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UniProtKB - Q6UXM1 (LRIG3_HUMAN)

Protein

Leucine-rich repeats and immunoglobulin-like domains protein 3

Gene

LRIG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).By similarity

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

SIGNORiQ6UXM1

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 3
Short name:
LIG-3
Gene namesi
Name:LRIG3
Synonyms:LIG3
ORF Names:UNQ287/PRO326/PRO335
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139263.11
HGNCiHGNC:30991 LRIG3
MIMi608870 gene
neXtProtiNX_Q6UXM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei810 – 830HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi121227
OpenTargetsiENSG00000139263
PharmGKBiPA134864136

Polymorphism and mutation databases

BioMutaiLRIG3
DMDMi73621176

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001483125 – 1119Leucine-rich repeats and immunoglobulin-like domains protein 3Add BLAST1095

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi442N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi520 ↔ 581PROSITE-ProRule annotation
Disulfide bondi624 ↔ 676PROSITE-ProRule annotation
Glycosylationi688N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi718 ↔ 767PROSITE-ProRule annotation
Glycosylationi729N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi905N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi987N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi999N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1016N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ6UXM1
MaxQBiQ6UXM1
PaxDbiQ6UXM1
PeptideAtlasiQ6UXM1
PRIDEiQ6UXM1
ProteomicsDBi67636
67637 [Q6UXM1-2]

PTM databases

iPTMnetiQ6UXM1
PhosphoSitePlusiQ6UXM1

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000139263 Expressed in 164 organ(s), highest expression level in stomach
CleanExiHS_LIG3
HS_LRIG3
ExpressionAtlasiQ6UXM1 baseline and differential
GenevisibleiQ6UXM1 HS

Organism-specific databases

HPAiHPA010773

Interactioni

Subunit structurei

Interacts with EGFR, ERBB2 and ERBB4 (in vitro).By similarity

Protein-protein interaction databases

BioGridi125712, 20 interactors
IntActiQ6UXM1, 1 interactor
STRINGi9606.ENSP00000326759

Structurei

3D structure databases

ProteinModelPortaliQ6UXM1
SMRiQ6UXM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 74LRRNTAdd BLAST37
Repeati75 – 96LRR 1Add BLAST22
Repeati99 – 120LRR 2Add BLAST22
Repeati122 – 142LRR 3Add BLAST21
Repeati146 – 167LRR 4Add BLAST22
Repeati168 – 189LRR 5Add BLAST22
Repeati193 – 214LRR 6Add BLAST22
Repeati216 – 237LRR 7Add BLAST22
Repeati240 – 261LRR 8Add BLAST22
Repeati264 – 285LRR 9Add BLAST22
Repeati288 – 309LRR 10Add BLAST22
Repeati312 – 333LRR 11Add BLAST22
Repeati336 – 357LRR 12Add BLAST22
Repeati360 – 382LRR 13Add BLAST23
Repeati387 – 408LRR 14Add BLAST22
Repeati411 – 432LRR 15Add BLAST22
Domaini444 – 495LRRCTAdd BLAST52
Domaini499 – 598Ig-like C2-type 1Add BLAST100
Domaini603 – 692Ig-like C2-type 2Add BLAST90
Domaini697 – 783Ig-like C2-type 3Add BLAST87

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG4194 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148957
HOGENOMiHOG000113380
HOVERGENiHBG052353
InParanoidiQ6UXM1
OMAiERTDFQQ
OrthoDBiEOG091G04H0
PhylomeDBiQ6UXM1
TreeFamiTF325380

