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Protein

Arylsulfatase K

Gene

ARSK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40CalciumBy similarity1
Active sitei80NucleophileBy similarity1
Metal bindingi80Calcium; via 3-oxoalanineBy similarity1
Binding sitei128SubstrateBy similarity1
Binding sitei251SubstrateBy similarity1
Metal bindingi313CalciumBy similarity1
Metal bindingi314CalciumBy similarity1

GO - Molecular functioni

  • arylsulfatase activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1660662 Glycosphingolipid metabolism
R-HSA-1663150 The activation of arylsulfatases

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase K (EC:3.1.6.-)
Short name:
ASK
Alternative name(s):
Telethon sulfatase
Gene namesi
Name:ARSK
Synonyms:TSULF
ORF Names:UNQ630/PRO1246
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164291.16
HGNCiHGNC:25239 ARSK
MIMi610011 gene
neXtProtiNX_Q6UWY0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi153642
OpenTargetsiENSG00000164291
PharmGKBiPA143485311

Polymorphism and mutation databases

BioMutaiARSK
DMDMi74738157

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004221923 – 536Arylsulfatase KAdd BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei803-oxoalanine (Cys)By similarity1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi498N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6UWY0
MaxQBiQ6UWY0
PaxDbiQ6UWY0
PeptideAtlasiQ6UWY0
PRIDEiQ6UWY0
ProteomicsDBi67536

PTM databases

iPTMnetiQ6UWY0
PhosphoSitePlusiQ6UWY0

Expressioni

Gene expression databases

BgeeiENSG00000164291 Expressed in 196 organ(s), highest expression level in prostate gland
CleanExiHS_ARSK
ExpressionAtlasiQ6UWY0 baseline and differential
GenevisibleiQ6UWY0 HS

Organism-specific databases

HPAiHPA042384

Interactioni

Protein-protein interaction databases

BioGridi127507, 43 interactors
STRINGi9606.ENSP00000369346

Structurei

3D structure databases

ProteinModelPortaliQ6UWY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3731 Eukaryota
COG3119 LUCA
GeneTreeiENSGT00730000110906
HOGENOMiHOG000034080
HOVERGENiHBG054703
InParanoidiQ6UWY0
KOiK12376
OMAiKWKQSIG
OrthoDBiEOG091G061W
PhylomeDBiQ6UWY0
TreeFamiTF313545

Family and domain databases

Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q6UWY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLLWVSVVA ALALAVLAPG AGEQRRRAAK APNVVLVVSD SFDGRLTFHP
60 70 80 90 100
GSQVVKLPFI NFMKTRGTSF LNAYTNSPIC CPSRAAMWSG LFTHLTESWN
110 120 130 140 150
NFKGLDPNYT TWMDVMERHG YRTQKFGKLD YTSGHHSISN RVEAWTRDVA
160 170 180 190 200
FLLRQEGRPM VNLIRNRTKV RVMERDWQNT DKAVNWLRKE AINYTEPFVI
210 220 230 240 250
YLGLNLPHPY PSPSSGENFG SSTFHTSLYW LEKVSHDAIK IPKWSPLSEM
260 270 280 290 300
HPVDYYSSYT KNCTGRFTKK EIKNIRAFYY AMCAETDAML GEIILALHQL
310 320 330 340 350
DLLQKTIVIY SSDHGELAME HRQFYKMSMY EASAHVPLLM MGPGIKAGLQ
360 370 380 390 400
VSNVVSLVDI YPTMLDIAGI PLPQNLSGYS LLPLSSETFK NEHKVKNLHP
410 420 430 440 450
PWILSEFHGC NVNASTYMLR TNHWKYIAYS DGASILPQLF DLSSDPDELT
460 470 480 490 500
NVAVKFPEIT YSLDQKLHSI INYPKVSASV HQYNKEQFIK WKQSIGQNYS
510 520 530
NVIANLRWHQ DWQKEPRKYE NAIDQWLKTH MNPRAV
Length:536
Mass (Da):61,450
Last modified:July 5, 2004 - v1
Checksum:i5A6D1B0FD8FCF386
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PGI0E9PGI0_HUMAN
Arylsulfatase K
ARSK
395Annotation score:
D6RBR4D6RBR4_HUMAN
Arylsulfatase K
ARSK
153Annotation score:
D6R9F9D6R9F9_HUMAN
Arylsulfatase K
ARSK
46Annotation score:
H0Y9F6H0Y9F6_HUMAN
Arylsulfatase K
ARSK
92Annotation score:

