UniProtKB - Q6UWV6 (ENPP7_HUMAN)

BLAST

>sp|Q6UWV6|ENPP7_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 OS=Homo sapiens OX=9606 GN=ENPP7 PE=1 SV=3
MRGLAVLLTVALATLLAPGAGAPVQSQGSQNKLLLVSFDGFRWNYDQDVDTPNLDAMARD
GVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMYYNTTSKVKLPYHATLGIQRWWD
NGSVPIWITAQRQGLRAGSFFYPGGNVTYQGVAVTRSRKEGIAHNYKNETEWRANIDTVM
AWFTEEDLDLVTLYFGEPDSTGHRYGPESPERREMVRQVDRTVGYLRESIARNHLTDRLN
LIITSDHGMTTVDKRAGDLVEFHKFPNFTFRDIEFELLDYGPNGMLLPKEGRLEKVYDAL
KDAHPKLHVYKKEAFPEAFHYANNPRVTPLLMYSDLGYVIHGRINVQFNNGEHGFDNKDM
DMKTIFRAVGPSFRAGLEVEPFESVHVYELMCRLLGIVPEANDGHLATLLPMLHTESALP
PDGRPTLLPKGRSALPPSSRPLLVMGLLGTVILLSEVA

Align
Format
Add to basket Added to basket
History
Entry version 133 (07 Nov 2018)
Sequence version 3 (20 Mar 2007)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

Gene

ENPP7

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Converts sphingomyelin to ceramide and phosphocholine (PubMed:12885774, PubMed:12671034, PubMed:15205117, PubMed:28292932). Has also phospholipase C activity and can cleave phosphocholine from palmitoyl lyso-phosphatidylcholine (PubMed:12885774). Does not have nucleotide pyrophosphatase activity (PubMed:12885774).4 Publications

Miscellaneous

Decreased levels of alkaline sphingomyelin phosphodiesterase may be associated with colon cancer.2 Publications

Catalytic activityⁱ

Sphingomyelin + H₂O = N-acylsphingosine + phosphocholine.4 Publications

Cofactorⁱ

Zn²⁺1 Publication

Activity regulationⁱ

Inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Not inhibited by ADP, AMP and EDTA.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	39	Zinc 1Combined sources1 Publication	1
Active siteⁱ	75	Nucleophile1 Publication	1
Metal bindingⁱ	75	Zinc 1Combined sources1 Publication	1
Binding siteⁱ	96	SubstrateCombined sources1 Publication	1
Metal bindingⁱ	199	Zinc 2Combined sources1 Publication	1
Metal bindingⁱ	203	Zinc 2; via tele nitrogenCombined sources1 Publication	1
Metal bindingⁱ	246	Zinc 1Combined sources1 Publication	1
Metal bindingⁱ	247	Zinc 1; via tele nitrogenCombined sources1 Publication	1
Metal bindingⁱ	353	Zinc 2; via tele nitrogenCombined sources1 Publication	1

GO - Molecular functionⁱ

sphingomyelin phosphodiesterase activity
Source: UniProtKB
Inferred from direct assayⁱ
zinc ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 28292932

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

glycosphingolipid metabolic process Source: Reactome
negative regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 12671034
negative regulation of DNA replication
Source: UniProtKB
Inferred from direct assayⁱ
- 12671034
sphingomyelin catabolic process Source: InterPro
sphingomyelin metabolic process
Source: UniProtKB
Inferred from direct assayⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Lipid metabolism
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

BRENDAⁱ	3.1.4.12 2681
Reactomeⁱ	R-HSA-1660662 Glycosphingolipid metabolism

Chemistry databases

SwissLipidsⁱ	SLP:000000173

SwissLipidsⁱ

SLP:000000173

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (EC:3.1.4.124 Publications) Short name: E-NPP 7 Short name: NPP-7 Alternative name(s): Alkaline sphingomyelin phosphodiesterase Intestinal alkaline sphingomyelinase2 Publications Short name: Alk-SMase2 Publications
Gene namesⁱ	Name:ENPP7Imported ORF Names:UNQ3077/PRO9912
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000182156.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23764 ENPP7
MIMⁱ	616997 gene
neXtProtⁱ	NX_Q6UWV6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 433	ExtracellularCuratedAdd BLAST	412
Transmembraneⁱ	434 – 454	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	455 – 458	CytoplasmicCurated	4

