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Protein

Ly6/PLAUR domain-containing protein 5

Gene

LYPD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Ly6/PLAUR domain-containing protein 5
Gene namesi
Name:LYPD5
ORF Names:UNQ1908/PRO4356
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000159871.14
HGNCiHGNC:26397 LYPD5
neXtProtiNX_Q6UWN5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi284348
OpenTargetsiENSG00000159871
PharmGKBiPA142671492

Polymorphism and mutation databases

BioMutaiLYPD5
DMDMi90185272

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000022676326 – 225Ly6/PLAUR domain-containing protein 5Add BLAST200
PropeptideiPRO_0000226764226 – 251Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi225GPI-anchor amidated alanineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ6UWN5
PeptideAtlasiQ6UWN5
PRIDEiQ6UWN5
ProteomicsDBi67504
67505 [Q6UWN5-2]

PTM databases

iPTMnetiQ6UWN5
PhosphoSitePlusiQ6UWN5

Expressioni

Gene expression databases

BgeeiENSG00000159871
CleanExiHS_LYPD5
ExpressionAtlasiQ6UWN5 baseline and differential
GenevisibleiQ6UWN5 HS

Organism-specific databases

HPAiHPA042511
HPA054670

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129836, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ6UWN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 214UPAR/Ly6Add BLAST80

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX2N Eukaryota
ENOG4111DV8 LUCA
GeneTreeiENSGT00910000144240
HOGENOMiHOG000113416
HOVERGENiHBG081942
InParanoidiQ6UWN5
OMAiKGCWTGP
OrthoDBiEOG091G0FQ6
PhylomeDBiQ6UWN5
TreeFamiTF337629

Family and domain databases

InterProiView protein in InterPro
IPR018363 CD59_antigen_CS
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit
PROSITEiView protein in PROSITE
PS00983 LY6_UPAR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UWN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMGVPRVIL LCLFGAALCL TGSQALQCYS FEHTYFGPFD LRAMKLPSIS
60 70 80 90 100
CPHECFEAIL SLDTGYRAPV TLVRKGCWTG PPAGQTQSNA DALPPDYSVV
110 120 130 140 150
RGCTTDKCNA HLMTHDALPN LSQAPDPPTL SGAECYACIG VHQDDCAIGR
160 170 180 190 200
SRRVQCHQDQ TACFQGNGRM TVGNFSVPVY IRTCHRPSCT TEGTTSPWTA
210 220 230 240 250
IDLQGSCCEG YLCNRKSMTQ PFTSASATTP PRALQVLALL LPVLLLVGLS

A
Length:251
Mass (Da):26,936
Last modified:March 7, 2006 - v2
Checksum:i16AA033E01B115FC
GO
Isoform 2 (identifier: Q6UWN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: No experimental confirmation available.
Show »
Length:208
Mass (Da):22,241
Checksum:i926FBE6513EB6DF8
GO

Sequence cautioni

The sequence AAH57816 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti194T → S in AAH57816 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05270447P → A. Corresponds to variant dbSNP:rs11547806Ensembl.1
Natural variantiVAR_05988590A → P2 PublicationsCorresponds to variant dbSNP:rs11547806Ensembl.1
Natural variantiVAR_059886167N → S2 PublicationsCorresponds to variant dbSNP:rs349053Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0174471 – 43Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358719 mRNA Translation: AAQ89081.1
AK055031 mRNA Translation: BAB70840.1
BC057816 mRNA Translation: AAH57816.2 Different initiation.
CCDSiCCDS12631.1 [Q6UWN5-2]
CCDS46096.1 [Q6UWN5-1]
RefSeqiNP_001026919.2, NM_001031749.2 [Q6UWN5-1]
NP_001275692.1, NM_001288763.1 [Q6UWN5-2]
NP_872379.2, NM_182573.2 [Q6UWN5-2]
XP_011525096.1, XM_011526794.2 [Q6UWN5-2]
UniGeneiHs.44289
Hs.738790

Genome annotation databases

EnsembliENST00000377950; ENSP00000367185; ENSG00000159871 [Q6UWN5-1]
ENST00000414615; ENSP00000408433; ENSG00000159871 [Q6UWN5-2]
ENST00000594013; ENSP00000471692; ENSG00000159871 [Q6UWN5-2]
GeneIDi284348
KEGGihsa:284348
UCSCiuc002oxm.5 human [Q6UWN5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLYPD5_HUMAN
AccessioniPrimary (citable) accession number: Q6UWN5
Secondary accession number(s): Q6PEX9, Q96DR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: June 20, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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