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UniProtKB - Q6UWJ8 (C16L2_HUMAN)
Protein
CD164 sialomucin-like 2 protein
Gene
CD164L2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: CD164 sialomucin-like 2 protein |
Gene namesi | Name:CD164L2 ORF Names:UNQ6122/PRO20044 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:32043, CD164L2 |
neXtProti | NX_Q6UWJ8 |
VEuPathDBi | HostDB:ENSG00000174950 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Other locations
- cytoplasmic vesicle Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 141 | ExtracellularSequence analysisAdd BLAST | 112 | |
Transmembranei | 142 – 162 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 174 | CytoplasmicSequence analysisAdd BLAST | 12 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 388611 |
OpenTargetsi | ENSG00000174950 |
PharmGKBi | PA142672146 |
Miscellaneous databases
Pharosi | Q6UWJ8, Tdark |
Genetic variation databases
BioMutai | CD164L2 |
DMDMi | 85700457 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | 1 PublicationAdd BLAST | 29 | |
ChainiPRO_0000045779 | 30 – 174 | CD164 sialomucin-like 2 proteinAdd BLAST | 145 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 71 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q6UWJ8 |
PeptideAtlasi | Q6UWJ8 |
PRIDEi | Q6UWJ8 |
ProteomicsDBi | 67487 [Q6UWJ8-1] 67488 [Q6UWJ8-2] |
PTM databases
GlyGeni | Q6UWJ8, 2 sites |
iPTMneti | Q6UWJ8 |
PhosphoSitePlusi | Q6UWJ8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000174950, Expressed in right uterine tube and 81 other tissues |
Organism-specific databases
HPAi | ENSG00000174950, Tissue enhanced (esophagus, fallopian tube, salivary gland) |
Interactioni
Binary interactionsi
Isoform 2 [Q6UWJ8-2]
With | #Exp. | IntAct |
---|---|---|
DRAM1 [Q8N682] | 3 | EBI-13362802,EBI-10305400 |
PLLP [Q9Y342] | 3 | EBI-13362802,EBI-3919291 |
Protein-protein interaction databases
BioGRIDi | 132771, 36 interactors |
IntActi | Q6UWJ8, 7 interactors |
STRINGi | 9606.ENSP00000363139 |
Miscellaneous databases
RNActi | Q6UWJ8, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q6UWJ8 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the CD164 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S6M0, Eukaryota |
GeneTreei | ENSGT00530000063929 |
HOGENOMi | CLU_133331_0_0_1 |
InParanoidi | Q6UWJ8 |
OMAi | AVQGGCK |
OrthoDBi | 1643926at2759 |
PhylomeDBi | Q6UWJ8 |
TreeFami | TF333380 |
Family and domain databases
InterProi | View protein in InterPro IPR007947, CD164_MGC24 |
PANTHERi | PTHR11337, PTHR11337, 1 hit |
Pfami | View protein in Pfam PF05283, MGC-24, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q6UWJ8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAPGPRALR TALCGGCCCL LLCAQLAVAG KGARGFGRGA LIRLNIWPAV
60 70 80 90 100
QGACKQLEVC EHCVEGDGAR NLSSCVWEQC RPEEPGHCVA QSEVVKEGCS
110 120 130 140 150
IYNRSEACPA AHHHPTYEPK TVTTGSPPVP EAHSPGFDGA SFIGGVVLVL
160 170
SLQAVAFFVL HFLKAKDSTY QTLI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 68 | G → R in AAQ89121 (PubMed:12975309).Curated | 1 | |
Sequence conflicti | 68 | G → R in AAI37467 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 68 | G → R in CAI19568 (PubMed:16710414).Curated | 1 | |
Sequence conflicti | 68 | G → R in CAI19569 (PubMed:16710414).Curated | 1 | |
Sequence conflicti | 68 | G → R in EAX07755 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057508 | 76 | V → M. Corresponds to variant dbSNP:rs2504779Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017031 | 174 | Missing in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358761 mRNA Translation: AAQ89121.1 AL096774 Genomic DNA Translation: CAI19568.1 AL096774 Genomic DNA Translation: CAI19569.1 CH471059 Genomic DNA Translation: EAX07755.1 BC137466 mRNA Translation: AAI37467.1 |
