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Protein

Plexin domain-containing protein 2

Gene

PLXDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in tumor angiogenesis.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin domain-containing protein 2
Alternative name(s):
Tumor endothelial marker 7-related protein
Gene namesi
Name:PLXDC2
Synonyms:TEM7R
ORF Names:UNQ2514/PRO6003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000120594.16
HGNCiHGNC:21013 PLXDC2
MIMi606827 gene
neXtProtiNX_Q6UX71

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 454ExtracellularSequence analysisAdd BLAST424
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Topological domaini476 – 529CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84898
OpenTargetsiENSG00000120594
PharmGKBiPA134932187

Polymorphism and mutation databases

BioMutaiPLXDC2
DMDMi74749416

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000023457431 – 529Plexin domain-containing protein 2Add BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi160N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei506PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ6UX71
MaxQBiQ6UX71
PaxDbiQ6UX71
PeptideAtlasiQ6UX71
PRIDEiQ6UX71
ProteomicsDBi67571
67572 [Q6UX71-2]
67573 [Q6UX71-3]

PTM databases

GlyConnecti1616
iPTMnetiQ6UX71
PhosphoSitePlusiQ6UX71

Expressioni

Tissue specificityi

Expressed in the endothelial cells of the stroma but not in the endothelial cells of normal colonic tissue.1 Publication

Gene expression databases

BgeeiENSG00000120594 Expressed in 219 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_PLXDC2
GenevisibleiQ6UX71 HS

Organism-specific databases

HPAiHPA017268
HPA070793

Interactioni

Subunit structurei

Interacts with CTTN.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Zbp1A2APF72EBI-6115410,EBI-6115394From Mus musculus.

Protein-protein interaction databases

BioGridi124338, 46 interactors
DIPiDIP-46251N
IntActiQ6UX71, 4 interactors
MINTiQ6UX71
STRINGi9606.ENSP00000366460

Structurei

3D structure databases

ProteinModelPortaliQ6UX71
SMRiQ6UX71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini327 – 372PSIAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi383 – 427Thr-richAdd BLAST45

Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3848 Eukaryota
ENOG410Y7ZQ LUCA
GeneTreeiENSGT00440000033408
HOGENOMiHOG000234044
HOVERGENiHBG079500
InParanoidiQ6UX71
OMAiRVIYEYH
OrthoDBiEOG091G0827
PhylomeDBiQ6UX71
TreeFamiTF314400

Family and domain databases

InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR031152 PLXDC
IPR031154 PLXDC2
IPR016201 PSI
PANTHERiPTHR13055 PTHR13055, 1 hit
PTHR13055:SF11 PTHR13055:SF11, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6UX71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARFPKADLA AAGVMLLCHF FTDQFQFADG KPGDQILDWQ YGVTQAFPHT
60 70 80 90 100
EEEVEVDSHA YSHRWKRNLD FLKAVDTNRA SVGQDSPEPR SFTDLLLDDG
110 120 130 140 150
QDNNTQIEED TDHNYYISRI YGPSDSASRD LWVNIDQMEK DKVKIHGILS
160 170 180 190 200
NTHRQAARVN LSFDFPFYGH FLREITVATG GFIYTGEVVH RMLTATQYIA
210 220 230 240 250
PLMANFDPSV SRNSTVRYFD NGTALVVQWD HVHLQDNYNL GSFTFQATLL
260 270 280 290 300
MDGRIIFGYK EIPVLVTQIS STNHPVKVGL SDAFVVVHRI QQIPNVRRRT
310 320 330 340 350
IYEYHRVELQ MSKITNISAV EMTPLPTCLQ FNRCGPCVSS QIGFNCSWCS
360 370 380 390 400
KLQRCSSGFD RHRQDWVDSG CPEESKEKMC ENTEPVETSS RTTTTVGATT
410 420 430 440 450
TQFRVLTTTR RAVTSQFPTS LPTEDDTKIA LHLKDNGAST DDSAAEKKGG
460 470 480 490 500
TLHAGLIIGI LILVLIVATA ILVTVYMYHH PTSAASIFFI ERRPSRWPAM
510 520
KFRRGSGHPA YAEVEPVGEK EGFIVSEQC
Length:529
Mass (Da):59,583
Last modified:July 5, 2004 - v1
Checksum:iCCE911D6DF837B40
GO
Isoform 2 (identifier: Q6UX71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-157: Missing.

Show »
Length:480
Mass (Da):53,912
Checksum:iF8DB0E2631BC7816
GO
Isoform 3 (identifier: Q6UX71-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-378: Missing.

Show »
Length:151
Mass (Da):16,423
Checksum:iEAC2BCBFC94AB047
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026292396V → I2 PublicationsCorresponds to variant dbSNP:rs3817405Ensembl.1
Natural variantiVAR_026293458I → V2 PublicationsCorresponds to variant dbSNP:rs2778979Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0183771 – 378Missing in isoform 3. 1 PublicationAdd BLAST378
Alternative sequenceiVSP_018378109 – 157Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378757 mRNA Translation: AAL11994.1
AY358486 mRNA Translation: AAQ88850.1
AK027529 mRNA Translation: BAB55178.1
AC067743 Genomic DNA No translation available.
AC069549 Genomic DNA No translation available.
AL353147 Genomic DNA No translation available.
BC012885 mRNA Translation: AAH12885.1
CCDSiCCDS60497.1 [Q6UX71-2]
CCDS7132.1 [Q6UX71-1]
RefSeqiNP_001269665.1, NM_001282736.1 [Q6UX71-2]
NP_116201.7, NM_032812.8 [Q6UX71-1]
UniGeneiHs.658134
Hs.733859
Hs.99472

Genome annotation databases

EnsembliENST00000377242; ENSP00000366450; ENSG00000120594 [Q6UX71-2]
ENST00000377252; ENSP00000366460; ENSG00000120594 [Q6UX71-1]
GeneIDi84898
KEGGihsa:84898
UCSCiuc001iqg.3 human [Q6UX71-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378757 mRNA Translation: AAL11994.1
AY358486 mRNA Translation: AAQ88850.1
AK027529 mRNA Translation: BAB55178.1
AC067743 Genomic DNA No translation available.
AC069549 Genomic DNA No translation available.
AL353147 Genomic DNA No translation available.
BC012885 mRNA Translation: AAH12885.1
CCDSiCCDS60497.1 [Q6UX71-2]
CCDS7132.1 [Q6UX71-1]
RefSeqiNP_001269665.1, NM_001282736.1 [Q6UX71-2]
NP_116201.7, NM_032812.8 [Q6UX71-1]
UniGeneiHs.658134
Hs.733859
Hs.99472

3D structure databases

ProteinModelPortaliQ6UX71
SMRiQ6UX71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124338, 46 interactors
DIPiDIP-46251N
IntActiQ6UX71, 4 interactors
MINTiQ6UX71
STRINGi9606.ENSP00000366460

PTM databases

GlyConnecti1616
iPTMnetiQ6UX71
PhosphoSitePlusiQ6UX71

Polymorphism and mutation databases

BioMutaiPLXDC2
DMDMi74749416

Proteomic databases

EPDiQ6UX71
MaxQBiQ6UX71
PaxDbiQ6UX71
PeptideAtlasiQ6UX71
PRIDEiQ6UX71
ProteomicsDBi67571
67572 [Q6UX71-2]
67573 [Q6UX71-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377242; ENSP00000366450; ENSG00000120594 [Q6UX71-2]
ENST00000377252; ENSP00000366460; ENSG00000120594 [Q6UX71-1]
GeneIDi84898
KEGGihsa:84898
UCSCiuc001iqg.3 human [Q6UX71-1]

Organism-specific databases

CTDi84898
DisGeNETi84898
EuPathDBiHostDB:ENSG00000120594.16
GeneCardsiPLXDC2
HGNCiHGNC:21013 PLXDC2
HPAiHPA017268
HPA070793
MIMi606827 gene
neXtProtiNX_Q6UX71
OpenTargetsiENSG00000120594
PharmGKBiPA134932187
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3848 Eukaryota
ENOG410Y7ZQ LUCA
GeneTreeiENSGT00440000033408
HOGENOMiHOG000234044
HOVERGENiHBG079500
InParanoidiQ6UX71
OMAiRVIYEYH
OrthoDBiEOG091G0827
PhylomeDBiQ6UX71
TreeFamiTF314400

Miscellaneous databases

ChiTaRSiPLXDC2 human
GeneWikiiPLXDC2
GenomeRNAii84898
PROiPR:Q6UX71
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120594 Expressed in 219 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_PLXDC2
GenevisibleiQ6UX71 HS

Family and domain databases

InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR031152 PLXDC
IPR031154 PLXDC2
IPR016201 PSI
PANTHERiPTHR13055 PTHR13055, 1 hit
PTHR13055:SF11 PTHR13055:SF11, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPXDC2_HUMAN
AccessioniPrimary (citable) accession number: Q6UX71
Secondary accession number(s): Q96E59, Q96PD9, Q96SU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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