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Protein

Colipase-like protein 2

Gene

CLPSL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase-like protein 2
Gene namesi
Name:CLPSL2
Synonyms:C6orf126
ORF Names:UNQ3045/PRO9861
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000196748.9
HGNCiHGNC:21250 CLPSL2
neXtProtiNX_Q6UWE3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196748
PharmGKBiPA134977993

Polymorphism and mutation databases

DMDMi212276514

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000002260822 – 100Colipase-like protein 2Add BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 45PROSITE-ProRule annotation
Disulfide bondi40 ↔ 56PROSITE-ProRule annotation
Disulfide bondi44 ↔ 78PROSITE-ProRule annotation
Disulfide bondi66 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 97PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6UWE3
PeptideAtlasiQ6UWE3
PRIDEiQ6UWE3
ProteomicsDBi67468
67469 [Q6UWE3-2]
TopDownProteomicsiQ6UWE3-2 [Q6UWE3-2]

PTM databases

iPTMnetiQ6UWE3
PhosphoSitePlusiQ6UWE3

Expressioni

Gene expression databases

BgeeiENSG00000196748 Expressed in 44 organ(s), highest expression level in testis
CleanExiHS_C6orf126

Organism-specific databases

HPAiHPA043460
HPA051655

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN2Q9UHD94EBI-12183429,EBI-947187

Protein-protein interaction databases

IntActiQ6UWE3, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ6UWE3
SMRiQ6UWE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFYG Eukaryota
ENOG411160Z LUCA
GeneTreeiENSGT00390000011494
HOGENOMiHOG000111565
InParanoidiQ6UWE3
OMAiMICLPQW
OrthoDBiEOG091G0Z2E
PhylomeDBiQ6UWE3
TreeFamiTF343049

Family and domain databases

InterProiView protein in InterPro
IPR001981 Colipase
PANTHERiPTHR10041 PTHR10041, 1 hit
PfamiView protein in Pfam
PF15083 Colipase-like, 1 hit
PROSITEiView protein in PROSITE
PS51342 COLIPASE_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6UWE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAALALVAG VLSGAVLPLW SALPQYKKKI TDRCFHHSEC YSGCCLMDLD
60 70 80 90 100
SGGAFCAPRA RITMICLPQT KGATNIICPC RMGLTCISKD LMCSRRCHMI
Length:100
Mass (Da):10,812
Last modified:November 4, 2008 - v3
Checksum:i2458FFEA1F48C563
GO
Isoform 2 (identifier: Q6UWE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-100: TKGATNIICPCRMGLTCISKDLMCSRRCHMI → WLELFKGRDR...LPPTCSKSSS

Show »
Length:153
Mass (Da):16,885
Checksum:i0DCCCAE292DA2852
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q6UWE3-2)
Sequence conflicti79R → C in AAQ89182 (PubMed:12975309).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03562170 – 100TKGAT…RCHMI → WLELFKGRDRIIFIYEAPTP SLVSAHNQGSYQHHLPLPDG LDVHIQGLDVFPPVPYDLEE DAGWSLLPWGHRPWLPPTCS KSSS in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358823 mRNA Translation: AAQ89182.1
AL157823 Genomic DNA No translation available.
CCDSiCCDS4810.2 [Q6UWE3-1]
CCDS69095.1 [Q6UWE3-2]
RefSeqiNP_001273479.1, NM_001286550.1 [Q6UWE3-2]
NP_997292.2, NM_207409.3 [Q6UWE3-1]
UniGeneiHs.259563

Genome annotation databases

EnsembliENST00000360454; ENSP00000353639; ENSG00000196748 [Q6UWE3-2]
ENST00000403376; ENSP00000385898; ENSG00000196748 [Q6UWE3-1]
GeneIDi389383
KEGGihsa:389383
UCSCiuc003olc.3 human [Q6UWE3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358823 mRNA Translation: AAQ89182.1
AL157823 Genomic DNA No translation available.
CCDSiCCDS4810.2 [Q6UWE3-1]
CCDS69095.1 [Q6UWE3-2]
RefSeqiNP_001273479.1, NM_001286550.1 [Q6UWE3-2]
NP_997292.2, NM_207409.3 [Q6UWE3-1]
UniGeneiHs.259563

3D structure databases

ProteinModelPortaliQ6UWE3
SMRiQ6UWE3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6UWE3, 1 interactor

PTM databases

iPTMnetiQ6UWE3
PhosphoSitePlusiQ6UWE3

Polymorphism and mutation databases

DMDMi212276514

Proteomic databases

PaxDbiQ6UWE3
PeptideAtlasiQ6UWE3
PRIDEiQ6UWE3
ProteomicsDBi67468
67469 [Q6UWE3-2]
TopDownProteomicsiQ6UWE3-2 [Q6UWE3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360454; ENSP00000353639; ENSG00000196748 [Q6UWE3-2]
ENST00000403376; ENSP00000385898; ENSG00000196748 [Q6UWE3-1]
GeneIDi389383
KEGGihsa:389383
UCSCiuc003olc.3 human [Q6UWE3-1]

Organism-specific databases

CTDi389383
EuPathDBiHostDB:ENSG00000196748.9
GeneCardsiCLPSL2
H-InvDBiHIX0032864
HGNCiHGNC:21250 CLPSL2
HPAiHPA043460
HPA051655
neXtProtiNX_Q6UWE3
OpenTargetsiENSG00000196748
PharmGKBiPA134977993
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JFYG Eukaryota
ENOG411160Z LUCA
GeneTreeiENSGT00390000011494
HOGENOMiHOG000111565
InParanoidiQ6UWE3
OMAiMICLPQW
OrthoDBiEOG091G0Z2E
PhylomeDBiQ6UWE3
TreeFamiTF343049

Miscellaneous databases

GenomeRNAii389383
PROiPR:Q6UWE3

Gene expression databases

BgeeiENSG00000196748 Expressed in 44 organ(s), highest expression level in testis
CleanExiHS_C6orf126

Family and domain databases

InterProiView protein in InterPro
IPR001981 Colipase
PANTHERiPTHR10041 PTHR10041, 1 hit
PfamiView protein in Pfam
PF15083 Colipase-like, 1 hit
PROSITEiView protein in PROSITE
PS51342 COLIPASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOLL2_HUMAN
AccessioniPrimary (citable) accession number: Q6UWE3
Secondary accession number(s): B0QZ45, Q5T9G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 4, 2008
Last modified: September 12, 2018
This is version 97 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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