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Protein

Leucine-rich repeat neuronal protein 1

Gene

LRRN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 1
Alternative name(s):
Neuronal leucine-rich repeat protein 1
Short name:
NLRR-1
Gene namesi
Name:LRRN1
Synonyms:KIAA1497
ORF Names:Nbla10449, UNQ693/PRO1338
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000175928.5
HGNCiHGNC:20980 LRRN1
neXtProtiNX_Q6UXK5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 631ExtracellularSequence analysisAdd BLAST606
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 716CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57633
OpenTargetsiENSG00000175928
PharmGKBiPA134935557

Polymorphism and mutation databases

BioMutaiLRRN1
DMDMi60390188

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001484726 – 716Leucine-rich repeat neuronal protein 1Add BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi385N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi447 ↔ 499PROSITE-ProRule annotation
Glycosylationi517N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ6UXK5
MaxQBiQ6UXK5
PaxDbiQ6UXK5
PeptideAtlasiQ6UXK5
PRIDEiQ6UXK5
ProteomicsDBi67634

PTM databases

CarbonylDBiQ6UXK5
iPTMnetiQ6UXK5
PhosphoSitePlusiQ6UXK5

Expressioni

Gene expression databases

BgeeiENSG00000175928 Expressed in 153 organ(s), highest expression level in caudate nucleus
CleanExiHS_LRRN1
GenevisibleiQ6UXK5 HS

Organism-specific databases

HPAiHPA011071

Interactioni

Protein-protein interaction databases

BioGridi121675, 4 interactors
IntActiQ6UXK5, 1 interactor
STRINGi9606.ENSP00000314901

Structurei

3D structure databases

ProteinModelPortaliQ6UXK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 72LRRNTAdd BLAST47
Repeati73 – 95LRR 1Add BLAST23
Repeati96 – 117LRR 2Add BLAST22
Repeati120 – 141LRR 3Add BLAST22
Repeati144 – 165LRR 4Add BLAST22
Repeati168 – 189LRR 5Add BLAST22
Repeati192 – 213LRR 6Add BLAST22
Repeati216 – 237LRR 7Add BLAST22
Repeati240 – 261LRR 8Add BLAST22
Repeati264 – 285LRR 9Add BLAST22
Repeati313 – 335LRR 10Add BLAST23
Repeati338 – 359LRR 11Add BLAST22
Domaini371 – 424LRRCTAdd BLAST54
Domaini424 – 515Ig-like C2-typeAdd BLAST92
Domaini525 – 617Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST93

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000252914
HOVERGENiHBG052361
InParanoidiQ6UXK5
OMAiHDTFPNH
OrthoDBiEOG091G066E
PhylomeDBiQ6UXK5
TreeFamiTF334360

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 9 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 10 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARMSFVIAA CQLVLGLLMT SLTESSIQNS ECPQLCVCEI RPWFTPQSTY
60 70 80 90 100
REATTVDCND LRLTRIPSNL SSDTQVLLLQ SNNIAKTVDE LQQLFNLTEL
110 120 130 140 150
DFSQNNFTNI KEVGLANLTQ LTTLHLEENQ ITEMTDYCLQ DLSNLQELYI
160 170 180 190 200
NHNQISTISA HAFAGLKNLL RLHLNSNKLK VIDSRWFDST PNLEILMIGE
210 220 230 240 250
NPVIGILDMN FKPLANLRSL VLAGMYLTDI PGNALVGLDS LESLSFYDNK
260 270 280 290 300
LVKVPQLALQ KVPNLKFLDL NKNPIHKIQE GDFKNMLRLK ELGINNMGEL
310 320 330 340 350
VSVDRYALDN LPELTKLEAT NNPKLSYIHR LAFRSVPALE SLMLNNNALN
360 370 380 390 400
AIYQKTVESL PNLREISIHS NPLRCDCVIH WINSNKTNIR FMEPLSMFCA
410 420 430 440 450
MPPEYKGHQV KEVLIQDSSE QCLPMISHDS FPNRLNVDIG TTVFLDCRAM
460 470 480 490 500
AEPEPEIYWV TPIGNKITVE TLSDKYKLSS EGTLEISNIQ IEDSGRYTCV
510 520 530 540 550
AQNVQGADTR VATIKVNGTL LDGTQVLKIY VKQTESHSIL VSWKVNSNVM
560 570 580 590 600
TSNLKWSSAT MKIDNPHITY TARVPVDVHE YNLTHLQPST DYEVCLTVSN
610 620 630 640 650
IHQQTQKSCV NVTTKNAAFA VDISDQETST ALAAVMGSMF AVISLASIAV
660 670 680 690 700
YFAKRFKRKN YHHSLKKYMQ KTSSIPLNEL YPPLINLWEG DSEKDKDGSA
710
DTKPTQVDTS RSYYMW
Length:716
Mass (Da):80,716
Last modified:July 5, 2004 - v1
Checksum:iA6B84D3C7464799C
GO

