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Protein

Serine protease 55

Gene

PRSS55

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable serine protease.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108Charge relay systemBy similarity1
Active sitei156Charge relay systemBy similarity1
Active sitei250Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.299

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 55 (EC:3.4.21.-)
Alternative name(s):
Testis serine protease 1
Short name:
T-SP1
Gene namesi
Name:PRSS55
Synonyms:TSP1
ORF Names:UNQ9391/PRO34284
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000184647.10
HGNCiHGNC:30824 PRSS55
MIMi615144 gene
neXtProtiNX_Q6UWB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini68 – 326ExtracellularSequence analysisAdd BLAST259
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 352CytoplasmicSequence analysis5

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi203074
OpenTargetsiENSG00000184647
PharmGKBiPA165585933

Polymorphism and mutation databases

BioMutaiPRSS55
DMDMi296453030

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000042364319 – 67Activation propeptideBy similarityAdd BLAST49
ChainiPRO_000032881568 – 352Serine protease 55Add BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi93 ↔ 109PROSITE-ProRule annotation
Disulfide bondi189 ↔ 256PROSITE-ProRule annotation
Disulfide bondi222 ↔ 235PROSITE-ProRule annotation
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi246 ↔ 276PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UWB4
PeptideAtlasiQ6UWB4
PRIDEiQ6UWB4
ProteomicsDBi67463

Expressioni

Tissue specificityi

Only detected in testis. Expressed in spermatogonia, spermatocytes, spermatids, Leydig and Sertoli cells. Expressed in prostate cancer and ovarian cancer (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000184647 Expressed in 30 organ(s), highest expression level in right testis
ExpressionAtlasiQ6UWB4 baseline and differential
GenevisibleiQ6UWB4 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333003

Structurei

3D structure databases

ProteinModelPortaliQ6UWB4
SMRiQ6UWB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 300Peptidase S1PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00770000120569
HOGENOMiHOG000251820
HOVERGENiHBG078102
InParanoidiQ6UWB4
OMAiVNYNLWI
OrthoDBiEOG091G0AH5
PhylomeDBiQ6UWB4
TreeFamiTF338267

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UWB4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLFSVLLLL SLVTGTQLGP RTPLPEAGVA ILGRARGAHR PQPPHPPSPV
60 70 80 90 100
SECGDRSIFE GRTRYSRITG GMEAEVGEFP WQVSIQARSE PFCGGSILNK
110 120 130 140 150
WWILTAAHCL YSEELFPEEL SVVLGTNDLT SPSMEIKEVA SIILHKDFKR
160 170 180 190 200
ANMDNDIALL LLASPIKLDD LKVPICLPTQ PGPATWRECW VAGWGQTNAA
210 220 230 240 250
DKNSVKTDLM KAPMVIMDWE ECSKMFPKLT KNMLCAGYKN ESYDACKGDS
260 270 280 290 300
GGPLVCTPEP GEKWYQVGII SWGKSCGEKN TPGIYTSLVN YNLWIEKVTQ
310 320 330 340 350
LEGRPFNAEK RRTSVKQKPM GSPVSGVPEP GSPRSWLLLC PLSHVLFRAI

LY
Length:352
Mass (Da):38,856
Last modified:May 18, 2010 - v2
Checksum:i0DBDFC385D5413A4
GO
Isoform 2 (identifier: Q6UWB4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-352: GDSGGPLVCT...SHVLFRAILY → QSYFPTLQRMNTGSSQTKPPGSHTFHLQN

Show »
Length:276
Mass (Da):30,559
Checksum:i67146392FCFD41CA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBF5H0YBF5_HUMAN
Serine protease 55
PRSS55
182Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15G → R in BC033497 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04252544P → R1 PublicationCorresponds to variant dbSNP:rs4521726Ensembl.1
Natural variantiVAR_042526212A → V1 PublicationCorresponds to variant dbSNP:rs4406360Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044557248 – 352GDSGG…RAILY → QSYFPTLQRMNTGSSQTKPP GSHTFHLQN in isoform 2. 2 PublicationsAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358867 mRNA Translation: AAQ89226.1
AC104964 Genomic DNA No translation available.
BC033497 mRNA No translation available.
CCDSiCCDS56523.1 [Q6UWB4-2]
CCDS5976.1 [Q6UWB4-1]
RefSeqiNP_001183949.1, NM_001197020.1 [Q6UWB4-2]
NP_940866.2, NM_198464.3 [Q6UWB4-1]
UniGeneiHs.591394

Genome annotation databases

EnsembliENST00000328655; ENSP00000333003; ENSG00000184647 [Q6UWB4-1]
ENST00000522210; ENSP00000430459; ENSG00000184647 [Q6UWB4-2]
GeneIDi203074
KEGGihsa:203074
UCSCiuc003wta.4 human [Q6UWB4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358867 mRNA Translation: AAQ89226.1
AC104964 Genomic DNA No translation available.
BC033497 mRNA No translation available.
CCDSiCCDS56523.1 [Q6UWB4-2]
CCDS5976.1 [Q6UWB4-1]
RefSeqiNP_001183949.1, NM_001197020.1 [Q6UWB4-2]
NP_940866.2, NM_198464.3 [Q6UWB4-1]
UniGeneiHs.591394

3D structure databases

ProteinModelPortaliQ6UWB4
SMRiQ6UWB4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333003

Protein family/group databases

MEROPSiS01.299

Polymorphism and mutation databases

BioMutaiPRSS55
DMDMi296453030

Proteomic databases

PaxDbiQ6UWB4
PeptideAtlasiQ6UWB4
PRIDEiQ6UWB4
ProteomicsDBi67463

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328655; ENSP00000333003; ENSG00000184647 [Q6UWB4-1]
ENST00000522210; ENSP00000430459; ENSG00000184647 [Q6UWB4-2]
GeneIDi203074
KEGGihsa:203074
UCSCiuc003wta.4 human [Q6UWB4-1]

Organism-specific databases

CTDi203074
DisGeNETi203074
EuPathDBiHostDB:ENSG00000184647.10
GeneCardsiPRSS55
H-InvDBiHIX0034319
HGNCiHGNC:30824 PRSS55
MIMi615144 gene
neXtProtiNX_Q6UWB4
OpenTargetsiENSG00000184647
PharmGKBiPA165585933
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00770000120569
HOGENOMiHOG000251820
HOVERGENiHBG078102
InParanoidiQ6UWB4
OMAiVNYNLWI
OrthoDBiEOG091G0AH5
PhylomeDBiQ6UWB4
TreeFamiTF338267

Miscellaneous databases

GenomeRNAii203074
PROiPR:Q6UWB4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184647 Expressed in 30 organ(s), highest expression level in right testis
ExpressionAtlasiQ6UWB4 baseline and differential
GenevisibleiQ6UWB4 HS

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRS55_HUMAN
AccessioniPrimary (citable) accession number: Q6UWB4
Secondary accession number(s): E5RJX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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