UniProtKB - Q6UXM1 (LRIG3_HUMAN)
Protein
Leucine-rich repeats and immunoglobulin-like domains protein 3
Gene
LRIG3
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).By similarity
GO - Biological processi
- otolith morphogenesis Source: Ensembl
Keywordsi
Molecular function | Developmental protein |
Enzyme and pathway databases
PathwayCommonsi | Q6UXM1 |
SIGNORi | Q6UXM1 |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeats and immunoglobulin-like domains protein 3Short name: LIG-3 |
Gene namesi | Name:LRIG3 Synonyms:LIG3 ORF Names:UNQ287/PRO326/PRO335 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000139263.11 |
HGNCi | HGNC:30991, LRIG3 |
MIMi | 608870, gene |
neXtProti | NX_Q6UXM1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- Cytoplasmic vesicle membrane By similarity; Single-pass type I membrane protein By similarity
Note: Detected in cytoplasmic vesicles when coexpressed with ERBB4.By similarity
Extracellular region or secreted
- extracellular matrix Source: GO_Central
- extracellular space Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 810 – 830 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, Cytoplasmic vesicle, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 121227 |
OpenTargetsi | ENSG00000139263 |
PharmGKBi | PA134864136 |
Miscellaneous databases
Pharosi | Q6UXM1, Tbio |
Polymorphism and mutation databases
BioMutai | LRIG3 |
DMDMi | 73621176 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000014831 | 25 – 1119 | Leucine-rich repeats and immunoglobulin-like domains protein 3Add BLAST | 1095 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 122 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 156 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 274 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 442 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 469 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 515 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 520 ↔ 581 | PROSITE-ProRule annotation | ||
Disulfide bondi | 624 ↔ 676 | PROSITE-ProRule annotation | ||
Glycosylationi | 688 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 718 ↔ 767 | PROSITE-ProRule annotation | ||
Glycosylationi | 729 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 905 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 987 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 999 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1016 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q6UXM1 |
jPOSTi | Q6UXM1 |
MassIVEi | Q6UXM1 |
MaxQBi | Q6UXM1 |
PaxDbi | Q6UXM1 |
PeptideAtlasi | Q6UXM1 |
PRIDEi | Q6UXM1 |
ProteomicsDBi | 67636 [Q6UXM1-1] 67637 [Q6UXM1-2] |
PTM databases
GlyGeni | Q6UXM1, 12 sites |
iPTMneti | Q6UXM1 |
PhosphoSitePlusi | Q6UXM1 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000139263, Expressed in stomach and 177 other tissues |
ExpressionAtlasi | Q6UXM1, baseline and differential |
Genevisiblei | Q6UXM1, HS |
Organism-specific databases
HPAi | ENSG00000139263, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with EGFR, ERBB2 and ERBB4 (in vitro).
By similarityBinary interactionsi
Hide detailsQ6UXM1
With | #Exp. | IntAct |
---|---|---|
LRIG1 [Q96JA1] | 7 | EBI-9207843,EBI-2865191 |
Isoform 1 [Q6UXM1-1]
With | #Exp. | IntAct |
---|---|---|
LIMCH1 - isoform 1 [Q9UPQ0-1] | 3 | EBI-25412632,EBI-25412679 |
LMO7 - isoform 3 [Q8WWI1-3] | 3 | EBI-25412632,EBI-4400717 |
Protein-protein interaction databases
BioGRIDi | 125712, 27 interactors |
IntActi | Q6UXM1, 10 interactors |
STRINGi | 9606.ENSP00000326759 |
