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Protein

Transmembrane and coiled-coil domain-containing protein 3

Gene

TMCO3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable Na+/H+ antiporter.By similarity

GO - Molecular functioni

Keywordsi

Biological processAntiport, Ion transport, Transport

Protein family/group databases

TCDBi2.A.37.1.11 the monovalent cation:proton antiporter-2 (cpa2) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and coiled-coil domain-containing protein 3
Alternative name(s):
Putative LAG1-interacting protein
Gene namesi
Name:TMCO3
Synonyms:C13orf11
ORF Names:UNQ2419/PRO4976
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000150403.17
HGNCiHGNC:20329 TMCO3
MIMi617134 gene
neXtProtiNX_Q6UWJ1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21
Transmembranei554 – 574HelicalSequence analysisAdd BLAST21
Transmembranei578 – 598HelicalSequence analysisAdd BLAST21
Transmembranei608 – 628HelicalSequence analysisAdd BLAST21
Transmembranei640 – 660HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150403
PharmGKBiPA134989495

Polymorphism and mutation databases

BioMutaiTMCO3
DMDMi74749389

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000024985623 – 677Transmembrane and coiled-coil domain-containing protein 3Add BLAST655

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6UWJ1
MaxQBiQ6UWJ1
PaxDbiQ6UWJ1
PeptideAtlasiQ6UWJ1
PRIDEiQ6UWJ1
ProteomicsDBi67484
67485 [Q6UWJ1-2]
67486 [Q6UWJ1-3]

PTM databases

iPTMnetiQ6UWJ1
PhosphoSitePlusiQ6UWJ1

Expressioni

Tissue specificityi

Expressed in the cornea, lens capsule and choroid-retinal pigment epithelium (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000150403 Expressed in 207 organ(s), highest expression level in thoracic aorta
CleanExiHS_TMCO3
ExpressionAtlasiQ6UWJ1 baseline and differential
GenevisibleiQ6UWJ1 HS

Organism-specific databases

HPAiHPA039561
HPA048126

Interactioni

Protein-protein interaction databases

BioGridi120334, 42 interactors
IntActiQ6UWJ1, 4 interactors
MINTiQ6UWJ1
STRINGi9606.ENSP00000389399

Structurei

3D structure databases

ProteinModelPortaliQ6UWJ1
SMRiQ6UWJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili124 – 204Sequence analysisAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi221 – 224Poly-Glu4

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1650 Eukaryota
COG0475 LUCA
GeneTreeiENSGT00390000001394
HOVERGENiHBG094066
InParanoidiQ6UWJ1
OMAiCIEPIRD
OrthoDBiEOG091G03W2
PhylomeDBiQ6UWJ1
TreeFamiTF329364

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR038770 Na+/solute_symporter_sf
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UWJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVLGRSFFW VLFPVLPWAV QAVEHEEVAQ RVIKLHRGRG VAAMQSRQWV
60 70 80 90 100
RDSCRKLSGL LRQKNAVLNK LKTAIGAVEK DVGLSDEEKL FQVHTFEIFQ
110 120 130 140 150
KELNESENSV FQAVYGLQRA LQGDYKDVVN MKESSRQRLE ALREAAIKEE
160 170 180 190 200
TEYMELLAAE KHQVEALKNM QHQNQSLSML DEILEDVRKA ADRLEEEIEE
210 220 230 240 250
HAFDDNKSVK GVNFEAVLRV EEEEANSKQN ITKREVEDDL GLSMLIDSQN
260 270 280 290 300
NQYILTKPRD STIPRADHHF IKDIVTIGML SLPCGWLCTA IGLPTMFGYI
310 320 330 340 350
ICGVLLGPSG LNSIKSIVQV ETLGEFGVFF TLFLVGLEFS PEKLRKVWKI
360 370 380 390 400
SLQGPCYMTL LMIAFGLLWG HLLRIKPTQS VFISTCLSLS STPLVSRFLM
410 420 430 440 450
GSARGDKEGD IDYSTVLLGM LVTQDVQLGL FMAVMPTLIQ AGASASSSIV
460 470 480 490 500
VEVLRILVLI GQILFSLAAV FLLCLVIKKY LIGPYYRKLH MESKGNKEIL
510 520 530 540 550
ILGISAFIFL MLTVTELLDV SMELGCFLAG ALVSSQGPVV TEEIATSIEP
560 570 580 590 600
IRDFLAIVFF ASIGLHVFPT FVAYELTVLV FLTLSVVVMK FLLAALVLSL
610 620 630 640 650
ILPRSSQYIK WIVSAGLAQV SEFSFVLGSR ARRAGVISRE VYLLILSVTT
660 670
LSLLLAPVLW RAAITRCVPR PERRSSL
Length:677
Mass (Da):75,598
Last modified:July 5, 2004 - v1
Checksum:i138AA9B424D4A668
GO
Isoform 2 (identifier: Q6UWJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     515-524: TELLDVSMEL → ILKLCVIYVI
     525-677: Missing.

