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Protein

V-set and transmembrane domain-containing protein 1

Gene

VSTM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 2: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).
Isoform 1: Inhibitory immune receptor involved in the regulation of phagocytes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and transmembrane domain-containing protein 1
Alternative name(s):
Signal inhibitory receptor on leukocytes-1
Short name:
SIRL-1
Gene namesi
Name:VSTM1
ORF Names:UNQ3033/PRO9835
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000189068.9
HGNCiHGNC:29455 VSTM1
neXtProtiNX_Q6UX27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 135ExtracellularSequence analysisAdd BLAST119
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 236CytoplasmicSequence analysisAdd BLAST80

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi284415
OpenTargetsiENSG00000189068
PharmGKBiPA147357166

Polymorphism and mutation databases

BioMutaiVSTM1
DMDMi296452860

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
ChainiPRO_000027226917 – 236V-set and transmembrane domain-containing protein 1Add BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi49 ↔ 96PROSITE-ProRule annotation
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Isoform 2 is N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UX27
PeptideAtlasiQ6UX27
PRIDEiQ6UX27
ProteomicsDBi67552
67553 [Q6UX27-2]
67554 [Q6UX27-3]

Expressioni

Tissue specificityi

Expressed on myeloid (neutrophils, eosinophils and monocytes) but not on lymphoid cells.1 Publication

Gene expression databases

BgeeiENSG00000189068 Expressed in 60 organ(s), highest expression level in blood
CleanExiHS_VSTM1
ExpressionAtlasiQ6UX27 baseline and differential

Organism-specific databases

HPAiHPA059365

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129868, 13 interactors
IntActiQ6UX27, 24 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6UX27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 114Ig-like V-typeAdd BLAST88

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi204 – 209ITIM motif 16
Motifi229 – 234ITIM motif 26

Domaini

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAT8 Eukaryota
ENOG4111920 LUCA
GeneTreeiENSGT00440000034633
HOGENOMiHOG000169142
HOVERGENiHBG094149
InParanoidiQ6UX27
OMAiDSGYKQE
OrthoDBiEOG091G0V18
PhylomeDBiQ6UX27
TreeFamiTF336644

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UX27-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAEFLSLLC LGLCLGYEDE KKNEKPPKPS LHAWPSSVVE AESNVTLKCQ
60 70 80 90 100
AHSQNVTFVL RKVNDSGYKQ EQSSAENEAE FPFTDLKPKD AGRYFCAYKT
110 120 130 140 150
TASHEWSESS EHLQLVVTDK HDELEAPSMK TDTRTIFVAI FSCISILLLF
160 170 180 190 200
LSVFIIYRCS QHSSSSEEST KRTSHSKLPE QEAAEADLSN MERVSLSTAD
210 220 230
PQGVTYAELS TSALSEAASD TTQEPPGSHE YAALKV
Length:236
Mass (Da):26,109
Last modified:May 18, 2010 - v2
Checksum:i508E7881ADF6E1A5
GO
Isoform 2 (identifier: Q6UX27-2) [UniParc]FASTAAdd to basket
Also known as: VSTM1-v2

The sequence of this isoform differs from the canonical sequence as follows:
     132-163: DTRTIFVAIFSCISILLLFLSVFIIYRCSQHS → G

Note: Mainly detected in immune tissues and cells.
Show »
Length:205
Mass (Da):22,477
Checksum:i928B3164EBB56EA7
GO
Isoform 3 (identifier: Q6UX27-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-174: SSSEESTKRTS → ELRERKGREGE
     175-236: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:174
Mass (Da):19,769
Checksum:iE6C14FDA594C1DF4
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D2DJS5D2DJS5_HUMAN
V-set and transmembrane domain cont...
VSTM1
116Annotation score:
G8JLN4G8JLN4_HUMAN
V-set and transmembrane domain-cont...
VSTM1
143Annotation score:
A0A0G2JPS7A0A0G2JPS7_HUMAN
V-set and transmembrane domain-cont...
VSTM1
148Annotation score:
A0A2R8Y636A0A2R8Y636_HUMAN
V-set and transmembrane domain-cont...
VSTM1
229Annotation score:
H7C340H7C340_HUMAN
V-set and transmembrane domain-cont...
VSTM1
126Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030034163S → G3 PublicationsCorresponds to variant dbSNP:rs2433724Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022381132 – 163DTRTI…CSQHS → G in isoform 2. 2 PublicationsAdd BLAST32
Alternative sequenceiVSP_022382164 – 174SSSEESTKRTS → ELRERKGREGE in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_022383175 – 236Missing in isoform 3. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ584316 mRNA Translation: ACU00108.1
FJ584317 mRNA Translation: ACU00109.1
FJ584318 mRNA Translation: ACU00110.1
FN398145 mRNA Translation: CAZ61324.1
DQ479397 mRNA Translation: ABF19807.1
AY358542 mRNA Translation: AAQ88906.1
AC012314 Genomic DNA No translation available.
BC100942 mRNA Translation: AAI00943.1
BC100943 mRNA Translation: AAI00944.1
CCDSiCCDS12872.1 [Q6UX27-1]
CCDS74442.1 [Q6UX27-2]
RefSeqiNP_001275720.1, NM_001288791.1
NP_001275721.1, NM_001288792.1 [Q6UX27-2]
NP_001275722.1, NM_001288793.1
NP_940883.2, NM_198481.3 [Q6UX27-1]
XP_016882155.1, XM_017026666.1 [Q6UX27-3]
UniGeneiHs.444431

Genome annotation databases

EnsembliENST00000338372; ENSP00000343366; ENSG00000189068 [Q6UX27-1]
ENST00000376626; ENSP00000365813; ENSG00000189068 [Q6UX27-2]
ENST00000447872; ENSP00000401926; ENSG00000189068 [Q6UX27-3]
ENST00000610629; ENSP00000482197; ENSG00000274953 [Q6UX27-1]
ENST00000610794; ENSP00000478582; ENSG00000276159 [Q6UX27-1]
ENST00000610804; ENSP00000480533; ENSG00000274887 [Q6UX27-1]
ENST00000611293; ENSP00000482555; ENSG00000275330 [Q6UX27-1]
ENST00000612105; ENSP00000483412; ENSG00000275577 [Q6UX27-1]
ENST00000612436; ENSP00000482985; ENSG00000276066 [Q6UX27-1]
ENST00000612864; ENSP00000481977; ENSG00000275962 [Q6UX27-3]
ENST00000613042; ENSP00000479748; ENSG00000275577 [Q6UX27-2]
ENST00000615235; ENSP00000479198; ENSG00000277607 [Q6UX27-2]
ENST00000615508; ENSP00000484886; ENSG00000276066 [Q6UX27-2]
ENST00000616717; ENSP00000480383; ENSG00000274953 [Q6UX27-2]
ENST00000617115; ENSP00000481140; ENSG00000275330 [Q6UX27-2]
ENST00000617281; ENSP00000480547; ENSG00000277607 [Q6UX27-1]
ENST00000617776; ENSP00000484699; ENSG00000275962 [Q6UX27-2]
ENST00000617862; ENSP00000484844; ENSG00000276363 [Q6UX27-1]
ENST00000619024; ENSP00000483411; ENSG00000276159 [Q6UX27-2]
ENST00000619921; ENSP00000483797; ENSG00000276363 [Q6UX27-2]
ENST00000620474; ENSP00000484806; ENSG00000275962 [Q6UX27-1]
ENST00000622762; ENSP00000483104; ENSG00000274887 [Q6UX27-2]
GeneIDi284415
KEGGihsa:284415
UCSCiuc002qcw.5 human [Q6UX27-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ584316 mRNA Translation: ACU00108.1
FJ584317 mRNA Translation: ACU00109.1
FJ584318 mRNA Translation: ACU00110.1
FN398145 mRNA Translation: CAZ61324.1
DQ479397 mRNA Translation: ABF19807.1
AY358542 mRNA Translation: AAQ88906.1
AC012314 Genomic DNA No translation available.
BC100942 mRNA Translation: AAI00943.1
BC100943 mRNA Translation: AAI00944.1
CCDSiCCDS12872.1 [Q6UX27-1]
CCDS74442.1 [Q6UX27-2]
RefSeqiNP_001275720.1, NM_001288791.1
NP_001275721.1, NM_001288792.1 [Q6UX27-2]
NP_001275722.1, NM_001288793.1
NP_940883.2, NM_198481.3 [Q6UX27-1]
XP_016882155.1, XM_017026666.1 [Q6UX27-3]
UniGeneiHs.444431

