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Protein

Butyrophilin-like protein 3

Gene

BTNL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrophilin-like protein 3
Alternative name(s):
Butyrophilin-like receptor
Gene namesi
Name:BTNL3
Synonyms:BTNLR, COLF4100
ORF Names:UNQ744/PRO1472
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000168903.8
HGNCiHGNC:1143 BTNL3
MIMi606192 gene
neXtProtiNX_Q6UXE8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 237ExtracellularSequence analysisAdd BLAST220
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 466CytoplasmicSequence analysisAdd BLAST208

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168903
PharmGKBiPA25464

Polymorphism and mutation databases

BioMutaiBTNL3
DMDMi296434411

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001454018 – 466Butyrophilin-like protein 3Add BLAST449

Proteomic databases

PaxDbiQ6UXE8
PeptideAtlasiQ6UXE8
PRIDEiQ6UXE8
ProteomicsDBi67599
67600 [Q6UXE8-2]

Expressioni

Tissue specificityi

Expressed in small intestine, colon, testis, spleen, and leukocyte.1 Publication

Gene expression databases

BgeeiENSG00000168903
CleanExiHS_BTNL3
GenevisibleiQ6UXE8 HS

Interactioni

Protein-protein interaction databases

BioGridi116122, 10 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6UXE8
SMRiQ6UXE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 218Ig-like V-typeAdd BLAST81
Domaini270 – 463B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYU2 Eukaryota
ENOG411140Z LUCA
GeneTreeiENSGT00760000118933
HOGENOMiHOG000230860
HOVERGENiHBG050747
InParanoidiQ6UXE8
KOiK06712
OMAiCSIHLAE
OrthoDBiEOG091G0CXQ
PhylomeDBiQ6UXE8
TreeFamiTF331083

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR006574 PRY
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50835 IG_LIKE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UXE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFVLILVLS FYELVSGQWQ VTGPGKFVQA LVGEDAVFSC SLFPETSAEA
60 70 80 90 100
MEVRFFRNQF HAVVHLYRDG EDWESKQMPQ YRGRTEFVKD SIAGGRVSLR
110 120 130 140 150
LKNITPSDIG LYGCWFSSQI YDEEATWELR VAALGSLPLI SIVGYVDGGI
160 170 180 190 200
QLLCLSSGWF PQPTAKWKGP QGQDLSSDSR ANADGYSLYD VEISIIVQEN
210 220 230 240 250
AGSILCSIHL AEQSHEVESK VLIGETFFQP SPWRLASILL GLLCGALCGV
260 270 280 290 300
VMGMIIVFFK SKGKIQAELD WRRKHGQAEL RDARKHAVEV TLDPETAHPK
310 320 330 340 350
LCVSDLKTVT HRKAPQEVPH SEKRFTRKSV VASQGFQAGK HYWEVDVGQN
360 370 380 390 400
VGWYVGVCRD DVDRGKNNVT LSPNNGYWVL RLTTEHLYFT FNPHFISLPP
410 420 430 440 450
STPPTRVGVF LDYEGGTISF FNTNDQSLIY TLLTCQFEGL LRPYIQHAMY
460
DEEKGTPIFI CPVSWG
Length:466
Mass (Da):52,251
Last modified:May 18, 2010 - v2
Checksum:i00E451EDC19316DE
GO
Isoform 2 (identifier: Q6UXE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-227: Missing.
     269-269: L → LGMCHVLSLPHMVLPGPSLIHSLSLWTTLAAGWTGST

Note: No experimental confirmation available.
Show »
Length:432
Mass (Da):48,374
Checksum:i4CB10A0B7C7EC248
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti340K → R in AAQ88751 (PubMed:12975309).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012716158 – 227Missing in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_012717269L → LGMCHVLSLPHMVLPGPSLI HSLSLWTTLAAGWTGST in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020625 mRNA Translation: BAA76664.1
AY358385 mRNA Translation: AAQ88751.1
AC091874 Genomic DNA No translation available.
CH471165 Genomic DNA Translation: EAW53730.1
BC100800 mRNA Translation: AAI00801.1
BC100801 mRNA Translation: AAI00802.1
BC100802 mRNA Translation: AAI00803.1
CCDSiCCDS47358.1 [Q6UXE8-1]
RefSeqiNP_932079.1, NM_197975.2 [Q6UXE8-1]
UniGeneiHs.225949

Genome annotation databases

EnsembliENST00000342868; ENSP00000341787; ENSG00000168903 [Q6UXE8-1]
GeneIDi10917
KEGGihsa:10917
UCSCiuc003mmr.3 human [Q6UXE8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBTNL3_HUMAN
AccessioniPrimary (citable) accession number: Q6UXE8
Secondary accession number(s): Q496L7, Q9Y2C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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