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Protein

Ly6/PLAUR domain-containing protein 8

Gene

LYPD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Ly6/PLAUR domain-containing protein 8Curated
Gene namesi
Name:LYPD8Imported
ORF Names:UNQ511/PRO10261 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000259823.5
HGNCiHGNC:44208 LYPD8
neXtProtiNX_Q6UX82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi646627
OpenTargetsiENSG00000259823

Polymorphism and mutation databases

DMDMi74738190

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000031773920 – 215Ly6/PLAUR domain-containing protein 8Add BLAST196
PropeptideiPRO_0000317740216 – 237Removed in mature formSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi215GPI-anchor amidated asparagineSequence analysis1

Post-translational modificationi

Highly N-glycosylated. Not O-glycosylated.By similarity
GPI-anchored. The GPI-anchor is cleaved, leading to secretion into the colonic lumen.By similarity

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ6UX82
PeptideAtlasiQ6UX82
PRIDEiQ6UX82
ProteomicsDBi67577

PTM databases

iPTMnetiQ6UX82
PhosphoSitePlusiQ6UX82

Expressioni

Tissue specificityi

Expressed in the large intestine. Preferentially expressed on the epithelial layer exposed to the lumen (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000259823 Expressed in 59 organ(s), highest expression level in colonic mucosa
ExpressionAtlasiQ6UX82 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ6UX82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 176UPAR/Ly6Add BLAST52

Sequence similaritiesi

Belongs to the CNF-like-inhibitor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00570000079564
HOVERGENiHBG097751
InParanoidiQ6UX82
OMAiFRKFECA
OrthoDBiEOG091G0R4I
PhylomeDBiQ6UX82

Family and domain databases

InterProiView protein in InterPro
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6UX82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGILVAGIT AVLVAAVESL SCVQCNSWEK SCVNSIASEC PSHANTSCIS
60 70 80 90 100
SSASSSLETP VRLYQNMFCS AENCSEETHI TAFTVHVSAE EHFHFVSQCC
110 120 130 140 150
QGKECSNTSD ALDPPLKNVS SNAECPACYE SNGTSCHGKP WKCYEEEQCV
160 170 180 190 200
FLVAELKNDI ESKSLVLKGC SNVSNATCQF LSGENKTLGG VIFRKFECAN
210 220 230
VNSLTPTSAP TTSHNVGSKA SLYLLALASL LLRGLLP
Length:237
Mass (Da):25,265
Last modified:June 8, 2016 - v2
Checksum:iAB3EFE9E31274A3A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B732A0A075B732_HUMAN
Ly6/PLAUR domain-containing protein...
LYPD8
54Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137H → R in AAQ88833 (PubMed:12975309).1
Sequence conflicti137H → R in EAW57531 (Ref. 3) 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358469 mRNA Translation: AAQ88833.1
AEKP01210869 Genomic DNA No translation available.
CR589904 Genomic DNA No translation available.
FP476111 Genomic DNA No translation available.
FP885904 Genomic DNA No translation available.
CH471257 Genomic DNA Translation: EAW57531.1
CCDSiCCDS73059.1
RefSeqiNP_001078943.1, NM_001085474.1
NP_001278212.1, NM_001291283.1
UniGeneiHs.146268
Hs.632511

Genome annotation databases

EnsembliENST00000590317; ENSP00000466070; ENSG00000259823
GeneIDi646627
KEGGihsa:646627
UCSCiuc031vuv.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358469 mRNA Translation: AAQ88833.1
AEKP01210869 Genomic DNA No translation available.
CR589904 Genomic DNA No translation available.
FP476111 Genomic DNA No translation available.
FP885904 Genomic DNA No translation available.
CH471257 Genomic DNA Translation: EAW57531.1
CCDSiCCDS73059.1
RefSeqiNP_001078943.1, NM_001085474.1
NP_001278212.1, NM_001291283.1
UniGeneiHs.146268
Hs.632511

3D structure databases

ProteinModelPortaliQ6UX82
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6UX82
PhosphoSitePlusiQ6UX82

Polymorphism and mutation databases

DMDMi74738190

Proteomic databases

PaxDbiQ6UX82
PeptideAtlasiQ6UX82
PRIDEiQ6UX82
ProteomicsDBi67577

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000590317; ENSP00000466070; ENSG00000259823
GeneIDi646627
KEGGihsa:646627
UCSCiuc031vuv.2 human

Organism-specific databases

CTDi646627
DisGeNETi646627
EuPathDBiHostDB:ENSG00000259823.5
GeneCardsiLYPD8
HGNCiHGNC:44208 LYPD8
neXtProtiNX_Q6UX82
OpenTargetsiENSG00000259823
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00570000079564
HOVERGENiHBG097751
InParanoidiQ6UX82
OMAiFRKFECA
OrthoDBiEOG091G0R4I
PhylomeDBiQ6UX82

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRSiLYPD8 human
GenomeRNAii646627
PROiPR:Q6UX82

Gene expression databases

BgeeiENSG00000259823 Expressed in 59 organ(s), highest expression level in colonic mucosa
ExpressionAtlasiQ6UX82 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLYPD8_HUMAN
AccessioniPrimary (citable) accession number: Q6UX82
Secondary accession number(s): A0A075B722, K7ELG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 8, 2016
Last modified: September 12, 2018
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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