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Entry version 130 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Plexin domain-containing protein 2

Gene

PLXDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in tumor angiogenesis.1 Publication

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6UX71

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plexin domain-containing protein 2
Alternative name(s):
Tumor endothelial marker 7-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLXDC2
Synonyms:TEM7R
ORF Names:UNQ2514/PRO6003
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000120594.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21013, PLXDC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606827, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UX71

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 454ExtracellularSequence analysisAdd BLAST424
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Topological domaini476 – 529CytoplasmicSequence analysisAdd BLAST54

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84898

Open Targets

More...
OpenTargetsi
ENSG00000120594

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134932187

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6UX71, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLXDC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749416

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023457431 – 529Plexin domain-containing protein 2Add BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi103N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi160N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei506PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6UX71

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6UX71

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6UX71

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6UX71

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UX71

PeptideAtlas

More...
PeptideAtlasi
Q6UX71

PRoteomics IDEntifications database

More...
PRIDEi
Q6UX71

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67571 [Q6UX71-1]
67572 [Q6UX71-2]
67573 [Q6UX71-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1616, 5 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6UX71, 6 sites, 3 O-linked glycans (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6UX71

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UX71

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the endothelial cells of the stroma but not in the endothelial cells of normal colonic tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120594, Expressed in calcaneal tendon and 233 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6UX71, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000120594, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTTN.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124338, 49 interactors

Database of interacting proteins

More...
DIPi
DIP-46251N

Protein interaction database and analysis system

More...
IntActi
Q6UX71, 26 interactors

Molecular INTeraction database

More...
MINTi
Q6UX71

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366460

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6UX71, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6UX71

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini327 – 372PSIAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi383 – 427Thr-richAdd BLAST45

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3848, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000033408

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029494_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UX71

Identification of Orthologs from Complete Genome Data

More...
OMAi
RVIYEYH

Database of Orthologous Groups

More...
OrthoDBi
1361987at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UX71

TreeFam database of animal gene trees

More...
TreeFami
TF314400

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002165, Plexin_repeat
IPR031152, PLXDC
IPR031154, PLXDC2
IPR016201, PSI

The PANTHER Classification System

More...
PANTHERi
PTHR13055, PTHR13055, 1 hit
PTHR13055:SF11, PTHR13055:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01437, PSI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00423, PSI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6UX71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARFPKADLA AAGVMLLCHF FTDQFQFADG KPGDQILDWQ YGVTQAFPHT
60 70 80 90 100
EEEVEVDSHA YSHRWKRNLD FLKAVDTNRA SVGQDSPEPR SFTDLLLDDG
110 120 130 140 150
QDNNTQIEED TDHNYYISRI YGPSDSASRD LWVNIDQMEK DKVKIHGILS
160 170 180 190 200
NTHRQAARVN LSFDFPFYGH FLREITVATG GFIYTGEVVH RMLTATQYIA
210 220 230 240 250
PLMANFDPSV SRNSTVRYFD NGTALVVQWD HVHLQDNYNL GSFTFQATLL
260 270 280 290 300
MDGRIIFGYK EIPVLVTQIS STNHPVKVGL SDAFVVVHRI QQIPNVRRRT
310 320 330 340 350
IYEYHRVELQ MSKITNISAV EMTPLPTCLQ FNRCGPCVSS QIGFNCSWCS
360 370 380 390 400
KLQRCSSGFD RHRQDWVDSG CPEESKEKMC ENTEPVETSS RTTTTVGATT
410 420 430 440 450
TQFRVLTTTR RAVTSQFPTS LPTEDDTKIA LHLKDNGAST DDSAAEKKGG
460 470 480 490 500
TLHAGLIIGI LILVLIVATA ILVTVYMYHH PTSAASIFFI ERRPSRWPAM
510 520
KFRRGSGHPA YAEVEPVGEK EGFIVSEQC
Length:529
Mass (Da):59,583
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCE911D6DF837B40
GO
Isoform 2 (identifier: Q6UX71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-157: Missing.

Show »
Length:480
Mass (Da):53,912
Checksum:iF8DB0E2631BC7816
GO
Isoform 3 (identifier: Q6UX71-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-378: Missing.

