UniProtKB - Q6UX04 (CWC27_HUMAN)

BLAST

>sp|Q6UX04|CWC27_HUMAN Spliceosome-associated protein CWC27 homolog OS=Homo sapiens OX=9606 GN=CWC27 PE=1 SV=1
MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPG
FIVQGGDPTGTGSGGESIYGAPFKDEFHSRLRFNRRGLVAMANAGSHDNGSQFFFTLGRA
DELNNKHTIFGKVTGDTVYNMLRLSEVDIDDDERPHNPHKIKSCEVLFNPFDDIIPREIK
RLKKEKPEEEVKKLKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDP
HLSSVPVVESEKGDAPDLVDDGEDESAEHDEYIDGDEKNLMRERIAKKLKKDTSANVKSA
GEGEVEKKSVSRSEELRKEARQLKRELLAAKQKKVENAAKQAEKRSEEEEAPPDGAVAEY
RREKQKYEALRKQQSKKGTSREDQTLALLNQFKSKLTQAIAETPENDIPETEVEDDEGWM
SHVLQFEDKSRKVKDASMQDSDTFEIYDPRNPVNKRRREESKKLMREKKERR

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History
Entry version 141 (10 Oct 2018)
Sequence version 1 (05 Jul 2004)
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Protein

Spliceosome-associated protein CWC27 homolog

Gene

CWC27

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).2 Publications

Caution

Despite the fact that it belongs to the cyclophilin-type PPIase family, a report has shown that it has probably no peptidyl-prolyl cis-trans isomerase activity.1 Publication

GO - Molecular functionⁱ

peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA splicing, via spliceosome Source: Reactome
protein folding Source: InterPro

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

BRENDAⁱ	5.2.1.8 2681
Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Spliceosome-associated protein CWC27 homologCurated Alternative name(s): Antigen NY-CO-101 Publication Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog1 Publication Short name: PPIase CWC271 Publication Serologically defined colon cancer antigen 10
Gene namesⁱ	Name:CWC27Imported Synonyms:SDCCAG101 Publication ORF Names:UNQ438/PRO8711 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000153015.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10664 CWC27
MIMⁱ	617170 gene
neXtProtⁱ	NX_Q6UX04

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Retinitis pigmentosa with or without skeletal anomalies (RPSKA)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disease characterized by retinal degeneration, brachydactyly, short stature, craniofacial dysmorphism, and neurologic defects. Retinal defects are consistent with retinitis pigmentosa in most patients. Neurologic manifestations include mild-to-moderate intellectual disability and psychomotor retardation.

Keywords - Diseaseⁱ

Disease mutation, Dwarfism, Mental retardation, Retinitis pigmentosa

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10283
MalaCards human disease database More...MalaCardsⁱ	CWC27
MIMⁱ	250410 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000153015
PharmGKBⁱ	PA35594

Polymorphism and mutation databases

BioMutaⁱ	CWC27
DMDMⁱ	74749411

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000313647	2 – 472	Spliceosome-associated protein CWC27 homologAdd BLAST		471

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Glycosylationⁱ	109	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	201	N-linked (GlcNAc...) asparagine1 Publication	1
Modified residueⁱ	346	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q6UX04
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6UX04
PaxDbⁱ	Q6UX04
PeptideAtlas More...PeptideAtlasⁱ	Q6UX04
PRIDEⁱ	Q6UX04
ProteomicsDBⁱ	67545 67546 [Q6UX04-2]

PTM databases

iPTMnetⁱ	Q6UX04
PhosphoSitePlusⁱ	Q6UX04

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000153015 Expressed in 203 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_SDCCAG10
ExpressionAtlasⁱ	Q6UX04 baseline and differential
Genevisibleⁱ	Q6UX04 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA020344 HPA024149 HPA065809

HPAⁱ

HPA020344
HPA024149
HPA065809

Interactionⁱ

Subunit structureⁱ

Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this complex as he matures to the spliceosome C complex.1 Publication

Protein-protein interaction databases

BioGridⁱ	115572, 20 interactors
CORUMⁱ	Q6UX04
IntActⁱ	Q6UX04, 8 interactors
Molecular INTeraction database More...MINTⁱ	Q6UX04
STRINGⁱ	9606.ENSP00000370460