Note: No experimental confirmation available.
Show »
Length:524
Mass (Da):58,948
Checksum:i16458F3A1FE89251
GO
Isoform 3 (identifier: Q6UWJ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-414: DIDYS → NRTAL
     415-677: Missing.

Note: No experimental confirmation available.
Show »
Length:414
Mass (Da):46,844
Checksum:i631085E3692A4A46
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVR2A0A087WVR2_HUMAN
Transmembrane and coiled-coil domai...
TMCO3
94Annotation score:
A0A087X2E0A0A087X2E0_HUMAN
Transmembrane and coiled-coil domai...
TMCO3
84Annotation score:
A0A087WXI4A0A087WXI4_HUMAN
Transmembrane and coiled-coil domai...
TMCO3
163Annotation score:
A0A087WZ28A0A087WZ28_HUMAN
Transmembrane and coiled-coil domai...
TMCO3
126Annotation score:
A0A087WUP6A0A087WUP6_HUMAN
Transmembrane and coiled-coil domai...
TMCO3
145Annotation score:

Sequence cautioni

The sequence AAM92892 differs from that shown. Reason: Frameshift at positions 367 and 378.Curated
The sequence BAB85074 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223E → G in BAA91295 (PubMed:14702039).Curated1
Sequence conflicti380S → N in AAM92892 (Ref. 5) Curated1
Sequence conflicti388S → A in AAM92892 (Ref. 5) Curated1
Sequence conflicti436P → R in AAH68515 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07696414P → L Found in a patient with cornea guttata with anterior polar cataracts; unknown pathological significance. Corresponds to variant dbSNP:rs185071949Ensembl.1
Natural variantiVAR_050037443A → T. Corresponds to variant dbSNP:rs2260335Ensembl.1
Natural variantiVAR_050038445A → T1 PublicationCorresponds to variant dbSNP:rs7319493Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020561410 – 414DIDYS → NRTAL in isoform 3. 1 Publication5
Alternative sequenceiVSP_020562415 – 677Missing in isoform 3. 1 PublicationAdd BLAST263
Alternative sequenceiVSP_020563515 – 524TELLDVSMEL → ILKLCVIYVI in isoform 2. 1 Publication10
Alternative sequenceiVSP_020564525 – 677Missing in isoform 2. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358768 mRNA Translation: AAQ89128.1
AK000630 mRNA Translation: BAA91295.1
AK074415 mRNA Translation: BAB85074.1 Different initiation.
AL442125 Genomic DNA No translation available.
BC068515 mRNA Translation: AAH68515.1
BC012564 mRNA Translation: AAH12564.1
AF209505 mRNA Translation: AAM92892.1 Frameshift.
CCDSiCCDS86365.1 [Q6UWJ1-2]
CCDS9537.1 [Q6UWJ1-1]
RefSeqiNP_060375.4, NM_017905.4 [Q6UWJ1-1]
XP_006720032.1, XM_006719969.1 [Q6UWJ1-1]
XP_011535800.1, XM_011537498.2 [Q6UWJ1-1]
UniGeneiHs.317593

Genome annotation databases

EnsembliENST00000375391; ENSP00000364540; ENSG00000150403 [Q6UWJ1-3]
ENST00000434316; ENSP00000389399; ENSG00000150403 [Q6UWJ1-1]
ENST00000474393; ENSP00000484053; ENSG00000150403 [Q6UWJ1-2]
GeneIDi55002
KEGGihsa:55002
UCSCiuc001vtt.5 human [Q6UWJ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358768 mRNA Translation: AAQ89128.1
AK000630 mRNA Translation: BAA91295.1
AK074415 mRNA Translation: BAB85074.1 Different initiation.
AL442125 Genomic DNA No translation available.
BC068515 mRNA Translation: AAH68515.1
BC012564 mRNA Translation: AAH12564.1
AF209505 mRNA Translation: AAM92892.1 Frameshift.
CCDSiCCDS86365.1 [Q6UWJ1-2]
CCDS9537.1 [Q6UWJ1-1]
RefSeqiNP_060375.4, NM_017905.4 [Q6UWJ1-1]
XP_006720032.1, XM_006719969.1 [Q6UWJ1-1]
XP_011535800.1, XM_011537498.2 [Q6UWJ1-1]
UniGeneiHs.317593

3D structure databases

ProteinModelPortaliQ6UWJ1
SMRiQ6UWJ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120334, 42 interactors
IntActiQ6UWJ1, 4 interactors
MINTiQ6UWJ1
STRINGi9606.ENSP00000389399

Protein family/group databases

TCDBi2.A.37.1.11 the monovalent cation:proton antiporter-2 (cpa2) family

PTM databases

iPTMnetiQ6UWJ1
PhosphoSitePlusiQ6UWJ1

Polymorphism and mutation databases

BioMutaiTMCO3
DMDMi74749389

Proteomic databases

EPDiQ6UWJ1
MaxQBiQ6UWJ1
PaxDbiQ6UWJ1
PeptideAtlasiQ6UWJ1
PRIDEiQ6UWJ1
ProteomicsDBi67484
67485 [Q6UWJ1-2]
67486 [Q6UWJ1-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375391; ENSP00000364540; ENSG00000150403 [Q6UWJ1-3]
ENST00000434316; ENSP00000389399; ENSG00000150403 [Q6UWJ1-1]
ENST00000474393; ENSP00000484053; ENSG00000150403 [Q6UWJ1-2]
GeneIDi55002
KEGGihsa:55002
UCSCiuc001vtt.5 human [Q6UWJ1-1]

Organism-specific databases

CTDi55002
EuPathDBiHostDB:ENSG00000150403.17
GeneCardsiTMCO3
HGNCiHGNC:20329 TMCO3
HPAiHPA039561
HPA048126
MIMi617134 gene
neXtProtiNX_Q6UWJ1
OpenTargetsiENSG00000150403
PharmGKBiPA134989495
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1650 Eukaryota
COG0475 LUCA
GeneTreeiENSGT00390000001394
HOVERGENiHBG094066
InParanoidiQ6UWJ1
OMAiCIEPIRD
OrthoDBiEOG091G03W2
PhylomeDBiQ6UWJ1
TreeFamiTF329364

Miscellaneous databases

ChiTaRSiTMCO3 human
GenomeRNAii55002
PROiPR:Q6UWJ1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150403 Expressed in 207 organ(s), highest expression level in thoracic aorta
CleanExiHS_TMCO3
ExpressionAtlasiQ6UWJ1 baseline and differential
GenevisibleiQ6UWJ1 HS

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR038770 Na+/solute_symporter_sf
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMCO3_HUMAN
AccessioniPrimary (citable) accession number: Q6UWJ1
Secondary accession number(s): Q5JSB1
, Q6NUN1, Q8NG29, Q8TCI6, Q96EA6, Q9NWT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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