Show »
Length:151
Mass (Da):16,423
Checksum:iEAC2BCBFC94AB047
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026292396V → I2 PublicationsCorresponds to variant dbSNP:rs3817405Ensembl.1
Natural variantiVAR_026293458I → V2 PublicationsCorresponds to variant dbSNP:rs2778979Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0183771 – 378Missing in isoform 3. 1 PublicationAdd BLAST378
Alternative sequenceiVSP_018378109 – 157Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF378757 mRNA Translation: AAL11994.1
AY358486 mRNA Translation: AAQ88850.1
AK027529 mRNA Translation: BAB55178.1
AC067743 Genomic DNA No translation available.
AC069549 Genomic DNA No translation available.
AL353147 Genomic DNA No translation available.
BC012885 mRNA Translation: AAH12885.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS60497.1 [Q6UX71-2]
CCDS7132.1 [Q6UX71-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001269665.1, NM_001282736.1 [Q6UX71-2]
NP_116201.7, NM_032812.8 [Q6UX71-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000377242; ENSP00000366450; ENSG00000120594 [Q6UX71-2]
ENST00000377252; ENSP00000366460; ENSG00000120594 [Q6UX71-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84898

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84898

UCSC genome browser

More...
UCSCi
uc001iqg.3, human [Q6UX71-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378757 mRNA Translation: AAL11994.1
AY358486 mRNA Translation: AAQ88850.1
AK027529 mRNA Translation: BAB55178.1
AC067743 Genomic DNA No translation available.
AC069549 Genomic DNA No translation available.
AL353147 Genomic DNA No translation available.
BC012885 mRNA Translation: AAH12885.1
CCDSiCCDS60497.1 [Q6UX71-2]
CCDS7132.1 [Q6UX71-1]
RefSeqiNP_001269665.1, NM_001282736.1 [Q6UX71-2]
NP_116201.7, NM_032812.8 [Q6UX71-1]

3D structure databases

SMRiQ6UX71
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124338, 49 interactors
DIPiDIP-46251N
IntActiQ6UX71, 26 interactors
MINTiQ6UX71
STRINGi9606.ENSP00000366460

PTM databases

GlyConnecti1616, 5 N-Linked glycans (3 sites)
GlyGeniQ6UX71, 6 sites, 3 O-linked glycans (2 sites)
iPTMnetiQ6UX71
PhosphoSitePlusiQ6UX71

Polymorphism and mutation databases

BioMutaiPLXDC2
DMDMi74749416

Proteomic databases

EPDiQ6UX71
jPOSTiQ6UX71
MassIVEiQ6UX71
MaxQBiQ6UX71
PaxDbiQ6UX71
PeptideAtlasiQ6UX71
PRIDEiQ6UX71
ProteomicsDBi67571 [Q6UX71-1]
67572 [Q6UX71-2]
67573 [Q6UX71-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25453, 165 antibodies

Genome annotation databases

EnsembliENST00000377242; ENSP00000366450; ENSG00000120594 [Q6UX71-2]
ENST00000377252; ENSP00000366460; ENSG00000120594 [Q6UX71-1]
GeneIDi84898
KEGGihsa:84898
UCSCiuc001iqg.3, human [Q6UX71-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84898
DisGeNETi84898
EuPathDBiHostDB:ENSG00000120594.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLXDC2
HGNCiHGNC:21013, PLXDC2
HPAiENSG00000120594, Low tissue specificity
MIMi606827, gene
neXtProtiNX_Q6UX71
OpenTargetsiENSG00000120594
PharmGKBiPA134932187

GenAtlas: human gene database

More...
GenAtlasi
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Phylogenomic databases

eggNOGiKOG3848, Eukaryota
GeneTreeiENSGT00440000033408
HOGENOMiCLU_029494_3_1_1
InParanoidiQ6UX71
OMAiRVIYEYH
OrthoDBi1361987at2759
PhylomeDBiQ6UX71
TreeFamiTF314400

Enzyme and pathway databases

PathwayCommonsiQ6UX71

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84898, 4 hits in 867 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PLXDC2, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PLXDC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84898
PharosiQ6UX71, Tbio

Protein Ontology

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PROi
PR:Q6UX71
RNActiQ6UX71, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000120594, Expressed in calcaneal tendon and 233 other tissues
GenevisibleiQ6UX71, HS

Family and domain databases

InterProiView protein in InterPro
IPR002165, Plexin_repeat
IPR031152, PLXDC
IPR031154, PLXDC2
IPR016201, PSI
PANTHERiPTHR13055, PTHR13055, 1 hit
PTHR13055:SF11, PTHR13055:SF11, 1 hit
PfamiView protein in Pfam
PF01437, PSI, 1 hit
SMARTiView protein in SMART
SM00423, PSI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPXDC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UX71
Secondary accession number(s): Q96E59, Q96PD9, Q96SU9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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