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	76	S → F: Loss of activity. 1 Publication	1
Mutagenesisⁱ	78	C → N: Strongly reduces activity. 1 Publication	1
Mutagenesisⁱ	100	N → Q: Strongly reduces N-glycosylation and enzyme activity; when associated with Q-121; Q-146; Q-168 and Q-267. 1 Publication	1
Mutagenesisⁱ	109	Y → L: Decreased enzyme activity with sphingomyelin and para-nitrophenylphosphorylcholine. 1 Publication	1
Mutagenesisⁱ	121	N → Q: Strongly reduces N-glycosylation and enzyme activity; when associated with Q-100; Q-146; Q-168 and Q-267. 1 Publication	1
Mutagenesisⁱ	146	N → Q: Strongly reduces N-glycosylation and enzyme activity; when associated with Q-100; Q-146; Q-168 and Q-267. 1 Publication	1
Mutagenesisⁱ	166	Y → L: Decreased enzyme activity with sphingomyelin and para-nitrophenylphosphorylcholine. 1 Publication	1
Mutagenesisⁱ	168	N → Q: Strongly reduces N-glycosylation and enzyme activity; when associated with Q-100; Q-121; Q-168 and Q-267. 1 Publication	1
Mutagenesisⁱ	267	N → Q: Strongly reduces N-glycosylation and enzyme activity; when associated with Q-100; Q-121; Q-146 and Q-168. 1 Publication	1
Mutagenesisⁱ	271	R → E: Decreased enzyme activity; when associated with E-343. 1 Publication	1
Mutagenesisⁱ	343	R → E: Decreased enzyme activity; when associated with E-271. 1 Publication	1
Mutagenesisⁱ	344 – 348	INVQF → ENEQE: Loss of enzyme activity with sphingomyelin. 1 Publication	5
Mutagenesisⁱ	344 – 348	INVQF → NNNQN: Loss of enzyme activity with sphingomyelin. 1 Publication	5
Mutagenesisⁱ	353	H → A: Loss of activity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	339221
PharmGKBⁱ	PA134986550

Chemistry databases

ChEMBLⁱ

CHEMBL6058

Polymorphism and mutation databases

DMDMⁱ	134047772

DMDMⁱ

134047772

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Sequence analysis1 PublicationAdd BLAST		21
ChainⁱPRO_0000036403	22 – 458	Ectonucleotide pyrophosphatase/phosphodiesterase family member 7Add BLAST		437

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	100	N-linked (GlcNAc...) asparagineCombined sources2 Publications	1
Glycosylationⁱ	121	N-linked (GlcNAc...) asparagineCombined sources2 Publications	1
Glycosylationⁱ	146	N-linked (GlcNAc...) asparagineCombined sources3 Publications	1
Glycosylationⁱ	168	N-linked (GlcNAc...) asparagineCombined sources2 Publications	1
Glycosylationⁱ	267	N-linked (GlcNAc...) asparagineCombined sources2 Publications	1

Post-translational modificationⁱ

N-glycosylated; required for activity and transport to the plasma membrane.2 Publications

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q6UWV6
PeptideAtlas More...PeptideAtlasⁱ	Q6UWV6
PRIDEⁱ	Q6UWV6
ProteomicsDBⁱ	67528

PTM databases

iPTMnetⁱ	Q6UWV6
PhosphoSitePlusⁱ	Q6UWV6

Expressionⁱ

Tissue specificityⁱ

Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000182156 Expressed in 138 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_ENPP7
ExpressionAtlasⁱ	Q6UWV6 baseline and differential
Genevisibleⁱ	Q6UWV6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024603

HPAⁱ

HPA024603

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	130844, 12 interactors
IntActⁱ	Q6UWV6, 8 interactors
STRINGⁱ	9606.ENSP00000332656

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	32 – 38	Combined sources	7
Turnⁱ	43 – 48	Combined sources	6
Helixⁱ	52 – 60	Combined sources	9
Beta strandⁱ	61 – 65	Combined sources	5
Helixⁱ	75 – 84	Combined sources	10
Helixⁱ	88 – 91	Combined sources	4
Beta strandⁱ	96 – 100	Combined sources	5
Turnⁱ	101 – 104	Combined sources	4
Beta strandⁱ	105 – 107	Combined sources	3
Helixⁱ	109 – 112	Combined sources	4
Helixⁱ	116 – 119	Combined sources	4
Helixⁱ	126 – 131	Combined sources	6
Turnⁱ	132 – 134	Combined sources	3
Beta strandⁱ	137 – 141	Combined sources	5
Turnⁱ	143 – 146	Combined sources	4
Beta strandⁱ	155 – 158	Combined sources	4
Helixⁱ	169 – 185	Combined sources	17
Beta strandⁱ	189 – 195	Combined sources	7
Helixⁱ	199 – 205	Combined sources	7
Helixⁱ	210 – 232	Combined sources	23
Turnⁱ	236 – 238	Combined sources	3
Beta strandⁱ	239 – 244	Combined sources	6
Helixⁱ	262 – 264	Combined sources	3
Helixⁱ	270 – 272	Combined sources	3
Beta strandⁱ	273 – 277	Combined sources	5
Beta strandⁱ	283 – 288	Combined sources	6
Helixⁱ	293 – 300	Combined sources	8
Beta strandⁱ	307 – 311	Combined sources	5
Helixⁱ	312 – 314	Combined sources	3
Helixⁱ	317 – 319	Combined sources	3
Beta strandⁱ	329 – 334	Combined sources	6
Beta strandⁱ	350 – 352	Combined sources	3
Helixⁱ	360 – 362	Combined sources	3
Beta strandⁱ	366 – 370	Combined sources	5
Beta strandⁱ	375 – 379	Combined sources	5
Helixⁱ	384 – 386	Combined sources	3
Helixⁱ	387 – 395	Combined sources	9
Helixⁱ	406 – 408	Combined sources	3
Helixⁱ	410 – 412	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q6UWV6
SMRⁱ	Q6UWV6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	72 – 78	Required for enzyme activity1 Publication		7

Sequence similaritiesⁱ

Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2645 Eukaryota COG1524 LUCA
HOGENOMⁱ	HOG000231018
HOVERGENⁱ	HBG106748
InParanoidⁱ	Q6UWV6
KEGG Orthology (KO) More...KOⁱ	K12354
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06NA
PhylomeDBⁱ	Q6UWV6
TreeFamⁱ	TF330032

Family and domain databases

Gene3Dⁱ	3.40.720.10, 1 hit
InterProⁱ	View protein in InterPro IPR017849 Alkaline_Pase-like_a/b/a IPR017850 Alkaline_phosphatase_core_sf IPR029895 ENPP7 IPR002591 Phosphodiest/P_Trfase
PANTHERⁱ	PTHR10151:SF63 PTHR10151:SF63, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01663 Phosphodiest, 1 hit
SUPFAMⁱ	SSF53649 SSF53649, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q6UWV6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRGLAVLLTV ALATLLAPGA GAPVQSQGSQ NKLLLVSFDG FRWNYDQDVD 
        60         70         80         90        100
TPNLDAMARD GVKARYMTPA FVTMTSPCHF TLVTGKYIEN HGVVHNMYYN 
       110        120        130        140        150
TTSKVKLPYH ATLGIQRWWD NGSVPIWITA QRQGLRAGSF FYPGGNVTYQ 
       160        170        180        190        200
GVAVTRSRKE GIAHNYKNET EWRANIDTVM AWFTEEDLDL VTLYFGEPDS 
       210        220        230        240        250
TGHRYGPESP ERREMVRQVD RTVGYLRESI ARNHLTDRLN LIITSDHGMT 
       260        270        280        290        300
TVDKRAGDLV EFHKFPNFTF RDIEFELLDY GPNGMLLPKE GRLEKVYDAL 
       310        320        330        340        350
KDAHPKLHVY KKEAFPEAFH YANNPRVTPL LMYSDLGYVI HGRINVQFNN 
       360        370        380        390        400
GEHGFDNKDM DMKTIFRAVG PSFRAGLEVE PFESVHVYEL MCRLLGIVPE 
       410        420        430        440        450
ANDGHLATLL PMLHTESALP PDGRPTLLPK GRSALPPSSR PLLVMGLLGT 

VILLSEVA

Length:458

Mass (Da):51,494

Last modified:March 20, 2007 - v3

Checksum:ⁱF6A06913C33E4398

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	I3L3G5	I3L3G5_HUMAN		Ectonucleotide pyrophosphatase/phos... Ectonucleotide pyrophosphatase/phosphodiesterase family member 7	ENPP7	159	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	101	T → I in AAQ88985 (PubMed:12975309).Curated		1
Sequence conflictⁱ	388	Y → N in BAC86504 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_021506	4	L → P3 PublicationsCorresponds to variant dbSNP:rs8074547Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY230663 mRNA Translation: AAP69661.1 AY358622 mRNA Translation: AAQ88985.1 AK126250 mRNA Translation: BAC86504.1 BC041453 mRNA Translation: AAH41453.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11763.1
NCBI Reference Sequences More...RefSeqⁱ	NP_848638.3, NM_178543.4
UniGeneⁱ	Hs.114084

Genome annotation databases

Ensemblⁱ	ENST00000328313; ENSP00000332656; ENSG00000182156
GeneIDⁱ	339221
KEGGⁱ	hsa:339221
UCSC genome browser More...UCSCⁱ	uc002jxa.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6UWV6	Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (Fragment)		HUMAN		159	UniRef100_Q6UWV6

