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Entry version 116 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Transmembrane protein 107

Gene

TMEM107

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (PubMed:26518474).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 107Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM107Imported
ORF Names:DC20, UNQ638/PRO1268
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28128 TMEM107

Online Mendelian Inheritance in Man (OMIM)

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MIMi
616183 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UX40

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Meckel syndrome 13 (MKS13)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Meckel syndrome, a disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079329100Missing in MKS13 and OFD16; does not affect subcellular location at ciliary transition zone; significantly decreases cilium assembly from patient's skin primary fibroblast; impairs protein localization to cilium from patient's skin primary fibroblast. 2 Publications1
Orofaciodigital syndrome 16 (OFD16)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of orofaciodigital syndrome, a group of heterogeneous disorders characterized by malformations of the oral cavity, face and digits, and associated phenotypic abnormalities that lead to the delineation of various subtypes. OFD16 features include postaxial polydactyly of the hands and feet, multiple tongue cysts, and dysmorphic features, including frontal narrowing, short palpebral fissures, flat nasal bridge, retrognathia, and low-set ears. Neurologic features include delayed psychomotor development and severe cognitive impairment. OFD16 inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07932845E → G in OFD16; does not affect subcellular location at ciliary transition zone. 1 PublicationCorresponds to variant dbSNP:rs1555526172EnsemblClinVar.1
Natural variantiVAR_079329100Missing in MKS13 and OFD16; does not affect subcellular location at ciliary transition zone; significantly decreases cilium assembly from patient's skin primary fibroblast; impairs protein localization to cilium from patient's skin primary fibroblast. 2 Publications1

Keywords - Diseasei

Ciliopathy, Disease mutation, Meckel syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
84314

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
TMEM107

MalaCards human disease database

More...
MalaCardsi
TMEM107
MIMi617562 phenotype
617563 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000179029

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
564 Meckel syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670758

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6UX40

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM107

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74738174

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002545411 – 140Transmembrane protein 107Add BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6UX40

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UX40

PeptideAtlas

More...
PeptideAtlasi
Q6UX40

PRoteomics IDEntifications database

More...
PRIDEi
Q6UX40

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67558 [Q6UX40-1]
67559 [Q6UX40-2]
67560 [Q6UX40-3]
67561 [Q6UX40-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q6UX40-4 [Q6UX40-4]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000179029 Expressed in 189 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6UX40 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6UX40 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052555
HPA059653

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the tectonic-like complex (also named B9 complex).

Interacts with TMEM237, TMEM231, MKS1 and TMEM216.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MKS1Q9NXB02EBI-12845616,EBI-719269

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124040, 7 interactors

Database of interacting proteins

More...
DIPi
DIP-61993N

Protein interaction database and analysis system

More...
IntActi
Q6UX40, 37 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000314116

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IX7Q Eukaryota
ENOG4112136 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000014827

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000261639

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6UX40

KEGG Orthology (KO)

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KOi
K22764

Identification of Orthologs from Complete Genome Data

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OMAi
LGVSMFN

Database of Orthologous Groups

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OrthoDBi
1508335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UX40

TreeFam database of animal gene trees

More...
TreeFami
TF328441

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029248 TMEM107

The PANTHER Classification System

More...
PANTHERi
PTHR34341 PTHR34341, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14995 TMEM107, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UX40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRVSGLVPS RFLTLLAHLV VVITLFWSRD SNIQACLPLT FTPEEYDKQD
60 70 80 90 100
IQLVAALSVT LGLFAVELAG FLSGVSMFNS TQSLISIGAH CSASVALSFF
110 120 130 140
IFERWECTTY WYIFVFCSAL PAVTEMALFV TVFGLKKKPF
Length:140
Mass (Da):15,503
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2ED164C9F379EDD
GO
Isoform 2 (identifier: Q6UX40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-30: D → VRPTAALNPS...FNDVLNPAVY
     31-140: Missing.

Note: No experimental confirmation available.
Show »
Length:163
Mass (Da):17,605
Checksum:iFA733A83F522F896
GO
Isoform 3 (identifier: Q6UX40-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Q → HPLPLCR
     111-118: WYIFVFCS → C

Note: No experimental confirmation available.
Show »
Length:139
Mass (Da):15,249
Checksum:iC78CFAD7B8CBD8C7
GO
Isoform 4 (identifier: Q6UX40-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Q → HPLPLCR

Show »
Length:146
Mass (Da):16,192
Checksum:iA166E2EB1727C957
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KNL7B3KNL7_HUMAN
Transmembrane protein 107
TMEM107
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIH0E9PIH0_HUMAN
Transmembrane protein 107
TMEM107
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2RDT5B2RDT5_HUMAN
Transmembrane protein 107
TMEM107
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK38512 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07932845E → G in OFD16; does not affect subcellular location at ciliary transition zone. 1 PublicationCorresponds to variant dbSNP:rs1555526172EnsemblClinVar.1
Natural variantiVAR_079329100Missing in MKS13 and OFD16; does not affect subcellular location at ciliary transition zone; significantly decreases cilium assembly from patient's skin primary fibroblast; impairs protein localization to cilium from patient's skin primary fibroblast. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02121030D → VRPTAALNPSPFPSLSGPSP TLPPPSVLPSWVFLFPAAPR PALQPAPFSLLSAGWWPRSL SPWASLQWSWPVSSQESPCS TAPRASSVSFLPAHLSHTTH FYQDSLQPPDTIVSAVANPS SSKIFNDVLNPAVY in isoform 2. 1 Publication1
Alternative sequenceiVSP_02121131 – 140Missing in isoform 2. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_02121252Q → HPLPLCR in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_021213111 – 118WYIFVFCS → C in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF311338 mRNA Translation: AAK38512.1 Frameshift.
AY358525 mRNA Translation: AAQ88889.1
AK127891 mRNA Translation: BAC87177.1
AC129492 Genomic DNA No translation available.
BC070231 mRNA Translation: AAH70231.1
BC127649 mRNA Translation: AAI27650.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11132.1 [Q6UX40-4]
CCDS45607.1 [Q6UX40-1]
CCDS86572.1 [Q6UX40-3]

NCBI Reference Sequences

More...
RefSeqi
NP_115730.2, NM_032354.3 [Q6UX40-4]
NP_898888.1, NM_183065.2 [Q6UX40-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316425; ENSP00000314116; ENSG00000179029 [Q6UX40-4]
ENST00000437139; ENSP00000402732; ENSG00000179029 [Q6UX40-1]
ENST00000533070; ENSP00000436674; ENSG00000179029 [Q6UX40-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84314

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84314

UCSC genome browser

More...
UCSCi
uc002gkg.5 human [Q6UX40-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311338 mRNA Translation: AAK38512.1 Frameshift.
AY358525 mRNA Translation: AAQ88889.1
AK127891 mRNA Translation: BAC87177.1
AC129492 Genomic DNA No translation available.
BC070231 mRNA Translation: AAH70231.1
BC127649 mRNA Translation: AAI27650.1
CCDSiCCDS11132.1 [Q6UX40-4]
CCDS45607.1 [Q6UX40-1]
CCDS86572.1 [Q6UX40-3]
RefSeqiNP_115730.2, NM_032354.3 [Q6UX40-4]
NP_898888.1, NM_183065.2 [Q6UX40-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124040, 7 interactors
DIPiDIP-61993N
IntActiQ6UX40, 37 interactors
STRINGi9606.ENSP00000314116

Polymorphism and mutation databases

BioMutaiTMEM107
DMDMi74738174

Proteomic databases

MassIVEiQ6UX40
PaxDbiQ6UX40
PeptideAtlasiQ6UX40
PRIDEiQ6UX40
ProteomicsDBi67558 [Q6UX40-1]
67559 [Q6UX40-2]
67560 [Q6UX40-3]
67561 [Q6UX40-4]
TopDownProteomicsiQ6UX40-4 [Q6UX40-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84314

Genome annotation databases

EnsembliENST00000316425; ENSP00000314116; ENSG00000179029 [Q6UX40-4]
ENST00000437139; ENSP00000402732; ENSG00000179029 [Q6UX40-1]
ENST00000533070; ENSP00000436674; ENSG00000179029 [Q6UX40-3]
GeneIDi84314
KEGGihsa:84314
UCSCiuc002gkg.5 human [Q6UX40-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84314
DisGeNETi84314

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM107
GeneReviewsiTMEM107
HGNCiHGNC:28128 TMEM107
HPAiHPA052555
HPA059653
MalaCardsiTMEM107
MIMi616183 gene
617562 phenotype
617563 phenotype
neXtProtiNX_Q6UX40
OpenTargetsiENSG00000179029
Orphaneti564 Meckel syndrome
PharmGKBiPA142670758

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IX7Q Eukaryota
ENOG4112136 LUCA
GeneTreeiENSGT00390000014827
HOGENOMiHOG000261639
InParanoidiQ6UX40
KOiK22764
OMAiLGVSMFN
OrthoDBi1508335at2759
PhylomeDBiQ6UX40
TreeFamiTF328441

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMEM107 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84314
PharosiQ6UX40

Protein Ontology

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PROi
PR:Q6UX40

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000179029 Expressed in 189 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ6UX40 baseline and differential
GenevisibleiQ6UX40 HS

Family and domain databases

InterProiView protein in InterPro
IPR029248 TMEM107
PANTHERiPTHR34341 PTHR34341, 1 hit
PfamiView protein in Pfam
PF14995 TMEM107, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM107_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UX40
Secondary accession number(s): A0PJV7
, Q6NSE3, Q6ZRX9, Q96T82
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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