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Protein

Peptidase inhibitor 16

Gene

PI16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May inhibit cardiomyocyte growth.By similarity

Miscellaneous

May serve as a marker following prostatectomy for prostate cancer.

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase inhibitor 16
Short name:
PI-16
Alternative name(s):
Cysteine-rich secretory protein 9
Short name:
CRISP-9
PSP94-binding protein
CD_antigen: CD364
Gene namesi
Name:PI16
Synonyms:CRISP9, PSPBP
ORF Names:PSEC0164, UNQ289/PRO328
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000164530.13
HGNCiHGNC:21245 PI16
neXtProtiNX_Q6UXB8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi221476
OpenTargetsiENSG00000164530
PharmGKBiPA134867616

Polymorphism and mutation databases

BioMutaiPI16
DMDMi74749419

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000028763328 – 463Peptidase inhibitor 16Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi403N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6UXB8
PaxDbiQ6UXB8
PeptideAtlasiQ6UXB8
PRIDEiQ6UXB8
ProteomicsDBi67586
67587 [Q6UXB8-2]

PTM databases

iPTMnetiQ6UXB8
PhosphoSitePlusiQ6UXB8

Expressioni

Tissue specificityi

Expressed in prostate, testis, ovary and intestine. Concentrates in prostate cancer patient's sera.2 Publications

Gene expression databases

BgeeiENSG00000164530 Expressed in 192 organ(s), highest expression level in endocervix
CleanExiHS_PI16
GenevisibleiQ6UXB8 HS

Organism-specific databases

HPAiHPA076574

Interactioni

Subunit structurei

Interacts with PSP94/MSMB.1 Publication

Protein-protein interaction databases

IntActiQ6UXB8, 6 interactors
STRINGi9606.ENSP00000362778

Structurei

3D structure databases

ProteinModelPortaliQ6UXB8
SMRiQ6UXB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 165SCPAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni386 – 395O-glycosylated at one site10

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
HOGENOMiHOG000115539
HOVERGENiHBG104077
InParanoidiQ6UXB8
KOiK20412
OMAiEGTPCSQ
OrthoDBiEOG091G048D
PhylomeDBiQ6UXB8
TreeFamiTF316148

Family and domain databases

CDDicd05559 SCP_HrTT-1, 1 hit
Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR034124 SCP_PI16-like
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6UXB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHGSCSFLML LLPLLLLLVA TTGPVGALTD EEKRLMVELH NLYRAQVSPT
60 70 80 90 100
ASDMLHMRWD EELAAFAKAY ARQCVWGHNK ERGRRGENLF AITDEGMDVP
110 120 130 140 150
LAMEEWHHER EHYNLSAATC SPGQMCGHYT QVVWAKTERI GCGSHFCEKL
160 170 180 190 200
QGVEETNIEL LVCNYEPPGN VKGKRPYQEG TPCSQCPSGY HCKNSLCEPI
210 220 230 240 250
GSPEDAQDLP YLVTEAPSFR ATEASDSRKM GTPSSLATGI PAFLVTEVSG
260 270 280 290 300
SLATKALPAV ETQAPTSLAT KDPPSMATEA PPCVTTEVPS ILAAHSLPSL
310 320 330 340 350
DEEPVTFPKS THVPIPKSAD KVTDKTKVPS RSPENSLDPK MSLTGARELL
360 370 380 390 400
PHAQEEAEAE AELPPSSEVL ASVFPAQDKP GELQATLDHT GHTSSKSLPN
410 420 430 440 450
FPNTSATANA TGGRALALQS SLPGAEGPDK PSVVSGLNSG PGHVWGPLLG
460
LLLLPPLVLA GIF
Length:463
Mass (Da):49,471
Last modified:July 5, 2004 - v1
Checksum:i3B9E7565364CF0D2
GO
Isoform 2 (identifier: Q6UXB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-423: Missing.

Note: No experimental confirmation available.
Show »
Length:270
Mass (Da):29,674
Checksum:i04C0F6769E59B5C3
GO

Sequence cautioni

The sequence AAH22399 differs from that shown. Reason: Frameshift at position 400.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179E → G in BAC11640 (PubMed:16303743).Curated1
Sequence conflicti288V → A in BAC11640 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03233750T → P3 PublicationsCorresponds to variant dbSNP:rs1405069Ensembl.1
Natural variantiVAR_032338416L → V. Corresponds to variant dbSNP:rs16889318Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025574231 – 423Missing in isoform 2. 1 PublicationAdd BLAST193

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358422 mRNA Translation: AAQ88788.1
AK075470 mRNA Translation: BAC11640.1
AK124589 mRNA Translation: BAC85892.1
AL122034 Genomic DNA No translation available.
BC022399 mRNA Translation: AAH22399.2 Frameshift.
BC035634 mRNA Translation: AAH35634.2
CCDSiCCDS34440.1 [Q6UXB8-1]
RefSeqiNP_001186088.1, NM_001199159.1 [Q6UXB8-1]
NP_699201.2, NM_153370.2 [Q6UXB8-1]
XP_005248974.1, XM_005248917.2 [Q6UXB8-2]
XP_011512677.1, XM_011514375.2 [Q6UXB8-1]
XP_016865919.1, XM_017010430.1 [Q6UXB8-2]
UniGeneiHs.25391

Genome annotation databases

EnsembliENST00000373674; ENSP00000362778; ENSG00000164530 [Q6UXB8-1]
ENST00000611814; ENSP00000478888; ENSG00000164530 [Q6UXB8-1]
GeneIDi221476
KEGGihsa:221476
UCSCiuc003ona.3 human [Q6UXB8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358422 mRNA Translation: AAQ88788.1
AK075470 mRNA Translation: BAC11640.1
AK124589 mRNA Translation: BAC85892.1
AL122034 Genomic DNA No translation available.
BC022399 mRNA Translation: AAH22399.2 Frameshift.
BC035634 mRNA Translation: AAH35634.2
CCDSiCCDS34440.1 [Q6UXB8-1]
RefSeqiNP_001186088.1, NM_001199159.1 [Q6UXB8-1]
NP_699201.2, NM_153370.2 [Q6UXB8-1]
XP_005248974.1, XM_005248917.2 [Q6UXB8-2]
XP_011512677.1, XM_011514375.2 [Q6UXB8-1]
XP_016865919.1, XM_017010430.1 [Q6UXB8-2]
UniGeneiHs.25391

3D structure databases

ProteinModelPortaliQ6UXB8
SMRiQ6UXB8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6UXB8, 6 interactors
STRINGi9606.ENSP00000362778

PTM databases

iPTMnetiQ6UXB8
PhosphoSitePlusiQ6UXB8

Polymorphism and mutation databases

BioMutaiPI16
DMDMi74749419

Proteomic databases

MaxQBiQ6UXB8
PaxDbiQ6UXB8
PeptideAtlasiQ6UXB8
PRIDEiQ6UXB8
ProteomicsDBi67586
67587 [Q6UXB8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373674; ENSP00000362778; ENSG00000164530 [Q6UXB8-1]
ENST00000611814; ENSP00000478888; ENSG00000164530 [Q6UXB8-1]
GeneIDi221476
KEGGihsa:221476
UCSCiuc003ona.3 human [Q6UXB8-1]

Organism-specific databases

CTDi221476
DisGeNETi221476
EuPathDBiHostDB:ENSG00000164530.13
GeneCardsiPI16
HGNCiHGNC:21245 PI16
HPAiHPA076574
neXtProtiNX_Q6UXB8
OpenTargetsiENSG00000164530
PharmGKBiPA134867616
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
HOGENOMiHOG000115539
HOVERGENiHBG104077
InParanoidiQ6UXB8
KOiK20412
OMAiEGTPCSQ
OrthoDBiEOG091G048D
PhylomeDBiQ6UXB8
TreeFamiTF316148

Miscellaneous databases

GenomeRNAii221476
PROiPR:Q6UXB8

Gene expression databases

BgeeiENSG00000164530 Expressed in 192 organ(s), highest expression level in endocervix
CleanExiHS_PI16
GenevisibleiQ6UXB8 HS

Family and domain databases

CDDicd05559 SCP_HrTT-1, 1 hit
Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR034124 SCP_PI16-like
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPI16_HUMAN
AccessioniPrimary (citable) accession number: Q6UXB8
Secondary accession number(s): Q6ZVG9
, Q8IYL8, Q8NBK0, Q8TCB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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