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Protein

Olfactomedin-4

Gene

OLFM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.3 Publications

GO - Molecular functioni

  • cadherin binding Source: UniProtKB
  • catalytic activity Source: InterPro
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactomedin-4
Short name:
OLM4
Alternative name(s):
Antiapoptotic protein GW112
G-CSF-stimulated clone 1 protein
Short name:
hGC-1
hOLfD
Gene namesi
Name:OLFM4
Synonyms:GW112
ORF Names:UNQ362/PRO698
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102837.6
HGNCiHGNC:17190 OLFM4
MIMi614061 gene
neXtProtiNX_Q6UX06

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi83C → A: Abolishes secretion. No effect on multimer formation. 1 Publication1
Mutagenesisi85C → A: Abolishes secretion. No effect on multimer formation. 1 Publication1
Mutagenesisi226C → A: No effect on secretion. Affects multimer formation. 1 Publication1
Mutagenesisi246C → A: Abolishes secretion. No effect on multimer formation. 1 Publication1
Mutagenesisi437C → A: Abolishes secretion. No effect on multimer formation. 1 Publication1

Organism-specific databases

DisGeNETi10562
OpenTargetsiENSG00000102837
PharmGKBiPA134984745

Polymorphism and mutation databases

BioMutaiOLFM4
DMDMi74749412

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000031139821 – 510Olfactomedin-4Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi246 ↔ 437PROSITE-ProRule annotation
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UX06
PeptideAtlasiQ6UX06
PRIDEiQ6UX06
ProteomicsDBi67547

PTM databases

iPTMnetiQ6UX06
PhosphoSitePlusiQ6UX06

Expressioni

Tissue specificityi

Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues.4 Publications

Developmental stagei

Elevated expression during the early S phase of the cell cycle, followed by a gradual decrease during late S phase.1 Publication

Inductioni

By retinoic acid. This induction requires functional NFKB pathway.1 Publication

Gene expression databases

BgeeiENSG00000102837 Expressed in 145 organ(s), highest expression level in caecum
CleanExiHS_OLFM4
ExpressionAtlasiQ6UX06 baseline and differential
GenevisibleiQ6UX06 HS

Organism-specific databases

HPAiHPA077718

Interactioni

Subunit structurei

Homomultimer; disulfide-linked. Interacts with NDUFA13. Interacts with cell surface lectins (locutions ricinus communis agglutinin I, concanavalin-A and wheat germ agglutinin) and cadherin.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115813, 37 interactors
DIPiDIP-59533N
IntActiQ6UX06, 31 interactors
STRINGi9606.ENSP00000219022

Structurei

3D structure databases

ProteinModelPortaliQ6UX06
SMRiQ6UX06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini245 – 507Olfactomedin-likePROSITE-ProRule annotationAdd BLAST263

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili155 – 234Sequence analysisAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 71Ser-richAdd BLAST41

Domaini

The olfactomedin-like domain is involved in the interaction with cadherin.1 Publication

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410INPB Eukaryota
ENOG410ZRPP LUCA
GeneTreeiENSGT00760000119005
HOGENOMiHOG000115264
HOVERGENiHBG106662
InParanoidiQ6UX06
OMAiGTCQCSV
OrthoDBiEOG091G0688
PhylomeDBiQ6UX06
TreeFamiTF315964

Family and domain databases

InterProiView protein in InterPro
IPR003112 Olfac-like_dom
IPR031221 Olfactomedin-4
IPR011041 Quinoprot_gluc/sorb_DH
PANTHERiPTHR23192:SF7 PTHR23192:SF7, 1 hit
PfamiView protein in Pfam
PF02191 OLF, 1 hit
SMARTiView protein in SMART
SM00284 OLF, 1 hit
SUPFAMiSSF50952 SSF50952, 1 hit
PROSITEiView protein in PROSITE
PS51132 OLF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UX06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPGLSFLLA LLFFLGQAAG DLGDVGPPIP SPGFSSFPGV DSSSSFSSSS
60 70 80 90 100
RSGSSSSRSL GSGGSVSQLF SNFTGSVDDR GTCQCSVSLP DTTFPVDRVE
110 120 130 140 150
RLEFTAHVLS QKFEKELSKV REYVQLISVY EKKLLNLTVR IDIMEKDTIS
160 170 180 190 200
YTELDFELIK VEVKEMEKLV IQLKESFGGS SEIVDQLEVE IRNMTLLVEK
210 220 230 240 250
LETLDKNNVL AIRREIVALK TKLKECEASK DQNTPVVHPP PTPGSCGHGG
260 270 280 290 300
VVNISKPSVV QLNWRGFSYL YGAWGRDYSP QHPNKGLYWV APLNTDGRLL
310 320 330 340 350
EYYRLYNTLD DLLLYINARE LRITYGQGSG TAVYNNNMYV NMYNTGNIAR
360 370 380 390 400
VNLTTNTIAV TQTLPNAAYN NRFSYANVAW QDIDFAVDEN GLWVIYSTEA
410 420 430 440 450
STGNMVISKL NDTTLQVLNT WYTKQYKPSA SNAFMVCGVL YATRTMNTRT
460 470 480 490 500
EEIFYYYDTN TGKEGKLDIV MHKMQEKVQS INYNPFDQKL YVYNDGYLLN
510
YDLSVLQKPQ
Length:510
Mass (Da):57,280
Last modified:April 12, 2005 - v1
Checksum:iACF03365D2164900
GO