Sequence cautioni

The sequence BAA96021 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14500 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti264N → S in AAH34947 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049896395L → V. Corresponds to variant dbSNP:rs35362954Ensembl.1
Natural variantiVAR_049897702T → P. Corresponds to variant dbSNP:rs34611357Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074161 mRNA Translation: BAE45733.1
AB040930 mRNA Translation: BAA96021.1 Different initiation.
AY358312 mRNA Translation: AAQ88679.1
BC034947 mRNA Translation: AAH34947.1
AK023273 mRNA Translation: BAB14500.1 Different initiation.
CCDSiCCDS33685.1
RefSeqiNP_001311117.1, NM_001324188.1
NP_001311118.1, NM_001324189.1
NP_065924.3, NM_020873.6
UniGeneiHs.163244
Hs.737660

Genome annotation databases

EnsembliENST00000319331; ENSP00000314901; ENSG00000175928
GeneIDi57633
KEGGihsa:57633
UCSCiuc003bpt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074161 mRNA Translation: BAE45733.1
AB040930 mRNA Translation: BAA96021.1 Different initiation.
AY358312 mRNA Translation: AAQ88679.1
BC034947 mRNA Translation: AAH34947.1
AK023273 mRNA Translation: BAB14500.1 Different initiation.
CCDSiCCDS33685.1
RefSeqiNP_001311117.1, NM_001324188.1
NP_001311118.1, NM_001324189.1
NP_065924.3, NM_020873.6
UniGeneiHs.163244
Hs.737660

3D structure databases

ProteinModelPortaliQ6UXK5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121675, 4 interactors
IntActiQ6UXK5, 1 interactor
STRINGi9606.ENSP00000314901

PTM databases

CarbonylDBiQ6UXK5
iPTMnetiQ6UXK5
PhosphoSitePlusiQ6UXK5

Polymorphism and mutation databases

BioMutaiLRRN1
DMDMi60390188

Proteomic databases

EPDiQ6UXK5
MaxQBiQ6UXK5
PaxDbiQ6UXK5
PeptideAtlasiQ6UXK5
PRIDEiQ6UXK5
ProteomicsDBi67634

Protocols and materials databases

DNASUi57633
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319331; ENSP00000314901; ENSG00000175928
GeneIDi57633
KEGGihsa:57633
UCSCiuc003bpt.4 human

Organism-specific databases

CTDi57633
DisGeNETi57633
EuPathDBiHostDB:ENSG00000175928.5
GeneCardsiLRRN1
HGNCiHGNC:20980 LRRN1
HPAiHPA011071
neXtProtiNX_Q6UXK5
OpenTargetsiENSG00000175928
PharmGKBiPA134935557
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000252914
HOVERGENiHBG052361
InParanoidiQ6UXK5
OMAiHDTFPNH
OrthoDBiEOG091G066E
PhylomeDBiQ6UXK5
TreeFamiTF334360

Miscellaneous databases

GeneWikiiLRRN1
GenomeRNAii57633
PROiPR:Q6UXK5

Gene expression databases

BgeeiENSG00000175928 Expressed in 153 organ(s), highest expression level in caudate nucleus
CleanExiHS_LRRN1
GenevisibleiQ6UXK5 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 9 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRRN1_HUMAN
AccessioniPrimary (citable) accession number: Q6UXK5
Secondary accession number(s): Q3LID5
, Q8IYV5, Q9H8V1, Q9P231
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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