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Protein

CD164 sialomucin-like 2 protein

Gene

CD164L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
CD164 sialomucin-like 2 protein
Gene namesi
Name:CD164L2
ORF Names:UNQ6122/PRO20044
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000174950.10
HGNCiHGNC:32043 CD164L2
neXtProtiNX_Q6UWJ8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 141ExtracellularSequence analysisAdd BLAST112
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 174CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174950
PharmGKBiPA142672146

Polymorphism and mutation databases

BioMutaiCD164L2
DMDMi85700457

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
ChainiPRO_000004577930 – 174CD164 sialomucin-like 2 proteinAdd BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6UWJ8
PeptideAtlasiQ6UWJ8
PRIDEiQ6UWJ8
ProteomicsDBi67487
67488 [Q6UWJ8-2]

PTM databases

iPTMnetiQ6UWJ8
PhosphoSitePlusiQ6UWJ8

Expressioni

Gene expression databases

BgeeiENSG00000174950 Expressed in 63 organ(s), highest expression level in right uterine tube
CleanExiHS_CD164L2

Organism-specific databases

HPAiHPA062915

Interactioni

Protein-protein interaction databases

BioGridi132771, 6 interactors
IntActiQ6UWJ8, 2 interactors
STRINGi9606.ENSP00000363139

Family & Domainsi

Sequence similaritiesi

Belongs to the CD164 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8SQ Eukaryota
ENOG410Z06V LUCA
GeneTreeiENSGT00530000063929
HOGENOMiHOG000060100
HOVERGENiHBG056403
InParanoidiQ6UWJ8
OrthoDBiEOG091G141K
PhylomeDBiQ6UWJ8
TreeFamiTF333380

Family and domain databases

InterProiView protein in InterPro
IPR007947 CD164_MGC24
PANTHERiPTHR11337 PTHR11337, 1 hit
PfamiView protein in Pfam
PF05283 MGC-24, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6UWJ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAPGPRALR TALCGGCCCL LLCAQLAVAG KGARGFGRGA LIRLNIWPAV
60 70 80 90 100
QGACKQLEVC EHCVEGDGAR NLSSCVWEQC RPEEPGHCVA QSEVVKEGCS
110 120 130 140 150
IYNRSEACPA AHHHPTYEPK TVTTGSPPVP EAHSPGFDGA SFIGGVVLVL
160 170
SLQAVAFFVL HFLKAKDSTY QTLI
Length:174
Mass (Da):18,403
Last modified:September 12, 2018 - v3
Checksum:i530099138820ADFB
GO
Isoform 2 (identifier: Q6UWJ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-174: Missing.

Show »
Length:173
Mass (Da):18,290
Checksum:i9099138820ADFB26
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68G → R in AAQ89121 (PubMed:12975309).Curated1
Sequence conflicti68G → R in AAI37467 (PubMed:15489334).Curated1
Sequence conflicti68G → R in CAI19568 (PubMed:16710414).Curated1
Sequence conflicti68G → R in CAI19569 (PubMed:16710414).Curated1
Sequence conflicti68G → R in EAX07755 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05750876V → M. Corresponds to variant dbSNP:rs2504779Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017031174Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358761 mRNA Translation: AAQ89121.1
AL096774 Genomic DNA Translation: CAI19568.1
AL096774 Genomic DNA Translation: CAI19569.1
CH471059 Genomic DNA Translation: EAX07755.1
BC137466 mRNA Translation: AAI37467.1
CCDSiCCDS302.1 [Q6UWJ8-2]
CCDS81287.1 [Q6UWJ8-1]
RefSeqiNP_001317377.1, NM_001330448.1 [Q6UWJ8-1]
NP_997280.2, NM_207397.4 [Q6UWJ8-2]
XP_011539743.1, XM_011541441.1 [Q6UWJ8-2]
UniGeneiHs.664836

Genome annotation databases

EnsembliENST00000374027; ENSP00000363139; ENSG00000174950 [Q6UWJ8-2]
ENST00000374030; ENSP00000363142; ENSG00000174950 [Q6UWJ8-1]
GeneIDi388611
KEGGihsa:388611
UCSCiuc031tuv.2 human [Q6UWJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358761 mRNA Translation: AAQ89121.1
AL096774 Genomic DNA Translation: CAI19568.1
AL096774 Genomic DNA Translation: CAI19569.1
CH471059 Genomic DNA Translation: EAX07755.1
BC137466 mRNA Translation: AAI37467.1
CCDSiCCDS302.1 [Q6UWJ8-2]
CCDS81287.1 [Q6UWJ8-1]
RefSeqiNP_001317377.1, NM_001330448.1 [Q6UWJ8-1]
NP_997280.2, NM_207397.4 [Q6UWJ8-2]
XP_011539743.1, XM_011541441.1 [Q6UWJ8-2]
UniGeneiHs.664836

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132771, 6 interactors
IntActiQ6UWJ8, 2 interactors
STRINGi9606.ENSP00000363139

PTM databases

iPTMnetiQ6UWJ8
PhosphoSitePlusiQ6UWJ8

Polymorphism and mutation databases

BioMutaiCD164L2
DMDMi85700457

Proteomic databases

PaxDbiQ6UWJ8
PeptideAtlasiQ6UWJ8
PRIDEiQ6UWJ8
ProteomicsDBi67487
67488 [Q6UWJ8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374027; ENSP00000363139; ENSG00000174950 [Q6UWJ8-2]
ENST00000374030; ENSP00000363142; ENSG00000174950 [Q6UWJ8-1]
GeneIDi388611
KEGGihsa:388611
UCSCiuc031tuv.2 human [Q6UWJ8-1]

Organism-specific databases

CTDi388611
EuPathDBiHostDB:ENSG00000174950.10
GeneCardsiCD164L2
HGNCiHGNC:32043 CD164L2
HPAiHPA062915
neXtProtiNX_Q6UWJ8
OpenTargetsiENSG00000174950
PharmGKBiPA142672146
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8SQ Eukaryota
ENOG410Z06V LUCA
GeneTreeiENSGT00530000063929
HOGENOMiHOG000060100
HOVERGENiHBG056403
InParanoidiQ6UWJ8
OrthoDBiEOG091G141K
PhylomeDBiQ6UWJ8
TreeFamiTF333380

Miscellaneous databases

GenomeRNAii388611
PROiPR:Q6UWJ8

Gene expression databases

BgeeiENSG00000174950 Expressed in 63 organ(s), highest expression level in right uterine tube
CleanExiHS_CD164L2

Family and domain databases

InterProiView protein in InterPro
IPR007947 CD164_MGC24
PANTHERiPTHR11337 PTHR11337, 1 hit
PfamiView protein in Pfam
PF05283 MGC-24, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC16L2_HUMAN
AccessioniPrimary (citable) accession number: Q6UWJ8
Secondary accession number(s): B2RPJ0, Q5JXD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: September 12, 2018
Last modified: November 7, 2018
This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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