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UniProtKB - Q6UX65 (DRAM2_HUMAN)

Entry version 125 (10 Feb 2021)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

DNA damage-regulated autophagy modulator protein 2

Gene

DRAM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Autophagy

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6UX65

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q6UX65

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.113.1.9, the tentonin or tmem150 (tmem150) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA damage-regulated autophagy modulator protein 2
Alternative name(s):
Transmembrane protein 77
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DRAM2
Synonyms:TMEM77
ORF Names:PSEC0031, UNQ154/PRO180
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28769, DRAM2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613360, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6UX65

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000156171.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cone-rod dystrophy 21 (CORD21)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of cone-rod dystrophy, an inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07507322Missing in CORD21. 1 Publication1
Natural variantiVAR_07507427Y → H in CORD21. 1 PublicationCorresponds to variant dbSNP:rs786205662EnsemblClinVar.1
Natural variantiVAR_07507544S → N in CORD21. 1 PublicationCorresponds to variant dbSNP:rs786205665EnsemblClinVar.1
Natural variantiVAR_07507673 – 75Missing in CORD21. 1 Publication3
Natural variantiVAR_075077121H → L in CORD21. 1 PublicationCorresponds to variant dbSNP:rs786205664EnsemblClinVar.1

Keywords - Diseasei

Cone-rod dystrophy, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		128338

MalaCards human disease database

More...MalaCardsi		DRAM2
MIMi616502, phenotype

Open Targets

More...OpenTargetsi		ENSG00000156171

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1872, Cone rod dystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165751270

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6UX65, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DRAM2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74749415

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002541021 – 266DNA damage-regulated autophagy modulator protein 2Add BLAST266

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6UX65

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6UX65

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6UX65

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6UX65

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6UX65

PeptideAtlas

More...PeptideAtlasi		Q6UX65

PRoteomics IDEntifications database

More...PRIDEi		Q6UX65

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67568

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6UX65

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6UX65

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q6UX65

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest levels in placenta and heart. Expressed in the retina. Not detected in brain or thymus.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Not induced by p53/TP53 or TP73/p73.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000156171, Expressed in small intestine Peyer's patch and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6UX65, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6UX65, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000156171, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126108, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q6UX65, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000286692

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6UX65, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DRAM/TMEM150 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4320, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214507

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_059992_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6UX65

Identification of Orthologs from Complete Genome Data

More...OMAi		LVQKLHW

Database of Orthologous Groups

More...OrthoDBi		1199230at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6UX65

TreeFam database of animal gene trees

More...TreeFami		TF314508

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032990, DRAM2
IPR019402, Frag1/DRAM/Sfk1

The PANTHER Classification System

More...PANTHERi		PTHR21324:SF10, PTHR21324:SF10, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10277, Frag1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6UX65-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWWFQQGLSF LPSALVIWTS AAFIFSYITA VTLHHIDPAL PYISDTGTVA 
        60         70         80         90        100
PEKCLFGAML NIAAVLCIAT IYVRYKQVHA LSPEENVIIK LNKAGLVLGI 
       110        120        130        140        150
LSCLGLSIVA NFQKTTLFAA HVSGAVLTFG MGSLYMFVQT ILSYQMQPKI 
       160        170        180        190        200
HGKQVFWIRL LLVIWCGVSA LSMLTCSSVL HSGNFGTDLE QKLHWNPEDK 
       210        220        230        240        250
GYVLHMITTA AEWSMSFSFF GFFLTYIRDF QKISLRVEAN LHGLTLYDTA 
       260 
PCPINNERTR LLSRDI
Length:266
Mass (Da):29,766
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F91D5C212D458E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R2Z2S4R2Z2_HUMAN
DNA damage-regulated autophagy modu...
DRAM2
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11562 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti221G → V in AAR02410 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07507322Missing in CORD21. 1 Publication1
Natural variantiVAR_07507427Y → H in CORD21. 1 PublicationCorresponds to variant dbSNP:rs786205662EnsemblClinVar.1
Natural variantiVAR_07507544S → N in CORD21. 1 PublicationCorresponds to variant dbSNP:rs786205665EnsemblClinVar.1
Natural variantiVAR_07507673 – 75Missing in CORD21. 1 Publication3
Natural variantiVAR_075077121H → L in CORD21. 1 PublicationCorresponds to variant dbSNP:rs786205664EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY336747 mRNA Translation: AAR02410.1
EF710624 mRNA Translation: ABR27678.1
AY358492 mRNA Translation: AAQ88856.1
AL355816 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56464.1
BC047025 mRNA Translation: AAH47025.3
BC091509 mRNA Translation: AAH91509.1
AK075350 mRNA Translation: BAC11562.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30801.1

NCBI Reference Sequences

More...RefSeqi		NP_848549.3, NM_178454.4
XP_005270526.1, XM_005270469.2
XP_005270527.1, XM_005270470.1
XP_011539009.1, XM_011540707.1
XP_011539010.1, XM_011540708.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000286692; ENSP00000286692; ENSG00000156171
ENST00000539140; ENSP00000437718; ENSG00000156171

Database of genes from NCBI RefSeq genomes

More...GeneIDi		128338

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:128338

UCSC genome browser

More...UCSCi		uc001ead.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336747 mRNA Translation: AAR02410.1
EF710624 mRNA Translation: ABR27678.1
AY358492 mRNA Translation: AAQ88856.1
AL355816 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56464.1
BC047025 mRNA Translation: AAH47025.3
BC091509 mRNA Translation: AAH91509.1
AK075350 mRNA Translation: BAC11562.1 Different initiation.
CCDSiCCDS30801.1
RefSeqiNP_848549.3, NM_178454.4
XP_005270526.1, XM_005270469.2
XP_005270527.1, XM_005270470.1
XP_011539009.1, XM_011540707.1
XP_011539010.1, XM_011540708.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126108, 5 interactors
IntActiQ6UX65, 5 interactors
STRINGi9606.ENSP00000286692

Protein family/group databases

TCDBi8.A.113.1.9, the tentonin or tmem150 (tmem150) family

PTM databases

iPTMnetiQ6UX65
PhosphoSitePlusiQ6UX65
SwissPalmiQ6UX65

Genetic variation databases

BioMutaiDRAM2
DMDMi74749415

Proteomic databases

EPDiQ6UX65
jPOSTiQ6UX65
MassIVEiQ6UX65
MaxQBiQ6UX65
PaxDbiQ6UX65
PeptideAtlasiQ6UX65
PRIDEiQ6UX65
ProteomicsDBi67568

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20104, 70 antibodies

Genome annotation databases

EnsembliENST00000286692; ENSP00000286692; ENSG00000156171
ENST00000539140; ENSP00000437718; ENSG00000156171
GeneIDi128338
KEGGihsa:128338
UCSCiuc001ead.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		128338
DisGeNETi128338

GeneCards: human genes, protein and diseases

More...GeneCardsi		DRAM2
HGNCiHGNC:28769, DRAM2
HPAiENSG00000156171, Low tissue specificity
MalaCardsiDRAM2
MIMi613360, gene
616502, phenotype
neXtProtiNX_Q6UX65
OpenTargetsiENSG00000156171
Orphaneti1872, Cone rod dystrophy
PharmGKBiPA165751270
VEuPathDBiHostDB:ENSG00000156171.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4320, Eukaryota
GeneTreeiENSGT01000000214507
HOGENOMiCLU_059992_2_2_1
InParanoidiQ6UX65
OMAiLVQKLHW
OrthoDBi1199230at2759
PhylomeDBiQ6UX65
TreeFamiTF314508

Enzyme and pathway databases

PathwayCommonsiQ6UX65
SIGNORiQ6UX65

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		128338, 5 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DRAM2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		128338
PharosiQ6UX65, Tbio

Protein Ontology

More...PROi		PR:Q6UX65
RNActiQ6UX65, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000156171, Expressed in small intestine Peyer's patch and 214 other tissues
ExpressionAtlasiQ6UX65, baseline and differential
GenevisibleiQ6UX65, HS

Family and domain databases

InterProiView protein in InterPro
IPR032990, DRAM2
IPR019402, Frag1/DRAM/Sfk1
PANTHERiPTHR21324:SF10, PTHR21324:SF10, 1 hit
PfamiView protein in Pfam
PF10277, Frag1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRAM2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UX65
Secondary accession number(s): B3SUG9
, Q4VWF6, Q86VD3, Q8NBQ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: February 10, 2021
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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