UniProtKB - Q6UWH6 (TX261_HUMAN)
Protein
Protein TEX261
Gene
TEX261
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- COPII receptor activity Source: GO_Central
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- positive regulation of apoptotic process Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q6UWH6 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein TEX261 |
Gene namesi | Name:TEX261 ORF Names:UNQ1882/PRO4325 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30712, TEX261 |
MIMi | 618562, gene |
neXtProti | NX_Q6UWH6 |
VEuPathDBi | HostDB:ENSG00000144043.11 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- integral component of endoplasmic reticulum membrane Source: GO_Central
Golgi apparatus
- integral component of Golgi membrane Source: GO_Central
Other locations
- COPII-coated ER to Golgi transport vesicle Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 3 – 23 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 42 – 62 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 70 – 90 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 97 – 117 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 125 – 145 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000144043 |
PharmGKBi | PA134885680 |
Miscellaneous databases
Pharosi | Q6UWH6, Tdark |
Genetic variation databases
BioMutai | TEX261 |
DMDMi | 74749387 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247433 | 1 – 196 | Protein TEX261Add BLAST | 196 |
Proteomic databases
MassIVEi | Q6UWH6 |
PaxDbi | Q6UWH6 |
PeptideAtlasi | Q6UWH6 |
PRIDEi | Q6UWH6 |
ProteomicsDBi | 67481 |
PTM databases
iPTMneti | Q6UWH6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000144043, Expressed in testis and 244 other tissues |
ExpressionAtlasi | Q6UWH6, baseline and differential |
Genevisiblei | Q6UWH6, HS |
Organism-specific databases
HPAi | ENSG00000144043, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 125244, 1 interactor |
IntActi | Q6UWH6, 1 interactor |
STRINGi | 9606.ENSP00000272438 |
Miscellaneous databases
RNActi | Q6UWH6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the SVP26 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4136, Eukaryota |
GeneTreei | ENSGT00390000010888 |
HOGENOMi | CLU_058268_2_0_1 |
InParanoidi | Q6UWH6 |
OMAi | FEDLPWS |
OrthoDBi | 1338610at2759 |
PhylomeDBi | Q6UWH6 |
TreeFami | TF324741 |
Family and domain databases
InterProi | View protein in InterPro IPR007277, Svp26/Tex261 |
PANTHERi | PTHR13144, PTHR13144, 1 hit |
Pfami | View protein in Pfam PF04148, Erv26, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6UWH6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWFMYLLSWL SLFIQVAFIT LAVAAGLYYL AELIEEYTVA TSRIIKYMIW
60 70 80 90 100
FSTAVLIGLY VFERFPTSMI GVGLFTNLVY FGLLQTFPFI MLTSPNFILS
110 120 130 140 150
CGLVVVNHYL AFQFFAEEYY PFSEVLAYFT FCLWIIPFAF FVSLSAGENV
160 170 180 190
LPSTMQPGDD VVSNYFTKGK RGKRLGILVV FSFIKEAILP SRQKIY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WAR8 | F8WAR8_HUMAN | Protein TEX261 | TEX261 | 51 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358783 mRNA Translation: AAQ89143.1 CH471053 Genomic DNA Translation: EAW99783.1 CH471053 Genomic DNA Translation: EAW99785.1 BC020251 mRNA Translation: AAH20251.2 BC128461 mRNA Translation: AAI28462.1 BC128462 mRNA Translation: AAI28463.1 |
CCDSi | CCDS1914.1 |
RefSeqi | NP_653183.2, NM_144582.2 |
Genome annotation databases
Ensembli | ENST00000272438; ENSP00000272438; ENSG00000144043 |
GeneIDi | 113419 |
KEGGi | hsa:113419 |
UCSCi | uc002shn.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358783 mRNA Translation: AAQ89143.1 CH471053 Genomic DNA Translation: EAW99783.1 CH471053 Genomic DNA Translation: EAW99785.1 BC020251 mRNA Translation: AAH20251.2 BC128461 mRNA Translation: AAI28462.1 BC128462 mRNA Translation: AAI28463.1 |
CCDSi | CCDS1914.1 |
RefSeqi | NP_653183.2, NM_144582.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125244, 1 interactor |
IntActi | Q6UWH6, 1 interactor |
STRINGi | 9606.ENSP00000272438 |
PTM databases
iPTMneti | Q6UWH6 |
Genetic variation databases
BioMutai | TEX261 |
DMDMi | 74749387 |
Proteomic databases
MassIVEi | Q6UWH6 |
PaxDbi | Q6UWH6 |
PeptideAtlasi | Q6UWH6 |
PRIDEi | Q6UWH6 |
ProteomicsDBi | 67481 |
Protocols and materials databases
Antibodypediai | 16398, 73 antibodies |
DNASUi | 113419 |
Genome annotation databases
Ensembli | ENST00000272438; ENSP00000272438; ENSG00000144043 |
GeneIDi | 113419 |
KEGGi | hsa:113419 |
UCSCi | uc002shn.4, human |
Organism-specific databases
CTDi | 113419 |
GeneCardsi | TEX261 |
HGNCi | HGNC:30712, TEX261 |
HPAi | ENSG00000144043, Low tissue specificity |
MIMi | 618562, gene |
neXtProti | NX_Q6UWH6 |
OpenTargetsi | ENSG00000144043 |
PharmGKBi | PA134885680 |
VEuPathDBi | HostDB:ENSG00000144043.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4136, Eukaryota |
GeneTreei | ENSGT00390000010888 |
HOGENOMi | CLU_058268_2_0_1 |
InParanoidi | Q6UWH6 |
OMAi | FEDLPWS |
OrthoDBi | 1338610at2759 |
PhylomeDBi | Q6UWH6 |
TreeFami | TF324741 |
Enzyme and pathway databases
PathwayCommonsi | Q6UWH6 |
Miscellaneous databases
BioGRID-ORCSi | 113419, 3 hits in 862 CRISPR screens |
ChiTaRSi | TEX261, human |
GenomeRNAii | 113419 |
Pharosi | Q6UWH6, Tdark |
PROi | PR:Q6UWH6 |
RNActi | Q6UWH6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144043, Expressed in testis and 244 other tissues |
ExpressionAtlasi | Q6UWH6, baseline and differential |
Genevisiblei | Q6UWH6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007277, Svp26/Tex261 |
PANTHERi | PTHR13144, PTHR13144, 1 hit |
Pfami | View protein in Pfam PF04148, Erv26, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TX261_HUMAN | |
Accessioni | Q6UWH6Primary (citable) accession number: Q6UWH6 Secondary accession number(s): A1A587, D6W5G9, Q8WUJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM