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Entry version 135 (08 May 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Butyrophilin-like protein 8

Gene

BTNL8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8851680 Butyrophilin (BTN) family interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Butyrophilin-like protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BTNL8
ORF Names:UNQ702/PRO1347
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26131 BTNL8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615606 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UX41

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini18 – 238ExtracellularSequence analysisAdd BLAST221
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 500CytoplasmicSequence analysisAdd BLAST241

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000113303

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134918466

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BTNL8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
59799184

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 171 PublicationAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001454118 – 500Butyrophilin-like protein 8Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi40 ↔ 114PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi154 ↔ 206PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6UX41

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6UX41

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UX41

PeptideAtlas

More...
PeptideAtlasi
Q6UX41

PRoteomics IDEntifications database

More...
PRIDEi
Q6UX41

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67562
67563 [Q6UX41-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6UX41

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UX41

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neutrophils. Isoforms 1 and 5 are expressed at high levels in the colon, lung,testis, lymph nodes and thyroid tissue. Isoform 5, but not isoform 1, is detected in spleen.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in neutrophils after treatment with LPS and TNF.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113303 Expressed in 98 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6UX41 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6UX41 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039738

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TFF1P041553EBI-4314379,EBI-743871

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122991, 42 interactors

Protein interaction database and analysis system

More...
IntActi
Q6UX41, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000342197

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6UX41

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 132Ig-like V-type 1Add BLAST114
Domaini133 – 222Ig-like V-type 2Add BLAST90
Domaini270 – 466B30.2/SPRYPROSITE-ProRule annotationAdd BLAST197

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IYU2 Eukaryota
ENOG411140Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163611

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230860

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UX41

KEGG Orthology (KO)

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KOi
K06712

Identification of Orthologs from Complete Genome Data

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OMAi
WKGPQGH

Database of Orthologous Groups

More...
OrthoDBi
522383at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UX41

TreeFam database of animal gene trees

More...
TreeFami
TF331083

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR006574 PRY
IPR003877 SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF07686 V-set, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01407 BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 2 hits
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 2 hits
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UX41-1) [UniParc]FASTAAdd to basket
Also known as: BTN-like

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALMLSLVLS LLKLGSGQWQ VFGPDKPVQA LVGEDAAFSC FLSPKTNAEA
60 70 80 90 100
MEVRFFRGQF SSVVHLYRDG KDQPFMQMPQ YQGRTKLVKD SIAEGRISLR
110 120 130 140 150
LENITVLDAG LYGCRISSQS YYQKAIWELQ VSALGSVPLI SITGYVDRDI
160 170 180 190 200
QLLCQSSGWF PRPTAKWKGP QGQDLSTDSR TNRDMHGLFD VEISLTVQEN
210 220 230 240 250
AGSISCSMRH AHLSREVESR VQIGDTFFEP ISWHLATKVL GILCCGLFFG
260 270 280 290 300
IVGLKIFFSK FQWKIQAELD WRRKHGQAEL RDARKHAVEV TLDPETAHPK
310 320 330 340 350
LCVSDLKTVT HRKAPQEVPH SEKRFTRKSV VASQSFQAGK HYWEVDGGHN
360 370 380 390 400
KRWRVGVCRD DVDRRKEYVT LSPDHGYWVL RLNGEHLYFT LNPRFISVFP
410 420 430 440 450
RTPPTKIGVF LDYECGTISF FNINDQSLIY TLTCRFEGLL RPYIEYPSYN
460 470 480 490 500
EQNGTPIVIC PVTQESEKEA SWQRASAIPE TSNSESSSQA TTPFLPRGEM
Length:500
Mass (Da):56,748
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3314E96421533C74
GO
Isoform 2 (identifier: Q6UX41-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-347: WKIQAELDWR...AGKHYWEVDG → CKREREAWAG...ERRPETRSGG
     348-500: Missing.

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):36,733
Checksum:i14F6E13AB052026D
GO
Isoform 3 (identifier: Q6UX41-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-500: WKIQAELDWR...TTPFLPRGEM → CKREREAWAG...RDGSPEALRF

Note: No experimental confirmation available.
Show »
Length:340
Mass (Da):37,596
Checksum:i6B94F4F80E73C449
GO
Isoform 4 (identifier: Q6UX41-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.

Note: No experimental confirmation available.
Show »
Length:316
Mass (Da):36,222
Checksum:i2D45B9605F9999BD
GO
Isoform 5 (identifier: Q6UX41-5) [UniParc]FASTAAdd to basket
Also known as: B7-like

The sequence of this isoform differs from the canonical sequence as follows:
     263-347: WKIQAELDWR...AGKHYWEVDG → CKREREAWAG...RDGSPEALRF
     348-500: Missing.

Show »
Length:347
Mass (Da):38,209
Checksum:i12D617929E71A5E4
GO
Isoform 6 (identifier: Q6UX41-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-131: Missing.

Note: No experimental confirmation available.
Show »
Length:384
Mass (Da):43,609
Checksum:iCC0499D3FF7FD104
GO
Isoform 7 (identifier: Q6UX41-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MALMLSLV → MWTWFVKS
     9-133: Missing.

Note: No experimental confirmation available.
Show »
Length:375
Mass (Da):42,933
Checksum:iA72C44E56A523161
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIR7D6RIR7_HUMAN
Butyrophilin-like protein 8
BTNL8
293Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9I8D6R9I8_HUMAN
Butyrophilin-like protein 8
BTNL8
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti311H → E in BAH12847 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049839143T → A1 PublicationCorresponds to variant dbSNP:rs2276995Ensembl.1
Natural variantiVAR_049840229E → K1 PublicationCorresponds to variant dbSNP:rs7724813Ensembl.1
Natural variantiVAR_069135311H → Q1 PublicationCorresponds to variant dbSNP:rs146303629Ensembl.1
Natural variantiVAR_069136326T → K1 PublicationCorresponds to variant dbSNP:rs7703365Ensembl.1
Natural variantiVAR_069137477A → T1 PublicationCorresponds to variant dbSNP:rs113820381Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0454711 – 184Missing in isoform 4. 1 PublicationAdd BLAST184
Alternative sequenceiVSP_0460671 – 8MALMLSLV → MWTWFVKS in isoform 7. 1 Publication8
Alternative sequenceiVSP_0460689 – 133Missing in isoform 7. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_04606916 – 131Missing in isoform 6. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_045472263 – 500WKIQA…PRGEM → CKREREAWAGALFMVPAGTG SEMLPHPAASLLLVLASRGP GPKKLEKKARTGRIERRPET RSGGDSGSRDGSPEALRF in isoform 3. 1 PublicationAdd BLAST238
Alternative sequenceiVSP_012718263 – 347WKIQA…WEVDG → CKREREAWAGALFMVPAGTG SEMLPHPAASLLLVLASRGP GPKKENPGGTGLEKKARTGR IERRPETRSGG in isoform 2. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_045781263 – 347WKIQA…WEVDG → CKREREAWAGALFMVPAGTG SEMLPHPAASLLLVLASRGP GPKKENPGGTGLEKKARTGR IERRPETRSGGDSGSRDGSP EALRF in isoform 5. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_012719348 – 500Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST153

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358523 mRNA Translation: AAQ88887.1
AK025111 mRNA Translation: BAB15069.1
AK296597 mRNA Translation: BAH12395.1
AK298687 mRNA Translation: BAH12847.1
AK225213 mRNA No translation available.
AC022413 Genomic DNA No translation available.
AC091874 Genomic DNA No translation available.
CH471165 Genomic DNA Translation: EAW53732.1
BC119696 mRNA Translation: AAI19697.1
BC119697 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS43413.1 [Q6UX41-1]
CCDS4459.1 [Q6UX41-5]
CCDS54956.1 [Q6UX41-3]
CCDS54957.1 [Q6UX41-6]
CCDS54958.1 [Q6UX41-7]
CCDS54959.1 [Q6UX41-4]

NCBI Reference Sequences

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RefSeqi
NP_001035552.1, NM_001040462.2 [Q6UX41-1]
NP_001153179.1, NM_001159707.1 [Q6UX41-6]
NP_001153180.1, NM_001159708.1 [Q6UX41-3]
NP_001153181.1, NM_001159709.1 [Q6UX41-7]
NP_001153182.1, NM_001159710.1 [Q6UX41-4]
NP_079126.1, NM_024850.2 [Q6UX41-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000231229; ENSP00000231229; ENSG00000113303 [Q6UX41-5]
ENST00000340184; ENSP00000342197; ENSG00000113303 [Q6UX41-1]
ENST00000400707; ENSP00000383543; ENSG00000113303 [Q6UX41-7]
ENST00000508408; ENSP00000424585; ENSG00000113303 [Q6UX41-3]
ENST00000511704; ENSP00000425207; ENSG00000113303 [Q6UX41-6]
ENST00000533815; ENSP00000435098; ENSG00000113303 [Q6UX41-4]
ENST00000610640; ENSP00000483717; ENSG00000113303 [Q6UX41-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79908

