UniProtKB - Q6UXK2 (ISLR2_HUMAN)
Protein
Immunoglobulin superfamily containing leucine-rich repeat protein 2
Gene
ISLR2
Organism
Homo sapiens (Human)
Status
Functioni
Required for axon extension during neural development.By similarity
GO - Biological processi
- positive regulation of axon extension Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q6UXK2 |
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin superfamily containing leucine-rich repeat protein 2Alternative name(s): Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein |
Gene namesi | Name:ISLR2 Synonyms:KIAA1465, LINX ORF Names:UNQ1885/PRO4329 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167178.15 |
HGNCi | HGNC:29286, ISLR2 |
MIMi | 614179, gene |
neXtProti | NX_Q6UXK2 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell surface Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 589 | ExtracellularSequence analysisAdd BLAST | 571 | |
Transmembranei | 590 – 610 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 611 – 745 | CytoplasmicSequence analysisAdd BLAST | 135 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 57611 |
OpenTargetsi | ENSG00000167178 |
PharmGKBi | PA143485505 |
Miscellaneous databases
Pharosi | Q6UXK2, Tbio |
Polymorphism and mutation databases
BioMutai | ISLR2 |
DMDMi | 74758577 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000317498 | 19 – 745 | Immunoglobulin superfamily containing leucine-rich repeat protein 2Add BLAST | 727 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 52 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 121 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 260 ↔ 355 | PROSITE-ProRule annotation | ||
Glycosylationi | 337 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 364 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 474 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 563 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 719 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 720 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q6UXK2 |
PaxDbi | Q6UXK2 |
PeptideAtlasi | Q6UXK2 |
PRIDEi | Q6UXK2 |
ProteomicsDBi | 67633 |
PTM databases
GlyGeni | Q6UXK2, 6 sites |
iPTMneti | Q6UXK2 |
PhosphoSitePlusi | Q6UXK2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167178, Expressed in cortical plate and 115 other tissues |
ExpressionAtlasi | Q6UXK2, baseline and differential |
Genevisiblei | Q6UXK2, HS |
Organism-specific databases
HPAi | ENSG00000167178, Tissue enhanced (brain, testis) |
Interactioni
Subunit structurei
Homomultimer.
Interacts with NTRK1/TrkA (By similarity).
By similarityBinary interactionsi
Hide detailsQ6UXK2
Protein-protein interaction databases
BioGRIDi | 121658, 7 interactors |
CORUMi | Q6UXK2 |
IntActi | Q6UXK2, 7 interactors |
STRINGi | 9606.ENSP00000355402 |
Miscellaneous databases
RNActi | Q6UXK2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 51 | LRRNTAdd BLAST | 33 | |
Repeati | 52 – 73 | LRR 1Add BLAST | 22 | |
Repeati | 76 – 97 | LRR 2Add BLAST | 22 | |
Repeati | 100 – 123 | LRR 3Add BLAST | 24 | |
Repeati | 124 – 145 | LRR 4Add BLAST | 22 | |
Repeati | 148 – 169 | LRR 5Add BLAST | 22 | |
Domaini | 181 – 232 | LRRCTAdd BLAST | 52 | |
Domaini | 233 – 371 | Ig-likeAdd BLAST | 139 |
Keywords - Domaini
Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000162846 |
HOGENOMi | CLU_400948_0_0_1 |
InParanoidi | Q6UXK2 |
OMAi | GNYKQPS |
OrthoDBi | 282791at2759 |
PhylomeDBi | Q6UXK2 |
TreeFami | TF351112 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 5 hits SM00082, LRRCT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51450, LRR, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q6UXK2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFPLRALWLV WALLGVAGSC PEPCACVDKY AHQFADCAYK ELREVPEGLP
60 70 80 90 100
ANVTTLSLSA NKITVLRRGA FADVTQVTSL WLAHNEVRTV EPGALAVLSQ
110 120 130 140 150
LKNLDLSHNF ISSFPWSDLR NLSALQLLKM NHNRLGSLPR DALGALPDLR
160 170 180 190 200
SLRINNNRLR TLAPGTFDAL SALSHLQLYH NPFHCGCGLV WLQAWAASTR
210 220 230 240 250
VSLPEPDSIA CASPPALQGV PVYRLPALPC APPSVHLSAE PPLEAPGTPL
260 270 280 290 300
RAGLAFVLHC IADGHPTPRL QWQLQIPGGT VVLEPPVLSG EDDGVGAEEG
310 320 330 340 350
EGEGDGDLLT QTQAQTPTPA PAWPAPPATP RFLALANGSL LVPLLSAKEA
360 370 380 390 400
GVYTCRAHNE LGANSTSIRV AVAATGPPKH APGAGGEPDG QAPTSERKST
410 420 430 440 450
AKGRGNSVLP SKPEGKIKGQ GLAKVSILGE TETEPEEDTS EGEEAEDQIL
460 470 480 490 500