Miscellaneous databases
RNActi | Q6UXM1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 74 | LRRNTAdd BLAST | 37 | |
Repeati | 75 – 96 | LRR 1Add BLAST | 22 | |
Repeati | 99 – 120 | LRR 2Add BLAST | 22 | |
Repeati | 122 – 142 | LRR 3Add BLAST | 21 | |
Repeati | 146 – 167 | LRR 4Add BLAST | 22 | |
Repeati | 168 – 189 | LRR 5Add BLAST | 22 | |
Repeati | 193 – 214 | LRR 6Add BLAST | 22 | |
Repeati | 216 – 237 | LRR 7Add BLAST | 22 | |
Repeati | 240 – 261 | LRR 8Add BLAST | 22 | |
Repeati | 264 – 285 | LRR 9Add BLAST | 22 | |
Repeati | 288 – 309 | LRR 10Add BLAST | 22 | |
Repeati | 312 – 333 | LRR 11Add BLAST | 22 | |
Repeati | 336 – 357 | LRR 12Add BLAST | 22 | |
Repeati | 360 – 382 | LRR 13Add BLAST | 23 | |
Repeati | 387 – 408 | LRR 14Add BLAST | 22 | |
Repeati | 411 – 432 | LRR 15Add BLAST | 22 | |
Domaini | 444 – 495 | LRRCTAdd BLAST | 52 | |
Domaini | 499 – 598 | Ig-like C2-type 1Add BLAST | 100 | |
Domaini | 603 – 692 | Ig-like C2-type 2Add BLAST | 90 | |
Domaini | 697 – 783 | Ig-like C2-type 3Add BLAST | 87 |
Keywords - Domaini
Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0619, Eukaryota KOG4194, Eukaryota |
GeneTreei | ENSGT00940000157098 |
InParanoidi | Q6UXM1 |
OMAi | CHVDNSS |
OrthoDBi | 161719at2759 |
PhylomeDBi | Q6UXM1 |
TreeFami | TF325380 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF13855, LRR_8, 3 hits |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 3 hits SM00369, LRR_TYP, 14 hits SM00082, LRRCT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS51450, LRR, 15 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6UXM1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAPSLRARA AGLGLLLCAV LGRAGRSDSG GRGELGQPSG VAAERPCPTT
60 70 80 90 100
CRCLGDLLDC SRKRLARLPE PLPSWVARLD LSHNRLSFIK ASSMSHLQSL
110 120 130 140 150
REVKLNNNEL ETIPNLGPVS ANITLLSLAG NRIVEILPEH LKEFQSLETL
160 170 180 190 200
DLSSNNISEL QTAFPALQLK YLYLNSNRVT SMEPGYFDNL ANTLLVLKLN
210 220 230 240 250
RNRISAIPPK MFKLPQLQHL ELNRNKIKNV DGLTFQGLGA LKSLKMQRNG
260 270 280 290 300
VTKLMDGAFW GLSNMEILQL DHNNLTEITK GWLYGLLMLQ ELHLSQNAIN
310 320 330 340 350
RISPDAWEFC QKLSELDLTF NHLSRLDDSS FLGLSLLNTL HIGNNRVSYI
360 370 380 390 400
ADCAFRGLSS LKTLDLKNNE ISWTIEDMNG AFSGLDKLRR LILQGNRIRS
410 420 430 440 450
ITKKAFTGLD ALEHLDLSDN AIMSLQGNAF SQMKKLQQLH LNTSSLLCDC
460 470 480 490 500
QLKWLPQWVA ENNFQSFVNA SCAHPQLLKG RSIFAVSPDG FVCDDFPKPQ
510 520 530 540 550
ITVQPETQSA IKGSNLSFIC SAASSSDSPM TFAWKKDNEL LHDAEMENYA
560 570 580 590 600
HLRAQGGEVM EYTTILRLRE VEFASEGKYQ CVISNHFGSS YSVKAKLTVN
610 620 630 640 650
MLPSFTKTPM DLTIRAGAMA RLECAAVGHP APQIAWQKDG GTDFPAARER
660 670 680 690 700
RMHVMPEDDV FFIVDVKIED IGVYSCTAQN SAGSISANAT LTVLETPSFL
710 720 730 740 750
RPLLDRTVTK GETAVLQCIA GGSPPPKLNW TKDDSPLVVT ERHFFAAGNQ
760 770 780 790 800
LLIIVDSDVS DAGKYTCEMS NTLGTERGNV RLSVIPTPTC DSPQMTAPSL
810 820 830 840 850
DDDGWATVGV VIIAVVCCVV GTSLVWVVII YHTRRRNEDC SITNTDETNL
860 870 880 890 900
PADIPSYLSS QGTLADRQDG YVSSESGSHH QFVTSSGAGF FLPQHDSSGT
910 920 930 940 950
CHIDNSSEAD VEAATDLFLC PFLGSTGPMY LKGNVYGSDP FETYHTGCSP
960 970 980 990 1000
DPRTVLMDHY EPSYIKKKEC YPCSHPSEES CERSFSNISW PSHVRKLLNT
1010 1020 1030 1040 1050
SYSHNEGPGM KNLCLNKSSL DFSANPEPAS VASSNSFMGT FGKALRRPHL
1060 1070 1080 1090 1100
DAYSSFGQPS DCQPRAFYLK AHSSPDLDSG SEEDGKERTD FQEENHICTF
1110
KQTLENYRTP NFQSYDLDT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9K080 | C9K080_HUMAN | Leucine-rich repeats and immunoglob... | LRIG3 | 623 | Annotation score: | ||
F8VYZ5 | F8VYZ5_HUMAN | Leucine-rich repeats and immunoglob... | LRIG3 | 156 | Annotation score: | ||
H0YID8 | H0YID8_HUMAN | Leucine-rich repeats and immunoglob... | LRIG3 | 163 | Annotation score: |
Sequence cautioni
The sequence BAC11295 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015097 | 1 – 79 | MSAPS…WVARL → MVDVLLLFSLCLLFHISRP in isoform 2. 1 PublicationAdd BLAST | 79 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY505340 mRNA Translation: AAR98629.1 AY358288 mRNA Translation: AAQ88655.1 AY358295 mRNA Translation: AAQ88662.1 AK074921 mRNA Translation: BAC11295.1 Different initiation. |
CCDSi | CCDS44933.1 [Q6UXM1-2] CCDS8960.1 [Q6UXM1-1] |
RefSeqi | NP_001129523.1, NM_001136051.2 [Q6UXM1-2] NP_700356.2, NM_153377.4 [Q6UXM1-1] |
Genome annotation databases
Ensembli | ENST00000320743; ENSP00000326759; ENSG00000139263 [Q6UXM1-1] ENST00000379141; ENSP00000368436; ENSG00000139263 [Q6UXM1-2] |
GeneIDi | 121227 |
KEGGi | hsa:121227 |
UCSCi | uc001sqr.5, human [Q6UXM1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY505340 mRNA Translation: AAR98629.1 AY358288 mRNA Translation: AAQ88655.1 AY358295 mRNA Translation: AAQ88662.1 AK074921 mRNA Translation: BAC11295.1 Different initiation. |
CCDSi | CCDS44933.1 [Q6UXM1-2] CCDS8960.1 [Q6UXM1-1] |
RefSeqi | NP_001129523.1, NM_001136051.2 [Q6UXM1-2] NP_700356.2, NM_153377.4 [Q6UXM1-1] |
3D structure databases
SMRi | Q6UXM1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125712, 27 interactors |
IntActi | Q6UXM1, 10 interactors |
STRINGi | 9606.ENSP00000326759 |
PTM databases
GlyGeni | Q6UXM1, 12 sites |
iPTMneti | Q6UXM1 |
PhosphoSitePlusi | Q6UXM1 |
Polymorphism and mutation databases
BioMutai | LRIG3 |
DMDMi | 73621176 |
Proteomic databases
EPDi | Q6UXM1 |
jPOSTi | Q6UXM1 |
MassIVEi | Q6UXM1 |
MaxQBi | Q6UXM1 |
PaxDbi | Q6UXM1 |
PeptideAtlasi | Q6UXM1 |
PRIDEi | Q6UXM1 |
ProteomicsDBi | 67636 [Q6UXM1-1] 67637 [Q6UXM1-2] |
Protocols and materials databases
Antibodypediai | 2484, 145 antibodies |
Genome annotation databases
Ensembli | ENST00000320743; ENSP00000326759; ENSG00000139263 [Q6UXM1-1] ENST00000379141; ENSP00000368436; ENSG00000139263 [Q6UXM1-2] |
GeneIDi | 121227 |
KEGGi | hsa:121227 |
UCSCi | uc001sqr.5, human [Q6UXM1-1] |
Organism-specific databases
CTDi | 121227 |
DisGeNETi | 121227 |
EuPathDBi | HostDB:ENSG00000139263.11 |
GeneCardsi | LRIG3 |
HGNCi | HGNC:30991, LRIG3 |
HPAi | ENSG00000139263, Low tissue specificity |
MIMi | 608870, gene |
neXtProti | NX_Q6UXM1 |
OpenTargetsi | ENSG00000139263 |
PharmGKBi | PA134864136 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota KOG4194, Eukaryota |
GeneTreei | ENSGT00940000157098 |
InParanoidi | Q6UXM1 |
OMAi | CHVDNSS |
OrthoDBi | 161719at2759 |
PhylomeDBi | Q6UXM1 |
TreeFami | TF325380 |
Enzyme and pathway databases
PathwayCommonsi | Q6UXM1 |
SIGNORi | Q6UXM1 |
Miscellaneous databases
BioGRID-ORCSi | 121227, 2 hits in 846 CRISPR screens |
ChiTaRSi | LRIG3, human |
GenomeRNAii | 121227 |
Pharosi | Q6UXM1, Tbio |
PROi | PR:Q6UXM1 |
RNActi | Q6UXM1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000139263, Expressed in stomach and 177 other tissues |
ExpressionAtlasi | Q6UXM1, baseline and differential |
Genevisiblei | Q6UXM1, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF13855, LRR_8, 3 hits |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 3 hits SM00369, LRR_TYP, 14 hits SM00082, LRRCT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS51450, LRR, 15 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRIG3_HUMAN | |
Accessioni | Q6UXM1Primary (citable) accession number: Q6UXM1 Secondary accession number(s): Q6UXL7, Q8NC72 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM