UniProtKB - Q6UXG3 (CLM9_HUMAN)
Protein
CMRF35-like molecule 9
Gene
CD300LG
Organism
Homo sapiens (Human)
Status
Functioni
Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).By similarity
GO - Biological processi
- immune system process Source: UniProtKB-KW
- regulation of immune response Source: Reactome
Keywordsi
Molecular function | Receptor |
Biological process | Immunity |
Enzyme and pathway databases
PathwayCommonsi | Q6UXG3 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Names & Taxonomyi
Protein namesi | Recommended name: CMRF35-like molecule 9Short name: CLM-9 Alternative name(s): CD300 antigen-like family member G Triggering receptor expressed on myeloid cells 4 Short name: TREM-4 CD_antigen: CD300g |
Gene namesi | Name:CD300LG Synonyms:CLM9, TREM4 ORF Names:UNQ422/PRO846 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000161649.12 |
HGNCi | HGNC:30455, CD300LG |
MIMi | 610520, gene |
neXtProti | NX_Q6UXG3 |
Subcellular locationi
Plasma membrane
- Apical cell membrane By similarity; Single-pass type I membrane protein By similarity
- Basolateral cell membrane By similarity; Single-pass type I membrane protein By similarity
Endosome
- multivesicular body membrane By similarity; Single-pass type I membrane protein By similarity
Note: Transcytoses across the cytoplasm.By similarity
Endosome
- multivesicular body membrane Source: UniProtKB-SubCell
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- basolateral plasma membrane Source: UniProtKB-SubCell
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 247 | ExtracellularSequence analysisAdd BLAST | 229 | |
Transmembranei | 248 – 268 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 269 – 332 | CytoplasmicSequence analysisAdd BLAST | 64 |
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 146894 |
OpenTargetsi | ENSG00000161649 |
PharmGKBi | PA142672154 |
Miscellaneous databases
Pharosi | Q6UXG3, Tdark |
Polymorphism and mutation databases
BioMutai | CD300LG |
DMDMi | 296434455 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 1 PublicationAdd BLAST | 18 | |
ChainiPRO_0000306112 | 19 – 332 | CMRF35-like molecule 9Add BLAST | 314 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 37 ↔ 107 | PROSITE-ProRule annotation | ||
Glycosylationi | 96 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 137 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 143 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 144 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 155 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 161 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 170 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 171 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 177 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 187 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 195 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 196 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 199 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 201 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 202 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 207 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 208 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 213 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 214 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 222 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 223 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 224 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 228 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 229 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 237 | O-linked (GalNAc...) serineSequence analysis | 1 |
Post-translational modificationi
O-glycosylated with sialylated oligosaccharides.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q6UXG3 |