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 4 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00369 LRR_TYP, 14 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS51450 LRR, 15 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UXM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAPSLRARA AGLGLLLCAV LGRAGRSDSG GRGELGQPSG VAAERPCPTT 
        60         70         80         90        100
CRCLGDLLDC SRKRLARLPE PLPSWVARLD LSHNRLSFIK ASSMSHLQSL 
       110        120        130        140        150
REVKLNNNEL ETIPNLGPVS ANITLLSLAG NRIVEILPEH LKEFQSLETL 
       160        170        180        190        200
DLSSNNISEL QTAFPALQLK YLYLNSNRVT SMEPGYFDNL ANTLLVLKLN 
       210        220        230        240        250
RNRISAIPPK MFKLPQLQHL ELNRNKIKNV DGLTFQGLGA LKSLKMQRNG 
       260        270        280        290        300
VTKLMDGAFW GLSNMEILQL DHNNLTEITK GWLYGLLMLQ ELHLSQNAIN 
       310        320        330        340        350
RISPDAWEFC QKLSELDLTF NHLSRLDDSS FLGLSLLNTL HIGNNRVSYI 
       360        370        380        390        400
ADCAFRGLSS LKTLDLKNNE ISWTIEDMNG AFSGLDKLRR LILQGNRIRS 
       410        420        430        440        450
ITKKAFTGLD ALEHLDLSDN AIMSLQGNAF SQMKKLQQLH LNTSSLLCDC 
       460        470        480        490        500
QLKWLPQWVA ENNFQSFVNA SCAHPQLLKG RSIFAVSPDG FVCDDFPKPQ 
       510        520        530        540        550
ITVQPETQSA IKGSNLSFIC SAASSSDSPM TFAWKKDNEL LHDAEMENYA 
       560        570        580        590        600
HLRAQGGEVM EYTTILRLRE VEFASEGKYQ CVISNHFGSS YSVKAKLTVN 
       610        620        630        640        650
MLPSFTKTPM DLTIRAGAMA RLECAAVGHP APQIAWQKDG GTDFPAARER 
       660        670        680        690        700
RMHVMPEDDV FFIVDVKIED IGVYSCTAQN SAGSISANAT LTVLETPSFL 
       710        720        730        740        750
RPLLDRTVTK GETAVLQCIA GGSPPPKLNW TKDDSPLVVT ERHFFAAGNQ 
       760        770        780        790        800
LLIIVDSDVS DAGKYTCEMS NTLGTERGNV RLSVIPTPTC DSPQMTAPSL 
       810        820        830        840        850
DDDGWATVGV VIIAVVCCVV GTSLVWVVII YHTRRRNEDC SITNTDETNL 
       860        870        880        890        900
PADIPSYLSS QGTLADRQDG YVSSESGSHH QFVTSSGAGF FLPQHDSSGT 
       910        920        930        940        950
CHIDNSSEAD VEAATDLFLC PFLGSTGPMY LKGNVYGSDP FETYHTGCSP 
       960        970        980        990       1000
DPRTVLMDHY EPSYIKKKEC YPCSHPSEES CERSFSNISW PSHVRKLLNT 
      1010       1020       1030       1040       1050
SYSHNEGPGM KNLCLNKSSL DFSANPEPAS VASSNSFMGT FGKALRRPHL 
      1060       1070       1080       1090       1100
DAYSSFGQPS DCQPRAFYLK AHSSPDLDSG SEEDGKERTD FQEENHICTF 
      1110 
KQTLENYRTP NFQSYDLDT
Length:1,119
Mass (Da):123,434
Last modified:July 5, 2004 - v1
Checksum:iEB3B6A391F3C8713
GO
Isoform 2 (identifier: Q6UXM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MSAPSLRARA...EPLPSWVARL → MVDVLLLFSLCLLFHISRP

Note: No experimental confirmation available.
Show »
Length:1,059
Mass (Da):117,438
Checksum:i757A89BC1E91C20B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9K080C9K080_HUMAN
Leucine-rich repeats and immunoglob...
LRIG3
623Annotation score:
F8VYZ5F8VYZ5_HUMAN
Leucine-rich repeats and immunoglob...
LRIG3
156Annotation score:
H0YID8H0YID8_HUMAN
Leucine-rich repeats and immunoglob...
LRIG3
163Annotation score:

