CXCL17

Functionⁱ

Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).5 Publications

4-Cys CXCL17: seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.1 Publication

GO - Biological processⁱ

activation of MAPK activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23115081
angiogenesis Source: UniProtKB-KW
cell differentiation Source: UniProtKB-KW
macrophage chemotaxis Source: Ensembl
negative regulation of inflammatory response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23115081
positive regulation of macrophage chemotaxis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23115081
positive regulation of monocyte chemotaxis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23115081
positive regulation of vascular endothelial growth factor production
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23115081

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Angiogenesis, Chemotaxis, Differentiation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-X-C motif chemokine 17 Short name: 6-Cys CXCL171 Publication Alternative name(s): Dendritic cell and monocyte chemokine-like protein Short name: DMC VEGF coregulated chemokine 1 Cleaved into the following chain: 4-Cys CXCL171 Publication
Gene namesⁱ	Name:CXCL17 Synonyms:VCC1 ORF Names:UNQ473/PRO842
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000189377.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19232 CXCL17
MIMⁱ	611387 gene
neXtProtⁱ	NX_Q6UXB2

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	50	C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-52; S-75; S-77; S-103 and S-110. 1 Publication	1
Mutagenesisⁱ	52	C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-75; S-77; S-103 and S-110. 1 Publication	1
Mutagenesisⁱ	75	C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-77; S-103 and S-110. 1 Publication	1
Mutagenesisⁱ	77	C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-103 and S-110. 1 Publication	1
Mutagenesisⁱ	103	C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-110. 1 Publication	1
Mutagenesisⁱ	110	C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-103. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	284340
Open Targets More...OpenTargetsⁱ	ENSG00000189377
PharmGKBⁱ	PA162383045

Polymorphism and mutation databases

BioMutaⁱ	CXCL17
DMDMⁱ	74738198

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 21	1 PublicationAdd BLAST	21
ChainⁱPRO_0000311097	22 – 119	C-X-C motif chemokine 17Add BLAST	98
ChainⁱPRO_0000438487	64 – 119	4-Cys CXCL17CuratedAdd BLAST	56

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	75 ↔ 103	1 Publication
Disulfide bondⁱ	77 ↔ 110	1 Publication

Post-translational modificationⁱ

Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	63 – 64	CleavageBy similarity		2

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbⁱ	Q6UXB2
PeptideAtlas More...PeptideAtlasⁱ	Q6UXB2
PRIDEⁱ	Q6UXB2
ProteomicsDBⁱ	67583

Expressionⁱ

Tissue specificityⁱ

Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.2 Publications

Developmental stageⁱ

Detected in fetal lung.

Inductionⁱ

Found to be up-regulated in duodenal mucosa during acute cholera.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000189377 Expressed in 119 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_CXCL17
ExpressionAtlasⁱ	Q6UXB2 baseline and differential
Genevisibleⁱ	Q6UXB2 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CCL5	P13501	2	EBI-16804198,EBI-2848366
CXCL12	P48061	2	EBI-16804198,EBI-3913254
PF4	P02776	2	EBI-16804198,EBI-2565740

Protein-protein interaction databases

IntActⁱ	Q6UXB2, 17 interactors
STRINGⁱ	9606.ENSP00000472467

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6UXB2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the intercrine alpha (chemokine CxC) family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J1ND Eukaryota ENOG41118M3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002861
HOGENOMⁱ	HOG000154812
HOVERGENⁱ	HBG097374
InParanoidⁱ	Q6UXB2
KEGG Orthology (KO) More...KOⁱ	K22627
OMAⁱ	GHRDQRQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Y5M
PhylomeDBⁱ	Q6UXB2
TreeFamⁱ	TF342477

Family and domain databases

InterProⁱ	View protein in InterPro IPR029183 CXCL17
PANTHERⁱ	PTHR37351 PTHR37351, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15211 CXCL17, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q6UXB2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKVLISSLLL LLPLMLMSMV SSSLNPGVAR GHRDRGQASR RWLQEGGQEC 
        60         70         80         90        100
ECKDWFLRAP RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS 
       110 
RACQQFLKQC QLRSFALPL

Length:119

Mass (Da):13,819

Last modified:July 5, 2004 - v1

Checksum:ⁱF2D2FD686E47CC9B

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	X6R584	X6R584_HUMAN		C-X-C motif chemokine 17 C-X-C motif chemokine 17	CXCL17	62	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY598464 mRNA Translation: AAU04875.1 AY358433 mRNA Translation: AAQ88799.1 AK292985 mRNA Translation: BAF85674.1 AC011497 Genomic DNA No translation available. BC093946 mRNA Translation: AAH93946.1 BC112095 mRNA Translation: AAI12096.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12608.1
NCBI Reference Sequences More...RefSeqⁱ	NP_940879.1, NM_198477.2
UniGeneⁱ	Hs.445586

Genome annotation databases

Ensemblⁱ	ENST00000601181; ENSP00000472467; ENSG00000189377
GeneIDⁱ	284340
KEGGⁱ	hsa:284340
UCSC genome browser More...UCSCⁱ	uc002otu.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6UXB2	C-X-C motif chemokine ligand 17		PANTR		119	UniRef90_Q6UXB2
Uncharacterized protein		PANPA		119
Uncharacterized protein		MACFA		119
Uncharacterized protein		MACMU		119
Uncharacterized protein		MACNE		119
+15

Protein	Similar proteins		Species	Score	Length	Source
Q6UXB2	C-X-C motif chemokine 17		MOUSE		119	UniRef50_Q6UXB2
C-X-C motif chemokine 17		BOVIN		118
Uncharacterized protein		MACFA		119
Uncharacterized protein		MACMU		119
Uncharacterized protein		MACNE		119
+106

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

CXCL17 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY598464 mRNA Translation: AAU04875.1 AY358433 mRNA Translation: AAQ88799.1 AK292985 mRNA Translation: BAF85674.1 AC011497 Genomic DNA No translation available. BC093946 mRNA Translation: AAH93946.1 BC112095 mRNA Translation: AAI12096.1
CCDSⁱ	CCDS12608.1
RefSeqⁱ	NP_940879.1, NM_198477.2
UniGeneⁱ	Hs.445586

3D structure databases

ProteinModelPortalⁱ	Q6UXB2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q6UXB2, 17 interactors
STRINGⁱ	9606.ENSP00000472467

Polymorphism and mutation databases

BioMutaⁱ	CXCL17
DMDMⁱ	74738198

Proteomic databases

PaxDbⁱ	Q6UXB2
PeptideAtlasⁱ	Q6UXB2
PRIDEⁱ	Q6UXB2
ProteomicsDBⁱ	67583

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000601181; ENSP00000472467; ENSG00000189377
GeneIDⁱ	284340
KEGGⁱ	hsa:284340
UCSCⁱ	uc002otu.4 human

Organism-specific databases

CTDⁱ	284340
DisGeNETⁱ	284340
EuPathDBⁱ	HostDB:ENSG00000189377.8
GeneCardsⁱ	CXCL17
HGNCⁱ	HGNC:19232 CXCL17
MIMⁱ	611387 gene
neXtProtⁱ	NX_Q6UXB2
OpenTargetsⁱ	ENSG00000189377
PharmGKBⁱ	PA162383045
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J1ND Eukaryota ENOG41118M3 LUCA
GeneTreeⁱ	ENSGT00390000002861
HOGENOMⁱ	HOG000154812
HOVERGENⁱ	HBG097374
InParanoidⁱ	Q6UXB2
KOⁱ	K22627
OMAⁱ	GHRDQRQ
OrthoDBⁱ	EOG091G0Y5M
PhylomeDBⁱ	Q6UXB2
TreeFamⁱ	TF342477

Miscellaneous databases

GenomeRNAiⁱ	284340
Protein Ontology More...PROⁱ	PR:Q6UXB2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000189377 Expressed in 119 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_CXCL17
ExpressionAtlasⁱ	Q6UXB2 baseline and differential
Genevisibleⁱ	Q6UXB2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029183 CXCL17
PANTHERⁱ	PTHR37351 PTHR37351, 1 hit
Pfamⁱ	View protein in Pfam PF15211 CXCL17, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXL17_HUMAN
Accessionⁱ	Q6UXB2Primary (citable) accession number: Q6UXB2 Secondary accession number(s): A8KAC0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6UXB2 (CXL17_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

C-X-C motif chemokine 17

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