MassIVEi | Q6UXG3 |
PaxDbi | Q6UXG3 |
PeptideAtlasi | Q6UXG3 |
PRIDEi | Q6UXG3 |
ProteomicsDBi | 27553 30350 67609 [Q6UXG3-1] 67610 [Q6UXG3-2] 67611 [Q6UXG3-3] |
PTM databases
GlyGeni | Q6UXG3, 25 sites |
iPTMneti | Q6UXG3 |
PhosphoSitePlusi | Q6UXG3 |
Expressioni
Tissue specificityi
Highly expressed in heart, skeletal muscle and placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000161649, Expressed in adipose tissue and 156 other tissues |
ExpressionAtlasi | Q6UXG3, baseline and differential |
Genevisiblei | Q6UXG3, HS |
Organism-specific databases
HPAi | ENSG00000161649, Tissue enhanced (adipose tissue, breast) |
Interactioni
Binary interactionsi
Hide detailsQ6UXG3
Protein-protein interaction databases
BioGRIDi | 127023, 7 interactors |
IntActi | Q6UXG3, 6 interactors |
STRINGi | 9606.ENSP00000321005 |
Miscellaneous databases
RNActi | Q6UXG3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 121 | Ig-like V-typeAdd BLAST | 103 |
Domaini
Ig-like V-type domain mediates binding to lymphocyte.By similarity
Sequence similaritiesi
Belongs to the CD300 family.Curated
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SURU, Eukaryota |
GeneTreei | ENSGT00940000162429 |
HOGENOMi | CLU_051023_1_0_1 |
InParanoidi | Q6UXG3 |
OMAi | SVHDNPR |
OrthoDBi | 1494510at2759 |
PhylomeDBi | Q6UXG3 |
TreeFami | TF334441 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6UXG3-1) [UniParc]FASTAAdd to basket
Also known as: CD300LG-gamma
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRLLVLLWGC LLLPGYEALE GPEEISGFEG DTVSLQCTYR EELRDHRKYW
60 70 80 90 100
CRKGGILFSR CSGTIYAEEE GQETMKGRVS IRDSRQELSL IVTLWNLTLQ
110 120 130 140 150
DAGEYWCGVE KRGPDESLLI SLFVFPGPCC PPSPSPTFQP LATTRLQPKA
160 170 180 190 200
KAQQTQPPGL TSPGLYPAAT TAKQGKTGAE APPLPGTSQY GHERTSQYTG
210 220 230 240 250
TSPHPATSPP AGSSRPPMQL DSTSAEDTSP ALSSGSSKPR VSIPMVRILA
260 270 280 290 300
PVLVLLSLLS AAGLIAFCSH LLLWRKEAQQ ATETQRNEKF CLSRLTAEEK
310 320 330
EAPSQAPEGD VISMPPLHTS EEELGFSKFV SA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7EL06 | K7EL06_HUMAN | CMRF35-like molecule 9 | CD300LG | 150 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | C → W in AAN86134 (Ref. 1) Curated | 1 | |
Sequence conflicti | 10 | C → W in AAN86135 (Ref. 1) Curated | 1 | |
Sequence conflicti | 45 | D → G in AAN86134 (Ref. 1) Curated | 1 | |
Sequence conflicti | 45 | D → G in AAN86135 (Ref. 1) Curated | 1 | |
Sequence conflicti | 64 | T → H in AAN86134 (Ref. 1) Curated | 1 | |
Sequence conflicti | 64 | T → H in AAN86135 (Ref. 1) Curated | 1 | |
Sequence conflicti | 79 | V → L in AAN86134 (Ref. 1) Curated | 1 | |
Sequence conflicti | 79 | V → L in AAN86135 (Ref. 1) Curated | 1 | |
Sequence conflicti | 113 | G → A in AAN86134 (Ref. 1) Curated | 1 | |
Sequence conflicti | 113 | G → A in AAN86135 (Ref. 1) Curated | 1 | |
Sequence conflicti | 291 | C → W in AAQ88730 (PubMed:12975309).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035261 | 221 | D → N1 PublicationCorresponds to variant dbSNP:rs17852267Ensembl. | 1 | |
Natural variantiVAR_035262 | 228 | T → A1 PublicationCorresponds to variant dbSNP:rs12453522Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028410 | 127 – 211 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 85 | |
Alternative sequenceiVSP_045362 | 127 – 161 | GPCCP…PPGLT → A in isoform 5. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_028411 | 296 – 332 | TAEEK…KFVSA → NHRTSELDPDEAFEISSLTF LSV in isoform 2. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_028412 | 296 – 332 | TAEEK…KFVSA → NSLMFSLSLPWL in isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF427619 mRNA Translation: AAN86134.1 AF427620 mRNA Translation: AAN86135.1 AY358364 mRNA Translation: AAQ88730.1 AK298112 mRNA Translation: BAG60397.1 AK309938 mRNA No translation available. AC007993 Genomic DNA No translation available. AC015937 Genomic DNA No translation available. BC025395 mRNA Translation: AAH25395.1 |
CCDSi | CCDS11470.1 [Q6UXG3-1] CCDS54131.1 [Q6UXG3-4] CCDS54132.1 [Q6UXG3-5] CCDS54133.1 [Q6UXG3-2] |
RefSeqi | NP_001161794.1, NM_001168322.1 [Q6UXG3-4] NP_001161795.1, NM_001168323.1 [Q6UXG3-5] NP_001161796.1, NM_001168324.1 [Q6UXG3-2] NP_660316.2, NM_145273.3 [Q6UXG3-1] |
Genome annotation databases
Ensembli | ENST00000293396; ENSP00000293396; ENSG00000161649 [Q6UXG3-2] ENST00000317310; ENSP00000321005; ENSG00000161649 [Q6UXG3-1] ENST00000377203; ENSP00000366408; ENSG00000161649 [Q6UXG3-5] ENST00000539718; ENSP00000442368; ENSG00000161649 [Q6UXG3-4] ENST00000586233; ENSP00000468800; ENSG00000161649 [Q6UXG3-3] |
GeneIDi | 146894 |
KEGGi | hsa:146894 |
UCSCi | uc002iel.3, human [Q6UXG3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF427619 mRNA Translation: AAN86134.1 AF427620 mRNA Translation: AAN86135.1 AY358364 mRNA Translation: AAQ88730.1 AK298112 mRNA Translation: BAG60397.1 AK309938 mRNA No translation available. AC007993 Genomic DNA No translation available. AC015937 Genomic DNA No translation available. BC025395 mRNA Translation: AAH25395.1 |
CCDSi | CCDS11470.1 [Q6UXG3-1] CCDS54131.1 [Q6UXG3-4] CCDS54132.1 [Q6UXG3-5] CCDS54133.1 [Q6UXG3-2] |
RefSeqi | NP_001161794.1, NM_001168322.1 [Q6UXG3-4] NP_001161795.1, NM_001168323.1 [Q6UXG3-5] NP_001161796.1, NM_001168324.1 [Q6UXG3-2] NP_660316.2, NM_145273.3 [Q6UXG3-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127023, 7 interactors |
IntActi | Q6UXG3, 6 interactors |
STRINGi | 9606.ENSP00000321005 |
PTM databases
GlyGeni | Q6UXG3, 25 sites |
iPTMneti | Q6UXG3 |
PhosphoSitePlusi | Q6UXG3 |
Polymorphism and mutation databases
BioMutai | CD300LG |
DMDMi | 296434455 |
Proteomic databases
jPOSTi | Q6UXG3 |
MassIVEi | Q6UXG3 |
PaxDbi | Q6UXG3 |
PeptideAtlasi | Q6UXG3 |
PRIDEi | Q6UXG3 |
ProteomicsDBi | 27553 30350 67609 [Q6UXG3-1] 67610 [Q6UXG3-2] 67611 [Q6UXG3-3] |
Protocols and materials databases
Antibodypediai | 1022, 85 antibodies |
DNASUi | 146894 |
Genome annotation databases
Ensembli | ENST00000293396; ENSP00000293396; ENSG00000161649 [Q6UXG3-2] ENST00000317310; ENSP00000321005; ENSG00000161649 [Q6UXG3-1] ENST00000377203; ENSP00000366408; ENSG00000161649 [Q6UXG3-5] ENST00000539718; ENSP00000442368; ENSG00000161649 [Q6UXG3-4] ENST00000586233; ENSP00000468800; ENSG00000161649 [Q6UXG3-3] |
GeneIDi | 146894 |
KEGGi | hsa:146894 |
UCSCi | uc002iel.3, human [Q6UXG3-1] |
Organism-specific databases
CTDi | 146894 |
DisGeNETi | 146894 |
EuPathDBi | HostDB:ENSG00000161649.12 |
GeneCardsi | CD300LG |
HGNCi | HGNC:30455, CD300LG |
HPAi | ENSG00000161649, Tissue enhanced (adipose tissue, breast) |
MIMi | 610520, gene |
neXtProti | NX_Q6UXG3 |
OpenTargetsi | ENSG00000161649 |
PharmGKBi | PA142672154 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SURU, Eukaryota |
GeneTreei | ENSGT00940000162429 |
HOGENOMi | CLU_051023_1_0_1 |
InParanoidi | Q6UXG3 |
OMAi | SVHDNPR |
OrthoDBi | 1494510at2759 |
PhylomeDBi | Q6UXG3 |
TreeFami | TF334441 |
Enzyme and pathway databases
PathwayCommonsi | Q6UXG3 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Miscellaneous databases
BioGRID-ORCSi | 146894, 6 hits in 842 CRISPR screens |
GenomeRNAii | 146894 |
Pharosi | Q6UXG3, Tdark |
PROi | PR:Q6UXG3 |
RNActi | Q6UXG3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000161649, Expressed in adipose tissue and 156 other tissues |
ExpressionAtlasi | Q6UXG3, baseline and differential |
Genevisiblei | Q6UXG3, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLM9_HUMAN | |
Accessioni | Q6UXG3Primary (citable) accession number: Q6UXG3 Secondary accession number(s): B4DNY5 Q8TA95 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries