UniProtKB - Q6UX07 (DHR13_HUMAN)
Protein
Dehydrogenase/reductase SDR family member 13
Gene
DHRS13
Organism
Homo sapiens (Human)
Status
Functioni
Putative oxidoreductase.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 170 | SubstrateSequence analysis | 1 | |
Active sitei | 197 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 43 – 49 | NAD or NADPBy similarity | 7 |
GO - Molecular functioni
- NADP-retinol dehydrogenase activity Source: GO_Central
GO - Biological processi
- retinal metabolic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD, NADP |
Enzyme and pathway databases
PathwayCommonsi | Q6UX07 |
Names & Taxonomyi
Protein namesi | Recommended name: Dehydrogenase/reductase SDR family member 13 (EC:1.1.-.-)Alternative name(s): Short chain dehydrogenase/reductase family 7C member 51 Publication |
Gene namesi | Name:DHRS13 Synonyms:SDR7C51 Publication ORF Names:UNQ419/PRO853 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28326, DHRS13 |
MIMi | 616157, gene |
neXtProti | NX_Q6UX07 |
VEuPathDBi | HostDB:ENSG00000167536.13 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Mitochondrion
- mitochondrial inner membrane Source: GO_Central
Other locations
- membrane Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 147015 |
OpenTargetsi | ENSG00000167536 |
PharmGKBi | PA147358144 |
Miscellaneous databases
Pharosi | Q6UX07, Tdark |
Genetic variation databases
BioMutai | DHRS13 |
DMDMi | 74738164 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000311920 | 26 – 377 | Dehydrogenase/reductase SDR family member 13Add BLAST | 352 |
Proteomic databases
EPDi | Q6UX07 |
jPOSTi | Q6UX07 |
MassIVEi | Q6UX07 |
MaxQBi | Q6UX07 |
PaxDbi | Q6UX07 |
PeptideAtlasi | Q6UX07 |
PRIDEi | Q6UX07 |
ProteomicsDBi | 4366 67548 [Q6UX07-1] 67549 [Q6UX07-2] |
TopDownProteomicsi | Q6UX07-1 [Q6UX07-1] |
PTM databases
iPTMneti | Q6UX07 |
PhosphoSitePlusi | Q6UX07 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167536, Expressed in prostate gland and 175 other tissues |
Genevisiblei | Q6UX07, HS |
Organism-specific databases
HPAi | ENSG00000167536, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127030, 11 interactors |
IntActi | Q6UX07, 4 interactors |
STRINGi | 9606.ENSP00000368173 |
Miscellaneous databases
RNActi | Q6UX07, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1208, Eukaryota |
GeneTreei | ENSGT00940000155599 |
HOGENOMi | CLU_010194_44_5_1 |
InParanoidi | Q6UX07 |
OMAi | CALQQVG |
OrthoDBi | 1076292at2759 |
PhylomeDBi | Q6UX07 |
TreeFami | TF105429 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH |
SUPFAMi | SSF51735, SSF51735, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q6UX07-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEALLLGAGL LLGAYVLVYY NLVKAPPCGG MGNLRGRTAV VTGANSGIGK
60 70 80 90 100
MTALELARRG ARVVLACRSQ ERGEAAAFDL RQESGNNEVI FMALDLASLA
110 120 130 140 150
SVRAFATAFL SSEPRLDILI HNAGISSCGR TREAFNLLLR VNHIGPFLLT
160 170 180 190 200
HLLLPCLKAC APSRVVVVAS AAHCRGRLDF KRLDRPVVGW RQELRAYADT
210 220 230 240 250
KLANVLFARE LANQLEATGV TCYAAHPGPV NSELFLRHVP GWLRPLLRPL
260 270 280 290 300
AWLVLRAPRG GAQTPLYCAL QEGIEPLSGR YFANCHVEEV PPAARDDRAA
310 320 330 340 350
HRLWEASKRL AGLGPGEDAE PDEDPQSEDS EAPSSLSTPH PEEPTVSQPY
360 370
PSPQSSPDLS KMTHRIQAKV EPEIQLS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037348 | 191 | R → Q. Corresponds to variant dbSNP:rs2277666Ensembl. | 1 | |
Natural variantiVAR_037349 | 336 | L → Q. Corresponds to variant dbSNP:rs4795472Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029640 | 1 – 50 | Missing in isoform 2. 1 PublicationAdd BLAST | 50 | |
Alternative sequenceiVSP_057529 | 43 – 123 | Missing in isoform 3. 1 PublicationAdd BLAST | 81 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358566 mRNA Translation: AAQ88929.1 AK296017 mRNA Translation: BAG58787.1 AC024267 Genomic DNA No translation available. CH471159 Genomic DNA Translation: EAW51159.1 CH471159 Genomic DNA Translation: EAW51153.1 BC015582 mRNA Translation: AAH15582.1 |
CCDSi | CCDS11246.2 [Q6UX07-1] |
RefSeqi | NP_653284.2, NM_144683.3 [Q6UX07-1] |
Genome annotation databases
Ensembli | ENST00000378895; ENSP00000368173; ENSG00000167536 [Q6UX07-1] ENST00000394901; ENSP00000378361; ENSG00000167536 [Q6UX07-2] ENST00000426464; ENSP00000412826; ENSG00000167536 [Q6UX07-3] |
GeneIDi | 147015 |
KEGGi | hsa:147015 |
UCSCi | uc002hdd.5, human [Q6UX07-1] uc010wba.3, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358566 mRNA Translation: AAQ88929.1 AK296017 mRNA Translation: BAG58787.1 AC024267 Genomic DNA No translation available. CH471159 Genomic DNA Translation: EAW51159.1 CH471159 Genomic DNA Translation: EAW51153.1 BC015582 mRNA Translation: AAH15582.1 |
CCDSi | CCDS11246.2 [Q6UX07-1] |
RefSeqi | NP_653284.2, NM_144683.3 [Q6UX07-1] |
3D structure databases
SMRi | Q6UX07 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127030, 11 interactors |
IntActi | Q6UX07, 4 interactors |
STRINGi | 9606.ENSP00000368173 |
PTM databases
iPTMneti | Q6UX07 |
PhosphoSitePlusi | Q6UX07 |
Genetic variation databases
BioMutai | DHRS13 |
DMDMi | 74738164 |
Proteomic databases
EPDi | Q6UX07 |
jPOSTi | Q6UX07 |
MassIVEi | Q6UX07 |
MaxQBi | Q6UX07 |
PaxDbi | Q6UX07 |
PeptideAtlasi | Q6UX07 |
PRIDEi | Q6UX07 |
ProteomicsDBi | 4366 67548 [Q6UX07-1] 67549 [Q6UX07-2] |
TopDownProteomicsi | Q6UX07-1 [Q6UX07-1] |
Protocols and materials databases
Antibodypediai | 14931, 78 antibodies |
Genome annotation databases
Ensembli | ENST00000378895; ENSP00000368173; ENSG00000167536 [Q6UX07-1] ENST00000394901; ENSP00000378361; ENSG00000167536 [Q6UX07-2] ENST00000426464; ENSP00000412826; ENSG00000167536 [Q6UX07-3] |
GeneIDi | 147015 |
KEGGi | hsa:147015 |
UCSCi | uc002hdd.5, human [Q6UX07-1] uc010wba.3, human |
Organism-specific databases
CTDi | 147015 |
DisGeNETi | 147015 |
GeneCardsi | DHRS13 |
HGNCi | HGNC:28326, DHRS13 |
HPAi | ENSG00000167536, Low tissue specificity |
MIMi | 616157, gene |
neXtProti | NX_Q6UX07 |
OpenTargetsi | ENSG00000167536 |
PharmGKBi | PA147358144 |
VEuPathDBi | HostDB:ENSG00000167536.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1208, Eukaryota |
GeneTreei | ENSGT00940000155599 |
HOGENOMi | CLU_010194_44_5_1 |
InParanoidi | Q6UX07 |
OMAi | CALQQVG |
OrthoDBi | 1076292at2759 |
PhylomeDBi | Q6UX07 |
TreeFami | TF105429 |
Enzyme and pathway databases
PathwayCommonsi | Q6UX07 |
Miscellaneous databases
BioGRID-ORCSi | 147015, 6 hits in 876 CRISPR screens |
ChiTaRSi | DHRS13, human |
GenomeRNAii | 147015 |
Pharosi | Q6UX07, Tdark |
PROi | PR:Q6UX07 |
RNActi | Q6UX07, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167536, Expressed in prostate gland and 175 other tissues |
Genevisiblei | Q6UX07, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH |
SUPFAMi | SSF51735, SSF51735, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DHR13_HUMAN | |
Accessioni | Q6UX07Primary (citable) accession number: Q6UX07 Secondary accession number(s): B4DJC5, Q96BH7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families