Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 115 (10 Apr 2019)
Sequence version 2 (18 May 2010)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

V-set and transmembrane domain-containing protein 1

Gene

VSTM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 2: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).
Isoform 1: Inhibitory immune receptor involved in the regulation of phagocytes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processImmunity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
V-set and transmembrane domain-containing protein 1
Alternative name(s):
Signal inhibitory receptor on leukocytes-1
Short name:
SIRL-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VSTM1
ORF Names:UNQ3033/PRO9835
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000189068.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29455 VSTM1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UX27

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini17 – 135ExtracellularSequence analysisAdd BLAST119
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 236CytoplasmicSequence analysisAdd BLAST80

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
284415

Open Targets

More...
OpenTargetsi
ENSG00000189068

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA147357166

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VSTM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452860

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 161 PublicationAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000027226917 – 236V-set and transmembrane domain-containing protein 1Add BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 96PROSITE-ProRule annotation
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 2 is N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UX27

PeptideAtlas

More...
PeptideAtlasi
Q6UX27

PRoteomics IDEntifications database

More...
PRIDEi
Q6UX27

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67552
67553 [Q6UX27-2]
67554 [Q6UX27-3]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed on myeloid (neutrophils, eosinophils and monocytes) but not on lymphoid cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000189068 Expressed in 60 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6UX27 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059365

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129868, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q6UX27, 24 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000343366

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6UX27

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 114Ig-like V-typeAdd BLAST88

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi204 – 209ITIM motif 16
Motifi229 – 234ITIM motif 26

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JAT8 Eukaryota
ENOG4111920 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183217

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000169142

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG094149

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UX27

Identification of Orthologs from Complete Genome Data

More...
OMAi
FFIYRCS

Database of Orthologous Groups

More...
OrthoDBi
1327293at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UX27

TreeFam database of animal gene trees

More...
TreeFami
TF336644

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13895 Ig_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UX27-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAEFLSLLC LGLCLGYEDE KKNEKPPKPS LHAWPSSVVE AESNVTLKCQ
60 70 80 90 100
AHSQNVTFVL RKVNDSGYKQ EQSSAENEAE FPFTDLKPKD AGRYFCAYKT
110 120 130 140 150
TASHEWSESS EHLQLVVTDK HDELEAPSMK TDTRTIFVAI FSCISILLLF
160 170 180 190 200
LSVFIIYRCS QHSSSSEEST KRTSHSKLPE QEAAEADLSN MERVSLSTAD
210 220 230
PQGVTYAELS TSALSEAASD TTQEPPGSHE YAALKV
Length:236
Mass (Da):26,109
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i508E7881ADF6E1A5
GO
Isoform 2 (identifier: Q6UX27-2) [UniParc]FASTAAdd to basket
Also known as: VSTM1-v2

The sequence of this isoform differs from the canonical sequence as follows:
     132-163: DTRTIFVAIFSCISILLLFLSVFIIYRCSQHS → G