Sequence cautioni

The sequence AAH36047 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti380S → P in CAD38634 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052516525Q → R1 PublicationCorresponds to variant dbSNP:rs17084927Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY875939 mRNA Translation: AAW66667.1
AY358596 mRNA Translation: AAQ88959.1
AK303855 mRNA Translation: BAG64796.1
BC036047 mRNA Translation: AAH36047.1 Different initiation.
BC130329 mRNA Translation: AAI30330.1
AL832711 mRNA Translation: CAD38634.1
CCDSiCCDS4073.1
RefSeqiNP_937793.1, NM_198150.2
UniGeneiHs.585051

Genome annotation databases

EnsembliENST00000380009; ENSP00000369346; ENSG00000164291
GeneIDi153642
KEGGihsa:153642
UCSCiuc003kld.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY875939 mRNA Translation: AAW66667.1
AY358596 mRNA Translation: AAQ88959.1
AK303855 mRNA Translation: BAG64796.1
BC036047 mRNA Translation: AAH36047.1 Different initiation.
BC130329 mRNA Translation: AAI30330.1
AL832711 mRNA Translation: CAD38634.1
CCDSiCCDS4073.1
RefSeqiNP_937793.1, NM_198150.2
UniGeneiHs.585051

3D structure databases

ProteinModelPortaliQ6UWY0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127507, 43 interactors
STRINGi9606.ENSP00000369346

PTM databases

iPTMnetiQ6UWY0
PhosphoSitePlusiQ6UWY0

Polymorphism and mutation databases

BioMutaiARSK
DMDMi74738157

Proteomic databases

EPDiQ6UWY0
MaxQBiQ6UWY0
PaxDbiQ6UWY0
PeptideAtlasiQ6UWY0
PRIDEiQ6UWY0
ProteomicsDBi67536

Protocols and materials databases

DNASUi153642
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380009; ENSP00000369346; ENSG00000164291
GeneIDi153642
KEGGihsa:153642
UCSCiuc003kld.4 human

Organism-specific databases

CTDi153642
DisGeNETi153642
EuPathDBiHostDB:ENSG00000164291.16
GeneCardsiARSK
HGNCiHGNC:25239 ARSK
HPAiHPA042384
MIMi610011 gene
neXtProtiNX_Q6UWY0
OpenTargetsiENSG00000164291
PharmGKBiPA143485311
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3731 Eukaryota
COG3119 LUCA
GeneTreeiENSGT00730000110906
HOGENOMiHOG000034080
HOVERGENiHBG054703
InParanoidiQ6UWY0
KOiK12376
OMAiKWKQSIG
OrthoDBiEOG091G061W
PhylomeDBiQ6UWY0
TreeFamiTF313545

Enzyme and pathway databases

ReactomeiR-HSA-1660662 Glycosphingolipid metabolism
R-HSA-1663150 The activation of arylsulfatases

Miscellaneous databases

GenomeRNAii153642
PROiPR:Q6UWY0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164291 Expressed in 196 organ(s), highest expression level in prostate gland
CleanExiHS_ARSK
ExpressionAtlasiQ6UWY0 baseline and differential
GenevisibleiQ6UWY0 HS

Family and domain databases

Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARSK_HUMAN
AccessioniPrimary (citable) accession number: Q6UWY0
Secondary accession number(s): A2BDE3
, B4E1I4, Q3ZCW3, Q8N3Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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