CD164L2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CD164 sialomucin-like 2 protein
Gene namesⁱ	Name:CD164L2 ORF Names:UNQ6122/PRO20044
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000174950.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:32043 CD164L2
neXtProtⁱ	NX_Q6UWJ8

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	30 – 141	ExtracellularSequence analysisAdd BLAST	112
Transmembraneⁱ	142 – 162	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	163 – 174	CytoplasmicSequence analysisAdd BLAST	12

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000174950
PharmGKBⁱ	PA142672146

Polymorphism and mutation databases

BioMutaⁱ	CD164L2
DMDMⁱ	85700457

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 29	1 PublicationAdd BLAST		29
ChainⁱPRO_0000045779	30 – 174	CD164 sialomucin-like 2 proteinAdd BLAST		145

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	71	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	103	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q6UWJ8
PeptideAtlas More...PeptideAtlasⁱ	Q6UWJ8
PRIDEⁱ	Q6UWJ8
ProteomicsDBⁱ	67487 67488 [Q6UWJ8-2]

PTM databases

iPTMnetⁱ	Q6UWJ8
PhosphoSitePlusⁱ	Q6UWJ8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000174950 Expressed in 63 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_CD164L2

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA062915

HPAⁱ

HPA062915

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	132771, 6 interactors
IntActⁱ	Q6UWJ8, 2 interactors
STRINGⁱ	9606.ENSP00000363139

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CD164 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J8SQ Eukaryota ENOG410Z06V LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063929
HOGENOMⁱ	HOG000060100
HOVERGENⁱ	HBG056403
InParanoidⁱ	Q6UWJ8
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G141K
PhylomeDBⁱ	Q6UWJ8
TreeFamⁱ	TF333380

Family and domain databases

InterProⁱ	View protein in InterPro IPR007947 CD164_MGC24
PANTHERⁱ	PTHR11337 PTHR11337, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05283 MGC-24, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q6UWJ8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAPGPRALR TALCGGCCCL LLCAQLAVAG KGARGFGRGA LIRLNIWPAV 
        60         70         80         90        100
QGACKQLEVC EHCVEGDGAR NLSSCVWEQC RPEEPGHCVA QSEVVKEGCS 
       110        120        130        140        150
IYNRSEACPA AHHHPTYEPK TVTTGSPPVP EAHSPGFDGA SFIGGVVLVL 
       160        170 
SLQAVAFFVL HFLKAKDSTY QTLI

Length:174

Mass (Da):18,403

Last modified:September 12, 2018 - v3

Checksum:ⁱ530099138820ADFB

GO

Isoform 2 (identifier: Q6UWJ8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
174-174: Missing.

« Hide

        10         20         30         40         50
MEAPGPRALR TALCGGCCCL LLCAQLAVAG KGARGFGRGA LIRLNIWPAV 
        60         70         80         90        100
QGACKQLEVC EHCVEGDGAR NLSSCVWEQC RPEEPGHCVA QSEVVKEGCS 
       110        120        130        140        150
IYNRSEACPA AHHHPTYEPK TVTTGSPPVP EAHSPGFDGA SFIGGVVLVL 
       160        170 
SLQAVAFFVL HFLKAKDSTY QTL

Show »

Length:173

Mass (Da):18,290

Checksum:ⁱ9099138820ADFB26

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	68	G → R in AAQ89121 (PubMed:12975309).Curated	1
Sequence conflictⁱ	68	G → R in AAI37467 (PubMed:15489334).Curated	1
Sequence conflictⁱ	68	G → R in CAI19568 (PubMed:16710414).Curated	1
Sequence conflictⁱ	68	G → R in CAI19569 (PubMed:16710414).Curated	1
Sequence conflictⁱ	68	G → R in EAX07755 (Ref. 3) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_057508	76	V → M. Corresponds to variant dbSNP:rs2504779Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_017031	174	Missing in isoform 2. 2 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358761 mRNA Translation: AAQ89121.1 AL096774 Genomic DNA Translation: CAI19568.1 AL096774 Genomic DNA Translation: CAI19569.1 CH471059 Genomic DNA Translation: EAX07755.1 BC137466 mRNA Translation: AAI37467.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS302.1 [Q6UWJ8-2] CCDS81287.1 [Q6UWJ8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001317377.1, NM_001330448.1 [Q6UWJ8-1] NP_997280.2, NM_207397.4 [Q6UWJ8-2] XP_011539743.1, XM_011541441.1 [Q6UWJ8-2]
UniGeneⁱ	Hs.664836

