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Entry version 124 (08 May 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Inactive serine protease PAMR1

Gene

PAMR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in regeneration of skeletal muscle.By similarity

Caution

Although related to peptidase S1 family, lacks the conserved active Ser residue in position 665 which is replaced by a Thr, suggesting that it has no protease activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionSerine protease homolog

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.998

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive serine protease PAMR1
Alternative name(s):
Peptidase domain-containing protein associated with muscle regeneration 1
Regeneration-associated muscle protease homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAMR1
Synonyms:RAMP
ORF Names:FP938, UNQ699/PRO1344
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24554 PAMR1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UXH9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25891

Open Targets

More...
OpenTargetsi
ENSG00000149090

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164724339

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PAMR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74738221

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028760222 – 720Inactive serine protease PAMR1Add BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi128 ↔ 150By similarity
Disulfide bondi177 ↔ 199By similarity
Disulfide bondi239 ↔ 250By similarity
Disulfide bondi244 ↔ 260By similarity
Disulfide bondi262 ↔ 271By similarity
Disulfide bondi280 ↔ 329By similarity
Disulfide bondi315 ↔ 342By similarity
Disulfide bondi414 ↔ 442By similarity
Disulfide bondi489 ↔ 505By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi614N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi630 ↔ 649By similarity
Disulfide bondi661 ↔ 697By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6UXH9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UXH9

PeptideAtlas

More...
PeptideAtlasi
Q6UXH9

PRoteomics IDEntifications database

More...
PRIDEi
Q6UXH9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67625
67626 [Q6UXH9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6UXH9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UXH9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Strongly down-regulated in muscle cell lines derived from biopsies of 5 Duchenne muscular dystrophy (DMD) patients compared to a normal muscle cell line.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149090 Expressed in 199 organ(s), highest expression level in decidua

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6UXH9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6UXH9 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q6UXH9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000482899

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini128 – 236CUBPROSITE-ProRule annotationAdd BLAST109
Domaini235 – 272EGF-likePROSITE-ProRule annotationAdd BLAST38
Domaini278 – 344Sushi 1PROSITE-ProRule annotationAdd BLAST67
Domaini387 – 444Sushi 2PROSITE-ProRule annotationAdd BLAST58
Domaini445 – 720Peptidase S1PROSITE-ProRule annotationAdd BLAST276

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi42 – 94Cys-richAdd BLAST53

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3627 Eukaryota
COG5640 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154234

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168611

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UXH9

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEDNECD

Database of Orthologous Groups

More...
OrthoDBi
267332at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UXH9

TreeFam database of animal gene trees

More...
TreeFami
TF351669

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 2 hits
cd00041 CUB, 1 hit
cd00190 Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001254 Trypsin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 1 hit
PF00008 EGF, 1 hit
PF00084 Sushi, 2 hits
PF00089 Trypsin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00722 CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 2 hits
SM00042 CUB, 1 hit
SM00181 EGF, 2 hits
SM00179 EGF_CA, 1 hit
SM00020 Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854 SSF49854, 1 hit
SSF50494 SSF50494, 1 hit
SSF57535 SSF57535, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180 CUB, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 2 hits
PS50240 TRYPSIN_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UXH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELGCWTQLG LTFLQLLLIS SLPREYTVIN EACPGAEWNI MCRECCEYDQ
60 70 80 90 100
IECVCPGKRE VVGYTIPCCR NEENECDSCL IHPGCTIFEN CKSCRNGSWG
110 120 130 140 150
GTLDDFYVKG FYCAECRAGW YGGDCMRCGQ VLRAPKGQIL LESYPLNAHC
160 170 180 190 200
EWTIHAKPGF VIQLRFVMLS LEFDYMCQYD YVEVRDGDNR DGQIIKRVCG
210 220 230 240 250
NERPAPIQSI GSSLHVLFHS DGSKNFDGFH AIYEEITACS SSPCFHDGTC
260 270 280 290 300
VLDKAGSYKC ACLAGYTGQR CENLLEERNC SDPGGPVNGY QKITGGPGLI
310 320 330 340 350
NGRHAKIGTV VSFFCNNSYV LSGNEKRTCQ QNGEWSGKQP ICIKACREPK
360 370 380 390 400
ISDLVRRRVL PMQVQSRETP LHQLYSAAFS KQKLQSAPTK KPALPFGDLP
410 420 430 440 450
MGYQHLHTQL QYECISPFYR RLGSSRRTCL RTGKWSGRAP SCIPICGKIE
460 470 480 490 500
NITAPKTQGL RWPWQAAIYR RTSGVHDGSL HKGAWFLVCS GALVNERTVV
510 520 530 540 550
VAAHCVTDLG KVTMIKTADL KVVLGKFYRD DDRDEKTIQS LQISAIILHP
560 570 580 590 600
NYDPILLDAD IAILKLLDKA RISTRVQPIC LAASRDLSTS FQESHITVAG
610 620 630 640 650
WNVLADVRSP GFKNDTLRSG VVSVVDSLLC EEQHEDHGIP VSVTDNMFCA
660 670 680 690 700
SWEPTAPSDI CTAETGGIAA VSFPGRASPE PRWHLMGLVS WSYDKTCSHR
710 720
LSTAFTKVLP FKDWIERNMK
Length:720
Mass (Da):80,199
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC898BC7241289D3
GO
Isoform 2 (identifier: Q6UXH9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-274: L → LLEAGKSKIKASEDSLSV

Show »
Length:737
Mass (Da):81,943
Checksum:iFD3BACCFE47778FE
GO
Isoform 3 (identifier: Q6UXH9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-238: RCGQVLRAPK...FHAIYEEITA → P

Note: No experimental confirmation available.
Show »
Length:609
Mass (Da):67,541
Checksum:iEFBDB755BCA816C4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQ70E9PQ70_HUMAN
Inactive serine protease PAMR1
PAMR1
675Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXE9A0A087WXE9_HUMAN
Inactive serine protease PAMR1
PAMR1
680Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMN5E9PMN5_HUMAN
Inactive serine protease PAMR1
PAMR1
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUR8A0A087WUR8_HUMAN
Inactive serine protease PAMR1
PAMR1
416Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ15224 differs from that shown. Reason: Frameshift at position 334.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti257S → P in BAB55404 (PubMed:14702039).Curated1
Sequence conflicti396F → S in BAH14559 (PubMed:14702039).Curated1
Sequence conflicti542Q → R in CAB43317 (PubMed:17974005).Curated1
Sequence conflicti542Q → R in CAI46203 (PubMed:17974005).Curated1
Sequence conflicti542Q → R in CAE45808 (PubMed:17974005).Curated1
Sequence conflicti665T → A in CAE45808 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032335305A → T. Corresponds to variant dbSNP:rs16927482Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055371127 – 238RCGQV…EEITA → P in isoform 3. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_025568274L → LLEAGKSKIKASEDSLSV in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358346 mRNA Translation: AAQ88712.1
AK027841 mRNA Translation: BAB55404.1
AK316188 mRNA Translation: BAH14559.1
AL050214 mRNA Translation: CAB43317.1
AL832391 mRNA Translation: CAI46203.1
BX640676 mRNA Translation: CAE45808.1
AC090625 Genomic DNA No translation available.
AL354921 Genomic DNA No translation available.
BC089434 mRNA Translation: AAH89434.1
AF370388 mRNA Translation: AAQ15224.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31460.1 [Q6UXH9-1]
CCDS60760.1 [Q6UXH9-3]
CCDS7898.1 [Q6UXH9-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T08805

NCBI Reference Sequences

More...
RefSeqi
NP_001001991.1, NM_001001991.2 [Q6UXH9-1]
NP_001269604.1, NM_001282675.1
NP_001269605.1, NM_001282676.1 [Q6UXH9-3]
NP_056245.2, NM_015430.3 [Q6UXH9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000615849; ENSP00000479260; ENSG00000149090 [Q6UXH9-3]
ENST00000619888; ENSP00000483703; ENSG00000149090 [Q6UXH9-1]
ENST00000622144; ENSP00000482899; ENSG00000149090 [Q6UXH9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25891

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25891

UCSC genome browser

More...
UCSCi
uc031xjw.2 human [Q6UXH9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358346 mRNA Translation: AAQ88712.1
AK027841 mRNA Translation: BAB55404.1
AK316188 mRNA Translation: BAH14559.1
AL050214 mRNA Translation: CAB43317.1
AL832391 mRNA Translation: CAI46203.1
BX640676 mRNA Translation: CAE45808.1
AC090625 Genomic DNA No translation available.
AL354921 Genomic DNA No translation available.
BC089434 mRNA Translation: AAH89434.1
AF370388 mRNA Translation: AAQ15224.1 Frameshift.
CCDSiCCDS31460.1 [Q6UXH9-1]
CCDS60760.1 [Q6UXH9-3]
CCDS7898.1 [Q6UXH9-2]
PIRiT08805
RefSeqiNP_001001991.1, NM_001001991.2 [Q6UXH9-1]
NP_001269604.1, NM_001282675.1
NP_001269605.1, NM_001282676.1 [Q6UXH9-3]
NP_056245.2, NM_015430.3 [Q6UXH9-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ6UXH9, 1 interactor
STRINGi9606.ENSP00000482899

Protein family/group databases

MEROPSiS01.998

PTM databases

iPTMnetiQ6UXH9
PhosphoSitePlusiQ6UXH9

Polymorphism and mutation databases

BioMutaiPAMR1
DMDMi74738221

Proteomic databases

jPOSTiQ6UXH9
PaxDbiQ6UXH9
PeptideAtlasiQ6UXH9
PRIDEiQ6UXH9
ProteomicsDBi67625
67626 [Q6UXH9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000615849; ENSP00000479260; ENSG00000149090 [Q6UXH9-3]
ENST00000619888; ENSP00000483703; ENSG00000149090 [Q6UXH9-1]
ENST00000622144; ENSP00000482899; ENSG00000149090 [Q6UXH9-2]
GeneIDi25891
KEGGihsa:25891
UCSCiuc031xjw.2 human [Q6UXH9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25891
DisGeNETi25891

GeneCards: human genes, protein and diseases

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GeneCardsi
PAMR1
HGNCiHGNC:24554 PAMR1
neXtProtiNX_Q6UXH9
OpenTargetsiENSG00000149090
PharmGKBiPA164724339

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00940000154234
HOGENOMiHOG000168611
InParanoidiQ6UXH9
OMAiNEDNECD
OrthoDBi267332at2759
PhylomeDBiQ6UXH9
TreeFamiTF351669

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PAMR1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25891

Protein Ontology

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PROi
PR:Q6UXH9

Gene expression databases

BgeeiENSG00000149090 Expressed in 199 organ(s), highest expression level in decidua
ExpressionAtlasiQ6UXH9 baseline and differential
GenevisibleiQ6UXH9 HS

Family and domain databases

CDDicd00033 CCP, 2 hits
cd00041 CUB, 1 hit
cd00190 Tryp_SPc, 1 hit
Gene3Di2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF00431 CUB, 1 hit
PF00008 EGF, 1 hit
PF00084 Sushi, 2 hits
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00042 CUB, 1 hit
SM00181 EGF, 2 hits
SM00179 EGF_CA, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
SSF50494 SSF50494, 1 hit
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 2 hits
PS50240 TRYPSIN_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAMR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UXH9
Secondary accession number(s): A8MQ58
, B7ZA73, Q5EBL7, Q5JPI4, Q6N062, Q71RE9, Q96JW2, Q9Y432
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: May 8, 2019
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Peptidase families
    Classification of peptidase families and list of entries
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