Note: Mainly detected in immune tissues and cells.
Show »
Length:205
Mass (Da):22,477
Checksum:i928B3164EBB56EA7
GO
Isoform 3 (identifier: Q6UX27-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-174: SSSEESTKRTS → ELRERKGREGE
     175-236: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:174
Mass (Da):19,769
Checksum:iE6C14FDA594C1DF4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D2DJS5D2DJS5_HUMAN
V-set and transmembrane domain cont...
VSTM1
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G8JLN4G8JLN4_HUMAN
V-set and transmembrane domain-cont...
VSTM1
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPS7A0A0G2JPS7_HUMAN
V-set and transmembrane domain-cont...
VSTM1
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y636A0A2R8Y636_HUMAN
V-set and transmembrane domain-cont...
VSTM1
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C340H7C340_HUMAN
V-set and transmembrane domain-cont...
VSTM1
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030034163S → G3 PublicationsCorresponds to variant dbSNP:rs2433724Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022381132 – 163DTRTI…CSQHS → G in isoform 2. 2 PublicationsAdd BLAST32
Alternative sequenceiVSP_022382164 – 174SSSEESTKRTS → ELRERKGREGE in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_022383175 – 236Missing in isoform 3. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FJ584316 mRNA Translation: ACU00108.1
FJ584317 mRNA Translation: ACU00109.1
FJ584318 mRNA Translation: ACU00110.1
FN398145 mRNA Translation: CAZ61324.1
DQ479397 mRNA Translation: ABF19807.1
AY358542 mRNA Translation: AAQ88906.1
AC012314 Genomic DNA No translation available.
BC100942 mRNA Translation: AAI00943.1
BC100943 mRNA Translation: AAI00944.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12872.1 [Q6UX27-1]
CCDS74442.1 [Q6UX27-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001275720.1, NM_001288791.1
NP_001275721.1, NM_001288792.1 [Q6UX27-2]
NP_001275722.1, NM_001288793.1
NP_940883.2, NM_198481.3 [Q6UX27-1]
XP_016882155.1, XM_017026666.1 [Q6UX27-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.444431

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338372; ENSP00000343366; ENSG00000189068 [Q6UX27-1]
ENST00000376626; ENSP00000365813; ENSG00000189068 [Q6UX27-2]
ENST00000447872; ENSP00000401926; ENSG00000189068 [Q6UX27-3]
ENST00000610629; ENSP00000482197; ENSG00000274953 [Q6UX27-1]
ENST00000610794; ENSP00000478582; ENSG00000276159 [Q6UX27-1]
ENST00000610804; ENSP00000480533; ENSG00000274887 [Q6UX27-1]
ENST00000611293; ENSP00000482555; ENSG00000275330 [Q6UX27-1]
ENST00000612105; ENSP00000483412; ENSG00000275577 [Q6UX27-1]
ENST00000612436; ENSP00000482985; ENSG00000276066 [Q6UX27-1]
ENST00000612864; ENSP00000481977; ENSG00000275962 [Q6UX27-3]
ENST00000613042; ENSP00000479748; ENSG00000275577 [Q6UX27-2]
ENST00000615235; ENSP00000479198; ENSG00000277607 [Q6UX27-2]
ENST00000615508; ENSP00000484886; ENSG00000276066 [Q6UX27-2]
ENST00000616717; ENSP00000480383; ENSG00000274953 [Q6UX27-2]
ENST00000617115; ENSP00000481140; ENSG00000275330 [Q6UX27-2]
ENST00000617281; ENSP00000480547; ENSG00000277607 [Q6UX27-1]
ENST00000617776; ENSP00000484699; ENSG00000275962 [Q6UX27-2]
ENST00000617862; ENSP00000484844; ENSG00000276363 [Q6UX27-1]
ENST00000619024; ENSP00000483411; ENSG00000276159 [Q6UX27-2]
ENST00000619921; ENSP00000483797; ENSG00000276363 [Q6UX27-2]
ENST00000620474; ENSP00000484806; ENSG00000275962 [Q6UX27-1]
ENST00000622762; ENSP00000483104; ENSG00000274887 [Q6UX27-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
284415

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:284415

UCSC genome browser

More...
UCSCi
uc002qcw.5 human [Q6UX27-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ584316 mRNA Translation: ACU00108.1
FJ584317 mRNA Translation: ACU00109.1
FJ584318 mRNA Translation: ACU00110.1
FN398145 mRNA Translation: CAZ61324.1
DQ479397 mRNA Translation: ABF19807.1
AY358542 mRNA Translation: AAQ88906.1
AC012314 Genomic DNA No translation available.
BC100942 mRNA Translation: AAI00943.1
BC100943 mRNA Translation: AAI00944.1
CCDSiCCDS12872.1 [Q6UX27-1]
CCDS74442.1 [Q6UX27-2]
RefSeqiNP_001275720.1, NM_001288791.1
NP_001275721.1, NM_001288792.1 [Q6UX27-2]
NP_001275722.1, NM_001288793.1
NP_940883.2, NM_198481.3 [Q6UX27-1]
XP_016882155.1, XM_017026666.1 [Q6UX27-3]
UniGeneiHs.444431