3D structure databases

ProteinModelPortaliQ6UX27
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129868, 13 interactors
IntActiQ6UX27, 24 interactors

Polymorphism and mutation databases

BioMutaiVSTM1
DMDMi296452860

Proteomic databases

PaxDbiQ6UX27
PeptideAtlasiQ6UX27
PRIDEiQ6UX27
ProteomicsDBi67552
67553 [Q6UX27-2]
67554 [Q6UX27-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338372; ENSP00000343366; ENSG00000189068 [Q6UX27-1]
ENST00000376626; ENSP00000365813; ENSG00000189068 [Q6UX27-2]
ENST00000447872; ENSP00000401926; ENSG00000189068 [Q6UX27-3]
ENST00000610629; ENSP00000482197; ENSG00000274953 [Q6UX27-1]
ENST00000610794; ENSP00000478582; ENSG00000276159 [Q6UX27-1]
ENST00000610804; ENSP00000480533; ENSG00000274887 [Q6UX27-1]
ENST00000611293; ENSP00000482555; ENSG00000275330 [Q6UX27-1]
ENST00000612105; ENSP00000483412; ENSG00000275577 [Q6UX27-1]
ENST00000612436; ENSP00000482985; ENSG00000276066 [Q6UX27-1]
ENST00000612864; ENSP00000481977; ENSG00000275962 [Q6UX27-3]
ENST00000613042; ENSP00000479748; ENSG00000275577 [Q6UX27-2]
ENST00000615235; ENSP00000479198; ENSG00000277607 [Q6UX27-2]
ENST00000615508; ENSP00000484886; ENSG00000276066 [Q6UX27-2]
ENST00000616717; ENSP00000480383; ENSG00000274953 [Q6UX27-2]
ENST00000617115; ENSP00000481140; ENSG00000275330 [Q6UX27-2]
ENST00000617281; ENSP00000480547; ENSG00000277607 [Q6UX27-1]
ENST00000617776; ENSP00000484699; ENSG00000275962 [Q6UX27-2]
ENST00000617862; ENSP00000484844; ENSG00000276363 [Q6UX27-1]
ENST00000619024; ENSP00000483411; ENSG00000276159 [Q6UX27-2]
ENST00000619921; ENSP00000483797; ENSG00000276363 [Q6UX27-2]
ENST00000620474; ENSP00000484806; ENSG00000275962 [Q6UX27-1]
ENST00000622762; ENSP00000483104; ENSG00000274887 [Q6UX27-2]
GeneIDi284415
KEGGihsa:284415
UCSCiuc002qcw.5 human [Q6UX27-1]

Organism-specific databases

CTDi284415
DisGeNETi284415
EuPathDBiHostDB:ENSG00000189068.9
GeneCardsiVSTM1
H-InvDBiHIX0202932
HGNCiHGNC:29455 VSTM1
HPAiHPA059365
neXtProtiNX_Q6UX27
OpenTargetsiENSG00000189068
PharmGKBiPA147357166
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAT8 Eukaryota
ENOG4111920 LUCA
GeneTreeiENSGT00440000034633
HOGENOMiHOG000169142
HOVERGENiHBG094149
InParanoidiQ6UX27
OMAiDSGYKQE
OrthoDBiEOG091G0V18
PhylomeDBiQ6UX27
TreeFamiTF336644

Miscellaneous databases

GenomeRNAii284415
PROiPR:Q6UX27

Gene expression databases

BgeeiENSG00000189068 Expressed in 60 organ(s), highest expression level in blood
CleanExiHS_VSTM1
ExpressionAtlasiQ6UX27 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVSTM1_HUMAN
AccessioniPrimary (citable) accession number: Q6UX27
Secondary accession number(s): B6A8C6
, D2DJS3, D2DJS4, Q496B6, Q496B7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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