CCDSi | CCDS302.1 [Q6UWJ8-2] CCDS81287.1 [Q6UWJ8-1] |
RefSeqi | NP_001317377.1, NM_001330448.1 [Q6UWJ8-1] NP_997280.2, NM_207397.4 [Q6UWJ8-2] XP_011539743.1, XM_011541441.1 [Q6UWJ8-2] |
Genome annotation databases
Ensembli | ENST00000374027.7; ENSP00000363139.3; ENSG00000174950.11 [Q6UWJ8-2] ENST00000374030.3; ENSP00000363142.1; ENSG00000174950.11 |
GeneIDi | 388611 |
KEGGi | hsa:388611 |
MANE-Selecti | ENST00000374030.3; ENSP00000363142.1; NM_001330448.1; NP_001317377.1 |
UCSCi | uc031tuv.2, human [Q6UWJ8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358761 mRNA Translation: AAQ89121.1 AL096774 Genomic DNA Translation: CAI19568.1 AL096774 Genomic DNA Translation: CAI19569.1 CH471059 Genomic DNA Translation: EAX07755.1 BC137466 mRNA Translation: AAI37467.1 |
CCDSi | CCDS302.1 [Q6UWJ8-2] CCDS81287.1 [Q6UWJ8-1] |
RefSeqi | NP_001317377.1, NM_001330448.1 [Q6UWJ8-1] NP_997280.2, NM_207397.4 [Q6UWJ8-2] XP_011539743.1, XM_011541441.1 [Q6UWJ8-2] |
3D structure databases
AlphaFoldDBi | Q6UWJ8 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 132771, 36 interactors |
IntActi | Q6UWJ8, 7 interactors |
STRINGi | 9606.ENSP00000363139 |
PTM databases
GlyGeni | Q6UWJ8, 2 sites |
iPTMneti | Q6UWJ8 |
PhosphoSitePlusi | Q6UWJ8 |
Genetic variation databases
BioMutai | CD164L2 |
DMDMi | 85700457 |
Proteomic databases
PaxDbi | Q6UWJ8 |
PeptideAtlasi | Q6UWJ8 |
PRIDEi | Q6UWJ8 |
ProteomicsDBi | 67487 [Q6UWJ8-1] 67488 [Q6UWJ8-2] |
Protocols and materials databases
Antibodypediai | 74085, 12 antibodies from 9 providers |
DNASUi | 388611 |
Genome annotation databases
Ensembli | ENST00000374027.7; ENSP00000363139.3; ENSG00000174950.11 [Q6UWJ8-2] ENST00000374030.3; ENSP00000363142.1; ENSG00000174950.11 |
GeneIDi | 388611 |
KEGGi | hsa:388611 |
MANE-Selecti | ENST00000374030.3; ENSP00000363142.1; NM_001330448.1; NP_001317377.1 |
UCSCi | uc031tuv.2, human [Q6UWJ8-1] |
Organism-specific databases
CTDi | 388611 |
DisGeNETi | 388611 |
GeneCardsi | CD164L2 |
HGNCi | HGNC:32043, CD164L2 |
HPAi | ENSG00000174950, Tissue enhanced (esophagus, fallopian tube, salivary gland) |
neXtProti | NX_Q6UWJ8 |
OpenTargetsi | ENSG00000174950 |
PharmGKBi | PA142672146 |
VEuPathDBi | HostDB:ENSG00000174950 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S6M0, Eukaryota |
GeneTreei | ENSGT00530000063929 |
HOGENOMi | CLU_133331_0_0_1 |
InParanoidi | Q6UWJ8 |
OMAi | AVQGGCK |
OrthoDBi | 1643926at2759 |
PhylomeDBi | Q6UWJ8 |
TreeFami | TF333380 |
Enzyme and pathway databases
PathwayCommonsi | Q6UWJ8 |
SignaLinki | Q6UWJ8 |
Miscellaneous databases
BioGRID-ORCSi | 388611, 11 hits in 1068 CRISPR screens |
GenomeRNAii | 388611 |
Pharosi | Q6UWJ8, Tdark |
PROi | PR:Q6UWJ8 |
RNActi | Q6UWJ8, protein |
Gene expression databases
Bgeei | ENSG00000174950, Expressed in right uterine tube and 81 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR007947, CD164_MGC24 |
PANTHERi | PTHR11337, PTHR11337, 1 hit |
Pfami | View protein in Pfam PF05283, MGC-24, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | C16L2_HUMAN | |
Accessioni | Q6UWJ8Primary (citable) accession number: Q6UWJ8 Secondary accession number(s): B2RPJ0, Q5JXD6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | September 12, 2018 | |
Last modified: | May 25, 2022 | |
This is version 118 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families