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Entry version 119 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Transmembrane and coiled-coil domain-containing protein 3

Gene

TMCO3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable Na+/H+ antiporter.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.37.1.11 the monovalent cation:proton antiporter-2 (cpa2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane and coiled-coil domain-containing protein 3
Alternative name(s):
Putative LAG1-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMCO3
Synonyms:C13orf11
ORF Names:UNQ2419/PRO4976
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000150403.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20329 TMCO3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617134 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UWJ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21
Transmembranei554 – 574HelicalSequence analysisAdd BLAST21
Transmembranei578 – 598HelicalSequence analysisAdd BLAST21
Transmembranei608 – 628HelicalSequence analysisAdd BLAST21
Transmembranei640 – 660HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000150403

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134989495

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6UWJ1 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMCO3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749389

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024985623 – 677Transmembrane and coiled-coil domain-containing protein 3Add BLAST655

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6UWJ1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6UWJ1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6UWJ1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6UWJ1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UWJ1

PeptideAtlas

More...
PeptideAtlasi
Q6UWJ1

PRoteomics IDEntifications database

More...
PRIDEi
Q6UWJ1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67484 [Q6UWJ1-1]
67485 [Q6UWJ1-2]
67486 [Q6UWJ1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6UWJ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UWJ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the cornea, lens capsule and choroid-retinal pigment epithelium (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000150403 Expressed in 207 organ(s), highest expression level in thoracic aorta

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6UWJ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6UWJ1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039561
HPA048126

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120334, 42 interactors

Protein interaction database and analysis system

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IntActi
Q6UWJ1, 40 interactors

Molecular INTeraction database

More...
MINTi
Q6UWJ1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000389399

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6UWJ1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6UWJ1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili124 – 204Sequence analysisAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi221 – 224Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1650 Eukaryota
COG0475 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001394

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UWJ1

Identification of Orthologs from Complete Genome Data

More...
OMAi
YSSIVME

Database of Orthologous Groups

More...
OrthoDBi
522572at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UWJ1

TreeFam database of animal gene trees

More...
TreeFami
TF329364

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006153 Cation/H_exchanger
IPR038770 Na+/solute_symporter_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00999 Na_H_Exchanger, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UWJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVLGRSFFW VLFPVLPWAV QAVEHEEVAQ RVIKLHRGRG VAAMQSRQWV
60 70 80 90 100
RDSCRKLSGL LRQKNAVLNK LKTAIGAVEK DVGLSDEEKL FQVHTFEIFQ
110 120 130 140 150
KELNESENSV FQAVYGLQRA LQGDYKDVVN MKESSRQRLE ALREAAIKEE
160 170 180 190 200
TEYMELLAAE KHQVEALKNM QHQNQSLSML DEILEDVRKA ADRLEEEIEE
210 220 230 240 250
HAFDDNKSVK GVNFEAVLRV EEEEANSKQN ITKREVEDDL GLSMLIDSQN
260 270 280 290 300
NQYILTKPRD STIPRADHHF IKDIVTIGML SLPCGWLCTA IGLPTMFGYI
310 320 330 340 350
ICGVLLGPSG LNSIKSIVQV ETLGEFGVFF TLFLVGLEFS PEKLRKVWKI
360 370 380 390 400
SLQGPCYMTL LMIAFGLLWG HLLRIKPTQS VFISTCLSLS STPLVSRFLM
410 420 430 440 450
GSARGDKEGD IDYSTVLLGM LVTQDVQLGL FMAVMPTLIQ AGASASSSIV
460 470 480 490 500
VEVLRILVLI GQILFSLAAV FLLCLVIKKY LIGPYYRKLH MESKGNKEIL
510 520 530 540 550
ILGISAFIFL MLTVTELLDV SMELGCFLAG ALVSSQGPVV TEEIATSIEP
560 570 580 590 600
IRDFLAIVFF ASIGLHVFPT FVAYELTVLV FLTLSVVVMK FLLAALVLSL
610 620 630 640 650
ILPRSSQYIK WIVSAGLAQV SEFSFVLGSR ARRAGVISRE VYLLILSVTT
660 670
LSLLLAPVLW RAAITRCVPR PERRSSL
Length:677
Mass (Da):75,598
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i138AA9B424D4A668
GO
Isoform 2 (identifier: Q6UWJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     515-524: TELLDVSMEL → ILKLCVIYVI
     525-677: Missing.

Show »
Length:524
Mass (Da):58,948
Checksum:i16458F3A1FE89251
GO
Isoform 3 (identifier: Q6UWJ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-414: DIDYS → NRTAL
     415-677: Missing.

Show »
Length:414
Mass (Da):46,844
Checksum:i631085E3692A4A46
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVR2A0A087WVR2_HUMAN
Transmembrane and coiled-coil domai...
TMCO3
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXI4A0A087WXI4_HUMAN
Transmembrane and coiled-coil domai...
TMCO3
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ28A0A087WZ28_HUMAN
Transmembrane and coiled-coil domai...
TMCO3
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X2E0A0A087X2E0_HUMAN
Transmembrane and coiled-coil domai...
TMCO3
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUP6A0A087WUP6_HUMAN
Transmembrane and coiled-coil domai...
TMCO3
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM92892 differs from that shown. Reason: Frameshift.Curated
The sequence BAB85074 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti223E → G in BAA91295 (PubMed:14702039).Curated1
Sequence conflicti380S → N in AAM92892 (Ref. 5) Curated1
Sequence conflicti388S → A in AAM92892 (Ref. 5) Curated1
Sequence conflicti436P → R in AAH68515 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07696414P → L Found in a patient with cornea guttata with anterior polar cataracts; unknown pathological significance. Corresponds to variant dbSNP:rs185071949Ensembl.1
Natural variantiVAR_050037443A → T. Corresponds to variant dbSNP:rs2260335Ensembl.1
Natural variantiVAR_050038445A → T1 PublicationCorresponds to variant dbSNP:rs7319493Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020561410 – 414DIDYS → NRTAL in isoform 3. 1 Publication5
Alternative sequenceiVSP_020562415 – 677Missing in isoform 3. 1 PublicationAdd BLAST263
Alternative sequenceiVSP_020563515 – 524TELLDVSMEL → ILKLCVIYVI in isoform 2. 1 Publication10
Alternative sequenceiVSP_020564525 – 677Missing in isoform 2. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358768 mRNA Translation: AAQ89128.1
AK000630 mRNA Translation: BAA91295.1
AK074415 mRNA Translation: BAB85074.1 Different initiation.
AL442125 Genomic DNA No translation available.
BC068515 mRNA Translation: AAH68515.1
BC012564 mRNA Translation: AAH12564.1
AF209505 mRNA Translation: AAM92892.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS86365.1 [Q6UWJ1-2]
CCDS9537.1 [Q6UWJ1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060375.4, NM_017905.4 [Q6UWJ1-1]
XP_006720032.1, XM_006719969.1 [Q6UWJ1-1]
XP_011535800.1, XM_011537498.2 [Q6UWJ1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375391; ENSP00000364540; ENSG00000150403 [Q6UWJ1-3]
ENST00000434316; ENSP00000389399; ENSG00000150403 [Q6UWJ1-1]
ENST00000474393; ENSP00000484053; ENSG00000150403 [Q6UWJ1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55002

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55002

UCSC genome browser

More...
UCSCi
uc001vtt.5 human [Q6UWJ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358768 mRNA Translation: AAQ89128.1
AK000630 mRNA Translation: BAA91295.1
AK074415 mRNA Translation: BAB85074.1 Different initiation.
AL442125 Genomic DNA No translation available.
BC068515 mRNA Translation: AAH68515.1
BC012564 mRNA Translation: AAH12564.1
AF209505 mRNA Translation: AAM92892.1 Frameshift.
CCDSiCCDS86365.1 [Q6UWJ1-2]
CCDS9537.1 [Q6UWJ1-1]
RefSeqiNP_060375.4, NM_017905.4 [Q6UWJ1-1]
XP_006720032.1, XM_006719969.1 [Q6UWJ1-1]
XP_011535800.1, XM_011537498.2 [Q6UWJ1-1]

3D structure databases

SMRiQ6UWJ1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120334, 42 interactors
IntActiQ6UWJ1, 40 interactors
MINTiQ6UWJ1
STRINGi9606.ENSP00000389399

Protein family/group databases

TCDBi2.A.37.1.11 the monovalent cation:proton antiporter-2 (cpa2) family

PTM databases

iPTMnetiQ6UWJ1
PhosphoSitePlusiQ6UWJ1

Polymorphism and mutation databases

BioMutaiTMCO3
DMDMi74749389

Proteomic databases

EPDiQ6UWJ1
jPOSTiQ6UWJ1
MassIVEiQ6UWJ1
MaxQBiQ6UWJ1
PaxDbiQ6UWJ1
PeptideAtlasiQ6UWJ1
PRIDEiQ6UWJ1
ProteomicsDBi67484 [Q6UWJ1-1]
67485 [Q6UWJ1-2]
67486 [Q6UWJ1-3]

Genome annotation databases

EnsembliENST00000375391; ENSP00000364540; ENSG00000150403 [Q6UWJ1-3]
ENST00000434316; ENSP00000389399; ENSG00000150403 [Q6UWJ1-1]
ENST00000474393; ENSP00000484053; ENSG00000150403 [Q6UWJ1-2]
GeneIDi55002
KEGGihsa:55002
UCSCiuc001vtt.5 human [Q6UWJ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55002
EuPathDBiHostDB:ENSG00000150403.17

GeneCards: human genes, protein and diseases

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GeneCardsi
TMCO3
HGNCiHGNC:20329 TMCO3
HPAiHPA039561
HPA048126
MIMi617134 gene
neXtProtiNX_Q6UWJ1
OpenTargetsiENSG00000150403
PharmGKBiPA134989495

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1650 Eukaryota
COG0475 LUCA
GeneTreeiENSGT00390000001394
InParanoidiQ6UWJ1
OMAiYSSIVME
OrthoDBi522572at2759
PhylomeDBiQ6UWJ1
TreeFamiTF329364

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMCO3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55002
PharosiQ6UWJ1 Tdark

Protein Ontology

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PROi
PR:Q6UWJ1
RNActiQ6UWJ1 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000150403 Expressed in 207 organ(s), highest expression level in thoracic aorta
ExpressionAtlasiQ6UWJ1 baseline and differential
GenevisibleiQ6UWJ1 HS

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR038770 Na+/solute_symporter_sf
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMCO3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UWJ1
Secondary accession number(s): Q5JSB1
, Q6NUN1, Q8NG29, Q8TCI6, Q96EA6, Q9NWT2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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