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Protein

ALK and LTK ligand 2

Gene

ALKAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation.2 Publications

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ALK and LTK ligand 2Imported
Alternative name(s):
Augmentor alpha1 Publication
Short name:
AUG-alpha1 Publication
Protein FAM150B
Gene namesi
Name:ALKAL2Imported
Synonyms:FAM150B
ORF Names:UNQ542/PRO1097
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000189292.15
HGNCiHGNC:27683 ALKAL2
neXtProtiNX_Q6UX46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189292
PharmGKBiPA162386448

Polymorphism and mutation databases

BioMutaiFAM150B
DMDMi229462850

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000031719325 – 152ALK and LTK ligand 2Add BLAST128

Proteomic databases

PaxDbiQ6UX46
PeptideAtlasiQ6UX46
PRIDEiQ6UX46
ProteomicsDBi67564
67565 [Q6UX46-2]

Expressioni

Tissue specificityi

Widely expressed with highest levels in adrenal gland and modest levels in pancreas, testis and uterus.1 Publication

Gene expression databases

BgeeiENSG00000189292 Expressed in 158 organ(s), highest expression level in right adrenal gland
CleanExiHS_FAM150B
ExpressionAtlasiQ6UX46 baseline and differential
GenevisibleiQ6UX46 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALKQ9UM735EBI-11691780,EBI-357361

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6UX46, 1 interactor
STRINGi9606.ENSP00000384604

Structurei

3D structure databases

ProteinModelPortaliQ6UX46
SMRiQ6UX46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALKAL family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX76 Eukaryota
ENOG410Y5NM LUCA
GeneTreeiENSGT00390000004054
HOGENOMiHOG000082506
HOVERGENiHBG107867
InParanoidiQ6UX46
OMAiYHSGESK
OrthoDBiEOG091G0WD7
PhylomeDBiQ6UX46
TreeFamiTF333390

Family and domain databases

InterProiView protein in InterPro
IPR029364 FAM150A/B
PANTHERiPTHR28676 PTHR28676, 1 hit
PfamiView protein in Pfam
PF15129 FAM150, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UX46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGPGHPLLL GLLLVLGAAG RGRGGAEPRE PADGQALLRL VVELVQELRK
60 70 80 90 100
HHSAEHKGLQ LLGRDCALGR AEAAGLGPSP EQRVEIVPRD LRMKDKFLKH
110 120 130 140 150
LTGPLYFSPK CSKHFHRLYH NTRDCTIPAY YKRCARLLTR LAVSPVCMED

KQ
Length:152
Mass (Da):16,915
Last modified:May 5, 2009 - v2
Checksum:i547047F0FFA23D01
GO
Isoform 2 (identifier: Q6UX46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-76: Missing.
     152-152: Missing.

Show »
Length:91
Mass (Da):10,542
Checksum:i0EE995ED103A46C4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1W8A0A0B4J1W8_HUMAN
ALK and LTK ligand 2
ALKAL2
151Annotation score:
B5MCG6B5MCG6_HUMAN
ALK and LTK ligand 2
ALKAL2
60Annotation score:
H0Y3U4H0Y3U4_HUMAN
ALK and LTK ligand 2
ALKAL2
102Annotation score:
B5MC33B5MC33_HUMAN
ALK and LTK ligand 2
ALKAL2
59Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03701717 – 76Missing in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_037018152Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358517 mRNA Translation: AAQ88881.1
AC079779 Genomic DNA No translation available.
CCDSiCCDS46218.1 [Q6UX46-1]
RefSeqiNP_001002919.2, NM_001002919.2 [Q6UX46-1]
XP_005264746.1, XM_005264689.4 [Q6UX46-1]
UniGeneiHs.355207

Genome annotation databases

EnsembliENST00000403610; ENSP00000384604; ENSG00000189292 [Q6UX46-1]
ENST00000619265; ENSP00000478180; ENSG00000189292 [Q6UX46-2]
GeneIDi285016
KEGGihsa:285016
UCSCiuc002qwi.5 human [Q6UX46-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358517 mRNA Translation: AAQ88881.1
AC079779 Genomic DNA No translation available.
CCDSiCCDS46218.1 [Q6UX46-1]
RefSeqiNP_001002919.2, NM_001002919.2 [Q6UX46-1]
XP_005264746.1, XM_005264689.4 [Q6UX46-1]
UniGeneiHs.355207

3D structure databases

ProteinModelPortaliQ6UX46
SMRiQ6UX46
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6UX46, 1 interactor
STRINGi9606.ENSP00000384604

Polymorphism and mutation databases

BioMutaiFAM150B
DMDMi229462850

Proteomic databases

PaxDbiQ6UX46
PeptideAtlasiQ6UX46
PRIDEiQ6UX46
ProteomicsDBi67564
67565 [Q6UX46-2]

Protocols and materials databases

DNASUi285016
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000403610; ENSP00000384604; ENSG00000189292 [Q6UX46-1]
ENST00000619265; ENSP00000478180; ENSG00000189292 [Q6UX46-2]
GeneIDi285016
KEGGihsa:285016
UCSCiuc002qwi.5 human [Q6UX46-1]

Organism-specific databases

CTDi285016
EuPathDBiHostDB:ENSG00000189292.15
GeneCardsiALKAL2
H-InvDBiHIX0029900
HGNCiHGNC:27683 ALKAL2
neXtProtiNX_Q6UX46
OpenTargetsiENSG00000189292
PharmGKBiPA162386448
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX76 Eukaryota
ENOG410Y5NM LUCA
GeneTreeiENSGT00390000004054
HOGENOMiHOG000082506
HOVERGENiHBG107867
InParanoidiQ6UX46
OMAiYHSGESK
OrthoDBiEOG091G0WD7
PhylomeDBiQ6UX46
TreeFamiTF333390

Miscellaneous databases

GenomeRNAii285016
PROiPR:Q6UX46

Gene expression databases

BgeeiENSG00000189292 Expressed in 158 organ(s), highest expression level in right adrenal gland
CleanExiHS_FAM150B
ExpressionAtlasiQ6UX46 baseline and differential
GenevisibleiQ6UX46 HS

Family and domain databases

InterProiView protein in InterPro
IPR029364 FAM150A/B
PANTHERiPTHR28676 PTHR28676, 1 hit
PfamiView protein in Pfam
PF15129 FAM150, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALKL2_HUMAN
AccessioniPrimary (citable) accession number: Q6UX46
Secondary accession number(s): B5MC76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 5, 2009
Last modified: September 12, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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