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Protein

Transmembrane protein 207

Gene

TMEM207

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 207
Gene namesi
Name:TMEM207
ORF Names:UNQ846/PRO1784
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000198398.2
HGNCiHGNC:33705 TMEM207
MIMi614786 gene
neXtProtiNX_Q6UWW9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi136 – 137PP → RS: Loss of WWOX-binding. 1 Publication2

Organism-specific databases

DisGeNETi131920
OpenTargetsiENSG00000198398
PharmGKBiPA162406407

Polymorphism and mutation databases

BioMutaiTMEM207
DMDMi74738156

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000031752530 – 146Transmembrane protein 207Add BLAST117

Proteomic databases

PaxDbiQ6UWW9
PRIDEiQ6UWW9
ProteomicsDBi67534

PTM databases

iPTMnetiQ6UWW9
PhosphoSitePlusiQ6UWW9

Expressioni

Tissue specificityi

Expressed in some signet-ring cell carcinoma, especially those showing high invasion and metastatic activity (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000198398
CleanExiHS_TMEM207
GenevisibleiQ6UWW9 HS

Organism-specific databases

HPAiHPA014332

Interactioni

Subunit structurei

Interacts with WWOX.1 Publication

Protein-protein interaction databases

BioGridi126299, 2 interactors
IntActiQ6UWW9, 9 interactors
STRINGi9606.ENSP00000346981

Structurei

3D structure databases

ProteinModelPortaliQ6UWW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYYW Eukaryota
ENOG41118MT LUCA
GeneTreeiENSGT00390000006126
HOGENOMiHOG000154622
HOVERGENiHBG108581
InParanoidiQ6UWW9
OMAiPTVGIHL
OrthoDBiEOG091G0RF7
PhylomeDBiQ6UWW9
TreeFamiTF342774

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSRLFSVT SAISTIGILC LPLFQLVLSD LPCEEDEMCV NYNDQHPNGW
60 70 80 90 100
YIWILLLLVL VAALLCGAVV LCLQCWLRRP RIDSHRRTMA VFAVGDLDSI
110 120 130 140
YGTEAAVSPT VGIHLQTQTP DLYPVPAPCF GPLGSPPPYE EIVKTT
Length:146
Mass (Da):16,116
Last modified:July 5, 2004 - v1
Checksum:i1FAB4346037B6DAE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05143657L → V. Corresponds to variant dbSNP:rs35161724Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358607 mRNA Translation: AAQ88970.1
CH471052 Genomic DNA Translation: EAW78105.1
BC071780 mRNA Translation: AAH71780.1
CCDSiCCDS3297.1
RefSeqiNP_997199.1, NM_207316.2
UniGeneiHs.335321

Genome annotation databases

EnsembliENST00000354905; ENSP00000346981; ENSG00000198398
GeneIDi131920
KEGGihsa:131920
UCSCiuc003fsj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM207_HUMAN
AccessioniPrimary (citable) accession number: Q6UWW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: July 18, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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