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	14 – 19	Combined sources	6
Beta strandⁱ	22 – 29	Combined sources	8
Turnⁱ	30 – 32	Combined sources	3
Helixⁱ	34 – 45	Combined sources	12
Turnⁱ	46 – 51	Combined sources	6
Beta strandⁱ	56 – 58	Combined sources	3
Turnⁱ	59 – 61	Combined sources	3
Beta strandⁱ	62 – 65	Combined sources	4
Beta strandⁱ	70 – 73	Combined sources	4
Beta strandⁱ	95 – 101	Combined sources	7
Beta strandⁱ	113 – 118	Combined sources	6
Helixⁱ	121 – 123	Combined sources	3
Turnⁱ	124 – 126	Combined sources	3
Beta strandⁱ	129 – 133	Combined sources	5
Helixⁱ	135 – 137	Combined sources	3
Helixⁱ	138 – 143	Combined sources	6
Helixⁱ	151 – 153	Combined sources	3
Beta strandⁱ	155 – 157	Combined sources	3
Beta strandⁱ	160 – 168	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q6UX04
SMRⁱ	Q6UX04
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q6UX04

EvolutionaryTraceⁱ

Q6UX04

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	11 – 166	PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST		156

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	206 – 230	Sequence analysisAdd BLAST		25
Coiled coilⁱ	306 – 377	Sequence analysisAdd BLAST		72

Sequence similaritiesⁱ

Belongs to the cyclophilin-type PPIase family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0885 Eukaryota COG0652 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119072
HOGENOMⁱ	HOG000161443
HOVERGENⁱ	HBG097993
InParanoidⁱ	Q6UX04
KEGG Orthology (KO) More...KOⁱ	K12737
OMAⁱ	SENHYIN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BVF
PhylomeDBⁱ	Q6UX04
TreeFamⁱ	TF105935

Family and domain databases

Gene3Dⁱ	2.40.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR029000 Cyclophilin-like_dom_sf IPR024936 Cyclophilin-type_PPIase IPR020892 Cyclophilin-type_PPIase_CS IPR002130 Cyclophilin-type_PPIase_dom
PANTHERⁱ	PTHR11071 PTHR11071, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00160 Pro_isomerase, 1 hit
PRINTSⁱ	PR00153 CSAPPISMRASE
SUPFAMⁱ	SSF50891 SSF50891, 1 hit
PROSITEⁱ	View protein in PROSITE PS00170 CSA_PPIASE_1, 1 hit PS50072 CSA_PPIASE_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q6UX04-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNIYIQEPP TNGKVLLKTT AGDIDIELWS KEAPKACRNF IQLCLEAYYD 
        60         70         80         90        100
NTIFHRVVPG FIVQGGDPTG TGSGGESIYG APFKDEFHSR LRFNRRGLVA 
       110        120        130        140        150
MANAGSHDNG SQFFFTLGRA DELNNKHTIF GKVTGDTVYN MLRLSEVDID 
       160        170        180        190        200
DDERPHNPHK IKSCEVLFNP FDDIIPREIK RLKKEKPEEE VKKLKPKGTK 
       210        220        230        240        250
NFSLLSFGEE AEEEEEEVNR VSQSMKGKSK SSHDLLKDDP HLSSVPVVES 
       260        270        280        290        300
EKGDAPDLVD DGEDESAEHD EYIDGDEKNL MRERIAKKLK KDTSANVKSA 
       310        320        330        340        350
GEGEVEKKSV SRSEELRKEA RQLKRELLAA KQKKVENAAK QAEKRSEEEE 
       360        370        380        390        400
APPDGAVAEY RREKQKYEAL RKQQSKKGTS REDQTLALLN QFKSKLTQAI 
       410        420        430        440        450
AETPENDIPE TEVEDDEGWM SHVLQFEDKS RKVKDASMQD SDTFEIYDPR 
       460        470 
NPVNKRRREE SKKLMREKKE RR

Length:472

Mass (Da):53,847

Last modified:July 5, 2004 - v1

Checksum:ⁱBB0102157083439D

Isoform 2 (identifier: Q6UX04-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
385-391: TLALLNQ → DVTCTS
392-472: Missing.