Genome annotation databases

Ensemblⁱ	ENST00000374027; ENSP00000363139; ENSG00000174950 [Q6UWJ8-2] ENST00000374030; ENSP00000363142; ENSG00000174950 [Q6UWJ8-1]
GeneIDⁱ	388611
KEGGⁱ	hsa:388611
UCSC genome browser More...UCSCⁱ	uc031tuv.2 human [Q6UWJ8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6UWJ8	Isoform 2 of CD164 sialomucin-like 2 protein		HUMAN		173	UniRef90_Q6UWJ8
Uncharacterized protein		NOMLE		179
CD164 molecule like 2		CHLSB		177
CD164 molecule like 2		PANTR		174
CD164 molecule like 2		PONAB		174
+35

Protein	Similar proteins		Species	Score	Length	Source
Q6UWJ8	CD164 sialomucin-like 2 protein		MOUSE		172	UniRef50_Q6UWJ8
Isoform 2 of CD164 sialomucin-like 2 protein		HUMAN		173
Uncharacterized protein		NOMLE		179
CD164 molecule like 2		CHLSB		177
Uncharacterized protein		MACFA		174
+151

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358761 mRNA Translation: AAQ89121.1 AL096774 Genomic DNA Translation: CAI19568.1 AL096774 Genomic DNA Translation: CAI19569.1 CH471059 Genomic DNA Translation: EAX07755.1 BC137466 mRNA Translation: AAI37467.1
CCDSⁱ	CCDS302.1 [Q6UWJ8-2] CCDS81287.1 [Q6UWJ8-1]
RefSeqⁱ	NP_001317377.1, NM_001330448.1 [Q6UWJ8-1] NP_997280.2, NM_207397.4 [Q6UWJ8-2] XP_011539743.1, XM_011541441.1 [Q6UWJ8-2]
UniGeneⁱ	Hs.664836

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	132771, 6 interactors
IntActⁱ	Q6UWJ8, 2 interactors
STRINGⁱ	9606.ENSP00000363139

PTM databases

iPTMnetⁱ	Q6UWJ8
PhosphoSitePlusⁱ	Q6UWJ8

Polymorphism and mutation databases

BioMutaⁱ	CD164L2
DMDMⁱ	85700457

Proteomic databases

PaxDbⁱ	Q6UWJ8
PeptideAtlasⁱ	Q6UWJ8
PRIDEⁱ	Q6UWJ8
ProteomicsDBⁱ	67487 67488 [Q6UWJ8-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000374027; ENSP00000363139; ENSG00000174950 [Q6UWJ8-2] ENST00000374030; ENSP00000363142; ENSG00000174950 [Q6UWJ8-1]
GeneIDⁱ	388611
KEGGⁱ	hsa:388611
UCSCⁱ	uc031tuv.2 human [Q6UWJ8-1]

Organism-specific databases

CTDⁱ	388611
EuPathDBⁱ	HostDB:ENSG00000174950.10
GeneCardsⁱ	CD164L2
HGNCⁱ	HGNC:32043 CD164L2
HPAⁱ	HPA062915
neXtProtⁱ	NX_Q6UWJ8
OpenTargetsⁱ	ENSG00000174950
PharmGKBⁱ	PA142672146
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J8SQ Eukaryota ENOG410Z06V LUCA
GeneTreeⁱ	ENSGT00530000063929
HOGENOMⁱ	HOG000060100
HOVERGENⁱ	HBG056403
InParanoidⁱ	Q6UWJ8
OrthoDBⁱ	EOG091G141K
PhylomeDBⁱ	Q6UWJ8
TreeFamⁱ	TF333380

Miscellaneous databases

GenomeRNAiⁱ	388611
Protein Ontology More...PROⁱ	PR:Q6UWJ8

Gene expression databases

Bgeeⁱ	ENSG00000174950 Expressed in 63 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_CD164L2

Family and domain databases

InterProⁱ	View protein in InterPro IPR007947 CD164_MGC24
PANTHERⁱ	PTHR11337 PTHR11337, 1 hit
Pfamⁱ	View protein in Pfam PF05283 MGC-24, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	C16L2_HUMAN
Accessionⁱ	Q6UWJ8Primary (citable) accession number: Q6UWJ8 Secondary accession number(s): B2RPJ0, Q5JXD6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
	Last sequence update:	September 12, 2018
	Last modified:	November 7, 2018
	This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q6UWJ8 (C16L2_HUMAN)

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CD164 sialomucin-like 2 protein

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