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UniProtKB - Q6UXM1 (LRIG3_HUMAN)

Entry version 134 (13 Feb 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Leucine-rich repeats and immunoglobulin-like domains protein 3

Gene

LRIG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q6UXM1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 3
Short name:
LIG-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRIG3
Synonyms:LIG3
ORF Names:UNQ287/PRO326/PRO335
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000139263.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:30991 LRIG3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608870 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6UXM1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei810 – 830HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		121227

Open Targets

More...OpenTargetsi		ENSG00000139263

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134864136

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LRIG3

Domain mapping of disease mutations (DMDM)

More...DMDMi		73621176

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001483125 – 1119Leucine-rich repeats and immunoglobulin-like domains protein 3Add BLAST1095

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi442N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi520 ↔ 581PROSITE-ProRule annotation
Disulfide bondi624 ↔ 676PROSITE-ProRule annotation
Glycosylationi688N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi718 ↔ 767PROSITE-ProRule annotation
Glycosylationi729N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi905N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi987N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi999N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1016N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6UXM1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6UXM1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6UXM1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6UXM1

PeptideAtlas

More...PeptideAtlasi		Q6UXM1

PRoteomics IDEntifications database

More...PRIDEi		Q6UXM1

ProteomicsDB human proteome resource

More...ProteomicsDBi		67636
67637 [Q6UXM1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6UXM1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6UXM1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000139263 Expressed in 164 organ(s), highest expression level in stomach

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6UXM1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6UXM1 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA010773

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EGFR, ERBB2 and ERBB4 (in vitro).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		125712, 20 interactors

Protein interaction database and analysis system

More...IntActi		Q6UXM1, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000326759

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q6UXM1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6UXM1

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 74LRRNTAdd BLAST37
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati75 – 96LRR 1Add BLAST22
Repeati99 – 120LRR 2Add BLAST22
Repeati122 – 142LRR 3Add BLAST21
Repeati146 – 167LRR 4Add BLAST22
Repeati168 – 189LRR 5Add BLAST22
Repeati193 – 214LRR 6Add BLAST22
Repeati216 – 237LRR 7Add BLAST22
Repeati240 – 261LRR 8Add BLAST22
Repeati264 – 285LRR 9Add BLAST22
Repeati288 – 309LRR 10Add BLAST22
Repeati312 – 333LRR 11Add BLAST22
Repeati336 – 357LRR 12Add BLAST22
Repeati360 – 382LRR 13Add BLAST23
Repeati387 – 408LRR 14Add BLAST22
Repeati411 – 432LRR 15Add BLAST22
Domaini444 – 495LRRCTAdd BLAST52
Domaini499 – 598Ig-like C2-type 1Add BLAST100
Domaini603 – 692Ig-like C2-type 2Add BLAST90
Domaini697 – 783Ig-like C2-type 3Add BLAST87

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0619 Eukaryota
KOG4194 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157098

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000113380

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG052353

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6UXM1

Identification of Orthologs from Complete Genome Data

More...OMAi		ERTDFQQ

Database of Orthologous Groups

More...OrthoDBi		161719at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6UXM1

TreeFam database of animal gene trees

More...TreeFami		TF325380

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 3 hits
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00369 LRR_TYP, 14 hits
SM00082 LRRCT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726 SSF48726, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS51450 LRR, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UXM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAPSLRARA AGLGLLLCAV LGRAGRSDSG GRGELGQPSG VAAERPCPTT 
        60         70         80         90        100
CRCLGDLLDC SRKRLARLPE PLPSWVARLD LSHNRLSFIK ASSMSHLQSL 
       110        120        130        140        150
REVKLNNNEL ETIPNLGPVS ANITLLSLAG NRIVEILPEH LKEFQSLETL 
       160        170        180        190        200
DLSSNNISEL QTAFPALQLK YLYLNSNRVT SMEPGYFDNL ANTLLVLKLN 
       210        220        230        240        250
RNRISAIPPK MFKLPQLQHL ELNRNKIKNV DGLTFQGLGA LKSLKMQRNG 
       260        270        280        290        300
VTKLMDGAFW GLSNMEILQL DHNNLTEITK GWLYGLLMLQ ELHLSQNAIN 
       310        320        330        340        350
RISPDAWEFC QKLSELDLTF NHLSRLDDSS FLGLSLLNTL HIGNNRVSYI 
       360        370        380        390        400
ADCAFRGLSS LKTLDLKNNE ISWTIEDMNG AFSGLDKLRR LILQGNRIRS 
       410        420        430        440        450
ITKKAFTGLD ALEHLDLSDN AIMSLQGNAF SQMKKLQQLH LNTSSLLCDC 
       460        470        480        490        500
QLKWLPQWVA ENNFQSFVNA SCAHPQLLKG RSIFAVSPDG FVCDDFPKPQ 
       510        520        530        540        550
ITVQPETQSA IKGSNLSFIC SAASSSDSPM TFAWKKDNEL LHDAEMENYA 
       560        570        580        590        600
HLRAQGGEVM EYTTILRLRE VEFASEGKYQ CVISNHFGSS YSVKAKLTVN 
       610        620        630        640        650
MLPSFTKTPM DLTIRAGAMA RLECAAVGHP APQIAWQKDG GTDFPAARER 
       660        670        680        690        700
RMHVMPEDDV FFIVDVKIED IGVYSCTAQN SAGSISANAT LTVLETPSFL 
       710        720        730        740        750
RPLLDRTVTK GETAVLQCIA GGSPPPKLNW TKDDSPLVVT ERHFFAAGNQ 
       760        770        780        790        800
LLIIVDSDVS DAGKYTCEMS NTLGTERGNV RLSVIPTPTC DSPQMTAPSL 
       810        820        830        840        850
DDDGWATVGV VIIAVVCCVV GTSLVWVVII YHTRRRNEDC SITNTDETNL 
       860        870        880        890        900
PADIPSYLSS QGTLADRQDG YVSSESGSHH QFVTSSGAGF FLPQHDSSGT 
       910        920        930        940        950
CHIDNSSEAD VEAATDLFLC PFLGSTGPMY LKGNVYGSDP FETYHTGCSP 
       960        970        980        990       1000
DPRTVLMDHY EPSYIKKKEC YPCSHPSEES CERSFSNISW PSHVRKLLNT 
      1010       1020       1030       1040       1050
SYSHNEGPGM KNLCLNKSSL DFSANPEPAS VASSNSFMGT FGKALRRPHL 
      1060       1070       1080       1090       1100
DAYSSFGQPS DCQPRAFYLK AHSSPDLDSG SEEDGKERTD FQEENHICTF 
      1110 
KQTLENYRTP NFQSYDLDT
Length:1,119
Mass (Da):123,434
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB3B6A391F3C8713
GO
Isoform 2 (identifier: Q6UXM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MSAPSLRARA...EPLPSWVARL → MVDVLLLFSLCLLFHISRP

