UniProtKB - Q6UWI4 (SHSA2_HUMAN)
Protein
Protein shisa-2 homolog
Gene
SHISA2
Organism
Homo sapiens (Human)
Status
Functioni
Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.By similarity
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- negative regulation of fibroblast growth factor receptor signaling pathway Source: GO_Central
- negative regulation of Wnt signaling pathway Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Enzyme and pathway databases
PathwayCommonsi | Q6UWI4 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein shisa-2 homologAlternative name(s): Transmembrane protein 46 |
Gene namesi | Name:SHISA2 Synonyms:C13orf13, TMEM46 ORF Names:UNQ9166/PRO28631 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20366, SHISA2 |
MIMi | 617324, gene |
neXtProti | NX_Q6UWI4 |
VEuPathDBi | HostDB:ENSG00000180730.4 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 34 – 110 | ExtracellularSequence analysisAdd BLAST | 77 | |
Transmembranei | 111 – 131 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 132 – 295 | CytoplasmicSequence analysisAdd BLAST | 164 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 387914 |
OpenTargetsi | ENSG00000180730 |
PharmGKBi | PA162403292 |
Miscellaneous databases
Pharosi | Q6UWI4, Tdark |
Genetic variation databases
BioMutai | SHISA2 |
DMDMi | 55583902 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | 1 PublicationAdd BLAST | 33 | |
ChainiPRO_0000022615 | 34 – 295 | Protein shisa-2 homologAdd BLAST | 262 |
Proteomic databases
EPDi | Q6UWI4 |
MassIVEi | Q6UWI4 |
PaxDbi | Q6UWI4 |
PeptideAtlasi | Q6UWI4 |
PRIDEi | Q6UWI4 |
ProteomicsDBi | 67483 |
PTM databases
iPTMneti | Q6UWI4 |
PhosphoSitePlusi | Q6UWI4 |
SwissPalmi | Q6UWI4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180730, Expressed in metanephros and 148 other tissues |
Genevisiblei | Q6UWI4, HS |
Organism-specific databases
HPAi | ENSG00000180730, Tissue enhanced (breast, skeletal muscle, thyroid gland) |
Interactioni
Binary interactionsi
Q6UWI4
With | #Exp. | IntAct |
---|---|---|
ATXN1L [P0C7T5] | 3 | EBI-11343474,EBI-8624731 |
Protein-protein interaction databases
BioGRIDi | 132503, 8 interactors |
IntActi | Q6UWI4, 5 interactors |
STRINGi | 9606.ENSP00000313079 |
Miscellaneous databases
RNActi | Q6UWI4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the shisa family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWT7, Eukaryota |
GeneTreei | ENSGT00940000157443 |
HOGENOMi | CLU_085916_0_0_1 |
InParanoidi | Q6UWI4 |
OMAi | ETIPMMA |
OrthoDBi | 1325567at2759 |
PhylomeDBi | Q6UWI4 |
TreeFami | TF330800 |
Family and domain databases
InterProi | View protein in InterPro IPR026910, Shisa |
PANTHERi | PTHR31395, PTHR31395, 1 hit |
Pfami | View protein in Pfam PF13908, Shisa, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6UWI4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWGARRSSVS SSWNAASLLQ LLLAALLAAG ARASGEYCHG WLDAQGVWRI
60 70 80 90 100
GFQCPERFDG GDATICCGSC ALRYCCSSAE ARLDQGGCDN DRQQGAGEPG
110 120 130 140 150
RADKDGPDGS AVPIYVPFLI VGSVFVAFII LGSLVAACCC RCLRPKQDPQ
160 170 180 190 200
QSRAPGGNRL METIPMIPSA STSRGSSSRQ SSTAASSSSS ANSGARAPPT
210 220 230 240 250
RSQTNCCLPE GTMNNVYVNM PTNFSVLNCQ QATQIVPHQG QYLHPPYVGY
260 270 280 290
TVQHDSVPMT AVPPFMDGLQ PGYRQIQSPF PHTNSEQKMY PAVTV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358775 mRNA Translation: AAQ89135.1 AL139004 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08378.1 BC132898 mRNA Translation: AAI32899.1 BC137092 mRNA Translation: AAI37093.1 |
CCDSi | CCDS31951.1 |
RefSeqi | NP_001007539.1, NM_001007538.1 |
Genome annotation databases
Ensembli | ENST00000319420; ENSP00000313079; ENSG00000180730 |
GeneIDi | 387914 |
KEGGi | hsa:387914 |
UCSCi | uc001uqm.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358775 mRNA Translation: AAQ89135.1 AL139004 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08378.1 BC132898 mRNA Translation: AAI32899.1 BC137092 mRNA Translation: AAI37093.1 |
CCDSi | CCDS31951.1 |
RefSeqi | NP_001007539.1, NM_001007538.1 |
3D structure databases
SMRi | Q6UWI4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 132503, 8 interactors |
IntActi | Q6UWI4, 5 interactors |
STRINGi | 9606.ENSP00000313079 |
PTM databases
iPTMneti | Q6UWI4 |
PhosphoSitePlusi | Q6UWI4 |
SwissPalmi | Q6UWI4 |
Genetic variation databases
BioMutai | SHISA2 |
DMDMi | 55583902 |
Proteomic databases
EPDi | Q6UWI4 |
MassIVEi | Q6UWI4 |
PaxDbi | Q6UWI4 |
PeptideAtlasi | Q6UWI4 |
PRIDEi | Q6UWI4 |
ProteomicsDBi | 67483 |
Protocols and materials databases
Antibodypediai | 53427, 57 antibodies |
Genome annotation databases
Ensembli | ENST00000319420; ENSP00000313079; ENSG00000180730 |
GeneIDi | 387914 |
KEGGi | hsa:387914 |
UCSCi | uc001uqm.2, human |
Organism-specific databases
CTDi | 387914 |
DisGeNETi | 387914 |
GeneCardsi | SHISA2 |
HGNCi | HGNC:20366, SHISA2 |
HPAi | ENSG00000180730, Tissue enhanced (breast, skeletal muscle, thyroid gland) |
MIMi | 617324, gene |
neXtProti | NX_Q6UWI4 |
OpenTargetsi | ENSG00000180730 |
PharmGKBi | PA162403292 |
VEuPathDBi | HostDB:ENSG00000180730.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWT7, Eukaryota |
GeneTreei | ENSGT00940000157443 |
HOGENOMi | CLU_085916_0_0_1 |
InParanoidi | Q6UWI4 |
OMAi | ETIPMMA |
OrthoDBi | 1325567at2759 |
PhylomeDBi | Q6UWI4 |
TreeFami | TF330800 |
Enzyme and pathway databases
PathwayCommonsi | Q6UWI4 |
Miscellaneous databases
BioGRID-ORCSi | 387914, 5 hits in 989 CRISPR screens |
GenomeRNAii | 387914 |
Pharosi | Q6UWI4, Tdark |
PROi | PR:Q6UWI4 |
RNActi | Q6UWI4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180730, Expressed in metanephros and 148 other tissues |
Genevisiblei | Q6UWI4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026910, Shisa |
PANTHERi | PTHR31395, PTHR31395, 1 hit |
Pfami | View protein in Pfam PF13908, Shisa, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHSA2_HUMAN | |
Accessioni | Q6UWI4Primary (citable) accession number: Q6UWI4 Secondary accession number(s): B9EH70, Q5W0G8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 9, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families