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Protein

C-X-C motif chemokine 17

Gene

CXCL17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).5 Publications
4-Cys CXCL17: seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.1 Publication

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Chemotaxis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 17
Short name:
6-Cys CXCL171 Publication
Alternative name(s):
Dendritic cell and monocyte chemokine-like protein
Short name:
DMC
VEGF coregulated chemokine 1
Cleaved into the following chain:
4-Cys CXCL171 Publication
Gene namesi
Name:CXCL17
Synonyms:VCC1
ORF Names:UNQ473/PRO842
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000189377.8
HGNCiHGNC:19232 CXCL17
MIMi611387 gene
neXtProtiNX_Q6UXB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi50C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-52; S-75; S-77; S-103 and S-110. 1 Publication1
Mutagenesisi52C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-75; S-77; S-103 and S-110. 1 Publication1
Mutagenesisi75C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-77; S-103 and S-110. 1 Publication1
Mutagenesisi77C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-103 and S-110. 1 Publication1
Mutagenesisi103C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-110. 1 Publication1
Mutagenesisi110C → S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-103. 1 Publication1

Organism-specific databases

DisGeNETi284340
OpenTargetsiENSG00000189377
PharmGKBiPA162383045

Polymorphism and mutation databases

BioMutaiCXCL17
DMDMi74738198

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000031109722 – 119C-X-C motif chemokine 17Add BLAST98
ChainiPRO_000043848764 – 1194-Cys CXCL17CuratedAdd BLAST56

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 1031 Publication
Disulfide bondi77 ↔ 1101 Publication

Post-translational modificationi

Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei63 – 64CleavageBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ6UXB2
PeptideAtlasiQ6UXB2
PRIDEiQ6UXB2
ProteomicsDBi67583

Expressioni

Tissue specificityi

Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.2 Publications

Developmental stagei

Detected in fetal lung.

Inductioni

Found to be up-regulated in duodenal mucosa during acute cholera.1 Publication

Gene expression databases

BgeeiENSG00000189377 Expressed in 119 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_CXCL17
ExpressionAtlasiQ6UXB2 baseline and differential
GenevisibleiQ6UXB2 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

IntActiQ6UXB2, 17 interactors
STRINGi9606.ENSP00000472467

Structurei

3D structure databases

ProteinModelPortaliQ6UXB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ND Eukaryota
ENOG41118M3 LUCA
GeneTreeiENSGT00390000002861
HOGENOMiHOG000154812
HOVERGENiHBG097374
InParanoidiQ6UXB2
KOiK22627
OMAiGHRDQRQ
OrthoDBiEOG091G0Y5M
PhylomeDBiQ6UXB2
TreeFamiTF342477

Family and domain databases

InterProiView protein in InterPro
IPR029183 CXCL17
PANTHERiPTHR37351 PTHR37351, 1 hit
PfamiView protein in Pfam
PF15211 CXCL17, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6UXB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVLISSLLL LLPLMLMSMV SSSLNPGVAR GHRDRGQASR RWLQEGGQEC
60 70 80 90 100
ECKDWFLRAP RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS
110
RACQQFLKQC QLRSFALPL
Length:119
Mass (Da):13,819
Last modified:July 5, 2004 - v1
Checksum:iF2D2FD686E47CC9B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R584X6R584_HUMAN
C-X-C motif chemokine 17
CXCL17
62Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598464 mRNA Translation: AAU04875.1
AY358433 mRNA Translation: AAQ88799.1
AK292985 mRNA Translation: BAF85674.1
AC011497 Genomic DNA No translation available.
BC093946 mRNA Translation: AAH93946.1
BC112095 mRNA Translation: AAI12096.1
CCDSiCCDS12608.1
RefSeqiNP_940879.1, NM_198477.2
UniGeneiHs.445586

Genome annotation databases

EnsembliENST00000601181; ENSP00000472467; ENSG00000189377
GeneIDi284340
KEGGihsa:284340
UCSCiuc002otu.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CXCL17 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598464 mRNA Translation: AAU04875.1
AY358433 mRNA Translation: AAQ88799.1
AK292985 mRNA Translation: BAF85674.1
AC011497 Genomic DNA No translation available.
BC093946 mRNA Translation: AAH93946.1
BC112095 mRNA Translation: AAI12096.1
CCDSiCCDS12608.1
RefSeqiNP_940879.1, NM_198477.2
UniGeneiHs.445586

3D structure databases

ProteinModelPortaliQ6UXB2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6UXB2, 17 interactors
STRINGi9606.ENSP00000472467

Polymorphism and mutation databases

BioMutaiCXCL17
DMDMi74738198

Proteomic databases

PaxDbiQ6UXB2
PeptideAtlasiQ6UXB2
PRIDEiQ6UXB2
ProteomicsDBi67583

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000601181; ENSP00000472467; ENSG00000189377
GeneIDi284340
KEGGihsa:284340
UCSCiuc002otu.4 human

Organism-specific databases

CTDi284340
DisGeNETi284340
EuPathDBiHostDB:ENSG00000189377.8
GeneCardsiCXCL17
HGNCiHGNC:19232 CXCL17
MIMi611387 gene
neXtProtiNX_Q6UXB2
OpenTargetsiENSG00000189377
PharmGKBiPA162383045
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1ND Eukaryota
ENOG41118M3 LUCA
GeneTreeiENSGT00390000002861
HOGENOMiHOG000154812
HOVERGENiHBG097374
InParanoidiQ6UXB2
KOiK22627
OMAiGHRDQRQ
OrthoDBiEOG091G0Y5M
PhylomeDBiQ6UXB2
TreeFamiTF342477

Miscellaneous databases

GenomeRNAii284340
PROiPR:Q6UXB2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189377 Expressed in 119 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_CXCL17
ExpressionAtlasiQ6UXB2 baseline and differential
GenevisibleiQ6UXB2 HS

Family and domain databases

InterProiView protein in InterPro
IPR029183 CXCL17
PANTHERiPTHR37351 PTHR37351, 1 hit
PfamiView protein in Pfam
PF15211 CXCL17, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXL17_HUMAN
AccessioniPrimary (citable) accession number: Q6UXB2
Secondary accession number(s): A8KAC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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