C16orf54

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein C16orf54
Gene namesⁱ	Name:C16orf54 ORF Names:UNQ9389/PRO34280
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000185905.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26649 C16orf54
neXtProtⁱ	NX_Q6UWD8

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	32 – 52	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000185905
PharmGKBⁱ	PA142672261

Polymorphism and mutation databases

BioMutaⁱ	C16orf54
DMDMⁱ	74738078

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000279442	1 – 224	Transmembrane protein C16orf54Add BLAST		224

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	4	O-linked (GalNAc...) threonine1 Publication	1
Modified residueⁱ	112	PhosphothreonineBy similarity	1
Modified residueⁱ	116	PhosphothreonineBy similarity	1
Modified residueⁱ	194	PhosphoserineBy similarity	1

Post-translational modificationⁱ

O-glycosylated with core 1 or possibly core 8 glycans.1 Publication

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q6UWD8
PeptideAtlas More...PeptideAtlasⁱ	Q6UWD8
PRIDEⁱ	Q6UWD8
ProteomicsDBⁱ	67464

PTM databases

GlyConnectⁱ	783
iPTMnetⁱ	Q6UWD8
PhosphoSitePlusⁱ	Q6UWD8
UniCarbKBⁱ	Q6UWD8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000185905 Expressed in 124 organ(s), highest expression level in blood
CleanExⁱ	HS_C16orf54
Genevisibleⁱ	Q6UWD8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA060546

HPAⁱ

HPA060546

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	129700, 4 interactors
IntActⁱ	Q6UWD8, 6 interactors
STRINGⁱ	9606.ENSP00000327506

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6UWD8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IPJ8 Eukaryota ENOG41115SA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014957
HOGENOMⁱ	HOG000111899
HOVERGENⁱ	HBG081314
InParanoidⁱ	Q6UWD8
OMAⁱ	PEWGLQP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0SQ2
PhylomeDBⁱ	Q6UWD8
TreeFamⁱ	TF337660

Family and domain databases

InterProⁱ	View protein in InterPro IPR031499 DUF4689
PANTHERⁱ	PTHR36134 PTHR36134, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15755 DUF4689, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6UWD8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPLTPEPPSG RVEGPPAWEA APWPSLPCGP CIPIMLVLAT LAALFILTTA 
        60         70         80         90        100
VLAERLFRRA LRPDPSHRAP TLVWRPGGEL WIEPMGTARE RSEDWYGSAV 
       110        120        130        140        150
PLLTDRAPEP PTQVGTLEAR ATAPPAPSAP NSAPSNLGPQ TVLEVPARST 
       160        170        180        190        200
FWGPQPWEGR PPATGLVSWA EPEQRPEASV QFGSPQARRQ RPGSPDPEWG 
       210        220 
LQPRVTLEQI SAFWKREGRT SVGF

Length:224

Mass (Da):24,360

Last modified:July 5, 2004 - v1

Checksum:ⁱF3556BF216B1044B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	215	K → E in BAC04015 (PubMed:14702039).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358833 mRNA Translation: AAQ89192.1 AK093000 mRNA Translation: BAC04015.1 CH471238 Genomic DNA Translation: EAW80012.1 BC104466 mRNA Translation: AAI04467.1 BC104467 mRNA Translation: AAI04468.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10652.1
NCBI Reference Sequences More...RefSeqⁱ	NP_787096.2, NM_175900.3 XP_011506896.1, XM_011508594.2
UniGeneⁱ	Hs.331095

Genome annotation databases

Ensemblⁱ	ENST00000329410; ENSP00000327506; ENSG00000185905
GeneIDⁱ	283897
KEGGⁱ	hsa:105369277 hsa:283897
UCSC genome browser More...UCSCⁱ	uc002dtp.3 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6UWD8	C16orf54 isoform 1		PANTR		224	UniRef90_Q6UWD8
C16orf54 isoform 1		PONAB		224
Chromosome 16 open reading frame 54		MACMU		224
Uncharacterized protein		MACFA		224
Chromosome 16 open reading frame 54		MACNE		224
+12

Protein	Similar proteins		Species	Score	Length	Source
Q6UWD8	Transmembrane protein C16orf54 homolog		RAT		225	UniRef50_Q6UWD8
Transmembrane protein C16orf54 homolog		MOUSE		225
Transmembrane protein C16orf54		MACMU		224
Uncharacterized protein		MACFA		224
Chromosome 16 open reading frame 54		MACNE		224
+91

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358833 mRNA Translation: AAQ89192.1 AK093000 mRNA Translation: BAC04015.1 CH471238 Genomic DNA Translation: EAW80012.1 BC104466 mRNA Translation: AAI04467.1 BC104467 mRNA Translation: AAI04468.1
CCDSⁱ	CCDS10652.1
RefSeqⁱ	NP_787096.2, NM_175900.3 XP_011506896.1, XM_011508594.2
UniGeneⁱ	Hs.331095

3D structure databases

ProteinModelPortalⁱ	Q6UWD8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129700, 4 interactors
IntActⁱ	Q6UWD8, 6 interactors
STRINGⁱ	9606.ENSP00000327506

PTM databases

GlyConnectⁱ	783
iPTMnetⁱ	Q6UWD8
PhosphoSitePlusⁱ	Q6UWD8
UniCarbKBⁱ	Q6UWD8

Polymorphism and mutation databases

BioMutaⁱ	C16orf54
DMDMⁱ	74738078

Proteomic databases

PaxDbⁱ	Q6UWD8
PeptideAtlasⁱ	Q6UWD8
PRIDEⁱ	Q6UWD8
ProteomicsDBⁱ	67464

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000329410; ENSP00000327506; ENSG00000185905
GeneIDⁱ	283897
KEGGⁱ	hsa:105369277 hsa:283897
UCSCⁱ	uc002dtp.3 human

Organism-specific databases

CTDⁱ	283897
EuPathDBⁱ	HostDB:ENSG00000185905.3
GeneCardsⁱ	C16orf54
H-InvDBⁱ	HIX0020232
HGNCⁱ	HGNC:26649 C16orf54
HPAⁱ	HPA060546
neXtProtⁱ	NX_Q6UWD8
OpenTargetsⁱ	ENSG00000185905
PharmGKBⁱ	PA142672261
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IPJ8 Eukaryota ENOG41115SA LUCA
GeneTreeⁱ	ENSGT00390000014957
HOGENOMⁱ	HOG000111899
HOVERGENⁱ	HBG081314
InParanoidⁱ	Q6UWD8
OMAⁱ	PEWGLQP
OrthoDBⁱ	EOG091G0SQ2
PhylomeDBⁱ	Q6UWD8
TreeFamⁱ	TF337660

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6UWD8

PROⁱ

PR:Q6UWD8

Gene expression databases

Bgeeⁱ	ENSG00000185905 Expressed in 124 organ(s), highest expression level in blood
CleanExⁱ	HS_C16orf54
Genevisibleⁱ	Q6UWD8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR031499 DUF4689
PANTHERⁱ	PTHR36134 PTHR36134, 1 hit
Pfamⁱ	View protein in Pfam PF15755 DUF4689, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP054_HUMAN
Accessionⁱ	Q6UWD8Primary (citable) accession number: Q6UWD8 Secondary accession number(s): A6NJR6, Q8NAB0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
	Last sequence update:	July 5, 2004
	Last modified:	September 12, 2018
	This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6UWD8 (CP054_HUMAN)

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Transmembrane protein C16orf54

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