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UniProtKB - Q6UWD8 (CP054_HUMAN)
Protein
Transmembrane protein C16orf54
Gene
C16orf54
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein C16orf54 |
Gene namesi | Name:C16orf54 ORF Names:UNQ9389/PRO34280 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26649, C16orf54 |
neXtProti | NX_Q6UWD8 |
VEuPathDBi | HostDB:ENSG00000185905 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 32 – 52 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000185905 |
PharmGKBi | PA142672261 |
Miscellaneous databases
Pharosi | Q6UWD8, Tdark |
Genetic variation databases
BioMutai | C16orf54 |
DMDMi | 74738078 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000279442 | 1 – 224 | Transmembrane protein C16orf54Add BLAST | 224 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Modified residuei | 112 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 116 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 194 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
O-glycosylated with core 1 or possibly core 8 glycans.1 Publication
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
CPTACi | CPTAC-959 |
jPOSTi | Q6UWD8 |
MassIVEi | Q6UWD8 |
PaxDbi | Q6UWD8 |
PeptideAtlasi | Q6UWD8 |
PRIDEi | Q6UWD8 |
ProteomicsDBi | 67464 |
PTM databases
GlyConnecti | 783, 2 O-Linked glycans (1 site) |
GlyGeni | Q6UWD8, 1 site, 3 O-linked glycans (1 site) |
iPTMneti | Q6UWD8 |
PhosphoSitePlusi | Q6UWD8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000185905, Expressed in blood and 140 other tissues |
Genevisiblei | Q6UWD8, HS |
Organism-specific databases
HPAi | ENSG00000185905, Group enriched (bone marrow, lymphoid tissue) |
Interactioni
Binary interactionsi
Q6UWD8
Protein-protein interaction databases
BioGRIDi | 129700, 14 interactors |
IntActi | Q6UWD8, 12 interactors |
STRINGi | 9606.ENSP00000327506 |
Miscellaneous databases
RNActi | Q6UWD8, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q6UWD8 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 104 – 138 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 152 – 203 | DisorderedSequence analysisAdd BLAST | 52 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SP19, Eukaryota |
GeneTreei | ENSGT00390000014957 |
HOGENOMi | CLU_1224436_0_0_1 |
InParanoidi | Q6UWD8 |
OMAi | PEWGLQP |
OrthoDBi | 1417661at2759 |
PhylomeDBi | Q6UWD8 |
TreeFami | TF337660 |
Family and domain databases
InterProi | View protein in InterPro IPR031499, DUF4689 |
PANTHERi | PTHR36134, PTHR36134, 1 hit |
Pfami | View protein in Pfam PF15755, DUF4689, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6UWD8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLTPEPPSG RVEGPPAWEA APWPSLPCGP CIPIMLVLAT LAALFILTTA
60 70 80 90 100
VLAERLFRRA LRPDPSHRAP TLVWRPGGEL WIEPMGTARE RSEDWYGSAV
110 120 130 140 150
PLLTDRAPEP PTQVGTLEAR ATAPPAPSAP NSAPSNLGPQ TVLEVPARST
160 170 180 190 200
FWGPQPWEGR PPATGLVSWA EPEQRPEASV QFGSPQARRQ RPGSPDPEWG
210 220
LQPRVTLEQI SAFWKREGRT SVGF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 215 | K → E in BAC04015 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358833 mRNA Translation: AAQ89192.1 AK093000 mRNA Translation: BAC04015.1 CH471238 Genomic DNA Translation: EAW80012.1 BC104466 mRNA Translation: AAI04467.1 BC104467 mRNA Translation: AAI04468.1 |
CCDSi | CCDS10652.1 |
RefSeqi | NP_787096.2, NM_175900.3 XP_011506896.1, XM_011508594.2 |
Genome annotation databases
Ensembli | ENST00000329410.4; ENSP00000327506.3; ENSG00000185905.4 |
GeneIDi | 283897 |
KEGGi | hsa:283897 |
MANE-Selecti | ENST00000329410.4; ENSP00000327506.3; NM_175900.4; NP_787096.2 |
UCSCi | uc002dtp.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358833 mRNA Translation: AAQ89192.1 AK093000 mRNA Translation: BAC04015.1 CH471238 Genomic DNA Translation: EAW80012.1 BC104466 mRNA Translation: AAI04467.1 BC104467 mRNA Translation: AAI04468.1 |
CCDSi | CCDS10652.1 |
RefSeqi | NP_787096.2, NM_175900.3 XP_011506896.1, XM_011508594.2 |
3D structure databases
AlphaFoldDBi | Q6UWD8 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 129700, 14 interactors |
IntActi | Q6UWD8, 12 interactors |
STRINGi | 9606.ENSP00000327506 |
PTM databases
GlyConnecti | 783, 2 O-Linked glycans (1 site) |
GlyGeni | Q6UWD8, 1 site, 3 O-linked glycans (1 site) |
iPTMneti | Q6UWD8 |
PhosphoSitePlusi | Q6UWD8 |
Genetic variation databases
BioMutai | C16orf54 |
DMDMi | 74738078 |
Proteomic databases
CPTACi | CPTAC-959 |
jPOSTi | Q6UWD8 |
MassIVEi | Q6UWD8 |
PaxDbi | Q6UWD8 |
PeptideAtlasi | Q6UWD8 |
PRIDEi | Q6UWD8 |
ProteomicsDBi | 67464 |
Protocols and materials databases
Antibodypediai | 54098, 54 antibodies from 13 providers |
DNASUi | 283897 |
Genome annotation databases
Ensembli | ENST00000329410.4; ENSP00000327506.3; ENSG00000185905.4 |
GeneIDi | 283897 |
KEGGi | hsa:283897 |
MANE-Selecti | ENST00000329410.4; ENSP00000327506.3; NM_175900.4; NP_787096.2 |
UCSCi | uc002dtp.3, human |
Organism-specific databases
CTDi | 283897 |
GeneCardsi | C16orf54 |
HGNCi | HGNC:26649, C16orf54 |
HPAi | ENSG00000185905, Group enriched (bone marrow, lymphoid tissue) |
neXtProti | NX_Q6UWD8 |
OpenTargetsi | ENSG00000185905 |
PharmGKBi | PA142672261 |
VEuPathDBi | HostDB:ENSG00000185905 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SP19, Eukaryota |
GeneTreei | ENSGT00390000014957 |
HOGENOMi | CLU_1224436_0_0_1 |
InParanoidi | Q6UWD8 |
OMAi | PEWGLQP |
OrthoDBi | 1417661at2759 |
PhylomeDBi | Q6UWD8 |
TreeFami | TF337660 |
Enzyme and pathway databases
PathwayCommonsi | Q6UWD8 |
SignaLinki | Q6UWD8 |
Miscellaneous databases
BioGRID-ORCSi | 283897, 14 hits in 1055 CRISPR screens |
Pharosi | Q6UWD8, Tdark |
PROi | PR:Q6UWD8 |
RNActi | Q6UWD8, protein |
Gene expression databases
Bgeei | ENSG00000185905, Expressed in blood and 140 other tissues |
Genevisiblei | Q6UWD8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031499, DUF4689 |
PANTHERi | PTHR36134, PTHR36134, 1 hit |
Pfami | View protein in Pfam PF15755, DUF4689, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP054_HUMAN | |
Accessioni | Q6UWD8Primary (citable) accession number: Q6UWD8 Secondary accession number(s): A6NJR6, Q8NAB0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM