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Protein

Interleukin-27 receptor subunit alpha

Gene

IL27RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.1 Publication

GO - Molecular functioni

  • interleukin-27 receptor activity Source: Ensembl
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-8984722 Interleukin-35 Signalling
R-HSA-9020956 Interleukin-27 signaling
SignaLinkiQ6UWB1
SIGNORiQ6UWB1

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-27 receptor subunit alpha
Short name:
IL-27 receptor subunit alpha
Short name:
IL-27R subunit alpha
Short name:
IL-27R-alpha
Short name:
IL-27RA
Alternative name(s):
Cytokine receptor WSX-1
Cytokine receptor-like 1
Type I T-cell cytokine receptor
Short name:
TCCR
ZcytoR1
Gene namesi
Name:IL27RA
Synonyms:CRL1, TCCR, WSX1
ORF Names:UNQ296/PRO336
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104998.3
HGNCiHGNC:17290 IL27RA
MIMi605350 gene
neXtProtiNX_Q6UWB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 516ExtracellularSequence analysisAdd BLAST484
Transmembranei517 – 537HelicalSequence analysisAdd BLAST21
Topological domaini538 – 636CytoplasmicSequence analysisAdd BLAST99

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9466
OpenTargetsiENSG00000104998
PharmGKBiPA134891276

Polymorphism and mutation databases

BioMutaiIL27RA
DMDMi116242518

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000001087633 – 636Interleukin-27 receptor subunit alphaAdd BLAST604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi467N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6UWB1
MaxQBiQ6UWB1
PaxDbiQ6UWB1
PeptideAtlasiQ6UWB1
PRIDEiQ6UWB1
ProteomicsDBi67462

PTM databases

iPTMnetiQ6UWB1
PhosphoSitePlusiQ6UWB1

Expressioni

Tissue specificityi

Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes.2 Publications

Gene expression databases

BgeeiENSG00000104998
CleanExiHS_IL27RA
GenevisibleiQ6UWB1 HS

Interactioni

Protein-protein interaction databases

BioGridi114852, 35 interactors
IntActiQ6UWB1, 6 interactors
STRINGi9606.ENSP00000263379

Structurei

3D structure databases

ProteinModelPortaliQ6UWB1
SMRiQ6UWB1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 231Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST101
Domaini322 – 417Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini419 – 511Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST93

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi217 – 221WSXWS motif5
Motifi554 – 562Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK7Q Eukaryota
ENOG411182T LUCA
GeneTreeiENSGT00700000104610
HOGENOMiHOG000036880
HOVERGENiHBG052068
InParanoidiQ6UWB1
KOiK19598
OMAiPCELWVT
OrthoDBiEOG091G0BPO
PhylomeDBiQ6UWB1
TreeFamiTF338122

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UWB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGGRGAPFW LWPLPKLALL PLLWVLFQRT RPQGSAGPLQ CYGVGPLGDL
60 70 80 90 100
NCSWEPLGDL GAPSELHLQS QKYRSNKTQT VAVAAGRSWV AIPREQLTMS
110 120 130 140 150
DKLLVWGTKA GQPLWPPVFV NLETQMKPNA PRLGPDVDFS EDDPLEATVH
160 170 180 190 200
WAPPTWPSHK VLICQFHYRR CQEAAWTLLE PELKTIPLTP VEIQDLELAT
210 220 230 240 250
GYKVYGRCRM EKEEDLWGEW SPILSFQTPP SAPKDVWVSG NLCGTPGGEE
260 270 280 290 300
PLLLWKAPGP CVQVSYKVWF WVGGRELSPE GITCCCSLIP SGAEWARVSA
310 320 330 340 350
VNATSWEPLT NLSLVCLDSA SAPRSVAVSS IAGSTELLVT WQPGPGEPLE
360 370 380 390 400
HVVDWARDGD PLEKLNWVRL PPGNLSALLP GNFTVGVPYR ITVTAVSASG
410 420 430 440 450
LASASSVWGF REELAPLVGP TLWRLQDAPP GTPAIAWGEV PRHQLRGHLT
460 470 480 490 500
HYTLCAQSGT SPSVCMNVSG NTQSVTLPDL PWGPCELWVT ASTIAGQGPP
510 520 530 540 550
GPILRLHLPD NTLRWKVLPG ILFLWGLFLL GCGLSLATSG RCYHLRHKVL
560 570 580 590 600
PRWVWEKVPD PANSSSGQPH MEQVPEAQPL GDLPILEVEE MEPPPVMESS
610 620 630
QPAQATAPLD SGYEKHFLPT PEELGLLGPP RPQVLA
Length:636
Mass (Da):69,474
Last modified:October 17, 2006 - v2
Checksum:iDC7DAAABA643CE97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7A → G in AAG27297 (PubMed:11057672).Curated1
Sequence conflicti7A → G in AAQ89235 (PubMed:12975309).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053004 mRNA Translation: AAC39755.1
AF106912 mRNA Translation: AAG26090.1
AF265242 mRNA Translation: AAG27297.1
EF064719 Genomic DNA Translation: ABK41902.1
AY358876 mRNA Translation: AAQ89235.1
BC028003 mRNA Translation: AAH28003.1
CCDSiCCDS12303.1
PIRiJW0047
RefSeqiNP_004834.1, NM_004843.3
UniGeneiHs.132781
Hs.352155

Genome annotation databases

EnsembliENST00000263379; ENSP00000263379; ENSG00000104998
GeneIDi9466
KEGGihsa:9466
UCSCiuc002mxx.5 human

Similar proteinsi

Entry informationi

Entry nameiI27RA_HUMAN
AccessioniPrimary (citable) accession number: Q6UWB1
Secondary accession number(s): A0N0L1, O60624
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 17, 2006
Last modified: July 18, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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