« Hide

        10         20         30         40         50
MSNIYIQEPP TNGKVLLKTT AGDIDIELWS KEAPKACRNF IQLCLEAYYD 
        60         70         80         90        100
NTIFHRVVPG FIVQGGDPTG TGSGGESIYG APFKDEFHSR LRFNRRGLVA 
       110        120        130        140        150
MANAGSHDNG SQFFFTLGRA DELNNKHTIF GKVTGDTVYN MLRLSEVDID 
       160        170        180        190        200
DDERPHNPHK IKSCEVLFNP FDDIIPREIK RLKKEKPEEE VKKLKPKGTK 
       210        220        230        240        250
NFSLLSFGEE AEEEEEEVNR VSQSMKGKSK SSHDLLKDDP HLSSVPVVES 
       260        270        280        290        300
EKGDAPDLVD DGEDESAEHD EYIDGDEKNL MRERIAKKLK KDTSANVKSA 
       310        320        330        340        350
GEGEVEKKSV SRSEELRKEA RQLKRELLAA KQKKVENAAK QAEKRSEEEE 
       360        370        380        390
APPDGAVAEY RREKQKYEAL RKQQSKKGTS REDQDVTCTS

Show »

Length:390

Mass (Da):43,989

Checksum:ⁱ29010D816F06A71E

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6REK3	D6REK3_HUMAN		Spliceosome-associated protein CWC2... Spliceosome-associated protein CWC27 homolog	CWC27	381	Annotation score:

Sequence cautionⁱ

The sequence AAC18041 differs from that shown. Reason: Frameshift at position 41.Curated

The sequence AAC18042 differs from that shown. Reason: Frameshift at position 136.Curated

The sequence AAH12117 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	111 – 112	SQ → TH in AAC18041 (PubMed:9610721).Curated		2
Sequence conflictⁱ	331	K → E in AAC18042 (PubMed:9610721).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_078981	7 – 472	Missing in RPSKA. 1 PublicationAdd BLAST	466
Natural variantⁱVAR_078982	143 – 472	Missing in RPSKA. 1 PublicationAdd BLAST	330
Natural variantⁱVAR_078983	206 – 472	Missing in RPSKA. 1 PublicationAdd BLAST	267
Natural variantⁱVAR_037686	256	P → A1 PublicationCorresponds to variant dbSNP:rs7735338Ensembl.	1
Natural variantⁱVAR_078984	315 – 472	Missing in RPSKA. 1 PublicationAdd BLAST	158

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_030082	385 – 391	TLALLNQ → DVTCTS in isoform 2. 1 Publication		7
Alternative sequenceⁱVSP_030083	392 – 472	Missing in isoform 2. 1 PublicationAdd BLAST		81

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF039692 mRNA Translation: AAC18041.1 Frameshift. AF039693 mRNA Translation: AAC18042.1 Frameshift. AY358569 mRNA Translation: AAQ88932.1 CH471137 Genomic DNA Translation: EAW51365.1 BC012117 mRNA Translation: AAH12117.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3982.2 [Q6UX04-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001284573.1, NM_001297644.1 NP_001284574.1, NM_001297645.1 NP_005860.2, NM_005869.3 [Q6UX04-1]
UniGeneⁱ	Hs.371372

Genome annotation databases

Ensemblⁱ	ENST00000381070; ENSP00000370460; ENSG00000153015 [Q6UX04-1]
GeneIDⁱ	10283
KEGGⁱ	hsa:10283
UCSC genome browser More...UCSCⁱ	uc003jtn.2 human [Q6UX04-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6UX04	Spliceosome-associated protein CWC27 homolog		BOVIN		473	UniRef90_Q6UX04
Spliceosome-associated protein CWC27 homolog		MACFA		473
Spliceosome-associated protein CWC27 homolog		PONAB		473
Spliceosome-associated protein CWC27 homolog		MOUSE		469
Putative cwc27 spliceosome-associated protein		DESRO		474
+122

Protein	Similar proteins		Species	Score	Length	Source
Q6UX04	Spliceosome-associated protein CWC27 homolog		MACFA		473	UniRef50_Q6UX04
Spliceosome-associated protein CWC27 homolog		BOVIN		473
Spliceosome-associated protein CWC27 homolog		PONAB		473
Spliceosome-associated protein CWC27 homolog		MOUSE		469
Peptidyl-prolyl cis-trans isomerase CWC27 like protein		FUKDA		474
+146