Sequence cautioni

The sequence BAC11295 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0150971 – 79MSAPS…WVARL → MVDVLLLFSLCLLFHISRP in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY505340 mRNA Translation: AAR98629.1
AY358288 mRNA Translation: AAQ88655.1
AY358295 mRNA Translation: AAQ88662.1
AK074921 mRNA Translation: BAC11295.1 Different initiation.
CCDSiCCDS44933.1 [Q6UXM1-2]
CCDS8960.1 [Q6UXM1-1]
RefSeqiNP_001129523.1, NM_001136051.2 [Q6UXM1-2]
NP_700356.2, NM_153377.4 [Q6UXM1-1]
UniGeneiHs.253736

Genome annotation databases

EnsembliENST00000320743; ENSP00000326759; ENSG00000139263 [Q6UXM1-1]
ENST00000379141; ENSP00000368436; ENSG00000139263 [Q6UXM1-2]
GeneIDi121227
KEGGihsa:121227
UCSCiuc001sqr.5 human [Q6UXM1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY505340 mRNA Translation: AAR98629.1
AY358288 mRNA Translation: AAQ88655.1
AY358295 mRNA Translation: AAQ88662.1
AK074921 mRNA Translation: BAC11295.1 Different initiation.
CCDSiCCDS44933.1 [Q6UXM1-2]
CCDS8960.1 [Q6UXM1-1]
RefSeqiNP_001129523.1, NM_001136051.2 [Q6UXM1-2]
NP_700356.2, NM_153377.4 [Q6UXM1-1]
UniGeneiHs.253736

3D structure databases

ProteinModelPortaliQ6UXM1
SMRiQ6UXM1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125712, 20 interactors
IntActiQ6UXM1, 1 interactor
STRINGi9606.ENSP00000326759

PTM databases

iPTMnetiQ6UXM1
PhosphoSitePlusiQ6UXM1

Polymorphism and mutation databases

BioMutaiLRIG3
DMDMi73621176

Proteomic databases

EPDiQ6UXM1
MaxQBiQ6UXM1
PaxDbiQ6UXM1
PeptideAtlasiQ6UXM1
PRIDEiQ6UXM1
ProteomicsDBi67636
67637 [Q6UXM1-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320743; ENSP00000326759; ENSG00000139263 [Q6UXM1-1]
ENST00000379141; ENSP00000368436; ENSG00000139263 [Q6UXM1-2]
GeneIDi121227
KEGGihsa:121227
UCSCiuc001sqr.5 human [Q6UXM1-1]

Organism-specific databases

CTDi121227
DisGeNETi121227
EuPathDBiHostDB:ENSG00000139263.11
GeneCardsiLRIG3
HGNCiHGNC:30991 LRIG3
HPAiHPA010773
MIMi608870 gene
neXtProtiNX_Q6UXM1
OpenTargetsiENSG00000139263
PharmGKBiPA134864136
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG4194 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148957
HOGENOMiHOG000113380
HOVERGENiHBG052353
InParanoidiQ6UXM1
OMAiERTDFQQ
OrthoDBiEOG091G04H0
PhylomeDBiQ6UXM1
TreeFamiTF325380

Enzyme and pathway databases

SIGNORiQ6UXM1

Miscellaneous databases

ChiTaRSiLRIG3 human
GenomeRNAii121227
PROiPR:Q6UXM1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139263 Expressed in 164 organ(s), highest expression level in stomach
CleanExiHS_LIG3
HS_LRIG3
ExpressionAtlasiQ6UXM1 baseline and differential
GenevisibleiQ6UXM1 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 4 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00369 LRR_TYP, 14 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS51450 LRR, 15 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRIG3_HUMAN
AccessioniPrimary (citable) accession number: Q6UXM1
Secondary accession number(s): Q6UXL7, Q8NC72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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