Sequence cautioni

The sequence AAC72970 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAC72970 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129V → L in AAC72970 (PubMed:11867215).Curated1
Sequence conflicti304R → I in AAC72970 (PubMed:11867215).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03724636S → P. Corresponds to variant dbSNP:rs35790097Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358567 mRNA Translation: AAQ88930.1
AL390736 Genomic DNA No translation available.
CH471124 Genomic DNA Translation: EAW52052.1
BC047740 mRNA Translation: AAH47740.1
BC117329 mRNA Translation: AAI17330.1
AF097021 mRNA Translation: AAC72970.1 Sequence problems.
CCDSiCCDS9440.1
RefSeqiNP_006409.3, NM_006418.4
UniGeneiHs.508113

Genome annotation databases

EnsembliENST00000219022; ENSP00000219022; ENSG00000102837
GeneIDi10562
KEGGihsa:10562
UCSCiuc001vhl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358567 mRNA Translation: AAQ88930.1
AL390736 Genomic DNA No translation available.
CH471124 Genomic DNA Translation: EAW52052.1
BC047740 mRNA Translation: AAH47740.1
BC117329 mRNA Translation: AAI17330.1
AF097021 mRNA Translation: AAC72970.1 Sequence problems.
CCDSiCCDS9440.1
RefSeqiNP_006409.3, NM_006418.4
UniGeneiHs.508113

3D structure databases

ProteinModelPortaliQ6UX06
SMRiQ6UX06
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115813, 37 interactors
DIPiDIP-59533N
IntActiQ6UX06, 31 interactors
STRINGi9606.ENSP00000219022

PTM databases

iPTMnetiQ6UX06
PhosphoSitePlusiQ6UX06

Polymorphism and mutation databases

BioMutaiOLFM4
DMDMi74749412

Proteomic databases

PaxDbiQ6UX06
PeptideAtlasiQ6UX06
PRIDEiQ6UX06
ProteomicsDBi67547

Protocols and materials databases

DNASUi10562
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219022; ENSP00000219022; ENSG00000102837
GeneIDi10562
KEGGihsa:10562
UCSCiuc001vhl.4 human

Organism-specific databases

CTDi10562
DisGeNETi10562
EuPathDBiHostDB:ENSG00000102837.6
GeneCardsiOLFM4
HGNCiHGNC:17190 OLFM4
HPAiHPA077718
MIMi614061 gene
neXtProtiNX_Q6UX06
OpenTargetsiENSG00000102837
PharmGKBiPA134984745
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INPB Eukaryota
ENOG410ZRPP LUCA
GeneTreeiENSGT00760000119005
HOGENOMiHOG000115264
HOVERGENiHBG106662
InParanoidiQ6UX06
OMAiGTCQCSV
OrthoDBiEOG091G0688
PhylomeDBiQ6UX06
TreeFamiTF315964

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiOLFM4 human
GenomeRNAii10562
PROiPR:Q6UX06
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102837 Expressed in 145 organ(s), highest expression level in caecum
CleanExiHS_OLFM4
ExpressionAtlasiQ6UX06 baseline and differential
GenevisibleiQ6UX06 HS

Family and domain databases

InterProiView protein in InterPro
IPR003112 Olfac-like_dom
IPR031221 Olfactomedin-4
IPR011041 Quinoprot_gluc/sorb_DH
PANTHERiPTHR23192:SF7 PTHR23192:SF7, 1 hit
PfamiView protein in Pfam
PF02191 OLF, 1 hit
SMARTiView protein in SMART
SM00284 OLF, 1 hit
SUPFAMiSSF50952 SSF50952, 1 hit
PROSITEiView protein in PROSITE
PS51132 OLF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOLFM4_HUMAN
AccessioniPrimary (citable) accession number: Q6UX06
Secondary accession number(s): O95362, Q5VWG0, Q86T22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: April 12, 2005
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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