ADPAEEQRCG NGDPSRYVSN HAFNQSAELK PHVFELGVIA LDVAEREARV
510 520 530 540 550
QLTPLAARWG PGPGGAGGAP RPGRRPLRLL YLCPAGGGAA VQWSRVEEGV
560 570 580 590 600
NAYWFRGLRP GTNYSVCLAL AGEACHVQVV FSTKKELPSL LVIVAVSVFL
610 620 630 640 650
LVLATVPLLG AACCHLLAKH PGKPYRLILR PQAPDPMEKR IAADFDPRAS
660 670 680 690 700
YLESEKSYPA GGEAGGEEPE DVQGEGLDED AEQGDPSGDL QREESLAACS
710 720 730 740
LVESQSKANQ EEFEAGSEYS DRLPLGAEAV NIAQEINGNY RQTAG
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ24JQ5 | Q24JQ5_HUMAN | ISLR2 protein | ISLR2 | 334 | Annotation score: | ||
H3BM69 | H3BM69_HUMAN | Immunoglobulin superfamily-containi... | ISLR2 | 114 | Annotation score: | ||
H3BNZ6 | H3BNZ6_HUMAN | Immunoglobulin superfamily-containi... | ISLR2 | 138 | Annotation score: | ||
H3BM95 | H3BM95_HUMAN | Immunoglobulin superfamily-containi... | ISLR2 | 89 | Annotation score: |
Sequence cautioni
The sequence BAA95989 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | S → P in BAF83156 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049881 | 137 | S → F. Corresponds to variant dbSNP:rs3889598Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB040898 mRNA Translation: BAA95989.2 Different initiation. AY358316 mRNA Translation: AAQ88682.1 AK290467 mRNA Translation: BAF83156.1 |
CCDSi | CCDS10259.1 |
RefSeqi | NP_001123608.1, NM_001130136.1 NP_001123609.1, NM_001130137.1 NP_001123610.1, NM_001130138.1 NP_065902.1, NM_020851.2 XP_011520142.1, XM_011521840.2 XP_011520143.1, XM_011521841.1 |
Genome annotation databases
Ensembli | ENST00000361742; ENSP00000355402; ENSG00000167178 ENST00000435464; ENSP00000411443; ENSG00000167178 ENST00000453268; ENSP00000411834; ENSG00000167178 ENST00000565159; ENSP00000455531; ENSG00000167178 ENST00000565540; ENSP00000458080; ENSG00000167178 |
GeneIDi | 57611 |
KEGGi | hsa:57611 |
UCSCi | uc002axd.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB040898 mRNA Translation: BAA95989.2 Different initiation. AY358316 mRNA Translation: AAQ88682.1 AK290467 mRNA Translation: BAF83156.1 |
CCDSi | CCDS10259.1 |
RefSeqi | NP_001123608.1, NM_001130136.1 NP_001123609.1, NM_001130137.1 NP_001123610.1, NM_001130138.1 NP_065902.1, NM_020851.2 XP_011520142.1, XM_011521840.2 XP_011520143.1, XM_011521841.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121658, 7 interactors |
CORUMi | Q6UXK2 |
IntActi | Q6UXK2, 7 interactors |
STRINGi | 9606.ENSP00000355402 |
PTM databases
GlyGeni | Q6UXK2, 6 sites |
iPTMneti | Q6UXK2 |
PhosphoSitePlusi | Q6UXK2 |
Polymorphism and mutation databases
BioMutai | ISLR2 |
DMDMi | 74758577 |
Proteomic databases
MassIVEi | Q6UXK2 |
PaxDbi | Q6UXK2 |
PeptideAtlasi | Q6UXK2 |
PRIDEi | Q6UXK2 |
ProteomicsDBi | 67633 |
Protocols and materials databases
Antibodypediai | 26861, 81 antibodies |
Genome annotation databases
Ensembli | ENST00000361742; ENSP00000355402; ENSG00000167178 ENST00000435464; ENSP00000411443; ENSG00000167178 ENST00000453268; ENSP00000411834; ENSG00000167178 ENST00000565159; ENSP00000455531; ENSG00000167178 ENST00000565540; ENSP00000458080; ENSG00000167178 |
GeneIDi | 57611 |
KEGGi | hsa:57611 |
UCSCi | uc002axd.3, human |
Organism-specific databases
CTDi | 57611 |
DisGeNETi | 57611 |
EuPathDBi | HostDB:ENSG00000167178.15 |
GeneCardsi | ISLR2 |
HGNCi | HGNC:29286, ISLR2 |
HPAi | ENSG00000167178, Tissue enhanced (brain, testis) |
MIMi | 614179, gene |
neXtProti | NX_Q6UXK2 |
OpenTargetsi | ENSG00000167178 |
PharmGKBi | PA143485505 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000162846 |
HOGENOMi | CLU_400948_0_0_1 |
InParanoidi | Q6UXK2 |
OMAi | GNYKQPS |
OrthoDBi | 282791at2759 |
PhylomeDBi | Q6UXK2 |
TreeFami | TF351112 |
Enzyme and pathway databases
PathwayCommonsi | Q6UXK2 |
Miscellaneous databases
BioGRID-ORCSi | 57611, 12 hits in 842 CRISPR screens |
ChiTaRSi | ISLR2, human |
GenomeRNAii | 57611 |
Pharosi | Q6UXK2, Tbio |
PROi | PR:Q6UXK2 |
RNActi | Q6UXK2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167178, Expressed in cortical plate and 115 other tissues |
ExpressionAtlasi | Q6UXK2, baseline and differential |
Genevisiblei | Q6UXK2, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 5 hits SM00082, LRRCT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51450, LRR, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ISLR2_HUMAN | |
Accessioni | Q6UXK2Primary (citable) accession number: Q6UXK2 Secondary accession number(s): A8K352, Q9P263 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations