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Entry version 129 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Myelin protein zero-like protein 3

Gene

MPZL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates homophilic cell-cell adhesion.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6UWV2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin protein zero-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MPZL3
ORF Names:UNQ2966/PRO7425
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160588.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27279, MPZL3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611707, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UWV2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 158ExtracellularSequence analysisAdd BLAST127
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 235CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
196264

Open Targets

More...
OpenTargetsi
ENSG00000160588

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162396160

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6UWV2, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MPZL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74758560

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 311 PublicationAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028028232 – 235Myelin protein zero-like protein 3Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi52 ↔ 128PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6UWV2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6UWV2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UWV2

PeptideAtlas

More...
PeptideAtlasi
Q6UWV2

PRoteomics IDEntifications database

More...
PRIDEi
Q6UWV2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4527
5822
67527 [Q6UWV2-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6UWV2, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6UWV2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UWV2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160588, Expressed in vagina and 156 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6UWV2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6UWV2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000160588, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
128193, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q6UWV2, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000278949

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6UWV2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6UWV2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 148Ig-like V-typeAdd BLAST117

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the myelin P0 protein family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RYH4, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203537

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_090350_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UWV2

Identification of Orthologs from Complete Genome Data

More...
OMAi
IKLRCTF

Database of Orthologous Groups

More...
OrthoDBi
1437254at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UWV2

TreeFam database of animal gene trees

More...
TreeFami
TF331728

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR029862, MPZL3
IPR000920, Myelin_P0-rel

The PANTHER Classification System

More...
PANTHERi
PTHR13869, PTHR13869, 1 hit
PTHR13869:SF20, PTHR13869:SF20, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07686, V-set, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00213, MYELINP0

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 1 hit
SM00406, IGv, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UWV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQQRGAAGSR GCALFPLLGV LFFQGVYIVF SLEIRADAHV RGYVGEKIKL
60 70 80 90 100
KCTFKSTSDV TDKLTIDWTY RPPSSSHTVS IFHYQSFQYP TTAGTFRDRI
110 120 130 140 150
SWVGNVYKGD ASISISNPTI KDNGTFSCAV KNPPDVHHNI PMTELTVTER
160 170 180 190 200
GFGTMLSSVA LLSILVFVPS AVVVALLLVR MGRKAAGLKK RSRSGYKKSS
210 220 230
IEVSDDTDQE EEEACMARLC VRCAECLDSD YEETY
Length:235
Mass (Da):25,989
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i009B7ED8C82C7B4F
GO
Isoform 2 (identifier: Q6UWV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-36: Missing.

Show »
Length:223
Mass (Da):24,640
Checksum:i5AF5E0CB143CA7EC
GO
Isoform 3 (identifier: Q6UWV2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-108: IFHYQSFQYPTTAGTFRDRISWVGNVYK → VLAPCFPLWPFFPSLSLCPQPWWLLCCW
     109-235: Missing.

Show »
Length:108
Mass (Da):12,187
Checksum:iFDB8F7E74B892B70
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PPB1E9PPB1_HUMAN
Myelin protein zero-like protein 3
MPZL3
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031108155M → V. Corresponds to variant dbSNP:rs17121966Ensembl.1
Natural variantiVAR_050455168V → G. Corresponds to variant dbSNP:rs36102742Ensembl.1
Natural variantiVAR_050456172V → M. Corresponds to variant dbSNP:rs34507994Ensembl.1
Natural variantiVAR_031109228D → V. Corresponds to variant dbSNP:rs7105729Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05398825 – 36Missing in isoform 2. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_05532481 – 108IFHYQ…GNVYK → VLAPCFPLWPFFPSLSLCPQ PWWLLCCW in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_055325109 – 235Missing in isoform 3. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358626 mRNA Translation: AAQ88989.1
AK289390 mRNA Translation: BAF82079.1
AK095399 mRNA Translation: BAG53045.1
AK296951 mRNA Translation: BAG59497.1
AK304292 mRNA Translation: BAG65150.1
AP002800 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67357.1
BC113586 mRNA Translation: AAI13587.1
BC143897 mRNA Translation: AAI43898.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS66241.1 [Q6UWV2-2]
CCDS8392.1 [Q6UWV2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001273081.1, NM_001286152.1 [Q6UWV2-2]
NP_938016.1, NM_198275.2 [Q6UWV2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000278949; ENSP00000278949; ENSG00000160588 [Q6UWV2-1]
ENST00000446386; ENSP00000393594; ENSG00000160588 [Q6UWV2-3]
ENST00000527472; ENSP00000432106; ENSG00000160588 [Q6UWV2-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
196264

