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Protein

Protein shisa-2 homolog

Gene

SHISA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein shisa-2 homolog
Alternative name(s):
Transmembrane protein 46
Gene namesi
Name:SHISA2
Synonyms:C13orf13, TMEM46
ORF Names:UNQ9166/PRO28631
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000180730.4
HGNCiHGNC:20366 SHISA2
MIMi617324 gene
neXtProtiNX_Q6UWI4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 110ExtracellularSequence analysisAdd BLAST77
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 295CytoplasmicSequence analysisAdd BLAST164

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180730
PharmGKBiPA162403292

Polymorphism and mutation databases

BioMutaiSHISA2
DMDMi55583902

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 331 PublicationAdd BLAST33
ChainiPRO_000002261534 – 295Protein shisa-2 homologAdd BLAST262

Proteomic databases

EPDiQ6UWI4
PaxDbiQ6UWI4
PeptideAtlasiQ6UWI4
PRIDEiQ6UWI4
ProteomicsDBi67483

PTM databases

iPTMnetiQ6UWI4
PhosphoSitePlusiQ6UWI4
SwissPalmiQ6UWI4

Expressioni

Gene expression databases

BgeeiENSG00000180730 Expressed in 131 organ(s), highest expression level in metanephros
CleanExiHS_SHISA2
GenevisibleiQ6UWI4 HS

Organism-specific databases

HPAiHPA049752
HPA050172

Interactioni

Protein-protein interaction databases

BioGridi132503, 4 interactors
IntActiQ6UWI4, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6UWI4
SMRiQ6UWI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the shisa family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE4F Eukaryota
ENOG410ZKJD LUCA
GeneTreeiENSGT00390000016402
HOGENOMiHOG000234350
HOVERGENiHBG059385
InParanoidiQ6UWI4
OMAiVPPFMDG
OrthoDBiEOG091G0TZW
PhylomeDBiQ6UWI4
TreeFamiTF330800

Family and domain databases

InterProiView protein in InterPro
IPR026910 Shisa
PANTHERiPTHR31395 PTHR31395, 1 hit
PfamiView protein in Pfam
PF13908 Shisa, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWGARRSSVS SSWNAASLLQ LLLAALLAAG ARASGEYCHG WLDAQGVWRI
60 70 80 90 100
GFQCPERFDG GDATICCGSC ALRYCCSSAE ARLDQGGCDN DRQQGAGEPG
110 120 130 140 150
RADKDGPDGS AVPIYVPFLI VGSVFVAFII LGSLVAACCC RCLRPKQDPQ
160 170 180 190 200
QSRAPGGNRL METIPMIPSA STSRGSSSRQ SSTAASSSSS ANSGARAPPT
210 220 230 240 250
RSQTNCCLPE GTMNNVYVNM PTNFSVLNCQ QATQIVPHQG QYLHPPYVGY
260 270 280 290
TVQHDSVPMT AVPPFMDGLQ PGYRQIQSPF PHTNSEQKMY PAVTV
Length:295
Mass (Da):31,375
Last modified:July 5, 2004 - v1
Checksum:i180416B9D6490803
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358775 mRNA Translation: AAQ89135.1
AL139004 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08378.1
BC132898 mRNA Translation: AAI32899.1
BC137092 mRNA Translation: AAI37093.1
CCDSiCCDS31951.1
RefSeqiNP_001007539.1, NM_001007538.1
UniGeneiHs.433791

Genome annotation databases

EnsembliENST00000319420; ENSP00000313079; ENSG00000180730
GeneIDi387914
KEGGihsa:387914
UCSCiuc001uqm.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358775 mRNA Translation: AAQ89135.1
AL139004 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08378.1
BC132898 mRNA Translation: AAI32899.1
BC137092 mRNA Translation: AAI37093.1
CCDSiCCDS31951.1
RefSeqiNP_001007539.1, NM_001007538.1
UniGeneiHs.433791

3D structure databases

ProteinModelPortaliQ6UWI4
SMRiQ6UWI4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132503, 4 interactors
IntActiQ6UWI4, 3 interactors

PTM databases

iPTMnetiQ6UWI4
PhosphoSitePlusiQ6UWI4
SwissPalmiQ6UWI4

Polymorphism and mutation databases

BioMutaiSHISA2
DMDMi55583902

Proteomic databases

EPDiQ6UWI4
PaxDbiQ6UWI4
PeptideAtlasiQ6UWI4
PRIDEiQ6UWI4
ProteomicsDBi67483

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319420; ENSP00000313079; ENSG00000180730
GeneIDi387914
KEGGihsa:387914
UCSCiuc001uqm.2 human

Organism-specific databases

CTDi387914
EuPathDBiHostDB:ENSG00000180730.4
GeneCardsiSHISA2
HGNCiHGNC:20366 SHISA2
HPAiHPA049752
HPA050172
MIMi617324 gene
neXtProtiNX_Q6UWI4
OpenTargetsiENSG00000180730
PharmGKBiPA162403292
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE4F Eukaryota
ENOG410ZKJD LUCA
GeneTreeiENSGT00390000016402
HOGENOMiHOG000234350
HOVERGENiHBG059385
InParanoidiQ6UWI4
OMAiVPPFMDG
OrthoDBiEOG091G0TZW
PhylomeDBiQ6UWI4
TreeFamiTF330800

Miscellaneous databases

GenomeRNAii387914
PROiPR:Q6UWI4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180730 Expressed in 131 organ(s), highest expression level in metanephros
CleanExiHS_SHISA2
GenevisibleiQ6UWI4 HS

Family and domain databases

InterProiView protein in InterPro
IPR026910 Shisa
PANTHERiPTHR31395 PTHR31395, 1 hit
PfamiView protein in Pfam
PF13908 Shisa, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSHSA2_HUMAN
AccessioniPrimary (citable) accession number: Q6UWI4
Secondary accession number(s): B9EH70, Q5W0G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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