UniProtKB - Q6UXB2 (CXL17_HUMAN)
Protein
C-X-C motif chemokine 17
Gene
CXCL17
Organism
Homo sapiens (Human)
Status
Functioni
Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).5 Publications
seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.1 Publication
GO - Biological processi
- activation of MAPK activity Source: UniProtKB
- angiogenesis Source: UniProtKB-KW
- cell differentiation Source: UniProtKB-KW
- macrophage chemotaxis Source: GO_Central
- negative regulation of inflammatory response Source: UniProtKB
- positive regulation of macrophage chemotaxis Source: UniProtKB
- positive regulation of monocyte chemotaxis Source: UniProtKB
- positive regulation of vascular endothelial growth factor production Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Angiogenesis, Chemotaxis, Differentiation |
Enzyme and pathway databases
PathwayCommonsi | Q6UXB2 |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C motif chemokine 17Short name: 6-Cys CXCL171 Publication Alternative name(s): Dendritic cell and monocyte chemokine-like protein Short name: DMC VEGF coregulated chemokine 1 Cleaved into the following chain: 4-Cys CXCL171 Publication |
Gene namesi | Name:CXCL17 Synonyms:VCC1 ORF Names:UNQ473/PRO842 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19232, CXCL17 |
MIMi | 611387, gene |
neXtProti | NX_Q6UXB2 |
VEuPathDBi | HostDB:ENSG00000189377.8 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 50 | C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-52; S-75; S-77; S-103 and S-110. 1 Publication | 1 | |
Mutagenesisi | 52 | C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-75; S-77; S-103 and S-110. 1 Publication | 1 | |
Mutagenesisi | 75 | C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-77; S-103 and S-110. 1 Publication | 1 | |
Mutagenesisi | 77 | C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-103 and S-110. 1 Publication | 1 | |
Mutagenesisi | 103 | C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-110. 1 Publication | 1 | |
Mutagenesisi | 110 | C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-103. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 284340 |
OpenTargetsi | ENSG00000189377 |
PharmGKBi | PA162383045 |
Miscellaneous databases
Pharosi | Q6UXB2, Tbio |
Genetic variation databases
BioMutai | CXCL17 |
DMDMi | 74738198 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 1 PublicationAdd BLAST | 21 | |
ChainiPRO_0000311097 | 22 – 119 | C-X-C motif chemokine 17Add BLAST | 98 | |
ChainiPRO_0000438487 | 64 – 119 | 4-Cys CXCL17CuratedAdd BLAST | 56 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 75 ↔ 103 | 1 Publication | ||
Disulfide bondi | 77 ↔ 110 | 1 Publication |
Post-translational modificationi
Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 63 – 64 | CleavageBy similarity | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondProteomic databases
MassIVEi | Q6UXB2 |
PaxDbi | Q6UXB2 |
PeptideAtlasi | Q6UXB2 |
PRIDEi | Q6UXB2 |
ProteomicsDBi | 67583 |
Expressioni
Tissue specificityi
Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.2 Publications
Developmental stagei
Detected in fetal lung.
Inductioni
Found to be up-regulated in duodenal mucosa during acute cholera.1 Publication
Gene expression databases
Bgeei | ENSG00000189377, Expressed in nasal cavity epithelium and 140 other tissues |
ExpressionAtlasi | Q6UXB2, baseline and differential |
Genevisiblei | Q6UXB2, HS |
Organism-specific databases
HPAi | ENSG00000189377, Tissue enhanced (esophagus, lung, stomach) |
Interactioni
Binary interactionsi
Hide detailsQ6UXB2
With | #Exp. | IntAct |
---|---|---|
CCL5 [P13501] | 2 | EBI-16804198,EBI-2848366 |
CXCL12 [P48061] | 2 | EBI-16804198,EBI-3913254 |
PF4 [P02776] | 2 | EBI-16804198,EBI-2565740 |
Protein-protein interaction databases
BioGRIDi | 129832, 16 interactors |
IntActi | Q6UXB2, 17 interactors |
STRINGi | 9606.ENSP00000472467 |
Miscellaneous databases
RNActi | Q6UXB2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine alpha (chemokine CxC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502TDC2, Eukaryota |
GeneTreei | ENSGT00390000002861 |
HOGENOMi | CLU_166962_0_0_1 |
InParanoidi | Q6UXB2 |
OMAi | KRCQLAS |
OrthoDBi | 1577529at2759 |
PhylomeDBi | Q6UXB2 |
TreeFami | TF342477 |
Family and domain databases
InterProi | View protein in InterPro IPR029183, CXCL17 |
PANTHERi | PTHR37351, PTHR37351, 1 hit |
Pfami | View protein in Pfam PF15211, CXCL17, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6UXB2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVLISSLLL LLPLMLMSMV SSSLNPGVAR GHRDRGQASR RWLQEGGQEC
60 70 80 90 100
ECKDWFLRAP RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS
110
RACQQFLKQC QLRSFALPL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX6R584 | X6R584_HUMAN | C-X-C motif chemokine 17 | CXCL17 | 62 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY598464 mRNA Translation: AAU04875.1 AY358433 mRNA Translation: AAQ88799.1 AK292985 mRNA Translation: BAF85674.1 AC011497 Genomic DNA No translation available. BC093946 mRNA Translation: AAH93946.1 BC112095 mRNA Translation: AAI12096.1 |
CCDSi | CCDS12608.1 |
RefSeqi | NP_940879.1, NM_198477.2 |
Genome annotation databases
Ensembli | ENST00000601181; ENSP00000472467; ENSG00000189377 |
GeneIDi | 284340 |
KEGGi | hsa:284340 |
UCSCi | uc002otu.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia CXCL17 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY598464 mRNA Translation: AAU04875.1 AY358433 mRNA Translation: AAQ88799.1 AK292985 mRNA Translation: BAF85674.1 AC011497 Genomic DNA No translation available. BC093946 mRNA Translation: AAH93946.1 BC112095 mRNA Translation: AAI12096.1 |
CCDSi | CCDS12608.1 |
RefSeqi | NP_940879.1, NM_198477.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 129832, 16 interactors |
IntActi | Q6UXB2, 17 interactors |
STRINGi | 9606.ENSP00000472467 |
Genetic variation databases
BioMutai | CXCL17 |
DMDMi | 74738198 |
Proteomic databases
MassIVEi | Q6UXB2 |
PaxDbi | Q6UXB2 |
PeptideAtlasi | Q6UXB2 |
PRIDEi | Q6UXB2 |
ProteomicsDBi | 67583 |
Protocols and materials databases
Antibodypediai | 66724, 94 antibodies |
Genome annotation databases
Ensembli | ENST00000601181; ENSP00000472467; ENSG00000189377 |
GeneIDi | 284340 |
KEGGi | hsa:284340 |
UCSCi | uc002otu.4, human |
Organism-specific databases
CTDi | 284340 |
DisGeNETi | 284340 |
GeneCardsi | CXCL17 |
HGNCi | HGNC:19232, CXCL17 |
HPAi | ENSG00000189377, Tissue enhanced (esophagus, lung, stomach) |
MIMi | 611387, gene |
neXtProti | NX_Q6UXB2 |
OpenTargetsi | ENSG00000189377 |
PharmGKBi | PA162383045 |
VEuPathDBi | HostDB:ENSG00000189377.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TDC2, Eukaryota |
GeneTreei | ENSGT00390000002861 |
HOGENOMi | CLU_166962_0_0_1 |
InParanoidi | Q6UXB2 |
OMAi | KRCQLAS |
OrthoDBi | 1577529at2759 |
PhylomeDBi | Q6UXB2 |
TreeFami | TF342477 |
Enzyme and pathway databases
PathwayCommonsi | Q6UXB2 |
Miscellaneous databases
BioGRID-ORCSi | 284340, 16 hits in 980 CRISPR screens |
GenomeRNAii | 284340 |
Pharosi | Q6UXB2, Tbio |
PROi | PR:Q6UXB2 |
RNActi | Q6UXB2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000189377, Expressed in nasal cavity epithelium and 140 other tissues |
ExpressionAtlasi | Q6UXB2, baseline and differential |
Genevisiblei | Q6UXB2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029183, CXCL17 |
PANTHERi | PTHR37351, PTHR37351, 1 hit |
Pfami | View protein in Pfam PF15211, CXCL17, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXL17_HUMAN | |
Accessioni | Q6UXB2Primary (citable) accession number: Q6UXB2 Secondary accession number(s): A8KAC0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families