Protein	Similar proteins		Species	Score	Length	Source
Q6UWV6	Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (Fragment)		HUMAN		159	UniRef90_Q6UWV6
Uncharacterized protein		MACNE		489
Uncharacterized protein		NOMLE		458
Ectonucleotide pyrophosphatase/phosphodiesterase 7		GORGO		458
ENPP7 isoform 1		PONAB		458
+23

Protein	Similar proteins		Species	Score	Length	Source
Q6UWV6	Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (Fragment)		HUMAN		159	UniRef50_Q6UWV6
Uncharacterized protein		MACNE		489
ENPP7 isoform 1		PANTR		458
Ectonucleotide pyrophosphatase/phosphodiesterase 7		GORGO		458
Uncharacterized protein		MACMU		458
+41

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY230663 mRNA Translation: AAP69661.1 AY358622 mRNA Translation: AAQ88985.1 AK126250 mRNA Translation: BAC86504.1 BC041453 mRNA Translation: AAH41453.2
CCDSⁱ	CCDS11763.1
RefSeqⁱ	NP_848638.3, NM_178543.4
UniGeneⁱ	Hs.114084

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5TCD	X-ray	2.40	A	22-433	[»]
	5UDY	X-ray	2.60	A	22-433	[»]
ProteinModelPortalⁱ	Q6UWV6
SMRⁱ	Q6UWV6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	130844, 12 interactors
IntActⁱ	Q6UWV6, 8 interactors
STRINGⁱ	9606.ENSP00000332656

Chemistry databases

ChEMBLⁱ	CHEMBL6058
SwissLipidsⁱ	SLP:000000173

PTM databases

iPTMnetⁱ	Q6UWV6
PhosphoSitePlusⁱ	Q6UWV6

Polymorphism and mutation databases

DMDMⁱ	134047772

DMDMⁱ

134047772

Proteomic databases

PaxDbⁱ	Q6UWV6
PeptideAtlasⁱ	Q6UWV6
PRIDEⁱ	Q6UWV6
ProteomicsDBⁱ	67528

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000328313; ENSP00000332656; ENSG00000182156
GeneIDⁱ	339221
KEGGⁱ	hsa:339221
UCSCⁱ	uc002jxa.5 human

Organism-specific databases

CTDⁱ	339221
DisGeNETⁱ	339221
EuPathDBⁱ	HostDB:ENSG00000182156.9
GeneCardsⁱ	ENPP7
H-InvDBⁱ	HIX0027161
HGNCⁱ	HGNC:23764 ENPP7
HPAⁱ	HPA024603
MIMⁱ	616997 gene
neXtProtⁱ	NX_Q6UWV6
PharmGKBⁱ	PA134986550
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2645 Eukaryota COG1524 LUCA
HOGENOMⁱ	HOG000231018
HOVERGENⁱ	HBG106748
InParanoidⁱ	Q6UWV6
KOⁱ	K12354
OrthoDBⁱ	EOG091G06NA
PhylomeDBⁱ	Q6UWV6
TreeFamⁱ	TF330032

Enzyme and pathway databases

BRENDAⁱ	3.1.4.12 2681
Reactomeⁱ	R-HSA-1660662 Glycosphingolipid metabolism

Miscellaneous databases

GeneWikiⁱ	ENPP7
GenomeRNAiⁱ	339221
Protein Ontology More...PROⁱ	PR:Q6UWV6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000182156 Expressed in 138 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_ENPP7
ExpressionAtlasⁱ	Q6UWV6 baseline and differential
Genevisibleⁱ	Q6UWV6 HS

Family and domain databases

Gene3Dⁱ	3.40.720.10, 1 hit
InterProⁱ	View protein in InterPro IPR017849 Alkaline_Pase-like_a/b/a IPR017850 Alkaline_phosphatase_core_sf IPR029895 ENPP7 IPR002591 Phosphodiest/P_Trfase
PANTHERⁱ	PTHR10151:SF63 PTHR10151:SF63, 1 hit
Pfamⁱ	View protein in Pfam PF01663 Phosphodiest, 1 hit
SUPFAMⁱ	SSF53649 SSF53649, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ENPP7_HUMAN
Accessionⁱ	Q6UWV6Primary (citable) accession number: Q6UWV6 Secondary accession number(s): Q6ZTS5, Q8IUS8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
	Last sequence update:	March 20, 2007
	Last modified:	November 7, 2018
	This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6UWV6 (ENPP7_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

ENPP7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