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Entry version 141 (08 May 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Leucine-rich repeat neuronal protein 1

Gene

LRRN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 1
Alternative name(s):
Neuronal leucine-rich repeat protein 1
Short name:
NLRR-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRN1
Synonyms:KIAA1497
ORF Names:Nbla10449, UNQ693/PRO1338
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20980 LRRN1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UXK5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 631ExtracellularSequence analysisAdd BLAST606
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 716CytoplasmicSequence analysisAdd BLAST64

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57633

Open Targets

More...
OpenTargetsi
ENSG00000175928

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134935557

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
60390188

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 251 PublicationAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001484726 – 716Leucine-rich repeat neuronal protein 1Add BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi385N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi447 ↔ 499PROSITE-ProRule annotation
Glycosylationi517N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6UXK5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6UXK5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6UXK5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UXK5

PeptideAtlas

More...
PeptideAtlasi
Q6UXK5

PRoteomics IDEntifications database

More...
PRIDEi
Q6UXK5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67634

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q6UXK5

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6UXK5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UXK5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175928 Expressed in 153 organ(s), highest expression level in caudate nucleus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6UXK5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011071

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121675, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q6UXK5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000314901

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 72LRRNTAdd BLAST47
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati73 – 95LRR 1Add BLAST23
Repeati96 – 117LRR 2Add BLAST22
Repeati120 – 141LRR 3Add BLAST22
Repeati144 – 165LRR 4Add BLAST22
Repeati168 – 189LRR 5Add BLAST22
Repeati192 – 213LRR 6Add BLAST22
Repeati216 – 237LRR 7Add BLAST22
Repeati240 – 261LRR 8Add BLAST22
Repeati264 – 285LRR 9Add BLAST22
Repeati313 – 335LRR 10Add BLAST23
Repeati338 – 359LRR 11Add BLAST22
Domaini371 – 424LRRCTAdd BLAST54
Domaini424 – 515Ig-like C2-typeAdd BLAST92
Domaini525 – 617Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST93

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157154

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252914

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UXK5

Identification of Orthologs from Complete Genome Data

More...
OMAi
HDTFPNH

Database of Orthologous Groups

More...
OrthoDBi
998247at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UXK5

TreeFam database of animal gene trees

More...
TreeFami
TF334360

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 9 hits
SM00082 LRRCT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARMSFVIAA CQLVLGLLMT SLTESSIQNS ECPQLCVCEI RPWFTPQSTY
60 70 80 90 100
REATTVDCND LRLTRIPSNL SSDTQVLLLQ SNNIAKTVDE LQQLFNLTEL
110 120 130 140 150
DFSQNNFTNI KEVGLANLTQ LTTLHLEENQ ITEMTDYCLQ DLSNLQELYI
160 170 180 190 200
NHNQISTISA HAFAGLKNLL RLHLNSNKLK VIDSRWFDST PNLEILMIGE
210 220 230 240 250
NPVIGILDMN FKPLANLRSL VLAGMYLTDI PGNALVGLDS LESLSFYDNK
260 270 280 290 300
LVKVPQLALQ KVPNLKFLDL NKNPIHKIQE GDFKNMLRLK ELGINNMGEL
310 320 330 340 350
VSVDRYALDN LPELTKLEAT NNPKLSYIHR LAFRSVPALE SLMLNNNALN
360 370 380 390 400
AIYQKTVESL PNLREISIHS NPLRCDCVIH WINSNKTNIR FMEPLSMFCA
410 420 430 440 450
MPPEYKGHQV KEVLIQDSSE QCLPMISHDS FPNRLNVDIG TTVFLDCRAM
460 470 480 490 500
AEPEPEIYWV TPIGNKITVE TLSDKYKLSS EGTLEISNIQ IEDSGRYTCV
510 520 530 540 550
AQNVQGADTR VATIKVNGTL LDGTQVLKIY VKQTESHSIL VSWKVNSNVM
560 570 580 590 600
TSNLKWSSAT MKIDNPHITY TARVPVDVHE YNLTHLQPST DYEVCLTVSN
610 620 630 640 650
IHQQTQKSCV NVTTKNAAFA VDISDQETST ALAAVMGSMF AVISLASIAV
660 670 680 690 700
YFAKRFKRKN YHHSLKKYMQ KTSSIPLNEL YPPLINLWEG DSEKDKDGSA
710
DTKPTQVDTS RSYYMW
Length:716
Mass (Da):80,716
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6B84D3C7464799C
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA96021 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14500 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti264N → S in AAH34947 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049896395L → V. Corresponds to variant dbSNP:rs35362954Ensembl.1
Natural variantiVAR_049897702T → P. Corresponds to variant dbSNP:rs34611357Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB074161 mRNA Translation: BAE45733.1
AB040930 mRNA Translation: BAA96021.1 Different initiation.
AY358312 mRNA Translation: AAQ88679.1
BC034947 mRNA Translation: AAH34947.1
AK023273 mRNA Translation: BAB14500.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33685.1

NCBI Reference Sequences

More...
RefSeqi
NP_001311117.1, NM_001324188.1
NP_001311118.1, NM_001324189.1
NP_065924.3, NM_020873.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319331; ENSP00000314901; ENSG00000175928

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57633

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57633

UCSC genome browser

More...
UCSCi
uc003bpt.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074161 mRNA Translation: BAE45733.1
AB040930 mRNA Translation: BAA96021.1 Different initiation.
AY358312 mRNA Translation: AAQ88679.1
BC034947 mRNA Translation: AAH34947.1
AK023273 mRNA Translation: BAB14500.1 Different initiation.
CCDSiCCDS33685.1
RefSeqiNP_001311117.1, NM_001324188.1
NP_001311118.1, NM_001324189.1
NP_065924.3, NM_020873.6

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121675, 4 interactors
IntActiQ6UXK5, 1 interactor
STRINGi9606.ENSP00000314901

PTM databases

CarbonylDBiQ6UXK5
iPTMnetiQ6UXK5
PhosphoSitePlusiQ6UXK5

Polymorphism and mutation databases

BioMutaiLRRN1
DMDMi60390188

Proteomic databases

EPDiQ6UXK5
jPOSTiQ6UXK5
MaxQBiQ6UXK5
PaxDbiQ6UXK5
PeptideAtlasiQ6UXK5
PRIDEiQ6UXK5
ProteomicsDBi67634

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57633
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319331; ENSP00000314901; ENSG00000175928
GeneIDi57633
KEGGihsa:57633
UCSCiuc003bpt.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57633
DisGeNETi57633

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRN1
HGNCiHGNC:20980 LRRN1
HPAiHPA011071
neXtProtiNX_Q6UXK5
OpenTargetsiENSG00000175928
PharmGKBiPA134935557

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000157154
HOGENOMiHOG000252914
InParanoidiQ6UXK5
OMAiHDTFPNH
OrthoDBi998247at2759
PhylomeDBiQ6UXK5
TreeFamiTF334360

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LRRN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57633

Protein Ontology

More...
PROi
PR:Q6UXK5

Gene expression databases

BgeeiENSG00000175928 Expressed in 153 organ(s), highest expression level in caudate nucleus
GenevisibleiQ6UXK5 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 9 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRRN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UXK5
Secondary accession number(s): Q3LID5
, Q8IYV5, Q9H8V1, Q9P231
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: May 8, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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