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79908

UCSC genome browser

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UCSCi
uc003mmp.4 human [Q6UX41-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358523 mRNA Translation: AAQ88887.1
AK025111 mRNA Translation: BAB15069.1
AK296597 mRNA Translation: BAH12395.1
AK298687 mRNA Translation: BAH12847.1
AK225213 mRNA No translation available.
AC022413 Genomic DNA No translation available.
AC091874 Genomic DNA No translation available.
CH471165 Genomic DNA Translation: EAW53732.1
BC119696 mRNA Translation: AAI19697.1
BC119697 mRNA No translation available.
CCDSiCCDS43413.1 [Q6UX41-1]
CCDS4459.1 [Q6UX41-5]
CCDS54956.1 [Q6UX41-3]
CCDS54957.1 [Q6UX41-6]
CCDS54958.1 [Q6UX41-7]
CCDS54959.1 [Q6UX41-4]
RefSeqiNP_001035552.1, NM_001040462.2 [Q6UX41-1]
NP_001153179.1, NM_001159707.1 [Q6UX41-6]
NP_001153180.1, NM_001159708.1 [Q6UX41-3]
NP_001153181.1, NM_001159709.1 [Q6UX41-7]
NP_001153182.1, NM_001159710.1 [Q6UX41-4]
NP_079126.1, NM_024850.2 [Q6UX41-5]

3D structure databases

SMRiQ6UX41
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122991, 42 interactors
IntActiQ6UX41, 5 interactors
STRINGi9606.ENSP00000342197

PTM databases

iPTMnetiQ6UX41
PhosphoSitePlusiQ6UX41

Polymorphism and mutation databases

BioMutaiBTNL8
DMDMi59799184

Proteomic databases

jPOSTiQ6UX41
MaxQBiQ6UX41
PaxDbiQ6UX41
PeptideAtlasiQ6UX41
PRIDEiQ6UX41
ProteomicsDBi67562
67563 [Q6UX41-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231229; ENSP00000231229; ENSG00000113303 [Q6UX41-5]
ENST00000340184; ENSP00000342197; ENSG00000113303 [Q6UX41-1]
ENST00000400707; ENSP00000383543; ENSG00000113303 [Q6UX41-7]
ENST00000508408; ENSP00000424585; ENSG00000113303 [Q6UX41-3]
ENST00000511704; ENSP00000425207; ENSG00000113303 [Q6UX41-6]
ENST00000533815; ENSP00000435098; ENSG00000113303 [Q6UX41-4]
ENST00000610640; ENSP00000483717; ENSG00000113303 [Q6UX41-7]
GeneIDi79908
KEGGihsa:79908
UCSCiuc003mmp.4 human [Q6UX41-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79908

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BTNL8
HGNCiHGNC:26131 BTNL8
HPAiHPA039738
MIMi615606 gene
neXtProtiNX_Q6UX41
OpenTargetsiENSG00000113303
PharmGKBiPA134918466

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IYU2 Eukaryota
ENOG411140Z LUCA
GeneTreeiENSGT00940000163611
HOGENOMiHOG000230860
InParanoidiQ6UX41
KOiK06712
OMAiWKGPQGH
OrthoDBi522383at2759
PhylomeDBiQ6UX41
TreeFamiTF331083

Enzyme and pathway databases

ReactomeiR-HSA-8851680 Butyrophilin (BTN) family interactions

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79908

Protein Ontology

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PROi
PR:Q6UX41

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113303 Expressed in 98 organ(s), highest expression level in intestine
ExpressionAtlasiQ6UX41 baseline and differential
GenevisibleiQ6UX41 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR006574 PRY
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBTNL8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UX41
Secondary accession number(s): A4QMZ8
, A6NEX6, B7Z409, B7Z5B1, E9PEF6, E9PG07, F2Z2B2, F8W712, Q9H730
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: May 8, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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