SHISA2

Functionⁱ

Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.By similarity

GO - Biological processⁱ

multicellular organism development Source: UniProtKB-KW
negative regulation of fibroblast growth factor receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of Wnt signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein

Molecular function

Developmental protein

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein shisa-2 homolog Alternative name(s): Transmembrane protein 46
Gene namesⁱ	Name:SHISA2 Synonyms:C13orf13, TMEM46 ORF Names:UNQ9166/PRO28631
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000180730.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20366 SHISA2
MIMⁱ	617324 gene
neXtProtⁱ	NX_Q6UWI4

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	34 – 110	ExtracellularSequence analysisAdd BLAST	77
Transmembraneⁱ	111 – 131	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	132 – 295	CytoplasmicSequence analysisAdd BLAST	164

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000180730
PharmGKBⁱ	PA162403292

Polymorphism and mutation databases

BioMutaⁱ	SHISA2
DMDMⁱ	55583902

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 33	1 PublicationAdd BLAST		33
ChainⁱPRO_0000022615	34 – 295	Protein shisa-2 homologAdd BLAST		262

Proteomic databases

EPDⁱ	Q6UWI4
PaxDbⁱ	Q6UWI4
PeptideAtlas More...PeptideAtlasⁱ	Q6UWI4
PRIDEⁱ	Q6UWI4
ProteomicsDBⁱ	67483

PTM databases

iPTMnetⁱ	Q6UWI4
PhosphoSitePlusⁱ	Q6UWI4
SwissPalmⁱ	Q6UWI4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000180730 Expressed in 131 organ(s), highest expression level in metanephros
CleanExⁱ	HS_SHISA2
Genevisibleⁱ	Q6UWI4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049752 HPA050172

HPAⁱ

HPA049752
HPA050172

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	132503, 4 interactors
IntActⁱ	Q6UWI4, 3 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6UWI4
SMRⁱ	Q6UWI4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the shisa family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IE4F Eukaryota ENOG410ZKJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016402
HOGENOMⁱ	HOG000234350
HOVERGENⁱ	HBG059385
InParanoidⁱ	Q6UWI4
OMAⁱ	VPPFMDG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TZW
PhylomeDBⁱ	Q6UWI4
TreeFamⁱ	TF330800

Family and domain databases

InterProⁱ	View protein in InterPro IPR026910 Shisa
PANTHERⁱ	PTHR31395 PTHR31395, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13908 Shisa, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q6UWI4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWGARRSSVS SSWNAASLLQ LLLAALLAAG ARASGEYCHG WLDAQGVWRI 
        60         70         80         90        100
GFQCPERFDG GDATICCGSC ALRYCCSSAE ARLDQGGCDN DRQQGAGEPG 
       110        120        130        140        150
RADKDGPDGS AVPIYVPFLI VGSVFVAFII LGSLVAACCC RCLRPKQDPQ 
       160        170        180        190        200
QSRAPGGNRL METIPMIPSA STSRGSSSRQ SSTAASSSSS ANSGARAPPT 
       210        220        230        240        250
RSQTNCCLPE GTMNNVYVNM PTNFSVLNCQ QATQIVPHQG QYLHPPYVGY 
       260        270        280        290 
TVQHDSVPMT AVPPFMDGLQ PGYRQIQSPF PHTNSEQKMY PAVTV

Length:295

Mass (Da):31,375

Last modified:July 5, 2004 - v1

Checksum:ⁱ180416B9D6490803

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358775 mRNA Translation: AAQ89135.1 AL139004 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08378.1 BC132898 mRNA Translation: AAI32899.1 BC137092 mRNA Translation: AAI37093.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31951.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001007539.1, NM_001007538.1
UniGeneⁱ	Hs.433791

Genome annotation databases

Ensemblⁱ	ENST00000319420; ENSP00000313079; ENSG00000180730
GeneIDⁱ	387914
KEGGⁱ	hsa:387914
UCSC genome browser More...UCSCⁱ	uc001uqm.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6UWI4	Uncharacterized protein		RABIT		296	UniRef90_Q6UWI4
Uncharacterized protein		OTOGA		295
Uncharacterized protein		ICTTR		295
Shisa family member 2		HORSE		295
Uncharacterized protein		MYOLU		295
+48

Protein	Similar proteins		Species	Score	Length	Source
Q6UWI4	Protein shisa-2 homolog		MOUSE		295	UniRef50_Q8QZV2
Protein shisa-2 homolog		BOVIN		289
Protein shisa-2		XENLA		288
Shisa family member 2		RAT		295
Uncharacterized protein		NEOLE		295
+160

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358775 mRNA Translation: AAQ89135.1 AL139004 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08378.1 BC132898 mRNA Translation: AAI32899.1 BC137092 mRNA Translation: AAI37093.1
CCDSⁱ	CCDS31951.1
RefSeqⁱ	NP_001007539.1, NM_001007538.1
UniGeneⁱ	Hs.433791

3D structure databases

ProteinModelPortalⁱ	Q6UWI4
SMRⁱ	Q6UWI4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	132503, 4 interactors
IntActⁱ	Q6UWI4, 3 interactors

PTM databases

iPTMnetⁱ	Q6UWI4
PhosphoSitePlusⁱ	Q6UWI4
SwissPalmⁱ	Q6UWI4

Polymorphism and mutation databases

BioMutaⁱ	SHISA2
DMDMⁱ	55583902

Proteomic databases

EPDⁱ	Q6UWI4
PaxDbⁱ	Q6UWI4
PeptideAtlasⁱ	Q6UWI4
PRIDEⁱ	Q6UWI4
ProteomicsDBⁱ	67483

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000319420; ENSP00000313079; ENSG00000180730
GeneIDⁱ	387914
KEGGⁱ	hsa:387914
UCSCⁱ	uc001uqm.2 human

Organism-specific databases

CTDⁱ	387914
EuPathDBⁱ	HostDB:ENSG00000180730.4
GeneCardsⁱ	SHISA2
HGNCⁱ	HGNC:20366 SHISA2
HPAⁱ	HPA049752 HPA050172
MIMⁱ	617324 gene
neXtProtⁱ	NX_Q6UWI4
OpenTargetsⁱ	ENSG00000180730
PharmGKBⁱ	PA162403292
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IE4F Eukaryota ENOG410ZKJD LUCA
GeneTreeⁱ	ENSGT00390000016402
HOGENOMⁱ	HOG000234350
HOVERGENⁱ	HBG059385
InParanoidⁱ	Q6UWI4
OMAⁱ	VPPFMDG
OrthoDBⁱ	EOG091G0TZW
PhylomeDBⁱ	Q6UWI4
TreeFamⁱ	TF330800

Miscellaneous databases

GenomeRNAiⁱ	387914
Protein Ontology More...PROⁱ	PR:Q6UWI4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000180730 Expressed in 131 organ(s), highest expression level in metanephros
CleanExⁱ	HS_SHISA2
Genevisibleⁱ	Q6UWI4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026910 Shisa
PANTHERⁱ	PTHR31395 PTHR31395, 1 hit
Pfamⁱ	View protein in Pfam PF13908 Shisa, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SHSA2_HUMAN
Accessionⁱ	Q6UWI4Primary (citable) accession number: Q6UWI4 Secondary accession number(s): B9EH70, Q5W0G8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 9, 2004
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q6UWI4 (SHSA2_HUMAN)

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Protein shisa-2 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