalSequence analysisAdd BLAST20
Topological domaini30 – 152CytoplasmicSequence analysisAdd BLAST123

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000196860

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162406689

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6UXN7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TOMM20L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74738230

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003177471 – 152TOMM20-like protein 1Add BLAST152

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6UXN7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UXN7

PeptideAtlas

More...
PeptideAtlasi
Q6UXN7

PRoteomics IDEntifications database

More...
PRIDEi
Q6UXN7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67639

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196860, Expressed in testis and 112 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6UXN7, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000196860, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
132529, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q6UXN7, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354204

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6UXN7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6UXN7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Tom20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4056, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011698

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_100000_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UXN7

Identification of Orthologs from Complete Genome Data

More...
OMAi
GYCIYLD

Database of Orthologous Groups

More...
OrthoDBi
1316067at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UXN7

TreeFam database of animal gene trees

More...
TreeFami
TF106200

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.960.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002056, MAS20
IPR022422, MAS20_rcpt_metazoan
IPR023392, Tom20_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12430, PTHR12430, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02064, MAS20, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037707, MAS20_rcpt, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01989, EUOM20RECPTR
PR00351, OM20RECEPTOR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47157, SSF47157, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6UXN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSVRSLLRL LAAAAACGAF AFLGYCIYLN RKRRGDPAFK RRLRDKRRAE
60 70 80 90 100
PQKAEEQGTQ LWDPTKNKKL QELFLQEVRM GELWLSRGEH RMGIQHLGNA
110 120 130 140 150
LLVCEQPREL LKVFKHTLPP KVFEMLLHKI PLICQQFEAD MNEQDCLEDD

PD
Length:152
Mass (Da):17,700
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B9EE302E86FB919
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4A4G3V4A4_HUMAN
TOMM20-like protein 1
TOMM20L
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358266 mRNA Translation: AAQ88633.1
CH471061 Genomic DNA Translation: EAW80733.1
BC137557 mRNA Translation: AAI37558.1
BC137563 mRNA Translation: AAI37564.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9734.1

NCBI Reference Sequences

More...
RefSeqi
NP_997260.1, NM_207377.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360945; ENSP00000354204; ENSG00000196860

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
387990

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:387990

UCSC genome browser

More...
UCSCi
uc001xdr.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358266 mRNA Translation: AAQ88633.1
CH471061 Genomic DNA Translation: EAW80733.1
BC137557 mRNA Translation: AAI37558.1
BC137563 mRNA Translation: AAI37564.1
CCDSiCCDS9734.1
RefSeqiNP_997260.1, NM_207377.2

3D structure databases

SMRiQ6UXN7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi132529, 9 interactors
IntActiQ6UXN7, 6 interactors
STRINGi9606.ENSP00000354204

Genetic variation databases

BioMutaiTOMM20L
DMDMi74738230

Proteomic databases

MassIVEiQ6UXN7
PaxDbiQ6UXN7
PeptideAtlasiQ6UXN7
PRIDEiQ6UXN7
ProteomicsDBi67639

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
51460, 65 antibodies

Genome annotation databases

EnsembliENST00000360945; ENSP00000354204; ENSG00000196860
GeneIDi387990
KEGGihsa:387990
UCSCiuc001xdr.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
387990

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TOMM20L
HGNCiHGNC:33752, TOMM20L
HPAiENSG00000196860, Tissue enriched (testis)
neXtProtiNX_Q6UXN7
OpenTargetsiENSG00000196860
PharmGKBiPA162406689
VEuPathDBiHostDB:ENSG00000196860.7

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4056, Eukaryota
GeneTreeiENSGT00390000011698
HOGENOMiCLU_100000_2_0_1
InParanoidiQ6UXN7
OMAiGYCIYLD
OrthoDBi1316067at2759
PhylomeDBiQ6UXN7
TreeFamiTF106200

Enzyme and pathway databases

PathwayCommonsiQ6UXN7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
387990, 7 hits in 984 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
387990
PharosiQ6UXN7, Tdark

Protein Ontology

More...
PROi
PR:Q6UXN7
RNActiQ6UXN7, protein

Gene expression databases

BgeeiENSG00000196860, Expressed in testis and 112 other tissues
ExpressionAtlasiQ6UXN7, baseline and differential

Family and domain databases

Gene3Di1.20.960.10, 1 hit
InterProiView protein in InterPro
IPR002056, MAS20
IPR022422, MAS20_rcpt_metazoan
IPR023392, Tom20_dom_sf
PANTHERiPTHR12430, PTHR12430, 1 hit
PfamiView protein in Pfam
PF02064, MAS20, 1 hit
PIRSFiPIRSF037707, MAS20_rcpt, 1 hit
PRINTSiPR01989, EUOM20RECPTR
PR00351, OM20RECEPTOR
SUPFAMiSSF47157, SSF47157, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTO20L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UXN7
Secondary accession number(s): B2RPR0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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