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:196264

UCSC genome browser

More...
UCSCi
uc001psm.5, human [Q6UWV2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358626 mRNA Translation: AAQ88989.1
AK289390 mRNA Translation: BAF82079.1
AK095399 mRNA Translation: BAG53045.1
AK296951 mRNA Translation: BAG59497.1
AK304292 mRNA Translation: BAG65150.1
AP002800 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67357.1
BC113586 mRNA Translation: AAI13587.1
BC143897 mRNA Translation: AAI43898.1
CCDSiCCDS66241.1 [Q6UWV2-2]
CCDS8392.1 [Q6UWV2-1]
RefSeqiNP_001273081.1, NM_001286152.1 [Q6UWV2-2]
NP_938016.1, NM_198275.2 [Q6UWV2-1]

3D structure databases

SMRiQ6UWV2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128193, 2 interactors
IntActiQ6UWV2, 3 interactors
STRINGi9606.ENSP00000278949

PTM databases

GlyGeniQ6UWV2, 1 site
iPTMnetiQ6UWV2
PhosphoSitePlusiQ6UWV2

Polymorphism and mutation databases

BioMutaiMPZL3
DMDMi74758560

Proteomic databases

jPOSTiQ6UWV2
MassIVEiQ6UWV2
PaxDbiQ6UWV2
PeptideAtlasiQ6UWV2
PRIDEiQ6UWV2
ProteomicsDBi4527
5822
67527 [Q6UWV2-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32439, 88 antibodies

The DNASU plasmid repository

More...
DNASUi
196264

Genome annotation databases

EnsembliENST00000278949; ENSP00000278949; ENSG00000160588 [Q6UWV2-1]
ENST00000446386; ENSP00000393594; ENSG00000160588 [Q6UWV2-3]
ENST00000527472; ENSP00000432106; ENSG00000160588 [Q6UWV2-2]
GeneIDi196264
KEGGihsa:196264
UCSCiuc001psm.5, human [Q6UWV2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
196264
DisGeNETi196264
EuPathDBiHostDB:ENSG00000160588.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MPZL3
HGNCiHGNC:27279, MPZL3
HPAiENSG00000160588, Low tissue specificity
MIMi611707, gene
neXtProtiNX_Q6UWV2
OpenTargetsiENSG00000160588
PharmGKBiPA162396160

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RYH4, Eukaryota
GeneTreeiENSGT00990000203537
HOGENOMiCLU_090350_1_0_1
InParanoidiQ6UWV2
OMAiIKLRCTF
OrthoDBi1437254at2759
PhylomeDBiQ6UWV2
TreeFamiTF331728

Enzyme and pathway databases

PathwayCommonsiQ6UWV2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
196264, 4 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MPZL3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
196264
PharosiQ6UWV2, Tbio

Protein Ontology

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PROi
PR:Q6UWV2
RNActiQ6UWV2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000160588, Expressed in vagina and 156 other tissues
ExpressionAtlasiQ6UWV2, baseline and differential
GenevisibleiQ6UWV2, HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR029862, MPZL3
IPR000920, Myelin_P0-rel
PANTHERiPTHR13869, PTHR13869, 1 hit
PTHR13869:SF20, PTHR13869:SF20, 1 hit
PfamiView protein in Pfam
PF07686, V-set, 1 hit
PRINTSiPR00213, MYELINP0
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00406, IGv, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPZL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UWV2
Secondary accession number(s): A8K025, B4DLD5, B4E2I8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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