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF039692 mRNA Translation: AAC18041.1 Frameshift. AF039693 mRNA Translation: AAC18042.1 Frameshift. AY358569 mRNA Translation: AAQ88932.1 CH471137 Genomic DNA Translation: EAW51365.1 BC012117 mRNA Translation: AAH12117.1 Different initiation.
CCDSⁱ	CCDS3982.2 [Q6UX04-1]
RefSeqⁱ	NP_001284573.1, NM_001297644.1 NP_001284574.1, NM_001297645.1 NP_005860.2, NM_005869.3 [Q6UX04-1]
UniGeneⁱ	Hs.371372

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2HQ6	X-ray	1.75	A	8-173	[»]
	4R3E	X-ray	2.00	A	1-178	[»]
	6FF4	electron microscopy	16.00	s	1-472	[»]
ProteinModelPortalⁱ	Q6UX04
SMRⁱ	Q6UX04
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115572, 20 interactors
CORUMⁱ	Q6UX04
IntActⁱ	Q6UX04, 8 interactors
MINTⁱ	Q6UX04
STRINGⁱ	9606.ENSP00000370460

PTM databases

iPTMnetⁱ	Q6UX04
PhosphoSitePlusⁱ	Q6UX04

Polymorphism and mutation databases

BioMutaⁱ	CWC27
DMDMⁱ	74749411

Proteomic databases

EPDⁱ	Q6UX04
MaxQBⁱ	Q6UX04
PaxDbⁱ	Q6UX04
PeptideAtlasⁱ	Q6UX04
PRIDEⁱ	Q6UX04
ProteomicsDBⁱ	67545 67546 [Q6UX04-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000381070; ENSP00000370460; ENSG00000153015 [Q6UX04-1]
GeneIDⁱ	10283
KEGGⁱ	hsa:10283
UCSCⁱ	uc003jtn.2 human [Q6UX04-1]

Organism-specific databases

CTDⁱ	10283
DisGeNETⁱ	10283
EuPathDBⁱ	HostDB:ENSG00000153015.15
GeneCardsⁱ	CWC27
HGNCⁱ	HGNC:10664 CWC27
HPAⁱ	HPA020344 HPA024149 HPA065809
MalaCardsⁱ	CWC27
MIMⁱ	250410 phenotype 617170 gene
neXtProtⁱ	NX_Q6UX04
OpenTargetsⁱ	ENSG00000153015
PharmGKBⁱ	PA35594
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0885 Eukaryota COG0652 LUCA
GeneTreeⁱ	ENSGT00760000119072
HOGENOMⁱ	HOG000161443
HOVERGENⁱ	HBG097993
InParanoidⁱ	Q6UX04
KOⁱ	K12737
OMAⁱ	SENHYIN
OrthoDBⁱ	EOG091G0BVF
PhylomeDBⁱ	Q6UX04
TreeFamⁱ	TF105935

Enzyme and pathway databases

BRENDAⁱ	5.2.1.8 2681
Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSⁱ	CWC27 human
EvolutionaryTraceⁱ	Q6UX04
GenomeRNAiⁱ	10283
Protein Ontology More...PROⁱ	PR:Q6UX04
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000153015 Expressed in 203 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_SDCCAG10
ExpressionAtlasⁱ	Q6UX04 baseline and differential
Genevisibleⁱ	Q6UX04 HS

Family and domain databases

Gene3Dⁱ	2.40.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR029000 Cyclophilin-like_dom_sf IPR024936 Cyclophilin-type_PPIase IPR020892 Cyclophilin-type_PPIase_CS IPR002130 Cyclophilin-type_PPIase_dom
PANTHERⁱ	PTHR11071 PTHR11071, 1 hit
Pfamⁱ	View protein in Pfam PF00160 Pro_isomerase, 1 hit
PRINTSⁱ	PR00153 CSAPPISMRASE
SUPFAMⁱ	SSF50891 SSF50891, 1 hit
PROSITEⁱ	View protein in PROSITE PS00170 CSA_PPIASE_1, 1 hit PS50072 CSA_PPIASE_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CWC27_HUMAN
Accessionⁱ	Q6UX04Primary (citable) accession number: Q6UX04 Secondary accession number(s): O60529, O60530, Q96EM3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	July 5, 2004
	Last modified:	October 10, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q6UX04 (CWC27_HUMAN)

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Spliceosome-associated protein CWC27 homolog

CWC27

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