UniProtKB - Q6UWW0 (LCN15_HUMAN)
Protein
Lipocalin-15
Gene
LCN15
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- small molecule binding Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q6UWW0 |
Reactomei | R-HSA-804914, Transport of fatty acids |
Names & Taxonomyi
Protein namesi | Recommended name: Lipocalin-15 |
Gene namesi | Name:LCN15 ORF Names:UNQ2541/PRO6093 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33777, LCN15 |
neXtProti | NX_Q6UWW0 |
VEuPathDBi | HostDB:ENSG00000177984.6 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000177984 |
PharmGKBi | PA164722091 |
Miscellaneous databases
Pharosi | Q6UWW0, Tdark |
Genetic variation databases
BioMutai | LCN15 |
DMDMi | 74749403 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000317518 | 21 – 184 | Lipocalin-15Add BLAST | 164 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 83 ↔ 176 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | Q6UWW0 |
PaxDbi | Q6UWW0 |
PeptideAtlasi | Q6UWW0 |
PRIDEi | Q6UWW0 |
ProteomicsDBi | 67531 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177984, Expressed in colon and 77 other tissues |
Genevisiblei | Q6UWW0, HS |
Organism-specific databases
HPAi | ENSG00000177984, Group enriched (brain, ductus deferens, intestine, seminal vesicle) |
Interactioni
Binary interactionsi
Q6UWW0
With | #Exp. | IntAct |
---|---|---|
MEOX2 [Q6FHY5] | 3 | EBI-12176085,EBI-16439278 |
Protein-protein interaction databases
BioGRIDi | 133279, 10 interactors |
IntActi | Q6UWW0, 8 interactors |
STRINGi | 9606.ENSP00000313833 |
Miscellaneous databases
RNActi | Q6UWW0, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q6UWW0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q6UWW0 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S13A, Eukaryota |
GeneTreei | ENSGT00960000186615 |
HOGENOMi | CLU_094061_3_1_1 |
InParanoidi | Q6UWW0 |
OMAi | DFYPTVG |
OrthoDBi | 1107052at2759 |
PhylomeDBi | Q6UWW0 |
TreeFami | TF336103 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR002345, Lipocalin IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR11430, PTHR11430, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6UWW0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMSFLLGAIL TLLWAPTAQA EVLLQPDFNA EKFSGLWYVV SMASDCRVFL
60 70 80 90 100
GKKDHLSMST RAIRPTEEGG LHVHMEFPGA DGCNQVDAEY LKVGSEGHFR
110 120 130 140 150
VPALGYLDVR IVDTDYSSFA VLYIYKELEG ALSTMVQLYS RTQDVSPQAL
160 170 180
KSFQDFYPTL GLPKDMMVML PQSDACNPES KEAP
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059453 | 152 | S → A. Corresponds to variant dbSNP:rs2297723Ensembl. | 1 | |
Natural variantiVAR_059454 | 164 | K → E. Corresponds to variant dbSNP:rs2297722Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358618 mRNA Translation: AAQ88981.1 AL355987 Genomic DNA No translation available. BC093893 mRNA Translation: AAH93893.1 BC093895 mRNA Translation: AAH93895.1 |
CCDSi | CCDS7006.1 |
RefSeqi | NP_976222.1, NM_203347.1 |
Genome annotation databases
Ensembli | ENST00000316144; ENSP00000313833; ENSG00000177984 |
GeneIDi | 389812 |
KEGGi | hsa:389812 |
UCSCi | uc004cjd.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358618 mRNA Translation: AAQ88981.1 AL355987 Genomic DNA No translation available. BC093893 mRNA Translation: AAH93893.1 BC093895 mRNA Translation: AAH93895.1 |
CCDSi | CCDS7006.1 |
RefSeqi | NP_976222.1, NM_203347.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2XST | X-ray | 1.63 | A | 19-177 | [»] | |
SMRi | Q6UWW0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 133279, 10 interactors |
IntActi | Q6UWW0, 8 interactors |
STRINGi | 9606.ENSP00000313833 |
Genetic variation databases
BioMutai | LCN15 |
DMDMi | 74749403 |
Proteomic databases
MassIVEi | Q6UWW0 |
PaxDbi | Q6UWW0 |
PeptideAtlasi | Q6UWW0 |
PRIDEi | Q6UWW0 |
ProteomicsDBi | 67531 |
Protocols and materials databases
Antibodypediai | 53301, 31 antibodies |
Genome annotation databases
Ensembli | ENST00000316144; ENSP00000313833; ENSG00000177984 |
GeneIDi | 389812 |
KEGGi | hsa:389812 |
UCSCi | uc004cjd.3, human |
Organism-specific databases
CTDi | 389812 |
GeneCardsi | LCN15 |
HGNCi | HGNC:33777, LCN15 |
HPAi | ENSG00000177984, Group enriched (brain, ductus deferens, intestine, seminal vesicle) |
neXtProti | NX_Q6UWW0 |
OpenTargetsi | ENSG00000177984 |
PharmGKBi | PA164722091 |
VEuPathDBi | HostDB:ENSG00000177984.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S13A, Eukaryota |
GeneTreei | ENSGT00960000186615 |
HOGENOMi | CLU_094061_3_1_1 |
InParanoidi | Q6UWW0 |
OMAi | DFYPTVG |
OrthoDBi | 1107052at2759 |
PhylomeDBi | Q6UWW0 |
TreeFami | TF336103 |
Enzyme and pathway databases
PathwayCommonsi | Q6UWW0 |
Reactomei | R-HSA-804914, Transport of fatty acids |
Miscellaneous databases
BioGRID-ORCSi | 389812, 13 hits in 872 CRISPR screens |
EvolutionaryTracei | Q6UWW0 |
GenomeRNAii | 389812 |
Pharosi | Q6UWW0, Tdark |
PROi | PR:Q6UWW0 |
RNActi | Q6UWW0, protein |
Gene expression databases
Bgeei | ENSG00000177984, Expressed in colon and 77 other tissues |
Genevisiblei | Q6UWW0, HS |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR002345, Lipocalin IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR11430, PTHR11430, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LCN15_HUMAN | |
Accessioni | Q6UWW0Primary (citable) accession number: Q6UWW0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families