Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein GPR15L

Gene

GPR15L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic factor that mediates lymphocytes recruitement to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403).3 Publications
Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus (PubMed:25585381).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Cytokine
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GPR15L1 Publication
Alternative name(s):
Antimicrobial peptide with 57 amino acid residues1 Publication
Short name:
AP-571 Publication
Short name:
Antimicrobial peptide-571 Publication
Colon-derived SUSD2 binding factor1 Publication
Short name:
CSBF1 Publication
Secreted protein C10orf99
Gene namesi
Name:GPR15L1 Publication
Synonyms:C10orf99Imported
ORF Names:UNQ1833/PRO3446
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000188373.4
HGNCiHGNC:31428 C10orf99
MIMi617775 gene
neXtProtiNX_Q6UWK7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

OpenTargetsiENSG00000188373
PharmGKBiPA134990747

Polymorphism and mutation databases

BioMutaiC10orf99
DMDMi74749393

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000026008425 – 81Protein GPR15LAdd BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 63By similarity
Disulfide bondi41 ↔ 60By similarity
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UWK7
PeptideAtlasiQ6UWK7
PRIDEiQ6UWK7
ProteomicsDBi67489

PTM databases

iPTMnetiQ6UWK7
PhosphoSitePlusiQ6UWK7

Expressioni

Tissue specificityi

Expressed at high levels in colon, and cervix and at moderate level in tonsil (PubMed:25585381, PubMed:28900043). Highly reduced expression in primary colon cancer tissues compared with that in adjacent tissues (PubMed:25351403). Highest levels of expression detected in stomach and colon; expressed in epithelium of skin and esophagus, and in some tumor and/or tumor adjacent tissues (TAT), including TAT of esophagus cancer, hepatocellular carcinoma (HCC), squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and invasive ductal carcinoma (IDC) tissues (at protein level) (PubMed:25585381).2 Publications

Gene expression databases

BgeeiENSG00000188373 Expressed in 90 organ(s), highest expression level in colon
CleanExiHS_C10orf99
GenevisibleiQ6UWK7 HS

Organism-specific databases

HPAiHPA050920

Interactioni

Subunit structurei

Interacts with SUSD2; the interaction is direct.1 Publication

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ6UWK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JJ2R Eukaryota
ENOG41115Y9 LUCA
GeneTreeiENSGT00390000015172
HOGENOMiHOG000111701
InParanoidiQ6UWK7
OMAiCRPCKLK
OrthoDBiEOG091G1AMP
PhylomeDBiQ6UWK7
TreeFamiTF336385

Family and domain databases

InterProiView protein in InterPro
IPR031713 DUF4725
PfamiView protein in Pfam
PF15854 DUF4725, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWK7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLVLSSLL CILLLCFSIF STEGKRRPAK AWSGRRTRLC CHRVPSPNST
60 70 80
NLKGHHVRLC KPCKLEPEPR LWVVPGALPQ V
Length:81
Mass (Da):9,173
Last modified:July 5, 2004 - v1
Checksum:i276E720364160B8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358751 mRNA Translation: AAQ89111.1
AC022389 Genomic DNA No translation available.
CCDSiCCDS7371.1
RefSeqiNP_997256.1, NM_207373.2
UniGeneiHs.298713

Genome annotation databases

EnsembliENST00000372126; ENSP00000361199; ENSG00000188373
GeneIDi387695
KEGGihsa:387695
UCSCiuc001kcu.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358751 mRNA Translation: AAQ89111.1
AC022389 Genomic DNA No translation available.
CCDSiCCDS7371.1
RefSeqiNP_997256.1, NM_207373.2
UniGeneiHs.298713

3D structure databases

ProteinModelPortaliQ6UWK7
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6UWK7
PhosphoSitePlusiQ6UWK7

Polymorphism and mutation databases

BioMutaiC10orf99
DMDMi74749393

Proteomic databases

PaxDbiQ6UWK7
PeptideAtlasiQ6UWK7
PRIDEiQ6UWK7
ProteomicsDBi67489

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372126; ENSP00000361199; ENSG00000188373
GeneIDi387695
KEGGihsa:387695
UCSCiuc001kcu.4 human

Organism-specific databases

CTDi387695
EuPathDBiHostDB:ENSG00000188373.4
GeneCardsiC10orf99
HGNCiHGNC:31428 C10orf99
HPAiHPA050920
MIMi617775 gene
neXtProtiNX_Q6UWK7
OpenTargetsiENSG00000188373
PharmGKBiPA134990747
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JJ2R Eukaryota
ENOG41115Y9 LUCA
GeneTreeiENSGT00390000015172
HOGENOMiHOG000111701
InParanoidiQ6UWK7
OMAiCRPCKLK
OrthoDBiEOG091G1AMP
PhylomeDBiQ6UWK7
TreeFamiTF336385

Miscellaneous databases

ChiTaRSiC10orf99 human
GenomeRNAii387695
PROiPR:Q6UWK7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188373 Expressed in 90 organ(s), highest expression level in colon
CleanExiHS_C10orf99
GenevisibleiQ6UWK7 HS

Family and domain databases

InterProiView protein in InterPro
IPR031713 DUF4725
PfamiView protein in Pfam
PF15854 DUF4725, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGP15L_HUMAN
AccessioniPrimary (citable) accession number: Q6UWK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again