3D structure databases

ProteinModelPortaliQ6UX27
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129868, 13 interactors
IntActiQ6UX27, 24 interactors
STRINGi9606.ENSP00000343366

Polymorphism and mutation databases

BioMutaiVSTM1
DMDMi296452860

Proteomic databases

PaxDbiQ6UX27
PeptideAtlasiQ6UX27
PRIDEiQ6UX27
ProteomicsDBi67552
67553 [Q6UX27-2]
67554 [Q6UX27-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338372; ENSP00000343366; ENSG00000189068 [Q6UX27-1]
ENST00000376626; ENSP00000365813; ENSG00000189068 [Q6UX27-2]
ENST00000447872; ENSP00000401926; ENSG00000189068 [Q6UX27-3]
ENST00000610629; ENSP00000482197; ENSG00000274953 [Q6UX27-1]
ENST00000610794; ENSP00000478582; ENSG00000276159 [Q6UX27-1]
ENST00000610804; ENSP00000480533; ENSG00000274887 [Q6UX27-1]
ENST00000611293; ENSP00000482555; ENSG00000275330 [Q6UX27-1]
ENST00000612105; ENSP00000483412; ENSG00000275577 [Q6UX27-1]
ENST00000612436; ENSP00000482985; ENSG00000276066 [Q6UX27-1]
ENST00000612864; ENSP00000481977; ENSG00000275962 [Q6UX27-3]
ENST00000613042; ENSP00000479748; ENSG00000275577 [Q6UX27-2]
ENST00000615235; ENSP00000479198; ENSG00000277607 [Q6UX27-2]
ENST00000615508; ENSP00000484886; ENSG00000276066 [Q6UX27-2]
ENST00000616717; ENSP00000480383; ENSG00000274953 [Q6UX27-2]
ENST00000617115; ENSP00000481140; ENSG00000275330 [Q6UX27-2]
ENST00000617281; ENSP00000480547; ENSG00000277607 [Q6UX27-1]
ENST00000617776; ENSP00000484699; ENSG00000275962 [Q6UX27-2]
ENST00000617862; ENSP00000484844; ENSG00000276363 [Q6UX27-1]
ENST00000619024; ENSP00000483411; ENSG00000276159 [Q6UX27-2]
ENST00000619921; ENSP00000483797; ENSG00000276363 [Q6UX27-2]
ENST00000620474; ENSP00000484806; ENSG00000275962 [Q6UX27-1]
ENST00000622762; ENSP00000483104; ENSG00000274887 [Q6UX27-2]
GeneIDi284415
KEGGihsa:284415
UCSCiuc002qcw.5 human [Q6UX27-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
284415
DisGeNETi284415
EuPathDBiHostDB:ENSG00000189068.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
VSTM1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0202932
HGNCiHGNC:29455 VSTM1
HPAiHPA059365
neXtProtiNX_Q6UX27
OpenTargetsiENSG00000189068
PharmGKBiPA147357166

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JAT8 Eukaryota
ENOG4111920 LUCA
GeneTreeiENSGT00950000183217
HOGENOMiHOG000169142
HOVERGENiHBG094149
InParanoidiQ6UX27
OMAiFFIYRCS
OrthoDBi1327293at2759
PhylomeDBiQ6UX27
TreeFamiTF336644

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
284415

Protein Ontology

More...
PROi
PR:Q6UX27

Gene expression databases

BgeeiENSG00000189068 Expressed in 60 organ(s), highest expression level in blood
ExpressionAtlasiQ6UX27 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVSTM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UX27
Secondary accession number(s): B6A8C6
, D2DJS3, D2DJS4, Q496B6, Q496B7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 18, 2010
Last modified: April 10, 2019
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again