Note: No experimental confirmation available.
Show »
Length:1,059
Mass (Da):117,438
Checksum:i757A89BC1E91C20B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9K080C9K080_HUMAN
Leucine-rich repeats and immunoglob...
LRIG3
623Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VYZ5F8VYZ5_HUMAN
Leucine-rich repeats and immunoglob...
LRIG3
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YID8H0YID8_HUMAN
Leucine-rich repeats and immunoglob...
LRIG3
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11295 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0150971 – 79MSAPS…WVARL → MVDVLLLFSLCLLFHISRP in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY505340 mRNA Translation: AAR98629.1
AY358288 mRNA Translation: AAQ88655.1
AY358295 mRNA Translation: AAQ88662.1
AK074921 mRNA Translation: BAC11295.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44933.1 [Q6UXM1-2]
CCDS8960.1 [Q6UXM1-1]

NCBI Reference Sequences

More...RefSeqi		NP_001129523.1, NM_001136051.2 [Q6UXM1-2]
NP_700356.2, NM_153377.4 [Q6UXM1-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.253736

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000320743; ENSP00000326759; ENSG00000139263 [Q6UXM1-1]
ENST00000379141; ENSP00000368436; ENSG00000139263 [Q6UXM1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		121227

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:121227

UCSC genome browser

More...UCSCi		uc001sqr.5 human [Q6UXM1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY505340 mRNA Translation: AAR98629.1
AY358288 mRNA Translation: AAQ88655.1
AY358295 mRNA Translation: AAQ88662.1
AK074921 mRNA Translation: BAC11295.1 Different initiation.
CCDSiCCDS44933.1 [Q6UXM1-2]
CCDS8960.1 [Q6UXM1-1]
RefSeqiNP_001129523.1, NM_001136051.2 [Q6UXM1-2]
NP_700356.2, NM_153377.4 [Q6UXM1-1]
UniGeneiHs.253736

3D structure databases

ProteinModelPortaliQ6UXM1
SMRiQ6UXM1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125712, 20 interactors
IntActiQ6UXM1, 1 interactor
STRINGi9606.ENSP00000326759

PTM databases

iPTMnetiQ6UXM1
PhosphoSitePlusiQ6UXM1

Polymorphism and mutation databases

BioMutaiLRIG3
DMDMi73621176

Proteomic databases

EPDiQ6UXM1
jPOSTiQ6UXM1
MaxQBiQ6UXM1
PaxDbiQ6UXM1
PeptideAtlasiQ6UXM1
PRIDEiQ6UXM1
ProteomicsDBi67636
67637 [Q6UXM1-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320743; ENSP00000326759; ENSG00000139263 [Q6UXM1-1]
ENST00000379141; ENSP00000368436; ENSG00000139263 [Q6UXM1-2]
GeneIDi121227
KEGGihsa:121227
UCSCiuc001sqr.5 human [Q6UXM1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		121227
DisGeNETi121227
EuPathDBiHostDB:ENSG00000139263.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		LRIG3
HGNCiHGNC:30991 LRIG3
HPAiHPA010773
MIMi608870 gene
neXtProtiNX_Q6UXM1
OpenTargetsiENSG00000139263
PharmGKBiPA134864136

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG4194 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000157098
HOGENOMiHOG000113380
HOVERGENiHBG052353
InParanoidiQ6UXM1
OMAiERTDFQQ
OrthoDBi161719at2759
PhylomeDBiQ6UXM1
TreeFamiTF325380

Enzyme and pathway databases

SIGNORiQ6UXM1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LRIG3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		121227

Protein Ontology

More...PROi		PR:Q6UXM1

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000139263 Expressed in 164 organ(s), highest expression level in stomach
ExpressionAtlasiQ6UXM1 baseline and differential
GenevisibleiQ6UXM1 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 4 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00369 LRR_TYP, 14 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS51450 LRR, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRIG3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UXM1
Secondary accession number(s): Q6UXL7, Q8NC72
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: February 13, 2019
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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